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The map label for this gene is lpd [H]

Identifier: 218883607

GI number: 218883607

Start: 274306

End: 275676

Strand: Reverse

Name: lpd [H]

Synonym: DKAM_0296

Alternate gene names: 218883607

Gene position: 275676-274306 (Counterclockwise)

Preceding gene: 218883608

Following gene: 218883603

Centisome position: 20.19

GC content: 47.78

Gene sequence:

>1371_bases
GTGAGATATGACACGGTAGTAGTGGGCTCCGGCACGGGAGGCTACCCGGGAGCGATATACCTGGCTCAGAAGGGCTTAAA
GGTTGCAGTCGTAGAGGAACACTTGATCGGTGGAGAATGCACTAACTACGGATGCGTACCCAGTAAAGCCTTTTACCAGG
TAGCTGAGGCCATTAGGAGCATTGAGAAGATCGGTGGTGAAGCCTCGGTTAAATGGGAAAACCTGGTTGAATGGGTATCA
CAGGTAGTGAGGGAGAGCCGGGAGGGAATTAAGGGTTTATTCGAGTCACACGGGATAGACGTAATAGAGGGCAGGGCCAT
CCTCAAGACACAGCGTGAGATAGTTATTAGTGCCGGGGAAGAGAAGAGGCGGATTGAAGCCGGTAAAATACTTCTAGCCC
TAGGGACAGATCCCTCACCAATACCAGGGGTTTCATTCGACAGCGAGGGAATAATAAGTAACAGGGAGGCCCTCTACATG
AGGGAGAAACCCGGTGAAGTATTAATAATCGGTGGTGGAGTAATAGGTGTCGAACTAGCCAATATCCTCTCCTCTTTCAA
GGTAGGTGTTACAGTAGTGGAGTTAATGGATCACATACTGCCTACAATGGATAGGGATGTCGCGCAAGCGTTGAAGACGC
ATCTCTCTTCAAGGGGTGTGAAGATATATGAGAAGACAACGGTTAAATCCATGACTAAGACTGGTGGCAAATATTTAGCA
GAGCTCTCAAACGGCTTGAAGCTTGAGGTGGATAAGGTATTAATAGCAACTGGGAGAAAGCCTAGAACCAGGGAAGCTGG
ATTAGTTGAGAACAATATAGCACTGGATCAGAAGGGCTTCATAAAGATAAATGAGAGACAGGAGACAAGCATACCAGGCA
TATACGCCTCAGGCGATGTTGTCGGGGGGCCACTGCTCGCTCACAAGGCTATATTAGAGAGTATTTCAGCGGCTAGATGG
ATGAGTGGTGAGGAGGGCTTCCATATAGACTACTCATCCATACCCTCCACTATATTCACAGGGCTTGAAATCGCGTCAAT
AGGTTACACCGAGAAGGAGTTAACAAGCAGGGGAGTGAAATATGTTAAGGTGAGGATACCGGCCTACTATCTCTCAGCGG
TTAAGATTAAGGGCGGCAAGCAATCCTTCATAAAGGTGTTGCTCGATGAGAGGCAGGAGAAGATACTTGGAGTACATATA
GTTGCCCCCAACGCTTCAGAGGTTATCTCGGCATATATACCATTATACCTTGGTAAAATAGGCTTTGGAGACATCTCCAG
GATACCCTACCCGCATCTAACAGTATCTGAGTCCCTTAGAGACTTCGCCGAGTACTTGCTGGGTAATCCAGTACACTTAC
TCAAGAAGTAG

Upstream 100 bases:

>100_bases
ACACTAGTGTTGGAAGAGTTGATGTTCTCAAGGCTAATCACCCCAAGCATGTCACACCCACATGGAGAGTACATGTCAGG
AGGATGAGGGGAGAAATTCA

Downstream 100 bases:

>100_bases
GTTTTTCACTCTTAGCAACTACATCAATAATATTTTTCAATACCTTATATCCAGCCATACAGCATTCAACTGTATAGGGT
GAAAGACTGGGCTTCTTCAA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRYDTVVVGSGTGGYPGAIYLAQKGLKVAVVEEHLIGGECTNYGCVPSKAFYQVAEAIRSIEKIGGEASVKWENLVEWVS
QVVRESREGIKGLFESHGIDVIEGRAILKTQREIVISAGEEKRRIEAGKILLALGTDPSPIPGVSFDSEGIISNREALYM
REKPGEVLIIGGGVIGVELANILSSFKVGVTVVELMDHILPTMDRDVAQALKTHLSSRGVKIYEKTTVKSMTKTGGKYLA
ELSNGLKLEVDKVLIATGRKPRTREAGLVENNIALDQKGFIKINERQETSIPGIYASGDVVGGPLLAHKAILESISAARW
MSGEEGFHIDYSSIPSTIFTGLEIASIGYTEKELTSRGVKYVKVRIPAYYLSAVKIKGGKQSFIKVLLDERQEKILGVHI
VAPNASEVISAYIPLYLGKIGFGDISRIPYPHLTVSESLRDFAEYLLGNPVHLLKK

Sequences:

>Translated_456_residues
MRYDTVVVGSGTGGYPGAIYLAQKGLKVAVVEEHLIGGECTNYGCVPSKAFYQVAEAIRSIEKIGGEASVKWENLVEWVS
QVVRESREGIKGLFESHGIDVIEGRAILKTQREIVISAGEEKRRIEAGKILLALGTDPSPIPGVSFDSEGIISNREALYM
REKPGEVLIIGGGVIGVELANILSSFKVGVTVVELMDHILPTMDRDVAQALKTHLSSRGVKIYEKTTVKSMTKTGGKYLA
ELSNGLKLEVDKVLIATGRKPRTREAGLVENNIALDQKGFIKINERQETSIPGIYASGDVVGGPLLAHKAILESISAARW
MSGEEGFHIDYSSIPSTIFTGLEIASIGYTEKELTSRGVKYVKVRIPAYYLSAVKIKGGKQSFIKVLLDERQEKILGVHI
VAPNASEVISAYIPLYLGKIGFGDISRIPYPHLTVSESLRDFAEYLLGNPVHLLKK
>Mature_456_residues
MRYDTVVVGSGTGGYPGAIYLAQKGLKVAVVEEHLIGGECTNYGCVPSKAFYQVAEAIRSIEKIGGEASVKWENLVEWVS
QVVRESREGIKGLFESHGIDVIEGRAILKTQREIVISAGEEKRRIEAGKILLALGTDPSPIPGVSFDSEGIISNREALYM
REKPGEVLIIGGGVIGVELANILSSFKVGVTVVELMDHILPTMDRDVAQALKTHLSSRGVKIYEKTTVKSMTKTGGKYLA
ELSNGLKLEVDKVLIATGRKPRTREAGLVENNIALDQKGFIKINERQETSIPGIYASGDVVGGPLLAHKAILESISAARW
MSGEEGFHIDYSSIPSTIFTGLEIASIGYTEKELTSRGVKYVKVRIPAYYLSAVKIKGGKQSFIKVLLDERQEKILGVHI
VAPNASEVISAYIPLYLGKIGFGDISRIPYPHLTVSESLRDFAEYLLGNPVHLLKK

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=34.4978165938865, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI50301238, Length=468, Percent_Identity=29.7008547008547, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI22035672, Length=450, Percent_Identity=26.6666666666667, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI33519430, Length=400, Percent_Identity=24.25, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI33519428, Length=400, Percent_Identity=24.25, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI33519426, Length=400, Percent_Identity=24.25, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI148277065, Length=400, Percent_Identity=24.25, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI291045266, Length=410, Percent_Identity=25.609756097561, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI148277071, Length=400, Percent_Identity=24.25, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI291045268, Length=404, Percent_Identity=24.009900990099, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI65787454, Length=228, Percent_Identity=28.0701754385965, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21389617, Length=228, Percent_Identity=28.0701754385965, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI226437568, Length=228, Percent_Identity=28.0701754385965, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=27.1948608137045, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082354, Length=416, Percent_Identity=29.3269230769231, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=26.5350877192982, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1789915, Length=406, Percent_Identity=26.6009852216749, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=34.6578366445916, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=27.6507276507277, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71982272, Length=448, Percent_Identity=26.7857142857143, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=360, Percent_Identity=27.2222222222222, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=360, Percent_Identity=27.2222222222222, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559934, Length=239, Percent_Identity=27.6150627615063, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=31.5334773218143, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=29.1666666666667, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=25.369978858351, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21358499, Length=469, Percent_Identity=33.4754797441365, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24640549, Length=439, Percent_Identity=25.7403189066059, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24640553, Length=439, Percent_Identity=25.7403189066059, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24640551, Length=439, Percent_Identity=25.7403189066059, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI17737741, Length=449, Percent_Identity=27.3942093541203, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49594; Mature: 49594

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDTVVVGSGTGGYPGAIYLAQKGLKVAVVEEHLIGGECTNYGCVPSKAFYQVAEAIRS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHH
IEKIGGEASVKWENLVEWVSQVVRESREGIKGLFESHGIDVIEGRAILKTQREIVISAGE
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCEEEEEECCC
EKRRIEAGKILLALGTDPSPIPGVSFDSEGIISNREALYMREKPGEVLIIGGGVIGVELA
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHH
NILSSFKVGVTVVELMDHILPTMDRDVAQALKTHLSSRGVKIYEKTTVKSMTKTGGKYLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCHHHHH
ELSNGLKLEVDKVLIATGRKPRTREAGLVENNIALDQKGFIKINERQETSIPGIYASGDV
HHCCCCEEEEEEEEEECCCCCCCCCCCCEECCCEECCCCCEEECCCCCCCCCCEEECCCC
VGGPLLAHKAILESISAARWMSGEEGFHIDYSSIPSTIFTGLEIASIGYTEKELTSRGVK
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCHHHHCCCEEEECCCCHHHHHHCCCE
YVKVRIPAYYLSAVKIKGGKQSFIKVLLDERQEKILGVHIVAPNASEVISAYIPLYLGKI
EEEEEECEEEEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCC
GFGDISRIPYPHLTVSESLRDFAEYLLGNPVHLLKK
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MRYDTVVVGSGTGGYPGAIYLAQKGLKVAVVEEHLIGGECTNYGCVPSKAFYQVAEAIRS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHH
IEKIGGEASVKWENLVEWVSQVVRESREGIKGLFESHGIDVIEGRAILKTQREIVISAGE
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCEEEEEECCC
EKRRIEAGKILLALGTDPSPIPGVSFDSEGIISNREALYMREKPGEVLIIGGGVIGVELA
HHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHH
NILSSFKVGVTVVELMDHILPTMDRDVAQALKTHLSSRGVKIYEKTTVKSMTKTGGKYLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCHHHHH
ELSNGLKLEVDKVLIATGRKPRTREAGLVENNIALDQKGFIKINERQETSIPGIYASGDV
HHCCCCEEEEEEEEEECCCCCCCCCCCCEECCCEECCCCCEEECCCCCCCCCCEEECCCC
VGGPLLAHKAILESISAARWMSGEEGFHIDYSSIPSTIFTGLEIASIGYTEKELTSRGVK
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCHHHHCCCEEEECCCCHHHHHHCCCE
YVKVRIPAYYLSAVKIKGGKQSFIKVLLDERQEKILGVHIVAPNASEVISAYIPLYLGKI
EEEEEECEEEEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCC
GFGDISRIPYPHLTVSESLRDFAEYLLGNPVHLLKK
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA