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The map label for this gene is rnc [H]

Identifier: 218929790

GI number: 218929790

Start: 3046571

End: 3047251

Strand: Direct

Name: rnc [H]

Synonym: YPO2718

Alternate gene names: 218929790

Gene position: 3046571-3047251 (Clockwise)

Preceding gene: 218929789

Following gene: 218929791

Centisome position: 65.47

GC content: 49.78

Gene sequence:

>681_bases
ATGAATCCCATCGTAATAAACAGGCTGCAGCGGAAGCTGGGCTACACTTTCCAACAGCAGGAGCTCTTGCTGCAAGCACT
GACTCATCGTAGCGCCAGCAGCAAACACAATGAGCGTTTGGAGTTCCTGGGTGACTCTATATTAAGTTTTGTTATCGCCA
ATGAGCTATATCGCCGTTTCCCTCGCGTTGATGAAGGGGATATGAGTCGTATGCGGGCCACATTGGTTAGAGGGAATACA
CTTGCCGAAATGGCCCGTGAATTTGACCTTGGCGAATGTTTACGCCTTGGGCCGGGTGAATTGAAGAGTGGTGGTTTTCG
CCGCGAATCAATTTTAGCCGATACGGTAGAAGCCTTAATTGGCGGTGTATTCTTAGATAGCGATATCCATACGATTGAAC
GGCTGATCCTCGAGTGGTATCACAGTCGGTTAGAGGAAATCAGCCCTGGTGATAAGCAGAAAGACCCAAAAACGCGCTTG
CAAGAGTATTTGCAGGGCCGTCATCTGCCATTACCTTCATATCTGGTCGTGCAGGTTCGCGGCGAAGCACATGACCAGGA
ATTTACTATCCACTGCCAGGTGAGTGGCTTGAATGAACCAGTAATAGGTACTGGCTCAAGCCGTCGTAAAGCTGAGCAGG
CGGCAGCGGAACAAGCGCTGAAACAGTTGGAGCTTGAATGA

Upstream 100 bases:

>100_bases
AGCCACTGCAAACGAAACAGTTTTGTCTTGGTTACTTTTGTCGGTCAGACCTGTTCCGTATGCTGTAGTTTTTGACGCAT
TCTTGATCTATTGGTAACTC

Downstream 100 bases:

>100_bases
GCGAAGTAGAAAAAACGTATTGTGGTTTTATTGCCATTGTAGGGCGCCCGAATGTAGGCAAATCGACCTTACTAAATGAG
CTGTTGGGGCAAAAAATCTC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANELYRRFPRVDEGDMSRMRATLVRGNT
LAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIHTIERLILEWYHSRLEEISPGDKQKDPKTRL
QEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLNEPVIGTGSSRRKAEQAAAEQALKQLELE

Sequences:

>Translated_226_residues
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANELYRRFPRVDEGDMSRMRATLVRGNT
LAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIHTIERLILEWYHSRLEEISPGDKQKDPKTRL
QEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLNEPVIGTGSSRRKAEQAAAEQALKQLELE
>Mature_226_residues
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANELYRRFPRVDEGDMSRMRATLVRGNT
LAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIHTIERLILEWYHSRLEEISPGDKQKDPKTRL
QEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLNEPVIGTGSSRRKAEQAAAEQALKQLELE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=230, Percent_Identity=28.2608695652174, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=28.2608695652174, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1788920, Length=226, Percent_Identity=91.5929203539823, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17506883, Length=227, Percent_Identity=31.2775330396476, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193202651, Length=227, Percent_Identity=31.2775330396476, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323895, Length=204, Percent_Identity=28.921568627451, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=27.8260869565217, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25708; Mature: 25708

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANELYRRF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSDIHTIERLILEWYHSRLEEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVR
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLNEPVIGTGSSRRKAEQAAAEQALKQLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPIVINRLQRKLGYTFQQQELLLQALTHRSASSKHNERLEFLGDSILSFVIANELYRRF
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PRVDEGDMSRMRATLVRGNTLAEMAREFDLGECLRLGPGELKSGGFRRESILADTVEALI
CCCCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GGVFLDSDIHTIERLILEWYHSRLEEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVR
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
GEAHDQEFTIHCQVSGLNEPVIGTGSSRRKAEQAAAEQALKQLELE
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA