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The map label for this gene is lepB [H]

Identifier: 218929789

GI number: 218929789

Start: 3045221

End: 3046219

Strand: Direct

Name: lepB [H]

Synonym: YPO2717

Alternate gene names: 218929789

Gene position: 3045221-3046219 (Clockwise)

Preceding gene: 218929788

Following gene: 218929790

Centisome position: 65.44

GC content: 49.05

Gene sequence:

>999_bases
ATGGCTAACATGTTTGCTTTGATTCTGGCAATAGCAACGCTGTTGACGGGGATTATCTGGTGCTTCGAGCGGTTTAAATG
GGGGCCAGCCCGTCAGGCAAAAATTGCGGCAGTTAATGCACAAACTGCGGAAATCAAGGCCCAAACCGGGTGTGCCGTAG
ATAATAAAACCTTAGCCCAAGCTGCAAAGCAACCGGGTTGGATCGAGACATGTGCCTCTATCTTCCCGGTGCTGGCCTTG
GTCTTTATCGTGCGTTCGTTTATTTACGAGCCTTTCCAGATCCCTTCTGGTTCGATGATGCCAACGCTGCTTATCGGTGA
TTTTATTTTGGTTGAGAAATTTGCTTATGGGATTAAAGATCCCATTACTCAGACCACATTAATTCCAACAGGTAAGCCAA
ACCGCGGTGACATTGCGGTGTTTAAATATCCGTTGGATCCACGTTTGGATTATATCAAGCGTGTGGTGGGGCTGCCGGGG
GATCGGGTAATTTATAACCCGATAAGTAAAGAAGTCACGGTACAACCGTCATGTAATACCGGTACTTCTTGTGATAGTGC
GTTGGCCATCACTTACAGCACGTCTGAGCCAAGTGAGTTTGTGCAGACATTCCGTTATAGCGGTAATGGCGAAAGCTCCG
CAGGGTTCTTCCCAATCCCGCTAAATCAGGCAGTACCTGATGGCGGTGTCCGGTTACGTGAGCGTACTGAAAGCCTCGGC
CCGGTAGCGCATCACATTCTGACCGTCCCAGGGCGGCAGGATCCGTTAGGCTCTTATTATCAGCAACCCGATCAACCGTT
AGGGGTTTGGGTGGTACCGGAAGGCCATTACTTTATGATGGGTGATAACCGGGATAACAGTGCAGATAGCCGCTTCTGGG
GTTTTGTACCAGAACGTAATCTGGTAGGTAAGGCTACGGCTATTTGGATGAGTTTTGAAAAGCAAGAAGGTGAATGGCCA
ACGGGTGTGCGTTTAAGCCGAATTGGTGGAATTCACTAA

Upstream 100 bases:

>100_bases
CGGTAAGAAACGTATGAAGCAAGTCGGTAACGTTGAATTACCACAAGAGGCCTTCCTGGCTATTCTGCATGTTGGAAAAG
ACAGTAAATAAGGAGTTTTC

Downstream 100 bases:

>100_bases
AGCAGTGGATATTCCCCAAGCCGTTGATGTTGCAGTTAGGCAGTAAGGCCGTTATTGAGTGAACCCCGATGAGCTCTCTC
AGTGAGTGACTCGGGGCAAG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MANMFALILAIATLLTGIIWCFERFKWGPARQAKIAAVNAQTAEIKAQTGCAVDNKTLAQAAKQPGWIETCASIFPVLAL
VFIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPITQTTLIPTGKPNRGDIAVFKYPLDPRLDYIKRVVGLPG
DRVIYNPISKEVTVQPSCNTGTSCDSALAITYSTSEPSEFVQTFRYSGNGESSAGFFPIPLNQAVPDGGVRLRERTESLG
PVAHHILTVPGRQDPLGSYYQQPDQPLGVWVVPEGHYFMMGDNRDNSADSRFWGFVPERNLVGKATAIWMSFEKQEGEWP
TGVRLSRIGGIH

Sequences:

>Translated_332_residues
MANMFALILAIATLLTGIIWCFERFKWGPARQAKIAAVNAQTAEIKAQTGCAVDNKTLAQAAKQPGWIETCASIFPVLAL
VFIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPITQTTLIPTGKPNRGDIAVFKYPLDPRLDYIKRVVGLPG
DRVIYNPISKEVTVQPSCNTGTSCDSALAITYSTSEPSEFVQTFRYSGNGESSAGFFPIPLNQAVPDGGVRLRERTESLG
PVAHHILTVPGRQDPLGSYYQQPDQPLGVWVVPEGHYFMMGDNRDNSADSRFWGFVPERNLVGKATAIWMSFEKQEGEWP
TGVRLSRIGGIH
>Mature_331_residues
ANMFALILAIATLLTGIIWCFERFKWGPARQAKIAAVNAQTAEIKAQTGCAVDNKTLAQAAKQPGWIETCASIFPVLALV
FIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPITQTTLIPTGKPNRGDIAVFKYPLDPRLDYIKRVVGLPGD
RVIYNPISKEVTVQPSCNTGTSCDSALAITYSTSEPSEFVQTFRYSGNGESSAGFFPIPLNQAVPDGGVRLRERTESLGP
VAHHILTVPGRQDPLGSYYQQPDQPLGVWVVPEGHYFMMGDNRDNSADSRFWGFVPERNLVGKATAIWMSFEKQEGEWPT
GVRLSRIGGIH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=332, Percent_Identity=67.4698795180723, Blast_Score=467, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 36549; Mature: 36418

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANMFALILAIATLLTGIIWCFERFKWGPARQAKIAAVNAQTAEIKAQTGCAVDNKTLAQ
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHEEECCCCCCCCCHHHHH
AAKQPGWIETCASIFPVLALVFIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKD
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
PITQTTLIPTGKPNRGDIAVFKYPLDPRLDYIKRVVGLPGDRVIYNPISKEVTVQPSCNT
CCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCC
GTSCDSALAITYSTSEPSEFVQTFRYSGNGESSAGFFPIPLNQAVPDGGVRLRERTESLG
CCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHC
PVAHHILTVPGRQDPLGSYYQQPDQPLGVWVVPEGHYFMMGDNRDNSADSRFWGFVPERN
HHHHHEEECCCCCCCCCHHHCCCCCCCEEEEEECCCEEEEECCCCCCCCCCEECCCCCCC
LVGKATAIWMSFEKQEGEWPTGVRLSRIGGIH
CCCCCEEEEEEEECCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
ANMFALILAIATLLTGIIWCFERFKWGPARQAKIAAVNAQTAEIKAQTGCAVDNKTLAQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHEEECCCCCCCCCHHHHH
AAKQPGWIETCASIFPVLALVFIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKD
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
PITQTTLIPTGKPNRGDIAVFKYPLDPRLDYIKRVVGLPGDRVIYNPISKEVTVQPSCNT
CCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCC
GTSCDSALAITYSTSEPSEFVQTFRYSGNGESSAGFFPIPLNQAVPDGGVRLRERTESLG
CCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHC
PVAHHILTVPGRQDPLGSYYQQPDQPLGVWVVPEGHYFMMGDNRDNSADSRFWGFVPERN
HHHHHEEECCCCCCCCCHHHCCCCCCCEEEEEECCCEEEEECCCCCCCCCCEECCCCCCC
LVGKATAIWMSFEKQEGEWPTGVRLSRIGGIH
CCCCCEEEEEEEECCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]