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The map label for this gene is yhdN [H]

Identifier: 218884574

GI number: 218884574

Start: 1182256

End: 1183206

Strand: Direct

Name: yhdN [H]

Synonym: DKAM_1263

Alternate gene names: 218884574

Gene position: 1182256-1183206 (Clockwise)

Preceding gene: 218884571

Following gene: 218884578

Centisome position: 86.6

GC content: 45.95

Gene sequence:

>951_bases
ATGGAGTATACTACGCTAGGTTGGACAGATGAGAAGATCTCTAGGATAGGGCTTGGGACATGGCAGTACAGTGAGACATG
GGGTTTAACAGATTATGATGTAGCTAAAAAGGTGATTGGAAAAGCCATCGAGGTAGGCATAAACTTCTTTGACACTGCAA
TGGTTTACGGTAGAGGAATGAGCGAGGAATTCCTTGGGAAAGCGCTAAGGGAGCTGGGTGTTAAAAGAGACGAGGTATTT
ATAGCTACTAAGATACCCGGAGAATTCCTTAATCCCGACGACGTGTTCAAATCCGTCGACAGGTCATTGAGGAGGCTCGG
GGTTAACTCGATAGATTTGCTTCAACTGCACTGGCCCCCGTGCTGGCACAACTATCCCACTACATCATATGCACGGGCCC
TCGAGAGGCTTATAATACAGGGTAAAATAAGATATATTGGTGTAAGCAATTACCCAGTTGCCTTAATAGAGGAGCTCAGA
TCAGCGCTCTCAATCACGGATATCGTGAGCATGCAGTATAGATTCAACCTAGCTGAGAGATGGGCTGAAGAAGAGTTGAT
ACCATATGCCGAAGCCAATGACCTCACCTTTATACCTTGGAGCCCTCTGGCTAAAGGCGCTCTAACCGGTAAATACGCAT
TGGAGAATATAGGTTTATTCAGGGATTTAAGGACTAATGAAGCAGTGTTCCACCCCTCTAACTTCGAGAAGCTGATCCCA
TTAATCAACGCATTGAAAGAGTTGGCTTCAAAGTACGGTAAGACTCCATCCCAGGTAGCGTTAAACTGGTTGGTGAGGTA
TAGCCCTGTTATAGTTCCAATACCTGGCGCGAAGACCCCTGAGCAGGTTGTGGAGAACGCTGGTGCAGTAGGCTGGGAAC
TCAGCTTCGAGGATTGGATGATGTTGTATGATATAGCTAAAAACATTAAGGTAACCTATGTGACTTGGTGA

Upstream 100 bases:

>100_bases
TCCTGAACCTGGAGCTCATAAACACCACCATGGATCACTAATTGATGTAAAATATTGTTTTTATATTTTAGGGAAACCTA
ATATCAATGTAGTGATTGAA

Downstream 100 bases:

>100_bases
AGGAATTACAACTGAAAGCCCCGCTCTTTAGGGCTGGAGGAGCTCAGATCGGTGCATTTTGTTTTTTCCTATGTAACTCA
TATACTAGTATCCCGATTAA

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MEYTTLGWTDEKISRIGLGTWQYSETWGLTDYDVAKKVIGKAIEVGINFFDTAMVYGRGMSEEFLGKALRELGVKRDEVF
IATKIPGEFLNPDDVFKSVDRSLRRLGVNSIDLLQLHWPPCWHNYPTTSYARALERLIIQGKIRYIGVSNYPVALIEELR
SALSITDIVSMQYRFNLAERWAEEELIPYAEANDLTFIPWSPLAKGALTGKYALENIGLFRDLRTNEAVFHPSNFEKLIP
LINALKELASKYGKTPSQVALNWLVRYSPVIVPIPGAKTPEQVVENAGAVGWELSFEDWMMLYDIAKNIKVTYVTW

Sequences:

>Translated_316_residues
MEYTTLGWTDEKISRIGLGTWQYSETWGLTDYDVAKKVIGKAIEVGINFFDTAMVYGRGMSEEFLGKALRELGVKRDEVF
IATKIPGEFLNPDDVFKSVDRSLRRLGVNSIDLLQLHWPPCWHNYPTTSYARALERLIIQGKIRYIGVSNYPVALIEELR
SALSITDIVSMQYRFNLAERWAEEELIPYAEANDLTFIPWSPLAKGALTGKYALENIGLFRDLRTNEAVFHPSNFEKLIP
LINALKELASKYGKTPSQVALNWLVRYSPVIVPIPGAKTPEQVVENAGAVGWELSFEDWMMLYDIAKNIKVTYVTW
>Mature_316_residues
MEYTTLGWTDEKISRIGLGTWQYSETWGLTDYDVAKKVIGKAIEVGINFFDTAMVYGRGMSEEFLGKALRELGVKRDEVF
IATKIPGEFLNPDDVFKSVDRSLRRLGVNSIDLLQLHWPPCWHNYPTTSYARALERLIIQGKIRYIGVSNYPVALIEELR
SALSITDIVSMQYRFNLAERWAEEELIPYAEANDLTFIPWSPLAKGALTGKYALENIGLFRDLRTNEAVFHPSNFEKLIP
LINALKELASKYGKTPSQVALNWLVRYSPVIVPIPGAKTPEQVVENAGAVGWELSFEDWMMLYDIAKNIKVTYVTW

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436964, Length=310, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI27436962, Length=310, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI27436966, Length=310, Percent_Identity=28.7096774193548, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI24497577, Length=322, Percent_Identity=27.0186335403727, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI5174391, Length=322, Percent_Identity=27.0186335403727, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI27436969, Length=314, Percent_Identity=28.0254777070064, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4504825, Length=312, Percent_Identity=27.8846153846154, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI27436971, Length=313, Percent_Identity=28.1150159744409, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI223718702, Length=281, Percent_Identity=28.8256227758007, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI223468663, Length=324, Percent_Identity=24.3827160493827, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI41327764, Length=271, Percent_Identity=31.3653136531365, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI41152114, Length=282, Percent_Identity=29.4326241134752, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87081735, Length=314, Percent_Identity=35.031847133758, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788070, Length=334, Percent_Identity=30.8383233532934, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788081, Length=293, Percent_Identity=30.0341296928328, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789375, Length=316, Percent_Identity=29.4303797468354, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87082198, Length=276, Percent_Identity=28.9855072463768, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789199, Length=332, Percent_Identity=27.710843373494, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787674, Length=323, Percent_Identity=26.625386996904, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786400, Length=286, Percent_Identity=26.2237762237762, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17564128, Length=327, Percent_Identity=27.82874617737, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17552492, Length=294, Percent_Identity=25.1700680272109, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI212645785, Length=324, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17537075, Length=309, Percent_Identity=25.8899676375405, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537077, Length=322, Percent_Identity=25.4658385093168, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538386, Length=320, Percent_Identity=26.5625, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17566692, Length=292, Percent_Identity=27.0547945205479, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325169, Length=329, Percent_Identity=27.355623100304, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321896, Length=296, Percent_Identity=25, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324694, Length=324, Percent_Identity=24.3827160493827, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323998, Length=314, Percent_Identity=26.1146496815287, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319958, Length=276, Percent_Identity=25.7246376811594, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320576, Length=304, Percent_Identity=23.3552631578947, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319625, Length=296, Percent_Identity=25.3378378378378, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319951, Length=282, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322615, Length=252, Percent_Identity=25, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644950, Length=326, Percent_Identity=27.6073619631902, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646155, Length=221, Percent_Identity=33.0316742081448, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646159, Length=171, Percent_Identity=36.2573099415205, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24662789, Length=322, Percent_Identity=25.4658385093168, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640980, Length=320, Percent_Identity=26.5625, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45549126, Length=320, Percent_Identity=26.5625, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35983; Mature: 35983

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYTTLGWTDEKISRIGLGTWQYSETWGLTDYDVAKKVIGKAIEVGINFFDTAMVYGRGM
CCCCCCCCCHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
SEEFLGKALRELGVKRDEVFIATKIPGEFLNPDDVFKSVDRSLRRLGVNSIDLLQLHWPP
CHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCC
CWHNYPTTSYARALERLIIQGKIRYIGVSNYPVALIEELRSALSITDIVSMQYRFNLAER
CCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WAEEELIPYAEANDLTFIPWSPLAKGALTGKYALENIGLFRDLRTNEAVFHPSNFEKLIP
HHHHHCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHH
LINALKELASKYGKTPSQVALNWLVRYSPVIVPIPGAKTPEQVVENAGAVGWELSFEDWM
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCEEEECHHHHH
MLYDIAKNIKVTYVTW
HHHHHHCCCEEEEEEC
>Mature Secondary Structure
MEYTTLGWTDEKISRIGLGTWQYSETWGLTDYDVAKKVIGKAIEVGINFFDTAMVYGRGM
CCCCCCCCCHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
SEEFLGKALRELGVKRDEVFIATKIPGEFLNPDDVFKSVDRSLRRLGVNSIDLLQLHWPP
CHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCC
CWHNYPTTSYARALERLIIQGKIRYIGVSNYPVALIEELRSALSITDIVSMQYRFNLAER
CCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WAEEELIPYAEANDLTFIPWSPLAKGALTGKYALENIGLFRDLRTNEAVFHPSNFEKLIP
HHHHHCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHH
LINALKELASKYGKTPSQVALNWLVRYSPVIVPIPGAKTPEQVVENAGAVGWELSFEDWM
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCEEEECHHHHH
MLYDIAKNIKVTYVTW
HHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]