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The map label for this gene is cpdB [H]

Identifier: 218930544

GI number: 218930544

Start: 3941938

End: 3943908

Strand: Direct

Name: cpdB [H]

Synonym: YPO3530

Alternate gene names: 218930544

Gene position: 3941938-3943908 (Clockwise)

Preceding gene: 218930542

Following gene: 218930545

Centisome position: 84.7

GC content: 48.4

Gene sequence:

>1971_bases
ATGGAGAAAGCCATGTTCAAGCGTCCGCTGACGTTATCCCTCCTTGCCAGCCTGATTGCTGTCGCGACATCACTGTCTGC
TGCCACTGTTGATTTACGAGTATTGGAAACCACCGACCTACACAGCAACATGATGGATTTTGATTACTACAAAGATAAAC
CCACGGAAAAATTCGGGCTGGTACGCACTGCCAGCTTGATTATCGCAGCCCGGCAACAAGCCACTAACAGCGTGCTGGTG
GATAACGGTGACGTGATCCAGGGGAGTCCGCTTGGTGATTATATCGCGGCTAAAGGGTTAAACGACGGAGAGATTCACCC
AGTCTATAAAGCGATGAACACGCTGGATTATGCGGTCGGCAATATCGGTAACCATGAGTTTAACTATGGGCTGGACTACC
TGAAGAAATCACTGGCAGGGGCGAAATTCCCGTATGTTAACGCCAACGTGATTGATGTTAAAACAGGTAAACCCTTGTTC
CAGCCTTACCTGATCATCGATACCCCAGTGAAAGATCGTGACGGAAAGAGCCATAACCTGCGGATCGGGTACATTGGTTT
TGTACCGCCTCAAGTGATGATCTGGGATAAAGCGAATCTGAGTGGCAAAGTCACGGTGAACGATATCACTGAAACCGCCA
AGAAGTGGGTACCGGAGATGCGTGAACAAGGGGCTGATCTGGTTGTTGCTATCCCGCACTCTGGTCTTTCCAGCGATCCT
TATAAAACCATGGCTGAAAATTCGGTTTATTACCTCAGTCAAGTTCCAGGTATCGATGCCATCATGTTCGGCCACGCACA
TGGTGTGTTCCCCAGCAAAGATTTTGCCGCCATCAAAGGCGCGGATATCACTCAAGGTACCTTAAACGGTATTCCGGCAG
TGATGCCTGGCCAATGGGGTGACCATTTAGGCGTAGTCGATTTTGTCCTGAATAATGATCAGGGAAAATGGCAAGTTATC
GATGCCAAGGCTGAAGCCCGTCCTATCTACGATAAAACAGCACAAAAATCACTGGCGGCAGAAAATGCCAAACTGGTGGA
AGTACTGGCAGTTGATCACCAGAGCACCCGTGATTTTGTCAGCCAACCGATTGGTAAAGCATCAGATAACATGTACAGCT
ATCTGGCACTGATCCAAGATGACCCCACCGTGCAGATTGTGAATAACGCCCAGCGCGCGTATACCGAACATTTTATTCAG
GGCGATCCTGATTTAGCTGACCTCCCGGTACTGTCTGCCGCTGCACCGTTTAAAGCCGGTGGCCGCAAAAATGATCCCAC
CAGTTTTGTTGAGGTGGAAAAAGGGAAGCTGACCTTCCGTAACGCCGCGGATTTGTACCTTTATCCAAATACACTCGTCG
TCGTGAAAGCCAGTGGGGCTGAGGTTAAGCAGTGGCTGGAGTGTTCCGCCGCACAGTTTAATCAAATCGATATTAACAGC
AGCAAACCGCAATCGTTGATTAATTGGGATGGTTTTCGTACTTATAATTTCGATGTCATCGATGGTGTTGAGTATGAAAT
TGATGTCAGCCAGCCTGCCCGCTACGATGGCGAATGTACGCTAATCAACGACCAGGCAGAACGTATCAAAAACCTGACGT
TTAACGGTAAGCCAATCGATCCGAAAGCCACATTCCTGATTGCCACCAATAACTACCGCGCTTACAGCGGTAAGTTTGCC
GGTACCGGTGACAGCCATATCGCATTCGCTTCACCCGACGAAAATCGAGCGGTCCTGTCTGCATATATCAGTGCTGAAAC
CAAGAAAAAGGGTCAGGTCATCCCGCAAGCCGACAACAATTGGCGTCTGGCAATTCTTGATAGCAAGCAACCTTTGGATA
TTCGTTTTGAAACCTCTCCAACTGCTAAGGCCGCTGATTTTATTAAACAAAAAGCGCAATACCCAATGGAAGCACAGGGT
ACAGATGAAGTTGGCTTCGCCGTTTATCACATCGATTTACAGAGAAAGTAA

Upstream 100 bases:

>100_bases
ACACTTTGCTTTAGCAATTAATTAAAATTACATATTCTTTTGCGATACATATCGAATATACACCAAGTACGAAGGGTAGC
GTTTTTAATGGAAACCCACG

Downstream 100 bases:

>100_bases
TCTCTGGCGGCAACGCCTTACACTGTACGCTGCTGTCACCCCATAATACCCACTTGGAGTTATATCACAATCTATAACAT
GCATTTATTATGCATGTTAT

Product: bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MEKAMFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTASLIIAARQQATNSVLV
DNGDVIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLF
QPYLIIDTPVKDRDGKSHNLRIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDP
YKTMAENSVYYLSQVPGIDAIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLGVVDFVLNNDQGKWQVI
DAKAEARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPIGKASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQ
GDPDLADLPVLSAAAPFKAGGRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINS
SKPQSLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKATFLIATNNYRAYSGKFA
GTGDSHIAFASPDENRAVLSAYISAETKKKGQVIPQADNNWRLAILDSKQPLDIRFETSPTAKAADFIKQKAQYPMEAQG
TDEVGFAVYHIDLQRK

Sequences:

>Translated_656_residues
MEKAMFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTASLIIAARQQATNSVLV
DNGDVIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLF
QPYLIIDTPVKDRDGKSHNLRIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDP
YKTMAENSVYYLSQVPGIDAIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLGVVDFVLNNDQGKWQVI
DAKAEARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPIGKASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQ
GDPDLADLPVLSAAAPFKAGGRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINS
SKPQSLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKATFLIATNNYRAYSGKFA
GTGDSHIAFASPDENRAVLSAYISAETKKKGQVIPQADNNWRLAILDSKQPLDIRFETSPTAKAADFIKQKAQYPMEAQG
TDEVGFAVYHIDLQRK
>Mature_656_residues
MEKAMFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGLVRTASLIIAARQQATNSVLV
DNGDVIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVGNIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLF
QPYLIIDTPVKDRDGKSHNLRIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDP
YKTMAENSVYYLSQVPGIDAIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWGDHLGVVDFVLNNDQGKWQVI
DAKAEARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFVSQPIGKASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQ
GDPDLADLPVLSAAAPFKAGGRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINS
SKPQSLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPIDPKATFLIATNNYRAYSGKFA
GTGDSHIAFASPDENRAVLSAYISAETKKKGQVIPQADNNWRLAILDSKQPLDIRFETSPTAKAADFIKQKAQYPMEAQG
TDEVGFAVYHIDLQRK

Specific function: This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Escherichia coli, GI1790658, Length=646, Percent_Identity=76.0061919504644, Blast_Score=1051, Evalue=0.0,
Organism=Escherichia coli, GI1786687, Length=584, Percent_Identity=23.2876712328767, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24652512, Length=196, Percent_Identity=28.0612244897959, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921980, Length=196, Percent_Identity=28.0612244897959, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161076508, Length=196, Percent_Identity=28.0612244897959, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR006294
- InterPro:   IPR004843 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16 [H]

Molecular weight: Translated: 72096; Mature: 72096

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00785 5_NUCLEOTIDASE_1 ; PS00786 5_NUCLEOTIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAMFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGL
CCCHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHH
VRTASLIIAARQQATNSVLVDNGDVIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVG
HHHHHHHHEEHHHCCCEEEECCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHC
NIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLFQPYLIIDTPVKDRDGKSHNL
CCCCCCCCCCHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCEE
RIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDP
EEEEEECCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
YKTMAENSVYYLSQVPGIDAIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWG
CHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCHHCCCCCCCCCCCC
DHLGVVDFVLNNDQGKWQVIDAKAEARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFV
CCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHHHH
SQPIGKASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQGDPDLADLPVLSAAAPFKAG
HCCCCCCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCC
GRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINS
CCCCCCCCEEEEECCEEEEECCCEEEECCCEEEEEEECCHHHHHHHHHCCCCCCEEECCC
SKPQSLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPID
CCCCHHCCCCCEEEEEEEEECCEEEEEECCCCCCCCCEEEEECCHHHHHHCCCCCCCCCC
PKATFLIATNNYRAYSGKFAGTGDSHIAFASPDENRAVLSAYISAETKKKGQVIPQADNN
CCEEEEEEECCCEEECCCCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCCCCCCCCCCCC
WRLAILDSKQPLDIRFETSPTAKAADFIKQKAQYPMEAQGTDEVGFAVYHIDLQRK
EEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MEKAMFKRPLTLSLLASLIAVATSLSAATVDLRVLETTDLHSNMMDFDYYKDKPTEKFGL
CCCHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHH
VRTASLIIAARQQATNSVLVDNGDVIQGSPLGDYIAAKGLNDGEIHPVYKAMNTLDYAVG
HHHHHHHHEEHHHCCCEEEECCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHC
NIGNHEFNYGLDYLKKSLAGAKFPYVNANVIDVKTGKPLFQPYLIIDTPVKDRDGKSHNL
CCCCCCCCCCHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCEEEEECCCCCCCCCCCEE
RIGYIGFVPPQVMIWDKANLSGKVTVNDITETAKKWVPEMREQGADLVVAIPHSGLSSDP
EEEEEECCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
YKTMAENSVYYLSQVPGIDAIMFGHAHGVFPSKDFAAIKGADITQGTLNGIPAVMPGQWG
CHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCHHCCCCCCCCCCCC
DHLGVVDFVLNNDQGKWQVIDAKAEARPIYDKTAQKSLAAENAKLVEVLAVDHQSTRDFV
CCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHHHH
SQPIGKASDNMYSYLALIQDDPTVQIVNNAQRAYTEHFIQGDPDLADLPVLSAAAPFKAG
HCCCCCCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCC
GRKNDPTSFVEVEKGKLTFRNAADLYLYPNTLVVVKASGAEVKQWLECSAAQFNQIDINS
CCCCCCCCEEEEECCEEEEECCCEEEECCCEEEEEEECCHHHHHHHHHCCCCCCEEECCC
SKPQSLINWDGFRTYNFDVIDGVEYEIDVSQPARYDGECTLINDQAERIKNLTFNGKPID
CCCCHHCCCCCEEEEEEEEECCEEEEEECCCCCCCCCEEEEECCHHHHHHCCCCCCCCCC
PKATFLIATNNYRAYSGKFAGTGDSHIAFASPDENRAVLSAYISAETKKKGQVIPQADNN
CCEEEEEEECCCEEECCCCCCCCCCEEEEECCCCCCEEEEEEHHHCCCCCCCCCCCCCCC
WRLAILDSKQPLDIRFETSPTAKAADFIKQKAQYPMEAQGTDEVGFAVYHIDLQRK
EEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA