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The map label for this gene is phoQ [H]

Identifier: 218928769

GI number: 218928769

Start: 1858457

End: 1859911

Strand: Reverse

Name: phoQ [H]

Synonym: YPO1633

Alternate gene names: 218928769

Gene position: 1859911-1858457 (Counterclockwise)

Preceding gene: 218928770

Following gene: 218928768

Centisome position: 39.97

GC content: 46.25

Gene sequence:

>1455_bases
ATGCTCAGAAAAAATAATAAACCCTTCTCCCTTCGAGCCCGTTTTCTTATGGCGACAGCCGGCGTTATTTTAGCGCTGTC
GCTATCTTATGGCATGGTCGCGGTGGTAGGTTATATCGTCAGTTTTGATAAAAGCACCTTCAGAGCCCATCGTGGTGAAA
GTAATTTATTCTTCAGTCTGGCACAGTGGCATAACAATAAGCTCAGCATCTCTGTTCCGCCAGAACTTGAACTGAACGTC
CCCAGCCTGGTCCTGATTTACGACAAAGATGGTAATATTTTATGGCGTCAGCGTCATGTCCCTGAGCTGGAGTCGCACAT
TGAGAAAAGCTGGCTGCAAAAGCCGGGGTTTTATGAGCTGGATACCGGGACGCACATCAGTAGAATGATGATGGGTGACA
ACCCAAAAGCTCAAGATCAGTTAAAGAAATACGATGACACCGATGATAGCGCACTTACGCACTCAGTCTCCGTCAATACC
TACGCCGCGACCTCTCGTTTACCTCAACTCACCATCGTGGTGGTGGATACCATCCCACAAGAGCTACAACGTACTGATCT
AGTGTGGAACTGGTTCAGTTATGTCCTGCTGGCGAATTTATTATTAGTCATTCCCTTATTGTGGCTTGCTGCCTATTGGA
GCCTGCGGCCAATTAAAGCACTGGCTAGTCAAATCAGCCAGTTGGAAAAAGGTGAGCGTGAACAACTCGATGAAAACCCA
CCTCGTGAGTTACAAAGTTTAGTCCGTAACCTCAACATCTTGCTGATGAACGAACGTCAGCGCTATACCAAATATCGCAC
GACTCTGGCTGACCTCACTCACAGCCTTAAAACACCGCTGGCGGTGCTACAAACCACACTACGTTCTTTGCGTACCGGTA
AACAAACAACCATTGAAGAAGTAGAGCCGATTATGCTGGAGCAGATCAGCCGTATCTCGCAGCAAATTGGTTATTACCTG
CACCGCGCAAGTATGCGTTCCGAACATAATGTTCTAGGACGTGAAATTCATTCGGTTCCCGCGCTACTCGATAGTTTGTA
CAGCGCATTAAATAAAGTTTATCAACGCAAAGGGATTGCGCTGACACTGGACATCTCACCAGAGGTCACATTCTTGGGAG
AAAAGAATGATTTCATGGAAGTTATGGGGAATGTTTTAGAAAATGCCTGCAAATATTGCCTTGAGTTTGTTGAAGTCACC
ACCTTACACTCCGAAAAACAATTGACCATTGTGGTCGATGATGACGGCCCCGGTATTCCTGAAAATAAGCGCCAGTTAAT
TTTCCAACGTGGTCAACGGGTTGATACTTTACGTCCGGGGCAAGGGCTTGGTTTATCTATTGCAGCTGAAATTATTGAAC
AGTATCAAGGTAAAATCTCCATCACCGAAAGCCCCTTAGGGGGAGCCCGAATGATGGTGACGTTTGGTCAGCAACAAGAT
TGTCACGATGATTAA

Upstream 100 bases:

>100_bases
TAATGGGTCGACTACGTAAAAAACTGCTGGCAGAACATCAGGGTGAAGTCATTACGACTATTCGTAGTCAGGGATATCGT
TTTGACGTCAACTAGACACT

Downstream 100 bases:

>100_bases
TAATATTTGCCAGTCAGCCCCTGATACTGATGGCGGGTATCCGTTATAATCTCAGGCAATTTCACCTTTATCCTGGAATA
AACATGGATTACCAACTCGA

Product: sensor protein PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MLRKNNKPFSLRARFLMATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPELELNV
PSLVLIYDKDGNILWRQRHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNT
YAATSRLPQLTIVVVDTIPQELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKALASQISQLEKGEREQLDENP
PRELQSLVRNLNILLMNERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQIGYYL
HRASMRSEHNVLGREIHSVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVT
TLHSEKQLTIVVDDDGPGIPENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQD
CHDD

Sequences:

>Translated_484_residues
MLRKNNKPFSLRARFLMATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPELELNV
PSLVLIYDKDGNILWRQRHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNT
YAATSRLPQLTIVVVDTIPQELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKALASQISQLEKGEREQLDENP
PRELQSLVRNLNILLMNERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQIGYYL
HRASMRSEHNVLGREIHSVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVT
TLHSEKQLTIVVDDDGPGIPENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQD
CHDD
>Mature_484_residues
MLRKNNKPFSLRARFLMATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPELELNV
PSLVLIYDKDGNILWRQRHVPELESHIEKSWLQKPGFYELDTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNT
YAATSRLPQLTIVVVDTIPQELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKALASQISQLEKGEREQLDENP
PRELQSLVRNLNILLMNERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLEQISRISQQIGYYL
HRASMRSEHNVLGREIHSVPALLDSLYSALNKVYQRKGIALTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVT
TLHSEKQLTIVVDDDGPGIPENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQD
CHDD

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=478, Percent_Identity=62.1338912133891, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=25.0909090909091, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=28.3018867924528, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787894, Length=282, Percent_Identity=26.5957446808511, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786783, Length=285, Percent_Identity=21.7543859649123, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.4372294372294, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=26.0714285714286, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=220, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082128, Length=321, Percent_Identity=26.1682242990654, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55036; Mature: 55036

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKNNKPFSLRARFLMATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEH
AQWHNNKLSISVPPELELNVPSLVLIYDKDGNILWRQRHVPELESHIEKSWLQKPGFYEL
HHHCCCEEEEECCCCCEECCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCEEC
DTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNTYAATSRLPQLTIVVVDTIPQ
CCCCHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEECCEEHHHCCCCEEEEEEEECCHH
ELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKALASQISQLEKGEREQLDENP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCC
PRELQSLVRNLNILLMNERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEE
CHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHH
VEPIMLEQISRISQQIGYYLHRASMRSEHNVLGREIHSVPALLDSLYSALNKVYQRKGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVTTLHSEKQLTIVVDDDGPGIP
EEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
ENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQD
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCC
CHDD
CCCC
>Mature Secondary Structure
MLRKNNKPFSLRARFLMATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEH
AQWHNNKLSISVPPELELNVPSLVLIYDKDGNILWRQRHVPELESHIEKSWLQKPGFYEL
HHHCCCEEEEECCCCCEECCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCCEEC
DTGTHISRMMMGDNPKAQDQLKKYDDTDDSALTHSVSVNTYAATSRLPQLTIVVVDTIPQ
CCCCHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEECCEEHHHCCCCEEEEEEEECCHH
ELQRTDLVWNWFSYVLLANLLLVIPLLWLAAYWSLRPIKALASQISQLEKGEREQLDENP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCC
PRELQSLVRNLNILLMNERQRYTKYRTTLADLTHSLKTPLAVLQTTLRSLRTGKQTTIEE
CHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHH
VEPIMLEQISRISQQIGYYLHRASMRSEHNVLGREIHSVPALLDSLYSALNKVYQRKGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LTLDISPEVTFLGEKNDFMEVMGNVLENACKYCLEFVEVTTLHSEKQLTIVVDDDGPGIP
EEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
ENKRQLIFQRGQRVDTLRPGQGLGLSIAAEIIEQYQGKISITESPLGGARMMVTFGQQQD
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCC
CHDD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA