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The map label for this gene is mre11 [H]

Identifier: 218883924

GI number: 218883924

Start: 579717

End: 581000

Strand: Reverse

Name: mre11 [H]

Synonym: DKAM_0613

Alternate gene names: 218883924

Gene position: 581000-579717 (Counterclockwise)

Preceding gene: 218883925

Following gene: 218883923

Centisome position: 42.56

GC content: 42.37

Gene sequence:

>1284_bases
GTGTCATCCATGATGATTATTCATACAGGAGACCTACACTTAGGGTGCTCACTTTCCAGGGAGAGCCCCCTCGCCAGATT
CTACATAGATGTTCTAAAGGAGCTAGTGGAGAAAGCTATTCGTGAAAAAGCTATTGTGCTCATCTCGGGTGACTTCTTCG
ATCATTATGATGTAAGCTACTCTTTAATGATAGAGGTAGCCAGGTATCTCAGGCAATTACGCGATAATAATATAGAGGTG
GTTGTTGTACCGGGAAACCATGATAATGCTAGAAGCGGTAGAGGGGTGCTCGACCTGTTTAATGAAGCTGGGTTAATCAA
GTTAACCAGGTACGAGGAAATAGGGGGGCACCTGTTGCTTTATCCTTTGAGAATAAATGACTATGACTTCTATGGTGTAC
CGGGTTTCAGGAATCAGGCTGAGTCAAAGTATATTAAGGAAAACCGGGTGAAATTCGTTAAGAAGAATAATGAGAATAAT
GTAATCATCTTAGCACACGTGAGCGTGGAGTTTGCTGGTTTCAGGCCACGTGATTACAACAGGCAATATGGTATGATAGA
TGTCGTTGAGAATGAACTGTGGAGGATAATGCCTTCTGGGATAAAATATGTTGCACTAGGCCACATACATATCCCGATAC
CCCAGGAGAGAAAATTCAAATCCAACATAGCTTACCCCGGGGCACCAATAGGCATGAATATTGAGGACTTAAGGGAAACA
GCACTACTTGAGAGGAAAGGAGTTAGGAGAAGATTCCTCATGGTAGATTTAGAAGGAGATCTTCCCTTGGTAGAAGCCGT
AGAGCTGGAATCATCCCCGAAGATAATGTATGAGAAGGCCTCGTATATTAGTATTGATGAATTAAGGAAGCACATATCAA
GTATTGTTAAAGACGGAGCAGATTACCATGGATTCATATTCGAGGCTAAGGTTGAAGGATTAAAGGATGAACAGGTAAAC
GAGCTACGTTCCTTTATTCAGGAGATCCAGCGGAGCTATAATAAGCTGGTATACTTAAGACTCCCTGAAGTCAGCGGCGT
TGAAAACGTTTTCGCAGGCTACGACATCCATCAAGTAGATACAGGTAGTTTATCAATAGAGGAGATTGAAGAGAAAATCC
TCAACGAGTACGCTGGAAAACTAGGCTTAAGGATCCCCATTGAGAAAATCAAGGAGATCCTGAGGCTACTCTACGAAGAA
AAAGGTGAAAGGGGTAGATACTATTATAAGGAACTCTATGAGAAAATCAAGAGTATTCTCCAGGAATCCTATAAGGGGGG
CTGA

Upstream 100 bases:

>100_bases
AGGAATTCAGGAAGACTGCCCGCGAATTCTATGGTGTTTTAGCCTAGTCTTAATCAAATAAGGTTTTTCACTCCCTATCC
TAAATATTATTGCCTTGAGT

Downstream 100 bases:

>100_bases
GAACACTTGAATGTCTTCTCAGAGATCCTGGAGAAATATGCTAAGCTGATGCACAGCGATTACCTAAGATCACGTGAGAA
CATAATTGTCAGAGAGAGAA

Product: DNA double-strand break repair protein mre11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSSMMIIHTGDLHLGCSLSRESPLARFYIDVLKELVEKAIREKAIVLISGDFFDHYDVSYSLMIEVARYLRQLRDNNIEV
VVVPGNHDNARSGRGVLDLFNEAGLIKLTRYEEIGGHLLLYPLRINDYDFYGVPGFRNQAESKYIKENRVKFVKKNNENN
VIILAHVSVEFAGFRPRDYNRQYGMIDVVENELWRIMPSGIKYVALGHIHIPIPQERKFKSNIAYPGAPIGMNIEDLRET
ALLERKGVRRRFLMVDLEGDLPLVEAVELESSPKIMYEKASYISIDELRKHISSIVKDGADYHGFIFEAKVEGLKDEQVN
ELRSFIQEIQRSYNKLVYLRLPEVSGVENVFAGYDIHQVDTGSLSIEEIEEKILNEYAGKLGLRIPIEKIKEILRLLYEE
KGERGRYYYKELYEKIKSILQESYKGG

Sequences:

>Translated_427_residues
MSSMMIIHTGDLHLGCSLSRESPLARFYIDVLKELVEKAIREKAIVLISGDFFDHYDVSYSLMIEVARYLRQLRDNNIEV
VVVPGNHDNARSGRGVLDLFNEAGLIKLTRYEEIGGHLLLYPLRINDYDFYGVPGFRNQAESKYIKENRVKFVKKNNENN
VIILAHVSVEFAGFRPRDYNRQYGMIDVVENELWRIMPSGIKYVALGHIHIPIPQERKFKSNIAYPGAPIGMNIEDLRET
ALLERKGVRRRFLMVDLEGDLPLVEAVELESSPKIMYEKASYISIDELRKHISSIVKDGADYHGFIFEAKVEGLKDEQVN
ELRSFIQEIQRSYNKLVYLRLPEVSGVENVFAGYDIHQVDTGSLSIEEIEEKILNEYAGKLGLRIPIEKIKEILRLLYEE
KGERGRYYYKELYEKIKSILQESYKGG
>Mature_426_residues
SSMMIIHTGDLHLGCSLSRESPLARFYIDVLKELVEKAIREKAIVLISGDFFDHYDVSYSLMIEVARYLRQLRDNNIEVV
VVPGNHDNARSGRGVLDLFNEAGLIKLTRYEEIGGHLLLYPLRINDYDFYGVPGFRNQAESKYIKENRVKFVKKNNENNV
IILAHVSVEFAGFRPRDYNRQYGMIDVVENELWRIMPSGIKYVALGHIHIPIPQERKFKSNIAYPGAPIGMNIEDLRETA
LLERKGVRRRFLMVDLEGDLPLVEAVELESSPKIMYEKASYISIDELRKHISSIVKDGADYHGFIFEAKVEGLKDEQVNE
LRSFIQEIQRSYNKLVYLRLPEVSGVENVFAGYDIHQVDTGSLSIEEIEEKILNEYAGKLGLRIPIEKIKEILRLLYEEK
GERGRYYYKELYEKIKSILQESYKGG

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003701
- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 49351; Mature: 49220

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSMMIIHTGDLHLGCSLSRESPLARFYIDVLKELVEKAIREKAIVLISGDFFDHYDVSY
CCCEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHH
SLMIEVARYLRQLRDNNIEVVVVPGNHDNARSGRGVLDLFNEAGLIKLTRYEEIGGHLLL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHCCEEEE
YPLRINDYDFYGVPGFRNQAESKYIKENRVKFVKKNNENNVIILAHVSVEFAGFRPRDYN
EEEEECCEEEECCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEEEEEEECCCCCCCC
RQYGMIDVVENELWRIMPSGIKYVALGHIHIPIPQERKFKSNIAYPGAPIGMNIEDLRET
CCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHH
ALLERKGVRRRFLMVDLEGDLPLVEAVELESSPKIMYEKASYISIDELRKHISSIVKDGA
HHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCC
DYHGFIFEAKVEGLKDEQVNELRSFIQEIQRSYNKLVYLRLPEVSGVENVFAGYDIHQVD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHCCCCEEEEC
TGSLSIEEIEEKILNEYAGKLGLRIPIEKIKEILRLLYEEKGERGRYYYKELYEKIKSIL
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QESYKGG
HHHCCCC
>Mature Secondary Structure 
SSMMIIHTGDLHLGCSLSRESPLARFYIDVLKELVEKAIREKAIVLISGDFFDHYDVSY
CCEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHH
SLMIEVARYLRQLRDNNIEVVVVPGNHDNARSGRGVLDLFNEAGLIKLTRYEEIGGHLLL
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHCCEEEE
YPLRINDYDFYGVPGFRNQAESKYIKENRVKFVKKNNENNVIILAHVSVEFAGFRPRDYN
EEEEECCEEEECCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEEEEEEECCCCCCCC
RQYGMIDVVENELWRIMPSGIKYVALGHIHIPIPQERKFKSNIAYPGAPIGMNIEDLRET
CCCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHH
ALLERKGVRRRFLMVDLEGDLPLVEAVELESSPKIMYEKASYISIDELRKHISSIVKDGA
HHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCC
DYHGFIFEAKVEGLKDEQVNELRSFIQEIQRSYNKLVYLRLPEVSGVENVFAGYDIHQVD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHCCCCEEEEC
TGSLSIEEIEEKILNEYAGKLGLRIPIEKIKEILRLLYEEKGERGRYYYKELYEKIKSIL
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QESYKGG
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]