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The map label for this gene is gmhB

Identifier: 218928243

GI number: 218928243

Start: 1216470

End: 1217036

Strand: Direct

Name: gmhB

Synonym: YPO1074

Alternate gene names: 218928243

Gene position: 1216470-1217036 (Clockwise)

Preceding gene: 218928236

Following gene: 218928244

Centisome position: 26.14

GC content: 44.27

Gene sequence:

>567_bases
GTGACTCAGTCCGTTCCCGCAATATTTTTAGATCGTGATGGTACAGTTAATGTCGATCATGGTTATGTCCACGAAATTGA
CAACTTTCAATTTATCGATGGTGTTATTGATGCATGCCGTGAATTGAAAGAAATGGGTTTTGCGTTGGTGTTGGTAACCA
ATCAATCGGGTATCGCCCGCGGGATGTTTACCGAAGAACAGTTTTTAAGTCTAACCGAATGGATGGACTGGTCATTGGCT
GATCGCGGTGTTGATTTAGATGGCATCTATTTCTGCCCACATCATCCTGATGGCAGTGTCGCTGAATTCAGTGAAACATG
TGAATGCCGCAAACCATTACCCGGAATGTTATTGCAAGCGCAGAATGAACTTAATATTGATATGGCTGCTTCTTATATGG
TTGGCGACAAAATTGAAGATATGCAGGCGGCATTAGCGGCGAATATTGGCACTAAAGTATTGGTTCGAACGGGTAAGCCA
GTCACTGCCGAGGGTGAAGCAGCGGCCGATTGGGTGCTAAATAGTCTGGCAGACCTACCAAAAGCAATAAAAGCGCGTTA
TAAATAG

Upstream 100 bases:

>100_bases
TAGACGGCTAAGTCAACTGACAACGTGGATTCTCTTCCGTTCTCAATAGGTAATAAAACATGCGATACTATCGGGGTTTA
CAGCCCTCAGGAGTATATAA

Downstream 100 bases:

>100_bases
CCTGTACGTTCAAATAATCAACAAACGAAAAAAATGTGAAGATAAACCCTTGCCATTCTGAAGCAGCTCCCTATAATGCG
CATCCATCGACACGGCGCTG

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MTQSVPAIFLDRDGTVNVDHGYVHEIDNFQFIDGVIDACRELKEMGFALVLVTNQSGIARGMFTEEQFLSLTEWMDWSLA
DRGVDLDGIYFCPHHPDGSVAEFSETCECRKPLPGMLLQAQNELNIDMAASYMVGDKIEDMQAALAANIGTKVLVRTGKP
VTAEGEAAADWVLNSLADLPKAIKARYK

Sequences:

>Translated_188_residues
MTQSVPAIFLDRDGTVNVDHGYVHEIDNFQFIDGVIDACRELKEMGFALVLVTNQSGIARGMFTEEQFLSLTEWMDWSLA
DRGVDLDGIYFCPHHPDGSVAEFSETCECRKPLPGMLLQAQNELNIDMAASYMVGDKIEDMQAALAANIGTKVLVRTGKP
VTAEGEAAADWVLNSLADLPKAIKARYK
>Mature_187_residues
TQSVPAIFLDRDGTVNVDHGYVHEIDNFQFIDGVIDACRELKEMGFALVLVTNQSGIARGMFTEEQFLSLTEWMDWSLAD
RGVDLDGIYFCPHHPDGSVAEFSETCECRKPLPGMLLQAQNELNIDMAASYMVGDKIEDMQAALAANIGTKVLVRTGKPV
TAEGEAAADWVLNSLADLPKAIKARYK

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family

Homologues:

Organism=Escherichia coli, GI1786399, Length=188, Percent_Identity=80.8510638297872, Blast_Score=327, Evalue=3e-91,
Organism=Escherichia coli, GI87082027, Length=150, Percent_Identity=32.6666666666667, Blast_Score=80, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHB_YERPE (Q8ZH37)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0132
- RefSeq:   NP_670402.1
- RefSeq:   NP_994082.1
- RefSeq:   YP_002346118.1
- ProteinModelPortal:   Q8ZH37
- SMR:   Q8ZH37
- IntAct:   Q8ZH37
- GeneID:   1148050
- GeneID:   1173915
- GeneID:   2764223
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1074
- KEGG:   ypk:y3103
- KEGG:   ypm:YP_2775
- HOGENOM:   HBG613347
- OMA:   VVLDSIA
- ProtClustDB:   PRK08942
- BioCyc:   YPES187410:Y3103-MONOMER
- BioCyc:   YPES214092:YPO1074-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR00213
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: 3.1.1.-

Molecular weight: Translated: 20702; Mature: 20571

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSVPAIFLDRDGTVNVDHGYVHEIDNFQFIDGVIDACRELKEMGFALVLVTNQSGIAR
CCCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
GMFTEEQFLSLTEWMDWSLADRGVDLDGIYFCPHHPDGSVAEFSETCECRKPLPGMLLQA
CCCCHHHHHHHHHHHCCHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHC
QNELNIDMAASYMVGDKIEDMQAALAANIGTKVLVRTGKPVTAEGEAAADWVLNSLADLP
CCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
KAIKARYK
HHHHHCCC
>Mature Secondary Structure 
TQSVPAIFLDRDGTVNVDHGYVHEIDNFQFIDGVIDACRELKEMGFALVLVTNQSGIAR
CCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
GMFTEEQFLSLTEWMDWSLADRGVDLDGIYFCPHHPDGSVAEFSETCECRKPLPGMLLQA
CCCCHHHHHHHHHHHCCHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHC
QNELNIDMAASYMVGDKIEDMQAALAANIGTKVLVRTGKPVTAEGEAAADWVLNSLADLP
CCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
KAIKARYK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430; 12101286