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The map label for this gene is gcvPB [H]

Identifier: 218883608

GI number: 218883608

Start: 275673

End: 277238

Strand: Reverse

Name: gcvPB [H]

Synonym: DKAM_0297

Alternate gene names: 218883608

Gene position: 277238-275673 (Counterclockwise)

Preceding gene: 218883609

Following gene: 218883607

Centisome position: 20.31

GC content: 48.66

Gene sequence:

>1566_bases
ATGAACAGGTTCAGACAGGCTAGGAACTGGGAGCCATTAATATTCGAACTCGGGAGCAAGGGTAGAATAGGTTTCCTGGT
ACCAGAGCCAGAGGATGCAGCGAAGAAACGCGTGGGCAGTATAGACATACCACCGGAAATGAAGAGGACAAGGGATCCAG
AGCTCCCCGAGCTAAGTGAGGTCGAGGTTGTAAGGCACTTCACAAACCTCTCTCAAGCAGCATACGGGGTAGACAACGGT
CCCGTCCCCCTGGGCTCATGTACTATGAAGTATAACCCGAGGATAGCCTGGGAGATAGCCGGCGATCCAAGGATAGTTAA
TCTACACCCCTTACAGGATGAGAGAACGGTTCAGGGATTACTGGAGATCCTGTATGAGCTCCAGAAATGGCTTGCAAACA
TAACAGGTATGGATACATGCATATTGCATCCAGCGGCTGGGGCGCATGGAGAGCTAGCCGGTGTATTAACTATAAGGAGG
TATCACGAGGTAAAGAATCAACTGGATAAGAAGACAGATATAATAATACCTGACAGCGCGCATGGAACAAACCCAGCTAG
CGCGGCGATGGCTGGTTTCAGAGTTATAGAGATCCCATCTGCTGAGGATGGCAACATAGATATGGAGGCGTTGAAATCCG
TTGTAGGGGAGTCAACGGCTGGATTAATGATAACTAATCCAAGCACTCTAGGATTATTCGAGGAACACATACTAGAGATA
GCAGAGCTCCTGCATAAGCATGACGCAATAATATACTATGACGGGGCAAATCTCAACGGGATAATGGGTTACGCGAGACC
CGGTGACATGGGCTTCGATATAGCTCACCTGAATATACATAAAACCTTCGGGGCACCCCATGGTGGAGGAGGCCCTGGAG
CCGGGCCAATCTGTATAAAGGATAGGGTTGTCGATAGTGAAAAGAATATAATGCTCTCGGATCTTGCACCAGGCTACAGG
GTCGTCTATGATGAGTCGACGGGATTGTACAGGGTGAAGGGACCCGGGGAATATAGTACTGGATTACTTAAGGCCTTCTT
CGGTAATATAACGCCGCTGATATGGGGCTACGTATATATCCTTAGCATGGGTCCACAGGGATTAAGAAGGGTCACAGAGC
ACGCTGTACTCATAACTAACTACTTCATGAAGCTCATGGAGAACGTGAAAGGATATAATATACCATATGGTAGAGGACGC
TTCAGGAAGCATGAGGTAGTTCTGAGCGCGCAGCCCATGACTGACGAGGTCGGGGTAACAGCTGAAGACGTTGCGAAGGG
ACTGCTGGACGCTGGATTCTATGCTCCAACCATATACTTCCCGCTAATAGTCAAGGAAGCATTAATGACAGAGTTCACTG
AGACCGAGACACCGGAGAACGTTGAGAAGTATGCTGAGAGACTCAAGGAGATCAGTAAGATAGCCTACAGCAATCCAAGC
GAACCTAAGACATGGCCAAGGAACACTAGTGTTGGAAGAGTTGATGTTCTCAAGGCTAATCACCCCAAGCATGTCACACC
CACATGGAGAGTACATGTCAGGAGGATGAGGGGAGAAATTCAGTGA

Upstream 100 bases:

>100_bases
GTGAGACAGCCCTTTACGCCTTCACGGAACTACACTCCGTAAAGGCTATAGATAGGTTAATCGAGGTACTCGGTAAGGTG
ATCCGGGAGGTGGGAAGGTA

Downstream 100 bases:

>100_bases
GATATGACACGGTAGTAGTGGGCTCCGGCACGGGAGGCTACCCGGGAGCGATATACCTGGCTCAGAAGGGCTTAAAGGTT
GCAGTCGTAGAGGAACACTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MNRFRQARNWEPLIFELGSKGRIGFLVPEPEDAAKKRVGSIDIPPEMKRTRDPELPELSEVEVVRHFTNLSQAAYGVDNG
PVPLGSCTMKYNPRIAWEIAGDPRIVNLHPLQDERTVQGLLEILYELQKWLANITGMDTCILHPAAGAHGELAGVLTIRR
YHEVKNQLDKKTDIIIPDSAHGTNPASAAMAGFRVIEIPSAEDGNIDMEALKSVVGESTAGLMITNPSTLGLFEEHILEI
AELLHKHDAIIYYDGANLNGIMGYARPGDMGFDIAHLNIHKTFGAPHGGGGPGAGPICIKDRVVDSEKNIMLSDLAPGYR
VVYDESTGLYRVKGPGEYSTGLLKAFFGNITPLIWGYVYILSMGPQGLRRVTEHAVLITNYFMKLMENVKGYNIPYGRGR
FRKHEVVLSAQPMTDEVGVTAEDVAKGLLDAGFYAPTIYFPLIVKEALMTEFTETETPENVEKYAERLKEISKIAYSNPS
EPKTWPRNTSVGRVDVLKANHPKHVTPTWRVHVRRMRGEIQ

Sequences:

>Translated_521_residues
MNRFRQARNWEPLIFELGSKGRIGFLVPEPEDAAKKRVGSIDIPPEMKRTRDPELPELSEVEVVRHFTNLSQAAYGVDNG
PVPLGSCTMKYNPRIAWEIAGDPRIVNLHPLQDERTVQGLLEILYELQKWLANITGMDTCILHPAAGAHGELAGVLTIRR
YHEVKNQLDKKTDIIIPDSAHGTNPASAAMAGFRVIEIPSAEDGNIDMEALKSVVGESTAGLMITNPSTLGLFEEHILEI
AELLHKHDAIIYYDGANLNGIMGYARPGDMGFDIAHLNIHKTFGAPHGGGGPGAGPICIKDRVVDSEKNIMLSDLAPGYR
VVYDESTGLYRVKGPGEYSTGLLKAFFGNITPLIWGYVYILSMGPQGLRRVTEHAVLITNYFMKLMENVKGYNIPYGRGR
FRKHEVVLSAQPMTDEVGVTAEDVAKGLLDAGFYAPTIYFPLIVKEALMTEFTETETPENVEKYAERLKEISKIAYSNPS
EPKTWPRNTSVGRVDVLKANHPKHVTPTWRVHVRRMRGEIQ
>Mature_521_residues
MNRFRQARNWEPLIFELGSKGRIGFLVPEPEDAAKKRVGSIDIPPEMKRTRDPELPELSEVEVVRHFTNLSQAAYGVDNG
PVPLGSCTMKYNPRIAWEIAGDPRIVNLHPLQDERTVQGLLEILYELQKWLANITGMDTCILHPAAGAHGELAGVLTIRR
YHEVKNQLDKKTDIIIPDSAHGTNPASAAMAGFRVIEIPSAEDGNIDMEALKSVVGESTAGLMITNPSTLGLFEEHILEI
AELLHKHDAIIYYDGANLNGIMGYARPGDMGFDIAHLNIHKTFGAPHGGGGPGAGPICIKDRVVDSEKNIMLSDLAPGYR
VVYDESTGLYRVKGPGEYSTGLLKAFFGNITPLIWGYVYILSMGPQGLRRVTEHAVLITNYFMKLMENVKGYNIPYGRGR
FRKHEVVLSAQPMTDEVGVTAEDVAKGLLDAGFYAPTIYFPLIVKEALMTEFTETETPENVEKYAERLKEISKIAYSNPS
EPKTWPRNTSVGRVDVLKANHPKHVTPTWRVHVRRMRGEIQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=426, Percent_Identity=38.2629107981221, Blast_Score=233, Evalue=4e-61,
Organism=Escherichia coli, GI1789269, Length=437, Percent_Identity=36.3844393592677, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17535605, Length=422, Percent_Identity=37.4407582938389, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI32564013, Length=373, Percent_Identity=38.0697050938338, Blast_Score=209, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6323843, Length=446, Percent_Identity=37.219730941704, Blast_Score=239, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24645648, Length=421, Percent_Identity=38.9548693586698, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 57845; Mature: 57845

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFRQARNWEPLIFELGSKGRIGFLVPEPEDAAKKRVGSIDIPPEMKRTRDPELPELSE
CCCHHHHCCCCCEEEECCCCCCEEEECCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCHHH
VEVVRHFTNLSQAAYGVDNGPVPLGSCTMKYNPRIAWEIAGDPRIVNLHPLQDERTVQGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEECCCCEEEEECCCCCHHHHHHH
LEILYELQKWLANITGMDTCILHPAAGAHGELAGVLTIRRYHEVKNQLDKKTDIIIPDSA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCC
HGTNPASAAMAGFRVIEIPSAEDGNIDMEALKSVVGESTAGLMITNPSTLGLFEEHILEI
CCCCHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHH
AELLHKHDAIIYYDGANLNGIMGYARPGDMGFDIAHLNIHKTFGAPHGGGGPGAGPICIK
HHHHHHCCEEEEECCCCCCCEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEE
DRVVDSEKNIMLSDLAPGYRVVYDESTGLYRVKGPGEYSTGLLKAFFGNITPLIWGYVYI
CEEECCCCCEEEECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHH
LSMGPQGLRRVTEHAVLITNYFMKLMENVKGYNIPYGRGRFRKHEVVLSAQPMTDEVGVT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCC
AEDVAKGLLDAGFYAPTIYFPLIVKEALMTEFTETETPENVEKYAERLKEISKIAYSNPS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
EPKTWPRNTSVGRVDVLKANHPKHVTPTWRVHVRRMRGEIQ
CCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MNRFRQARNWEPLIFELGSKGRIGFLVPEPEDAAKKRVGSIDIPPEMKRTRDPELPELSE
CCCHHHHCCCCCEEEECCCCCCEEEECCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCHHH
VEVVRHFTNLSQAAYGVDNGPVPLGSCTMKYNPRIAWEIAGDPRIVNLHPLQDERTVQGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEECCCCEEEEECCCCCHHHHHHH
LEILYELQKWLANITGMDTCILHPAAGAHGELAGVLTIRRYHEVKNQLDKKTDIIIPDSA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCC
HGTNPASAAMAGFRVIEIPSAEDGNIDMEALKSVVGESTAGLMITNPSTLGLFEEHILEI
CCCCHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHH
AELLHKHDAIIYYDGANLNGIMGYARPGDMGFDIAHLNIHKTFGAPHGGGGPGAGPICIK
HHHHHHCCEEEEECCCCCCCEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEE
DRVVDSEKNIMLSDLAPGYRVVYDESTGLYRVKGPGEYSTGLLKAFFGNITPLIWGYVYI
CEEECCCCCEEEECCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHH
LSMGPQGLRRVTEHAVLITNYFMKLMENVKGYNIPYGRGRFRKHEVVLSAQPMTDEVGVT
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCC
AEDVAKGLLDAGFYAPTIYFPLIVKEALMTEFTETETPENVEKYAERLKEISKIAYSNPS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
EPKTWPRNTSVGRVDVLKANHPKHVTPTWRVHVRRMRGEIQ
CCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA