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The map label for this gene is phoP [H]

Identifier: 218928770

GI number: 218928770

Start: 1859917

End: 1860588

Strand: Reverse

Name: phoP [H]

Synonym: YPO1634

Alternate gene names: 218928770

Gene position: 1860588-1859917 (Counterclockwise)

Preceding gene: 218928771

Following gene: 218928769

Centisome position: 39.98

GC content: 47.92

Gene sequence:

>672_bases
ATGCGGGTTCTGGTTGTGGAAGATAACGCGTTGTTGCGTCACCATCTGACAGTGCAAATGCGTGAAATGGGCCATCAGGT
TGATGCCGCGGAAGATGCTAAAGAAGCAGACTATTTCTTACAAGAGCATGCCCCCGACATTGCTATTATCGATCTTGGTT
TGCCCGGTGAAGACGGGTTAAGCCTTATCCGTCGCTGGCGTAGCCATCAAGAAAACTTACCCATTTTGGTCCTGACCGCA
CGGGAAAGCTGGCAAGATAAAGTCGCTGTACTGGAAGCCGGTGCCGACGATTATGTGACCAAACCGTTCCATCTGGAAGA
GGTCATTGCCCGGATGCAAGCACTGATGCGGCGGAATATTGGCCTGGCCTCCCAAATTATTGAGCTACCGCCCTTCCAGA
TTGACCTTTCACGCCGTGAGTTATGTGTTAACCAACAACAAATTAAACTGACGGCATTTGAATACACTATCATTGAAACC
CTTATCCGCAACGCAGGGAAAGTCGTTAGTAAGGATACGTTGATGCTACAACTTTATCCGGATGCGGAATTGCGAGAGAG
CCATACTATCGATGTATTAATGGGTCGACTACGTAAAAAACTGCTGGCAGAACATCAGGGTGAAGTCATTACGACTATTC
GTAGTCAGGGATATCGTTTTGACGTCAACTAG

Upstream 100 bases:

>100_bases
TCGTGCTCAAGACGGTATAGCACCTACATAATGAGCGTCAAATTTTCACTTACCGGATAATATCCTGTTATCCGGTTAAC
GTTTTATCAAGGATTGGTGT

Downstream 100 bases:

>100_bases
ACACTATGCTCAGAAAAAATAATAAACCCTTCTCCCTTCGAGCCCGTTTTCTTATGGCGACAGCCGGCGTTATTTTAGCG
CTGTCGCTATCTTATGGCAT

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGLSLIRRWRSHQENLPILVLTA
RESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNIGLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIET
LIRNAGKVVSKDTLMLQLYPDAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRSQGYRFDVN

Sequences:

>Translated_223_residues
MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGLSLIRRWRSHQENLPILVLTA
RESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNIGLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIET
LIRNAGKVVSKDTLMLQLYPDAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRSQGYRFDVN
>Mature_223_residues
MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGLSLIRRWRSHQENLPILVLTA
RESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNIGLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIET
LIRNAGKVVSKDTLMLQLYPDAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRSQGYRFDVN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=81.0810810810811, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=35.3211009174312, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=33.9285714285714, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=32.8828828828829, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=32.7433628318584, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=33.4841628959276, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=32.4200913242009, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=31.858407079646, Blast_Score=107, Evalue=4e-25,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=30.6666666666667, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=29.5154185022026, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=26.7241379310345, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=30.5555555555556, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.0188679245283, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25585; Mature: 25585

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGL
CEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
SLIRRWRSHQENLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNI
HHHHHHHHHCCCCCEEEEECCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIETLIRNAGKVVSKDTLMLQLYP
CHHHHHHHCCCCEEECCHHHHHCCCHHEEEEHHHHHHHHHHHHCCCCEEECCEEEEEECC
DAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRSQGYRFDVN
CCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCC
>Mature Secondary Structure
MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGL
CEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
SLIRRWRSHQENLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNI
HHHHHHHHHCCCCCEEEEECCCCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQIIELPPFQIDLSRRELCVNQQQIKLTAFEYTIIETLIRNAGKVVSKDTLMLQLYP
CHHHHHHHCCCCEEECCHHHHHCCCHHEEEEHHHHHHHHHHHHCCCCEEECCEEEEEECC
DAELRESHTIDVLMGRLRKKLLAEHQGEVITTIRSQGYRFDVN
CCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA