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The map label for this gene is rth

Identifier: 218928217

GI number: 218928217

Start: 1190335

End: 1191093

Strand: Direct

Name: rth

Synonym: YPO1049

Alternate gene names: 218928217

Gene position: 1190335-1191093 (Clockwise)

Preceding gene: 218928216

Following gene: 218928218

Centisome position: 25.58

GC content: 44.93

Gene sequence:

>759_bases
ATGTCGCCTGTAAAAGAAGATAGGGCTAACTTGTCCCCCCGGAGTCCACGTCATGTTGCTATCATTATGGATGGTAATGG
ACGTTGGGCTAAAAATAAGGGTAAATTAAGAGTTTTCGGCCATAAAGCCGGGGTGAAGTCCGTTCGACGCGCAGTGAGTT
TTGCTGCGAAGCATAATTTAGATGCGCTCACTCTTTATGCTTTTAGCAGTGAAAACTGGAATCGCCCTGACCAAGAAGTG
ACCGCTCTGATGGAGCTTTTTGTTCGAGCACTAGACAGTGAAGTAAAAAGCTTGCATAAACATAATGTTCGTTTATCTAT
TATTGGTGATATCAGCCGTTTTAGTGGGCGTTTACAAGAGCGAATTCGTCGTTCAGAAAAATTAACGGCAAATAATGACG
GATTGAAACTCAACATTGCTGCCAATTATGGTGGCCGTTGGGATATCATCCAGGGGGTGCGCCATTTAGCTGAACAAGTT
CAGAAAGGGGAATTGCAACCTACAGATATCAGTGAAGAGTCGCTCAACTCGTATATCTGCCTGCATGAGCAATCTCAGGT
GGACTTAGTGATCAGAACCGGTGGTGAACATCGCATCAGTAATTTCTTGTTGTGGCAAATAGCCTATGCTGAACTTTACT
TTACAGATGTCCTCTGGCCTGATTTTGATGAAAATGTCTTTGAAGGTGCGCTGAATGCATTTGCACAACGCGAGCGTCGC
TTCGGGGGAACTACACCTATCGATGCCACTGCATCCTAG

Upstream 100 bases:

>100_bases
TCACTCCAGAAGCCGTGACTTGGTACACGGCTTTTTTTGTGCACTTGAGGCCTAATGTTCGGGACGAACAACTGATTTAT
TGAGGAAATAAGTTCGCGTT

Downstream 100 bases:

>100_bases
GGGGAACTTTTGCTGAAGTATCGTCTCATAACTGCTTTGATTTTGATTCCGGTTGTCATTGGTGCACTGTTCCTGCTTCC
GCCGGTTGGTTTCGCTATTG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSPVKEDRANLSPRSPRHVAIIMDGNGRWAKNKGKLRVFGHKAGVKSVRRAVSFAAKHNLDALTLYAFSSENWNRPDQEV
TALMELFVRALDSEVKSLHKHNVRLSIIGDISRFSGRLQERIRRSEKLTANNDGLKLNIAANYGGRWDIIQGVRHLAEQV
QKGELQPTDISEESLNSYICLHEQSQVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDENVFEGALNAFAQRERR
FGGTTPIDATAS

Sequences:

>Translated_252_residues
MSPVKEDRANLSPRSPRHVAIIMDGNGRWAKNKGKLRVFGHKAGVKSVRRAVSFAAKHNLDALTLYAFSSENWNRPDQEV
TALMELFVRALDSEVKSLHKHNVRLSIIGDISRFSGRLQERIRRSEKLTANNDGLKLNIAANYGGRWDIIQGVRHLAEQV
QKGELQPTDISEESLNSYICLHEQSQVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDENVFEGALNAFAQRERR
FGGTTPIDATAS
>Mature_251_residues
SPVKEDRANLSPRSPRHVAIIMDGNGRWAKNKGKLRVFGHKAGVKSVRRAVSFAAKHNLDALTLYAFSSENWNRPDQEVT
ALMELFVRALDSEVKSLHKHNVRLSIIGDISRFSGRLQERIRRSEKLTANNDGLKLNIAANYGGRWDIIQGVRHLAEQVQ
KGELQPTDISEESLNSYICLHEQSQVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDENVFEGALNAFAQRERRF
GGTTPIDATAS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=222, Percent_Identity=37.3873873873874, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI45580742, Length=222, Percent_Identity=37.3873873873874, Blast_Score=144, Evalue=8e-35,
Organism=Escherichia coli, GI1786371, Length=241, Percent_Identity=79.253112033195, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71993029, Length=215, Percent_Identity=36.2790697674419, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=212, Percent_Identity=36.3207547169811, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=213, Percent_Identity=32.3943661971831, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=34.2105263157895, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_YERPE (Q8ZH61)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0128
- RefSeq:   NP_670429.1
- RefSeq:   NP_994108.1
- RefSeq:   YP_002346092.1
- ProteinModelPortal:   Q8ZH61
- SMR:   Q8ZH61
- GeneID:   1148077
- GeneID:   1173889
- GeneID:   2766253
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1049
- KEGG:   ypk:y3130
- KEGG:   ypm:YP_2801
- HOGENOM:   HBG627837
- OMA:   FLWRIAY
- ProtClustDB:   PRK10240
- BioCyc:   YPES187410:Y3130-MONOMER
- BioCyc:   YPES214092:YPO1049-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28529; Mature: 28397

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 24-24

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVKEDRANLSPRSPRHVAIIMDGNGRWAKNKGKLRVFGHKAGVKSVRRAVSFAAKHNL
CCCCCCHHCCCCCCCCCEEEEEECCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHCCC
DALTLYAFSSENWNRPDQEVTALMELFVRALDSEVKSLHKHNVRLSIIGDISRFSGRLQE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
RIRRSEKLTANNDGLKLNIAANYGGRWDIIQGVRHLAEQVQKGELQPTDISEESLNSYIC
HHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEE
LHEQSQVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDENVFEGALNAFAQRERR
EECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FGGTTPIDATAS
CCCCCCCCCCCC
>Mature Secondary Structure 
SPVKEDRANLSPRSPRHVAIIMDGNGRWAKNKGKLRVFGHKAGVKSVRRAVSFAAKHNL
CCCCCHHCCCCCCCCCEEEEEECCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHCCC
DALTLYAFSSENWNRPDQEVTALMELFVRALDSEVKSLHKHNVRLSIIGDISRFSGRLQE
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHH
RIRRSEKLTANNDGLKLNIAANYGGRWDIIQGVRHLAEQVQKGELQPTDISEESLNSYIC
HHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEE
LHEQSQVDLVIRTGGEHRISNFLLWQIAYAELYFTDVLWPDFDENVFEGALNAFAQRERR
EECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FGGTTPIDATAS
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430