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The map label for this gene is degP [H]

Identifier: 218883744

GI number: 218883744

Start: 401938

End: 402876

Strand: Direct

Name: degP [H]

Synonym: DKAM_0433

Alternate gene names: 218883744

Gene position: 401938-402876 (Clockwise)

Preceding gene: 218883743

Following gene: 218883747

Centisome position: 29.44

GC content: 44.09

Gene sequence:

>939_bases
ATGGATCCCTACGAGTTATCCGTGAAGCTAACTAGAATGGTTGAGGAGATAGAGTCGTCAGTGGTAACCATAGCTACTCA
AATATCTTATCCAATTCCATTCTTCTTCAGTCAGGAACAGGCTAGAAGCTATGGATCAGGCTTCATTGTTTCAGAAGGCC
TGGTAGTAACTAATGCGCATGTGGTTAGAAATGCATCAGTTATCAAGATAATGTTTAGTGATGGATATATTAGTGAGGCT
GAAATAGTAGCCATAGACCCAAGCAGGGACCTAGCTCTCCTAAGGACTGAGAAACATGGTGTACCAATAAGGCTAGGAGA
CTCTAACATGGTTAAGCCCGGTGAAATAGTATTAGCCATAGGGTCTCCACTAGGATTGCCAGGTCCCAGTGTCACACTAG
GAGTAATAAGCGCGGTTGGAAGAACTCTTTCAAGTGGTGAAGTAATACTAGAGGACCTCATTCAGACAGATGCCGCAATA
AACCCAGGTAATAGCGGGGGGCCACTCGTGAATTTGAATGGAGAGGCTATCGGGGTAGCCACTGCAATAATACCTTATGC
ACAGGGAATCGGGTTCGCCATACCGGTGAACACGGTGAAGCGTTTCATAGAGATCATTAGAAAATATGGTAGACCGCTGA
GAGCATGGATAGGGGTCTACGTAGCACCATTAAACCCAACCACTTCTTCAATATATAGGCTACCAGTAAAGGAAGGATTG
TTAGTTGTAAGGGTTGTGCCAGGTATGCCAGCTTATAGAATGGGCATTAGGGAGGGAGATGTAATAGTAGCGGTTAATGG
AAAACCAGTGAGGAAAACCAGTGAGTTAAAGGAGACTATAGAGGAGAGCATAGATAATGGCGTTATTCAGCTGGAGATAA
TTAGAGGAGGCAAGTTATTCAAGATAGAAGTCCCAATAGTTGTTGAGGAACTCGAGTAA

Upstream 100 bases:

>100_bases
ACGAGGCTTTCGGTTGTAAAAGCCACGATAGGTGAGAAACACTTAATAAAGAATAAGGTATTTTAATTATTTCACCCTGA
TTTTATACTAGTGATCTATA

Downstream 100 bases:

>100_bases
GCCGTTTAGAAAGGGGGGTTCAGGGTCTGATATTAAGTTTATGTTGGCTGTGTTGTACCTTCATCTGGCTTAGGGGTGTT
GAGGGGTATCCTGAGACCCT

Product: Protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDPYELSVKLTRMVEEIESSVVTIATQISYPIPFFFSQEQARSYGSGFIVSEGLVVTNAHVVRNASVIKIMFSDGYISEA
EIVAIDPSRDLALLRTEKHGVPIRLGDSNMVKPGEIVLAIGSPLGLPGPSVTLGVISAVGRTLSSGEVILEDLIQTDAAI
NPGNSGGPLVNLNGEAIGVATAIIPYAQGIGFAIPVNTVKRFIEIIRKYGRPLRAWIGVYVAPLNPTTSSIYRLPVKEGL
LVVRVVPGMPAYRMGIREGDVIVAVNGKPVRKTSELKETIEESIDNGVIQLEIIRGGKLFKIEVPIVVEELE

Sequences:

>Translated_312_residues
MDPYELSVKLTRMVEEIESSVVTIATQISYPIPFFFSQEQARSYGSGFIVSEGLVVTNAHVVRNASVIKIMFSDGYISEA
EIVAIDPSRDLALLRTEKHGVPIRLGDSNMVKPGEIVLAIGSPLGLPGPSVTLGVISAVGRTLSSGEVILEDLIQTDAAI
NPGNSGGPLVNLNGEAIGVATAIIPYAQGIGFAIPVNTVKRFIEIIRKYGRPLRAWIGVYVAPLNPTTSSIYRLPVKEGL
LVVRVVPGMPAYRMGIREGDVIVAVNGKPVRKTSELKETIEESIDNGVIQLEIIRGGKLFKIEVPIVVEELE
>Mature_312_residues
MDPYELSVKLTRMVEEIESSVVTIATQISYPIPFFFSQEQARSYGSGFIVSEGLVVTNAHVVRNASVIKIMFSDGYISEA
EIVAIDPSRDLALLRTEKHGVPIRLGDSNMVKPGEIVLAIGSPLGLPGPSVTLGVISAVGRTLSSGEVILEDLIQTDAAI
NPGNSGGPLVNLNGEAIGVATAIIPYAQGIGFAIPVNTVKRFIEIIRKYGRPLRAWIGVYVAPLNPTTSSIYRLPVKEGL
LVVRVVPGMPAYRMGIREGDVIVAVNGKPVRKTSELKETIEESIDNGVIQLEIIRGGKLFKIEVPIVVEELE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=320, Percent_Identity=38.125, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4506141, Length=313, Percent_Identity=37.6996805111821, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI24308541, Length=269, Percent_Identity=36.4312267657993, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI7019477, Length=316, Percent_Identity=36.3924050632911, Blast_Score=138, Evalue=5e-33,
Organism=Escherichia coli, GI1786356, Length=271, Percent_Identity=40.590405904059, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1789629, Length=269, Percent_Identity=36.8029739776952, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789630, Length=285, Percent_Identity=34.3859649122807, Blast_Score=136, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646839, Length=309, Percent_Identity=36.2459546925566, Blast_Score=161, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 33555; Mature: 33555

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50106 PDZ ; PS00622 HTH_LUXR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPYELSVKLTRMVEEIESSVVTIATQISYPIPFFFSQEQARSYGSGFIVSEGLVVTNAH
CCCCEEHHHHHHHHHHHHHCEEEEEEEECCCCCEEECHHHHHHCCCCEEEECCEEEECCE
VVRNASVIKIMFSDGYISEAEIVAIDPSRDLALLRTEKHGVPIRLGDSNMVKPGEIVLAI
EEECCEEEEEEEECCCCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEE
GSPLGLPGPSVTLGVISAVGRTLSSGEVILEDLIQTDAAINPGNSGGPLVNLNGEAIGVA
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEHH
TAIIPYAQGIGFAIPVNTVKRFIEIIRKYGRPLRAWIGVYVAPLNPTTSSIYRLPVKEGL
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHEEEEEEEEEECCCCCCCEEEEEHHCCE
LVVRVVPGMPAYRMGIREGDVIVAVNGKPVRKTSELKETIEESIDNGVIQLEIIRGGKLF
EEEEECCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCEEE
KIEVPIVVEELE
EEECCEEEEECC
>Mature Secondary Structure
MDPYELSVKLTRMVEEIESSVVTIATQISYPIPFFFSQEQARSYGSGFIVSEGLVVTNAH
CCCCEEHHHHHHHHHHHHHCEEEEEEEECCCCCEEECHHHHHHCCCCEEEECCEEEECCE
VVRNASVIKIMFSDGYISEAEIVAIDPSRDLALLRTEKHGVPIRLGDSNMVKPGEIVLAI
EEECCEEEEEEEECCCCCCCEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEE
GSPLGLPGPSVTLGVISAVGRTLSSGEVILEDLIQTDAAINPGNSGGPLVNLNGEAIGVA
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEHH
TAIIPYAQGIGFAIPVNTVKRFIEIIRKYGRPLRAWIGVYVAPLNPTTSSIYRLPVKEGL
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHEEEEEEEEEECCCCCCCEEEEEHHCCE
LVVRVVPGMPAYRMGIREGDVIVAVNGKPVRKTSELKETIEESIDNGVIQLEIIRGGKLF
EEEEECCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCEEE
KIEVPIVVEELE
EEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]