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The map label for this gene is pgl [H]

Identifier: 218709296

GI number: 218709296

Start: 1404285

End: 1405001

Strand: Direct

Name: pgl [H]

Synonym: VS_1305

Alternate gene names: 218709296

Gene position: 1404285-1405001 (Clockwise)

Preceding gene: 218709295

Following gene: 218709297

Centisome position: 42.56

GC content: 47.56

Gene sequence:

>717_bases
ATGATCAATCACAAGATCTTTGCAACGCCTGAATTAGTCGTTGAAAACCTAGCAAACGAAATGAAAGCTTACAGCGAGCA
GGGTAAACCTGTTCACATTTCACTGTCGGGTGGCAGCACGCCAAAAATGCTTTTTAAGCTTTTAGCTCAAGCGCCATACG
CAGAAGGCATTCAATGGAATAACCTTCATTTCTGGTGGGGCGACGAACGTTGCGTTGCACCTGATGATGCAGAAAGCAAC
TTCGGCGAAGCGAACGCGCTACTTTTCTCGAACGTGAACCTTCCGGCAGAGAACATCCACCGCATCCGTGGTGAAGATGA
GCCAAAAGCAGAAGCAGAGCGTTTCGCGAAAGAGATGGCAGACGTGATTCCAACAGAAAACGGCACGCCTGTTTTCGATT
GGATCCTGCTAGGTGTTGGCGCAGACGGCCACACAGCTTCACTATTCCCGGGTGTAACTGACTACCAAGATGAGAACCTA
TCTGTATTAGCTTCTCACCCAGAGTCGGGCCAGATCCGTGTTTCTAAAACAGCGAAAGTTTTAGAAGCAGCAAAACGAAT
CAGCTACCTAGTACTGGGTGCAGGTAAAGTTGAGATCGTTAAAGAAATTCATACAACTCCTGCTTCAGAACTGCCTTACC
CGGCAGCGAAAATCCAGTCTAAAACTGGTGAGACAGAGTGGTTCCTAGATTCAAATGCAGCAAGTGCTATCGCATAA

Upstream 100 bases:

>100_bases
GTACTTGGGGCCCACAAGAAGCCGATGAGCTTCTGCAGCGTGATGGCCGCGCATGGCGTTTCCCATGCAAAAACTTAACA
GACACGGATTACTGCGAACT

Downstream 100 bases:

>100_bases
GTGCGAATAGCCGCAAGGAGATAAAATAATGAAAGGTGATATCGGTGTAATTGGCCTAGCAGTAATGGGTCAGAACCTTA
TCCTAAACATGAACGACCAC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MINHKIFATPELVVENLANEMKAYSEQGKPVHISLSGGSTPKMLFKLLAQAPYAEGIQWNNLHFWWGDERCVAPDDAESN
FGEANALLFSNVNLPAENIHRIRGEDEPKAEAERFAKEMADVIPTENGTPVFDWILLGVGADGHTASLFPGVTDYQDENL
SVLASHPESGQIRVSKTAKVLEAAKRISYLVLGAGKVEIVKEIHTTPASELPYPAAKIQSKTGETEWFLDSNAASAIA

Sequences:

>Translated_238_residues
MINHKIFATPELVVENLANEMKAYSEQGKPVHISLSGGSTPKMLFKLLAQAPYAEGIQWNNLHFWWGDERCVAPDDAESN
FGEANALLFSNVNLPAENIHRIRGEDEPKAEAERFAKEMADVIPTENGTPVFDWILLGVGADGHTASLFPGVTDYQDENL
SVLASHPESGQIRVSKTAKVLEAAKRISYLVLGAGKVEIVKEIHTTPASELPYPAAKIQSKTGETEWFLDSNAASAIA
>Mature_238_residues
MINHKIFATPELVVENLANEMKAYSEQGKPVHISLSGGSTPKMLFKLLAQAPYAEGIQWNNLHFWWGDERCVAPDDAESN
FGEANALLFSNVNLPAENIHRIRGEDEPKAEAERFAKEMADVIPTENGTPVFDWILLGVGADGHTASLFPGVTDYQDENL
SVLASHPESGQIRVSKTAKVLEAAKRISYLVLGAGKVEIVKEIHTTPASELPYPAAKIQSKTGETEWFLDSNAASAIA

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=236, Percent_Identity=34.3220338983051, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI6912586, Length=210, Percent_Identity=34.2857142857143, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI115533060, Length=230, Percent_Identity=30, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI115533058, Length=230, Percent_Identity=30, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324362, Length=211, Percent_Identity=29.8578199052133, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319918, Length=219, Percent_Identity=27.8538812785388, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321687, Length=221, Percent_Identity=30.316742081448, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321957, Length=213, Percent_Identity=30.5164319248826, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641119, Length=242, Percent_Identity=26.8595041322314, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25955; Mature: 25955

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINHKIFATPELVVENLANEMKAYSEQGKPVHISLSGGSTPKMLFKLLAQAPYAEGIQWN
CCCCCEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEC
NLHFWWGDERCVAPDDAESNFGEANALLFSNVNLPAENIHRIRGEDEPKAEAERFAKEMA
CEEEEECCCEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
DVIPTENGTPVFDWILLGVGADGHTASLFPGVTDYQDENLSVLASHPESGQIRVSKTAKV
HHCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEHHHHHH
LEAAKRISYLVLGAGKVEIVKEIHTTPASELPYPAAKIQSKTGETEWFLDSNAASAIA
HHHHHHHEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHCC
>Mature Secondary Structure
MINHKIFATPELVVENLANEMKAYSEQGKPVHISLSGGSTPKMLFKLLAQAPYAEGIQWN
CCCCCEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEC
NLHFWWGDERCVAPDDAESNFGEANALLFSNVNLPAENIHRIRGEDEPKAEAERFAKEMA
CEEEEECCCEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
DVIPTENGTPVFDWILLGVGADGHTASLFPGVTDYQDENLSVLASHPESGQIRVSKTAKV
HHCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEHHHHHH
LEAAKRISYLVLGAGKVEIVKEIHTTPASELPYPAAKIQSKTGETEWFLDSNAASAIA
HHHHHHHEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]