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The map label for this gene is gnd [H]

Identifier: 218709297

GI number: 218709297

Start: 1405030

End: 1406478

Strand: Direct

Name: gnd [H]

Synonym: VS_1306

Alternate gene names: 218709297

Gene position: 1405030-1406478 (Clockwise)

Preceding gene: 218709296

Following gene: 218709299

Centisome position: 42.59

GC content: 47.9

Gene sequence:

>1449_bases
ATGAAAGGTGATATCGGTGTAATTGGCCTAGCAGTAATGGGTCAGAACCTTATCCTAAACATGAACGACCACGGCTTCAA
AGTTGTGGCTCACAACCGTACTGCTGCTAAGGTAGACGAGTTCCTAGAAGGCCCAGCGAAGGGTACTAACATTGTTGGTG
CTTACTCTCTAGAAGAGCTAGTTGAGAAACTAGAAGCGCCACGTAAAGTGATGCTTATGGTTCGTGCTGGTGATGTTGTA
GATACGTTCATCGACAAGCTTGTACCACTTCTAGACAAAGGCGACATCATCATTGATGGTGGTAACACTAACTTCCCAGA
CACAAACCGTCGTGTTGCTGCTCTTCGCGAGAAAGGCATCCACTTCATCGGTACGGGTGTTTCTGGTGGTGAAGAAGGTG
CTCGTTTCGGTCCTTCTATCATGCCAGGCGGTTCTCCTGAAGCTTGGGAAGCGGTTAAGCCTATCTTCCAAGGTATCTCT
GCGAAAACTGACGCAGGTGAGCCTTGTTGTGATTGGGTTGGTAACGACGGTGCTGGTCACTTCGTTAAGATGGTTCACAA
TGGCATCGAATACGGTGACATGCAGCTTATCACTGAAGCATACCAGTTCATGAAAGATGGCTTAGGTATGAACCACGACG
AAATGCAGGCTGTATTTGCTGACTGGAACAAAACTGAGCTAGACAGCTACCTAGTAGAAATCACTGCTGACATCCTTGGC
TACAAAGATGAAGACGGTGAAGCGCTAGTTGAGAAGATCCTAGACACTGCTGGCCAAAAAGGTACAGGCAAATGGACAGG
TATCAATGCACTAGACATGGGTATCCCACTGACTCTAATCACTGAGTCTGTATTCTCTCGTTGCCTGTCTGCACTTAAAG
ATCAACGTGTTGAAGCTGAGAAACTGTTCGGCAAGACTGTTGCTCCAGTTGAAGGCGACAAGCAAGAGTGGGTTGATGCA
ATCCGTCAGGCTCTACTTGCTTCTAAGATCATCTCTTACGCTCAAGGTTTCATGCTAATGCGTGAAGCGTCGAACGAAAA
CGGCTGGGATCTAAACTACGGTAACGTTGCTCTTATGTGGCGTGGCGGTTGTATCATCCGTTCTGCATTCCTAGGCAACA
TTCGTGATGCTTACGAAGCGAACCCAGAGATCGCTTTCCTAGGTTCAGATGCATACTTCAAAGGCATCCTAGACAACTGC
ATGGGCGCTTGGCGTAAAGTTGCAGCTAAGTCTATGGAATCTGGTATCCCAATGCCATGTATGACTTCTGCACTAACGTT
CCTAGACGGCTACACTACAGCTCGTCTTCCAGCGAACCTTCTACAAGCTCAACGTGACTACTTCGGTGCTCACACTTACG
AGCGTACTGACCGTCCACGTGGTGAATTCTTCCACACAAACTGGACTGGTACAGGCGGCGACACTGCTTCTACAACTTAC
GACGTATAA

Upstream 100 bases:

>100_bases
GCGAAAATCCAGTCTAAAACTGGTGAGACAGAGTGGTTCCTAGATTCAAATGCAGCAAGTGCTATCGCATAAGTGCGAAT
AGCCGCAAGGAGATAAAATA

Downstream 100 bases:

>100_bases
TCGTTAGTTAGAATCAGTAAAGAACACGTTCGTTCTTTCAGCTGAAAACTAGAAAACAAAAGGATGCCAATTGGCATCCT
TTTTTGTTGGTTCGCGTTCT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIVGAYSLEELVEKLEAPRKVMLMVRAGDVV
DTFIDKLVPLLDKGDIIIDGGNTNFPDTNRRVAALREKGIHFIGTGVSGGEEGARFGPSIMPGGSPEAWEAVKPIFQGIS
AKTDAGEPCCDWVGNDGAGHFVKMVHNGIEYGDMQLITEAYQFMKDGLGMNHDEMQAVFADWNKTELDSYLVEITADILG
YKDEDGEALVEKILDTAGQKGTGKWTGINALDMGIPLTLITESVFSRCLSALKDQRVEAEKLFGKTVAPVEGDKQEWVDA
IRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMWRGGCIIRSAFLGNIRDAYEANPEIAFLGSDAYFKGILDNC
MGAWRKVAAKSMESGIPMPCMTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERTDRPRGEFFHTNWTGTGGDTASTTY
DV

Sequences:

>Translated_482_residues
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIVGAYSLEELVEKLEAPRKVMLMVRAGDVV
DTFIDKLVPLLDKGDIIIDGGNTNFPDTNRRVAALREKGIHFIGTGVSGGEEGARFGPSIMPGGSPEAWEAVKPIFQGIS
AKTDAGEPCCDWVGNDGAGHFVKMVHNGIEYGDMQLITEAYQFMKDGLGMNHDEMQAVFADWNKTELDSYLVEITADILG
YKDEDGEALVEKILDTAGQKGTGKWTGINALDMGIPLTLITESVFSRCLSALKDQRVEAEKLFGKTVAPVEGDKQEWVDA
IRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMWRGGCIIRSAFLGNIRDAYEANPEIAFLGSDAYFKGILDNC
MGAWRKVAAKSMESGIPMPCMTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERTDRPRGEFFHTNWTGTGGDTASTTY
DV
>Mature_482_residues
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIVGAYSLEELVEKLEAPRKVMLMVRAGDVV
DTFIDKLVPLLDKGDIIIDGGNTNFPDTNRRVAALREKGIHFIGTGVSGGEEGARFGPSIMPGGSPEAWEAVKPIFQGIS
AKTDAGEPCCDWVGNDGAGHFVKMVHNGIEYGDMQLITEAYQFMKDGLGMNHDEMQAVFADWNKTELDSYLVEITADILG
YKDEDGEALVEKILDTAGQKGTGKWTGINALDMGIPLTLITESVFSRCLSALKDQRVEAEKLFGKTVAPVEGDKQEWVDA
IRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMWRGGCIIRSAFLGNIRDAYEANPEIAFLGSDAYFKGILDNC
MGAWRKVAAKSMESGIPMPCMTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERTDRPRGEFFHTNWTGTGGDTASTTY
DV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=481, Percent_Identity=64.033264033264, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=55.5555555555556, Blast_Score=524, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17542558, Length=483, Percent_Identity=60.0414078674948, Blast_Score=604, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6321695, Length=486, Percent_Identity=59.0534979423868, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6321977, Length=488, Percent_Identity=60.0409836065574, Blast_Score=576, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24639279, Length=480, Percent_Identity=61.25, Blast_Score=585, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52561; Mature: 52561

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIVGAYSLEEL
CCCCCEEEEHEECCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEHHHHHHH
VEKLEAPRKVMLMVRAGDVVDTFIDKLVPLLDKGDIIIDGGNTNFPDTNRRVAALREKGI
HHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHCCC
HFIGTGVSGGEEGARFGPSIMPGGSPEAWEAVKPIFQGISAKTDAGEPCCDWVGNDGAGH
EEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHH
FVKMVHNGIEYGDMQLITEAYQFMKDGLGMNHDEMQAVFADWNKTELDSYLVEITADILG
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
YKDEDGEALVEKILDTAGQKGTGKWTGINALDMGIPLTLITESVFSRCLSALKDQRVEAE
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHH
KLFGKTVAPVEGDKQEWVDAIRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMW
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEE
RGGCIIRSAFLGNIRDAYEANPEIAFLGSDAYFKGILDNCMGAWRKVAAKSMESGIPMPC
ECCHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
MTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERTDRPRGEFFHTNWTGTGGDTASTTY
HHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
DV
CC
>Mature Secondary Structure
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIVGAYSLEEL
CCCCCEEEEHEECCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEHHHHHHH
VEKLEAPRKVMLMVRAGDVVDTFIDKLVPLLDKGDIIIDGGNTNFPDTNRRVAALREKGI
HHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHCCC
HFIGTGVSGGEEGARFGPSIMPGGSPEAWEAVKPIFQGISAKTDAGEPCCDWVGNDGAGH
EEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHH
FVKMVHNGIEYGDMQLITEAYQFMKDGLGMNHDEMQAVFADWNKTELDSYLVEITADILG
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
YKDEDGEALVEKILDTAGQKGTGKWTGINALDMGIPLTLITESVFSRCLSALKDQRVEAE
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHH
KLFGKTVAPVEGDKQEWVDAIRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMW
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEE
RGGCIIRSAFLGNIRDAYEANPEIAFLGSDAYFKGILDNCMGAWRKVAAKSMESGIPMPC
ECCHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
MTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERTDRPRGEFFHTNWTGTGGDTASTTY
HHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
DV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]