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The map label for this gene is purP [H]

Identifier: 218883842

GI number: 218883842

Start: 499085

End: 500152

Strand: Direct

Name: purP [H]

Synonym: DKAM_0531

Alternate gene names: 218883842

Gene position: 499085-500152 (Clockwise)

Preceding gene: 218883841

Following gene: 218883843

Centisome position: 36.56

GC content: 46.44

Gene sequence:

>1068_bases
ATGAACATCGATGAATTACTCAGGGGCTATGATACAGGTAACCTAGCGATCGGCACGCTTGCAAGTCACTCGGCACTACA
GATAATGCATGGAGCTAAGAAGGAGGGATTCACTACAATCCTTGTGGCACTCAGGGATAGAGCATGGTTCTACAGGGACT
TCGATCACCTAATAGATTTAATAATAGAGGTTAACTCATGGAGAGATATATGTAAGCCGGAGATCGTTGAGGAACTCAGG
GGCTATAACACTATCCTGGTTCCACATGGAAGCTTCGTGGAGTATGTTGGCCTTGAATGCGGTGAATCTATAAACGTACC
CCTATTCGGTACACGTAGCCTACTGAGGGTCGAGGCTGATCAAAAACTAAAAATGCTACTCCTCATGAAAGCTGGGATAC
CTACCCCACGCGTCTACGAGTTAAGCGATGATGTAAGGGGGCCCGTAATAGTGAAGTTACCGGGTGCTAAGGGTGGTAAA
GGATACTTCATTGCCTCAAGTAATAGTGAGATAGAGGCCAAGCTGAGGAAATATATTGAGGATGGCTTGCTAAGAAGCCC
CAGGGAGGCAATCATACAGGAGTACATAGTAGGGGTCACAGCATACTTCCACTACTTCTACAGCCCGGTATTAAACAGAC
TTGAGCTGCTTGGAGCCGATATAAGGTATGAAAGCGATGTTGATGGGCTACGTAGACTACCTGTTGGAATCCTAGAGGAA
CTAGGCATCGATCCCACGTTCACTGTAGTGGGAAACCTACCACTAGTGTTAAGAGAGAGCCTGCTCCCAAAGATAATCGA
GTACGGGAGGAGATTTGTAGATGCCTCACGTGGCATGGTTTCGCCAGGCGTTATAGGCCCATTCTGCCTTGAATCCGTTA
TAGATAGAGAGTTGAATGTAAAGGTGTTTGAGTTCTCTGGGAGAATTGTGGCTGGGACAAACCTGTATATTGATGGAAGC
CCGTATTCATACTTGTACTGGGATCAACCAGTTAGCATGGGTAGGAGAATAGCTATCGAGGTGAGGCTAGCCCTGGAGAA
GGGGTTATTGGAAAAAATCGTTACATAA

Upstream 100 bases:

>100_bases
AGTGCTTTGACTACTCGAAATACCTTGGCAACTACTCTGAGCTCATAGATAGAGTCTTGAAATATGTTAGAGAGCAGATT
GAAGTAGGGAGCATGTGATT

Downstream 100 bases:

>100_bases
TGTTTAATTCCACTCCCCATATAATTAGTTAAGTAGGGGTAGTTGAAGTGAGACTCGACTATAGGTTTATCAGTGTGGAT
TTATTGAGAGCGTACAAGGA

Product: 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase

Products: NA

Alternate protein names: 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNIDELLRGYDTGNLAIGTLASHSALQIMHGAKKEGFTTILVALRDRAWFYRDFDHLIDLIIEVNSWRDICKPEIVEELR
GYNTILVPHGSFVEYVGLECGESINVPLFGTRSLLRVEADQKLKMLLLMKAGIPTPRVYELSDDVRGPVIVKLPGAKGGK
GYFIASSNSEIEAKLRKYIEDGLLRSPREAIIQEYIVGVTAYFHYFYSPVLNRLELLGADIRYESDVDGLRRLPVGILEE
LGIDPTFTVVGNLPLVLRESLLPKIIEYGRRFVDASRGMVSPGVIGPFCLESVIDRELNVKVFEFSGRIVAGTNLYIDGS
PYSYLYWDQPVSMGRRIAIEVRLALEKGLLEKIVT

Sequences:

>Translated_355_residues
MNIDELLRGYDTGNLAIGTLASHSALQIMHGAKKEGFTTILVALRDRAWFYRDFDHLIDLIIEVNSWRDICKPEIVEELR
GYNTILVPHGSFVEYVGLECGESINVPLFGTRSLLRVEADQKLKMLLLMKAGIPTPRVYELSDDVRGPVIVKLPGAKGGK
GYFIASSNSEIEAKLRKYIEDGLLRSPREAIIQEYIVGVTAYFHYFYSPVLNRLELLGADIRYESDVDGLRRLPVGILEE
LGIDPTFTVVGNLPLVLRESLLPKIIEYGRRFVDASRGMVSPGVIGPFCLESVIDRELNVKVFEFSGRIVAGTNLYIDGS
PYSYLYWDQPVSMGRRIAIEVRLALEKGLLEKIVT
>Mature_355_residues
MNIDELLRGYDTGNLAIGTLASHSALQIMHGAKKEGFTTILVALRDRAWFYRDFDHLIDLIIEVNSWRDICKPEIVEELR
GYNTILVPHGSFVEYVGLECGESINVPLFGTRSLLRVEADQKLKMLLLMKAGIPTPRVYELSDDVRGPVIVKLPGAKGGK
GYFIASSNSEIEAKLRKYIEDGLLRSPREAIIQEYIVGVTAYFHYFYSPVLNRLELLGADIRYESDVDGLRRLPVGILEE
LGIDPTFTVVGNLPLVLRESLLPKIIEYGRRFVDASRGMVSPGVIGPFCLESVIDRELNVKVFEFSGRIVAGTNLYIDGS
PYSYLYWDQPVSMGRRIAIEVRLALEKGLLEKIVT

Specific function: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates [H]

COG id: COG1759

COG function: function code R; ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR009720
- InterPro:   IPR010672
- InterPro:   IPR013817 [H]

Pfam domain/function: PF06849 DUF1246; PF06973 DUF1297 [H]

EC number: NA

Molecular weight: Translated: 39858; Mature: 39858

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDELLRGYDTGNLAIGTLASHSALQIMHGAKKEGFTTILVALRDRAWFYRDFDHLIDL
CCHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHEEEHHHHCHHHHHHHHHHHHH
IIEVNSWRDICKPEIVEELRGYNTILVPHGSFVEYVGLECGESINVPLFGTRSLLRVEAD
HHHHCCCHHCCCHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCCCCCEECCCHHEEECCC
QKLKMLLLMKAGIPTPRVYELSDDVRGPVIVKLPGAKGGKGYFIASSNSEIEAKLRKYIE
HHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHH
DGLLRSPREAIIQEYIVGVTAYFHYFYSPVLNRLELLGADIRYESDVDGLRRLPVGILEE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHH
LGIDPTFTVVGNLPLVLRESLLPKIIEYGRRFVDASRGMVSPGVIGPFCLESVIDRELNV
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCE
KVFEFSGRIVAGTNLYIDGSPYSYLYWDQPVSMGRRIAIEVRLALEKGLLEKIVT
EEEEECCEEEECCEEEECCCCCEEEEECCCCCCCCEEEEEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MNIDELLRGYDTGNLAIGTLASHSALQIMHGAKKEGFTTILVALRDRAWFYRDFDHLIDL
CCHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCCHHHEEEHHHHCHHHHHHHHHHHHH
IIEVNSWRDICKPEIVEELRGYNTILVPHGSFVEYVGLECGESINVPLFGTRSLLRVEAD
HHHHCCCHHCCCHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCCCCCEECCCHHEEECCC
QKLKMLLLMKAGIPTPRVYELSDDVRGPVIVKLPGAKGGKGYFIASSNSEIEAKLRKYIE
HHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHH
DGLLRSPREAIIQEYIVGVTAYFHYFYSPVLNRLELLGADIRYESDVDGLRRLPVGILEE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHH
LGIDPTFTVVGNLPLVLRESLLPKIIEYGRRFVDASRGMVSPGVIGPFCLESVIDRELNV
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCE
KVFEFSGRIVAGTNLYIDGSPYSYLYWDQPVSMGRRIAIEVRLALEKGLLEKIVT
EEEEECCEEEECCEEEECCCCCEEEEECCCCCCCCEEEEEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA