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The map label for this gene is dxr

Identifier: 218928216

GI number: 218928216

Start: 1188915

End: 1190111

Strand: Direct

Name: dxr

Synonym: YPO1048

Alternate gene names: 218928216

Gene position: 1188915-1190111 (Clockwise)

Preceding gene: 218928215

Following gene: 218928217

Centisome position: 25.55

GC content: 46.28

Gene sequence:

>1197_bases
ATGAAGCAACTGACTATTCTTGGCTCTACTGGCTCCATCGGCAACAGCACGTTGAGTGTTGTGCGTGCAAACCCTGAATT
ATTTAAAGTCACGGCGTTAGTTGCCGGGCGTAATGTCAGGGAAATGGCGCAGCAATGCCTTGAGTTCTCCCCCCGCTATG
CAGCTATGTCTGATGAACACTCAGCTAAATCACTGCGTTTATTGTTGGCAGAACAGGGTTCAGACACCGAGGTCTATTCC
GGTGAAACGGCTGCCTGCGAATTGGCAGCTTTAGATGATGTCGATCAAGTGATGGCCGCGATTGTTGGCATTGCTGGTTT
ACCCTCAACATTGGCCGCTATTCGTGCAGGTAAACAAGTCTTGCTTGCCAATAAAGAGTCGCTGATTACCTGCGGTAAAC
TCTTTATGGATGAGGTTAAACGCAGCCGTGCTCAATTACTGCCAATTGATAGCGAGCATAACGCGATTTTTCAGAGTTTG
CCTGAAAGAATTCAGCGCCAATTAGGCTATTCTTCATTAAATGAAAATGGCGTTTCACGGATTATTTTGACTGGCTCTGG
TGGCCCATTTCGTGAAACTCCACTTTCGCAGTTTTCTGATGTCACCCCAGATCAAGCTTGTGCTCATCCAAATTGGTCTA
TGGGGCGGAAAATTTCTGTCGACTCAGCGACGATGATGAATAAAGGCCTGGAGTATATTGAGGCTCGATGGTTATTTAAT
GCCAGCGCAGAACAGATAGAGGTTGTGTTACATCCGCAGTCTGTTATTCACTCGATGGTTCGCTATCATGACGGAAGTAT
CCTGGCACAAATGGGGACTCCAGACATGCGGACACCGATTGCACATGCGATGGCTTACCCAATGCGAGTTAGCTCAGGTG
TTGCGCCATTGGATTTTTGCAAAGTAGGCGCGCTGACCTTTACAACCCCGGATTATCAACGTTATCCGTGCTTAAAGTTG
GCCATAGACGCCTGTAATGCGGGGCAGGCAGCGACAACAGCGCTGAATGCAGCAAATGAAATTTCAGTCATGGCATTTTT
AGATTCAAAAATTCGTTTCACTGATATTGAAGTGATTAACCGTACTGTTGTTGAAGGTTTATTATTATCAGAACCTACCA
GTGTGGAAGAGGTGTTGGTGATTGATCGCAAAGCTCGTGATGTCGCGGCCCAAGTCATTGCAAAATTAAATAATTAA

Upstream 100 bases:

>100_bases
TCGGCAGTCACTCGCCATAAAACCTGGAACGATGGTATCGTTTGCCATGCAGGCAAATTGATATCTCGCCTATCACCAAA
CAGTTATTCAGAGCGCCCTC

Downstream 100 bases:

>100_bases
ACCAGGTTCGCTGATCCGGTCATTTGTTAGGGAAAGGCTGAGATGGTATAGTCAACCCTATCAATGGATAGATAGACTGT
TGATTAGTGACCCAATAGGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTEVYS
GETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSL
PERIQRQLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFCKVGALTFTTPDYQRYPCLKL
AIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVINRTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN

Sequences:

>Translated_398_residues
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTEVYS
GETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSL
PERIQRQLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFCKVGALTFTTPDYQRYPCLKL
AIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVINRTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN
>Mature_398_residues
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEHSAKSLRLLLAEQGSDTEVYS
GETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQVLLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSL
PERIQRQLGYSSLNENGVSRIILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFCKVGALTFTTPDYQRYPCLKL
AIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVINRTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=72.2222222222222, Blast_Score=583, Evalue=1e-168,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_YERP3 (A7FFH3)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400001.1
- ProteinModelPortal:   A7FFH3
- SMR:   A7FFH3
- STRING:   A7FFH3
- GeneID:   5385708
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1017
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   YPSE349747:YPSIP31758_1017-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43116; Mature: 43116

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEH
CCEEEEEECCCCCCCCEEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHCCCCEECCCCCC
SAKSLRLLLAEQGSDTEVYSGETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQV
CHHHHEEHEECCCCCCEEECCCCCEEEEHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCEE
LLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSLPERIQRQLGYSSLNENGVSR
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHEEC
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFC
CCCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHHCCCCCCHHHH
KVGALTFTTPDYQRYPCLKLAIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVIN
HCCEEEECCCCCCCCCHHHEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCEEEHHHHHH
RTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN
HHHHHHHHHCCCCCCHHEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQLTILGSTGSIGNSTLSVVRANPELFKVTALVAGRNVREMAQQCLEFSPRYAAMSDEH
CCEEEEEECCCCCCCCEEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHCCCCEECCCCCC
SAKSLRLLLAEQGSDTEVYSGETAACELAALDDVDQVMAAIVGIAGLPSTLAAIRAGKQV
CHHHHEEHEECCCCCCEEECCCCCEEEEHHHCCHHHHHHHHHHHCCCHHHHHHHHCCCEE
LLANKESLITCGKLFMDEVKRSRAQLLPIDSEHNAIFQSLPERIQRQLGYSSLNENGVSR
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEE
IILTGSGGPFRETPLSQFSDVTPDQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCCHHHHCCCCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHEEC
ASAEQIEVVLHPQSVIHSMVRYHDGSILAQMGTPDMRTPIAHAMAYPMRVSSGVAPLDFC
CCCCEEEEEECCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCHHHCCCCCCHHHH
KVGALTFTTPDYQRYPCLKLAIDACNAGQAATTALNAANEISVMAFLDSKIRFTDIEVIN
HCCEEEECCCCCCCCCHHHEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCEEEHHHHHH
RTVVEGLLLSEPTSVEEVLVIDRKARDVAAQVIAKLNN
HHHHHHHHHCCCCCCHHEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA