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The map label for this gene is zwf [H]

Identifier: 218709295

GI number: 218709295

Start: 1402783

End: 1404288

Strand: Direct

Name: zwf [H]

Synonym: VS_1304

Alternate gene names: 218709295

Gene position: 1402783-1404288 (Clockwise)

Preceding gene: 218709294

Following gene: 218709296

Centisome position: 42.52

GC content: 45.29

Gene sequence:

>1506_bases
ATGATGGTAATACCTGAAAACAGCAGCATCGTTATTTTTGGTGCGTCGGGAGATCTAACTTACCGTAAGTTAATTCCTGC
TTTGTACCACCTGTATGCTAGCAATCAACTTCCAGAATCCTTTGCGATTCTTGGAGTGAGCCGTACTGAGTACAGCGACG
AGTCTTACCGTGAGAAGCTGAAGAAGTCTCTTCAGGAAATGGAAAAAACTGAGCCAGAGACGCTGAATGCATTTATTGAA
CATCTGCATTATCAAGCGATCAACACTTCAGATGTAGACGATTACGCTCGTCTAGCACAACGTCTGGATAAGCTTGAGCA
AGACTACCAATTCGAAAACCATAACACACTGTTCTACTTGGCAACCCCGCCAAGCCTTTACGGTGTGATCCCAGCAAACC
TTGCTGCACATGGCCTAAACGATGAGAAGAACGGCTGGCGTCGTCTGATTATTGAGAAGCCATTTGGTTACGATCTAGCA
TCAGCTCAAGCGCTGGATGAAGAGATCCATCATCACTTCCAAGAACACCAGATCTACCGTATCGACCATTACCTTGGTAA
AGAAACGGTACAAAACCTTCTAGTGCTTCGTTTCTCAAACGCGATGTTTGAACCTCTGTGGAACCGTAACTTCATTGAAT
ACGTTGAAATCACAGGTGCTGAGTTCCTTGGCGTTGAAGAACGTGGCGGATACTACGATGGTTCTGGCGCAGTTCGTGAC
ATGTTCCAAAACCACCTGCTACAAGTGCTAGCAATGGTTGGTATGGAGCCACCTGCTCAAATCAATGCAGATTCTATTCG
TGATGAAGTGGTTAAAGTACTTCAGTGTCTGAAACCATTAGAAGAAGATGATTTGCGTAAAGACTTAGTATTAGGTCAGT
ACACAGCATCAGATGTTCGTGGTCAGCACTTACTAGGTTACCGTGAAGAGCATGGTGTAGCGGATGATTCTCGTACTGAA
ACGTACATTGGCCTTAAAGCACACATCAATAACTGGCGTTGGAATGGGGTTCCTTTCTACGTACGTACGGGTAAACGCTT
ACCAACACGTGTGACTGAAATCGTGATTCACTTTAAGAACACACCTCACCCAGTATTTGGTCAAGATGCACCAGAGAACA
AACTGATTATCCGTATCCAACCGGATGAAGGTATTCAGATGAGCTTTGGTTTGAAAGAGCCAGGTGCAGGTTTCAAAGCA
AAAGAAGTGAAAATGAACTTCTCTTACTCTGATCTGCCTGAGACTCAGATGCTAACGGCTTATGAGCGTCTTCTTCTTGA
TGCATTAAACGGTGATGCGACTCTGTTTGCACGTACCGATGCAGTAGAAGCATGTTGGAAGTACGTTCAACCGATCTTAG
ATTTCAAGCAAGACCCTCAAGCACTGTTTGGCTATGCTTGTGGTACTTGGGGCCCACAAGAAGCCGATGAGCTTCTGCAG
CGTGATGGCCGCGCATGGCGTTTCCCATGCAAAAACTTAACAGACACGGATTACTGCGAACTATGA

Upstream 100 bases:

>100_bases
TAGGCACTCGCTATTGATGTAATAGCCAAGACCTATTATCTATTTTCGTATGTCGCTGATACCGTTGGCGAATACTAAAA
ACCTTGTTTTTATAGGAAAG

Downstream 100 bases:

>100_bases
TCAATCACAAGATCTTTGCAACGCCTGAATTAGTCGTTGAAAACCTAGCAAACGAAATGAAAGCTTACAGCGAGCAGGGT
AAACCTGTTCACATTTCACT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASNQLPESFAILGVSRTEYSDESYREKLKKSLQEMEKTEPETLNAFIE
HLHYQAINTSDVDDYARLAQRLDKLEQDYQFENHNTLFYLATPPSLYGVIPANLAAHGLNDEKNGWRRLIIEKPFGYDLA
SAQALDEEIHHHFQEHQIYRIDHYLGKETVQNLLVLRFSNAMFEPLWNRNFIEYVEITGAEFLGVEERGGYYDGSGAVRD
MFQNHLLQVLAMVGMEPPAQINADSIRDEVVKVLQCLKPLEEDDLRKDLVLGQYTASDVRGQHLLGYREEHGVADDSRTE
TYIGLKAHINNWRWNGVPFYVRTGKRLPTRVTEIVIHFKNTPHPVFGQDAPENKLIIRIQPDEGIQMSFGLKEPGAGFKA
KEVKMNFSYSDLPETQMLTAYERLLLDALNGDATLFARTDAVEACWKYVQPILDFKQDPQALFGYACGTWGPQEADELLQ
RDGRAWRFPCKNLTDTDYCEL

Sequences:

>Translated_501_residues
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASNQLPESFAILGVSRTEYSDESYREKLKKSLQEMEKTEPETLNAFIE
HLHYQAINTSDVDDYARLAQRLDKLEQDYQFENHNTLFYLATPPSLYGVIPANLAAHGLNDEKNGWRRLIIEKPFGYDLA
SAQALDEEIHHHFQEHQIYRIDHYLGKETVQNLLVLRFSNAMFEPLWNRNFIEYVEITGAEFLGVEERGGYYDGSGAVRD
MFQNHLLQVLAMVGMEPPAQINADSIRDEVVKVLQCLKPLEEDDLRKDLVLGQYTASDVRGQHLLGYREEHGVADDSRTE
TYIGLKAHINNWRWNGVPFYVRTGKRLPTRVTEIVIHFKNTPHPVFGQDAPENKLIIRIQPDEGIQMSFGLKEPGAGFKA
KEVKMNFSYSDLPETQMLTAYERLLLDALNGDATLFARTDAVEACWKYVQPILDFKQDPQALFGYACGTWGPQEADELLQ
RDGRAWRFPCKNLTDTDYCEL
>Mature_501_residues
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASNQLPESFAILGVSRTEYSDESYREKLKKSLQEMEKTEPETLNAFIE
HLHYQAINTSDVDDYARLAQRLDKLEQDYQFENHNTLFYLATPPSLYGVIPANLAAHGLNDEKNGWRRLIIEKPFGYDLA
SAQALDEEIHHHFQEHQIYRIDHYLGKETVQNLLVLRFSNAMFEPLWNRNFIEYVEITGAEFLGVEERGGYYDGSGAVRD
MFQNHLLQVLAMVGMEPPAQINADSIRDEVVKVLQCLKPLEEDDLRKDLVLGQYTASDVRGQHLLGYREEHGVADDSRTE
TYIGLKAHINNWRWNGVPFYVRTGKRLPTRVTEIVIHFKNTPHPVFGQDAPENKLIIRIQPDEGIQMSFGLKEPGAGFKA
KEVKMNFSYSDLPETQMLTAYERLLLDALNGDATLFARTDAVEACWKYVQPILDFKQDPQALFGYACGTWGPQEADELLQ
RDGRAWRFPCKNLTDTDYCEL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=480, Percent_Identity=38.9583333333333, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI109389365, Length=480, Percent_Identity=38.9583333333333, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI52145310, Length=487, Percent_Identity=28.952772073922, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=43.2098765432099, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17538218, Length=479, Percent_Identity=38.8308977035491, Blast_Score=349, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6324088, Length=489, Percent_Identity=36.8098159509202, Blast_Score=304, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24643352, Length=476, Percent_Identity=38.4453781512605, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24643350, Length=476, Percent_Identity=38.4453781512605, Blast_Score=312, Evalue=3e-85,
Organism=Drosophila melanogaster, GI221513548, Length=486, Percent_Identity=32.3045267489712, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57472; Mature: 57472

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASNQLPESFAILGVSRTEYSDESYREKL
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHH
KKSLQEMEKTEPETLNAFIEHLHYQAINTSDVDDYARLAQRLDKLEQDYQFENHNTLFYL
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
ATPPSLYGVIPANLAAHGLNDEKNGWRRLIIEKPFGYDLASAQALDEEIHHHFQEHQIYR
ECCCCCEEECCHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEE
IDHYLGKETVQNLLVLRFSNAMFEPLWNRNFIEYVEITGAEFLGVEERGGYYDGSGAVRD
HHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCEECCCHHHHH
MFQNHLLQVLAMVGMEPPAQINADSIRDEVVKVLQCLKPLEEDDLRKDLVLGQYTASDVR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCC
GQHLLGYREEHGVADDSRTETYIGLKAHINNWRWNGVPFYVRTGKRLPTRVTEIVIHFKN
CHHHCCCHHHCCCCCCCCCCEEEEEEEEECCEEECCEEEEEECCCCCHHHHHHEEEEECC
TPHPVFGQDAPENKLIIRIQPDEGIQMSFGLKEPGAGFKAKEVKMNFSYSDLPETQMLTA
CCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
YERLLLDALNGDATLFARTDAVEACWKYVQPILDFKQDPQALFGYACGTWGPQEADELLQ
HHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
RDGRAWRFPCKNLTDTDYCEL
CCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMVIPENSSIVIFGASGDLTYRKLIPALYHLYASNQLPESFAILGVSRTEYSDESYREKL
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHH
KKSLQEMEKTEPETLNAFIEHLHYQAINTSDVDDYARLAQRLDKLEQDYQFENHNTLFYL
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
ATPPSLYGVIPANLAAHGLNDEKNGWRRLIIEKPFGYDLASAQALDEEIHHHFQEHQIYR
ECCCCCEEECCHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEE
IDHYLGKETVQNLLVLRFSNAMFEPLWNRNFIEYVEITGAEFLGVEERGGYYDGSGAVRD
HHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCEECCCHHHHH
MFQNHLLQVLAMVGMEPPAQINADSIRDEVVKVLQCLKPLEEDDLRKDLVLGQYTASDVR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCC
GQHLLGYREEHGVADDSRTETYIGLKAHINNWRWNGVPFYVRTGKRLPTRVTEIVIHFKN
CHHHCCCHHHCCCCCCCCCCEEEEEEEEECCEEECCEEEEEECCCCCHHHHHHEEEEECC
TPHPVFGQDAPENKLIIRIQPDEGIQMSFGLKEPGAGFKAKEVKMNFSYSDLPETQMLTA
CCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
YERLLLDALNGDATLFARTDAVEACWKYVQPILDFKQDPQALFGYACGTWGPQEADELLQ
HHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHH
RDGRAWRFPCKNLTDTDYCEL
CCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]