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The map label for this gene is gcvPA [H]

Identifier: 218883609

GI number: 218883609

Start: 277238

End: 278656

Strand: Reverse

Name: gcvPA [H]

Synonym: DKAM_0298

Alternate gene names: 218883609

Gene position: 278656-277238 (Counterclockwise)

Preceding gene: 218883615

Following gene: 218883608

Centisome position: 20.41

GC content: 48.27

Gene sequence:

>1419_bases
GTGGTTGAAACGAGGCCTCATCCTTGGATACCTGGTTCCACCGAGGAATCGCTTAAGAAAATGCTGGATGTAATTGGCGT
TAAAAGCATTACCGAGCTCTTCAACGATATACCAAGGGAGGTACTGCTAGGGGAAGACGAGTGGAATAGACTGGAGATAG
GTGTGGGAAGGCCCCTATCCGAGATAGAGGCCAAAGAGATCGTTGATGAAAAGCTGGCTAAAAACAGGGTTTTCAATCCC
CCGCCATTTATGGGTGGAGGGGTCTACCCTCACTACGTGCCTCCCATTGTTAAATACATTATCTCAAGAGGAGAGTTTCT
CACAGCATACACACCCTACCAGGCCGAGATATCTCAGGGATTAATGCAGGCAATCTTCGAGTATCAGAGCATGATGGCTG
AGCTGCTTGAGATGGATATAGTTAACGCATCAATGTATGATTGGTCCTCATCCATTGCCGAGGCCGTATTAATGGCTTTC
AGAGTTAGAAAGGGGAGAAGGAAGATCCTGCTACCAGCCAACATGAACCCCCTCCATAAAAGGGTTGTGGAAACATATGT
CAAGCCTCATGGATTAAAGCTGGAAACCATACCCTATGATAGGGAGCTGGGCACAGTTGATGTGGAAGCGCTTAAATCAA
TGATCGATAATGATACAGCAGCAGTATACATCCAGTACCCCAACTTCTTCGGTATCGTGGAGGACAAGGCTAAAGCCATT
GGCGAGATAGCCCATGAGAAGCAGGCATTATTCATCACAGGTGTGTACCCAGTGGCCCTCGGGATCCTTAAGCCCCCTGG
TGAACTAGATGCCGATATTGCTGTAGGCGAGGGGCAATCACTTGGATTAGGCATGAACTATGGCGGCCCTCATCTCGGGA
TATTCGCCATCAAATACGATATGAACCTGGTTAGACAGATGCCTGGGAGGATAATAGGGTTGACGACTACCATTGATGGA
GGAGATAAAGCATTCGCGATGGTGTGGCAGGCGAGGGAGCAGCATATAAGGAGGGAGAAGGCTACGTCTAACATATGCAC
TAATGAGGCATTGATGGCCGTAGCGGCAGCCGTTTACATGGCTCTGCTGGGTAGGACAGGGTTTAGAAGGCTGGCTGAAC
TTATATACTATAGGGCTCACTACGCTGCAAGCAGGATAAGCGAGATCGGCTTGAGAAGGGTCTTCAAGGCTGAATTCTTC
AATGAATTCCCCATTTCATTCAATGAAGCAGGGGTCAAGTACTCGGTGATACATGAGAAACTACTTGAACACGGGTTACA
TGGAGGACTCTATATAGGCGGGTATTATCCTGAACTAGGTGAGACAGCCCTTTACGCCTTCACGGAACTACACTCCGTAA
AGGCTATAGATAGGTTAATCGAGGTACTCGGTAAGGTGATCCGGGAGGTGGGAAGGTAA

Upstream 100 bases:

>100_bases
TTTTTATACACCATAGTTTTAATGTTATCTATCTAAGTATTTATAGGTTCCATACACAGTTATAACTATATATACCTCGA
AACCATTATTTGTTTACTGG

Downstream 100 bases:

>100_bases
TGAACAGGTTCAGACAGGCTAGGAACTGGGAGCCATTAATATTCGAACTCGGGAGCAAGGGTAGAATAGGTTTCCTGGTA
CCAGAGCCAGAGGATGCAGC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MVETRPHPWIPGSTEESLKKMLDVIGVKSITELFNDIPREVLLGEDEWNRLEIGVGRPLSEIEAKEIVDEKLAKNRVFNP
PPFMGGGVYPHYVPPIVKYIISRGEFLTAYTPYQAEISQGLMQAIFEYQSMMAELLEMDIVNASMYDWSSSIAEAVLMAF
RVRKGRRKILLPANMNPLHKRVVETYVKPHGLKLETIPYDRELGTVDVEALKSMIDNDTAAVYIQYPNFFGIVEDKAKAI
GEIAHEKQALFITGVYPVALGILKPPGELDADIAVGEGQSLGLGMNYGGPHLGIFAIKYDMNLVRQMPGRIIGLTTTIDG
GDKAFAMVWQAREQHIRREKATSNICTNEALMAVAAAVYMALLGRTGFRRLAELIYYRAHYAASRISEIGLRRVFKAEFF
NEFPISFNEAGVKYSVIHEKLLEHGLHGGLYIGGYYPELGETALYAFTELHSVKAIDRLIEVLGKVIREVGR

Sequences:

>Translated_472_residues
MVETRPHPWIPGSTEESLKKMLDVIGVKSITELFNDIPREVLLGEDEWNRLEIGVGRPLSEIEAKEIVDEKLAKNRVFNP
PPFMGGGVYPHYVPPIVKYIISRGEFLTAYTPYQAEISQGLMQAIFEYQSMMAELLEMDIVNASMYDWSSSIAEAVLMAF
RVRKGRRKILLPANMNPLHKRVVETYVKPHGLKLETIPYDRELGTVDVEALKSMIDNDTAAVYIQYPNFFGIVEDKAKAI
GEIAHEKQALFITGVYPVALGILKPPGELDADIAVGEGQSLGLGMNYGGPHLGIFAIKYDMNLVRQMPGRIIGLTTTIDG
GDKAFAMVWQAREQHIRREKATSNICTNEALMAVAAAVYMALLGRTGFRRLAELIYYRAHYAASRISEIGLRRVFKAEFF
NEFPISFNEAGVKYSVIHEKLLEHGLHGGLYIGGYYPELGETALYAFTELHSVKAIDRLIEVLGKVIREVGR
>Mature_472_residues
MVETRPHPWIPGSTEESLKKMLDVIGVKSITELFNDIPREVLLGEDEWNRLEIGVGRPLSEIEAKEIVDEKLAKNRVFNP
PPFMGGGVYPHYVPPIVKYIISRGEFLTAYTPYQAEISQGLMQAIFEYQSMMAELLEMDIVNASMYDWSSSIAEAVLMAF
RVRKGRRKILLPANMNPLHKRVVETYVKPHGLKLETIPYDRELGTVDVEALKSMIDNDTAAVYIQYPNFFGIVEDKAKAI
GEIAHEKQALFITGVYPVALGILKPPGELDADIAVGEGQSLGLGMNYGGPHLGIFAIKYDMNLVRQMPGRIIGLTTTIDG
GDKAFAMVWQAREQHIRREKATSNICTNEALMAVAAAVYMALLGRTGFRRLAELIYYRAHYAASRISEIGLRRVFKAEFF
NEFPISFNEAGVKYSVIHEKLLEHGLHGGLYIGGYYPELGETALYAFTELHSVKAIDRLIEVLGKVIREVGR

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=386, Percent_Identity=34.4559585492228, Blast_Score=205, Evalue=8e-53,
Organism=Escherichia coli, GI1789269, Length=399, Percent_Identity=31.5789473684211, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535605, Length=395, Percent_Identity=34.4303797468354, Blast_Score=193, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323843, Length=386, Percent_Identity=30.8290155440415, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24645648, Length=368, Percent_Identity=35.8695652173913, Blast_Score=215, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52873; Mature: 52873

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVETRPHPWIPGSTEESLKKMLDVIGVKSITELFNDIPREVLLGEDEWNRLEIGVGRPLS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEECCCCHH
EIEAKEIVDEKLAKNRVFNPPPFMGGGVYPHYVPPIVKYIISRGEFLTAYTPYQAEISQG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LMQAIFEYQSMMAELLEMDIVNASMYDWSSSIAEAVLMAFRVRKGRRKILLPANMNPLHK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
RVVETYVKPHGLKLETIPYDRELGTVDVEALKSMIDNDTAAVYIQYPNFFGIVEDKAKAI
HHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCEECHHHHHHHHH
GEIAHEKQALFITGVYPVALGILKPPGELDADIAVGEGQSLGLGMNYGGPHLGIFAIKYD
HHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCEEECCCCCCCEECCCCCCCEEEEEEEHH
MNLVRQMPGRIIGLTTTIDGGDKAFAMVWQAREQHIRREKATSNICTNEALMAVAAAVYM
HHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLGRTGFRRLAELIYYRAHYAASRISEIGLRRVFKAEFFNEFPISFNEAGVKYSVIHEK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LLEHGLHGGLYIGGYYPELGETALYAFTELHSVKAIDRLIEVLGKVIREVGR
HHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVETRPHPWIPGSTEESLKKMLDVIGVKSITELFNDIPREVLLGEDEWNRLEIGVGRPLS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEECCCCHH
EIEAKEIVDEKLAKNRVFNPPPFMGGGVYPHYVPPIVKYIISRGEFLTAYTPYQAEISQG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LMQAIFEYQSMMAELLEMDIVNASMYDWSSSIAEAVLMAFRVRKGRRKILLPANMNPLHK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
RVVETYVKPHGLKLETIPYDRELGTVDVEALKSMIDNDTAAVYIQYPNFFGIVEDKAKAI
HHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCEECHHHHHHHHH
GEIAHEKQALFITGVYPVALGILKPPGELDADIAVGEGQSLGLGMNYGGPHLGIFAIKYD
HHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCEEECCCCCCCEECCCCCCCEEEEEEEHH
MNLVRQMPGRIIGLTTTIDGGDKAFAMVWQAREQHIRREKATSNICTNEALMAVAAAVYM
HHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLGRTGFRRLAELIYYRAHYAASRISEIGLRRVFKAEFFNEFPISFNEAGVKYSVIHEK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LLEHGLHGGLYIGGYYPELGETALYAFTELHSVKAIDRLIEVLGKVIREVGR
HHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA