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The map label for this gene is hlyB [H]

Identifier: 218709150

GI number: 218709150

Start: 1229152

End: 1230771

Strand: Direct

Name: hlyB [H]

Synonym: VS_1157

Alternate gene names: 218709150

Gene position: 1229152-1230771 (Clockwise)

Preceding gene: 218709149

Following gene: 218709151

Centisome position: 37.25

GC content: 43.33

Gene sequence:

>1620_bases
ATGCTATTGTCTCGCTATATCAACATTAAAGTACAGTTTATTGTACTGCTCTCAATAATATCTCTTAGCCTAGCTGCCAT
TATCTCAATAAATGTCTTTATTCATAATGATAATAGTCAGCGCCTAAAGCAGTTAGAGTCAAGTTACTACCCTGCACTTG
AGCATGCGACGAAAATATATTCTCTTTTACCTAACGTGAAGCAACAGTTCGAAGCTGCTGTCGTGATGGAAGATGAGCAA
GCTCTCGATTTTGCACGTCAAATTTCTTCTGAACTGCAAGTTGAAGCGAGTCGTGGTGCCGATGTTTTACCTTCACAAGC
GACAGCTTTTAATAAATTGTCACAACAACTAGCAAGGTACACGGATTCTGCGTACGCGCTGAGCGAAGATTTTATTAATC
TCAATGACTCTTTCGAGAGCCTGACCTCCAGAGCGAACCAACTTAGCACTGAATATGATTCATTAGTTGCGTTAAGCGAG
ACGTTACGCGCATCGGCGAGTCAGAAGGTCGTAGACACTATCTTGCACTCTGAAAAAGCCGCAAACGACGCTGCGAATCA
ATCTATTTGGTTAGGTGTGTTCTTTTTGATCTCTGTGATTTCGGTTGGTTACGCAATATTCAAATCGGTTATTAGCTCAA
TATTGCTTGTGACAGAAAAGATGAAGGCGATTGCGACTGGAGATGGTGACTTAACGGTACGCATCGACTACGCAGGAAAA
GATGAGATATCAACGCTTGTTGAGAGTTTCAATCAATTCATTGAAAAGCTACAAGGCATTATCGCGAGTACGTTAACCAT
TGGACACGAGCTTGAGGTTGTCAGCGACAAGATTCGTAGCGAGTCGAATCAAACCTTGGCTCTAAATAGCACTCAACGTG
ATCACATCGAAGAGGTTACCGAGGCGGTCAATAACATCATCGACCTCATAGAACAAGTTGTTAACTTTGCATCGCATGCA
GACTCTCAAGCTCAAAAAGCCAATTCTAGCGCTCAAACAGGAACACAAGTGGTTCTTAAAACGAGTAAAGAAATTGAAGA
GCTTGCGACAAACATCCGTGATACGGCCTGTAAGTTGAAAGAACTCGATCAGAATGCAAGCAATGTTGGCTCAATACTAA
ACACAATACAAAGTGTCGCTGAGCAAACGAATTTGTTAGCACTTAATGCTGCAATTGAAGCTGCGCGAGCTGGTGAACAT
GGCCGAGGCTTTGCTGTTGTTTCCGACGAAGTGCGCGTGTTAGCGAATAATACTCAACAATCAGCAACAGAAATTAATGC
CTTGTTGGTCGACCTTAAGTCCGGCTCGAACGCTGCTGTTGGCGCTATGGACCAAGGCCTAGCGAGCTCGTCACAGGCGG
TTGGAGACGCGCAAAACGCGGGTGACTATCTATTAGAAATTAGTGGCCAGGTAGAAGAAATTACCGAGCTCAACAAACAA
ATTGCAAGTACTACAGAGCACCAAGCTCGTGCTTCAAAACAAATCCACACCCATATGGATGATTTTAGACAGTGCTCTCA
TCAAGTGTCTCAGTCGACAGATCAACTCGAAGCTCTAAGTCACCAACTGAGTGGCATCGTTACAGAGCTGAGTAAATCAA
CATCACAATTTAAAGTATAA

Upstream 100 bases:

>100_bases
GGCTTTGAACATAACGGTAAATTTGTTTAGTGAATGTGTTCGCTATTAAATATGAACAAACGTTACCATCAGCCACAACC
AGCGCTAATGAAAAAACCTT

Downstream 100 bases:

>100_bases
CGGAGAACAACAATGACTAACTCCTCTTTTCGCTTATTGCCGTTAGCGGTAGCACTTGCGACTTCATTCGCTGCACACGC
TACAGATGAGCAAAAATTGG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MLLSRYINIKVQFIVLLSIISLSLAAIISINVFIHNDNSQRLKQLESSYYPALEHATKIYSLLPNVKQQFEAAVVMEDEQ
ALDFARQISSELQVEASRGADVLPSQATAFNKLSQQLARYTDSAYALSEDFINLNDSFESLTSRANQLSTEYDSLVALSE
TLRASASQKVVDTILHSEKAANDAANQSIWLGVFFLISVISVGYAIFKSVISSILLVTEKMKAIATGDGDLTVRIDYAGK
DEISTLVESFNQFIEKLQGIIASTLTIGHELEVVSDKIRSESNQTLALNSTQRDHIEEVTEAVNNIIDLIEQVVNFASHA
DSQAQKANSSAQTGTQVVLKTSKEIEELATNIRDTACKLKELDQNASNVGSILNTIQSVAEQTNLLALNAAIEAARAGEH
GRGFAVVSDEVRVLANNTQQSATEINALLVDLKSGSNAAVGAMDQGLASSSQAVGDAQNAGDYLLEISGQVEEITELNKQ
IASTTEHQARASKQIHTHMDDFRQCSHQVSQSTDQLEALSHQLSGIVTELSKSTSQFKV

Sequences:

>Translated_539_residues
MLLSRYINIKVQFIVLLSIISLSLAAIISINVFIHNDNSQRLKQLESSYYPALEHATKIYSLLPNVKQQFEAAVVMEDEQ
ALDFARQISSELQVEASRGADVLPSQATAFNKLSQQLARYTDSAYALSEDFINLNDSFESLTSRANQLSTEYDSLVALSE
TLRASASQKVVDTILHSEKAANDAANQSIWLGVFFLISVISVGYAIFKSVISSILLVTEKMKAIATGDGDLTVRIDYAGK
DEISTLVESFNQFIEKLQGIIASTLTIGHELEVVSDKIRSESNQTLALNSTQRDHIEEVTEAVNNIIDLIEQVVNFASHA
DSQAQKANSSAQTGTQVVLKTSKEIEELATNIRDTACKLKELDQNASNVGSILNTIQSVAEQTNLLALNAAIEAARAGEH
GRGFAVVSDEVRVLANNTQQSATEINALLVDLKSGSNAAVGAMDQGLASSSQAVGDAQNAGDYLLEISGQVEEITELNKQ
IASTTEHQARASKQIHTHMDDFRQCSHQVSQSTDQLEALSHQLSGIVTELSKSTSQFKV
>Mature_539_residues
MLLSRYINIKVQFIVLLSIISLSLAAIISINVFIHNDNSQRLKQLESSYYPALEHATKIYSLLPNVKQQFEAAVVMEDEQ
ALDFARQISSELQVEASRGADVLPSQATAFNKLSQQLARYTDSAYALSEDFINLNDSFESLTSRANQLSTEYDSLVALSE
TLRASASQKVVDTILHSEKAANDAANQSIWLGVFFLISVISVGYAIFKSVISSILLVTEKMKAIATGDGDLTVRIDYAGK
DEISTLVESFNQFIEKLQGIIASTLTIGHELEVVSDKIRSESNQTLALNSTQRDHIEEVTEAVNNIIDLIEQVVNFASHA
DSQAQKANSSAQTGTQVVLKTSKEIEELATNIRDTACKLKELDQNASNVGSILNTIQSVAEQTNLLALNAAIEAARAGEH
GRGFAVVSDEVRVLANNTQQSATEINALLVDLKSGSNAAVGAMDQGLASSSQAVGDAQNAGDYLLEISGQVEEITELNKQ
IASTTEHQARASKQIHTHMDDFRQCSHQVSQSTDQLEALSHQLSGIVTELSKSTSQFKV

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=331, Percent_Identity=28.3987915407855, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788195, Length=312, Percent_Identity=30.1282051282051, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788194, Length=347, Percent_Identity=26.2247838616715, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1787690, Length=339, Percent_Identity=28.023598820059, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789453, Length=215, Percent_Identity=30.6976744186047, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 58542; Mature: 58542

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSRYINIKVQFIVLLSIISLSLAAIISINVFIHNDNSQRLKQLESSYYPALEHATKIY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHH
SLLPNVKQQFEAAVVMEDEQALDFARQISSELQVEASRGADVLPSQATAFNKLSQQLARY
HHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHH
TDSAYALSEDFINLNDSFESLTSRANQLSTEYDSLVALSETLRASASQKVVDTILHSEKA
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANDAANQSIWLGVFFLISVISVGYAIFKSVISSILLVTEKMKAIATGDGDLTVRIDYAGK
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCH
DEISTLVESFNQFIEKLQGIIASTLTIGHELEVVSDKIRSESNQTLALNSTQRDHIEEVT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
EAVNNIIDLIEQVVNFASHADSQAQKANSSAQTGTQVVLKTSKEIEELATNIRDTACKLK
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELDQNASNVGSILNTIQSVAEQTNLLALNAAIEAARAGEHGRGFAVVSDEVRVLANNTQQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCHH
SATEINALLVDLKSGSNAAVGAMDQGLASSSQAVGDAQNAGDYLLEISGQVEEITELNKQ
HHHHHHHHHEEECCCCCCCCCCHHHCCCCCHHHCCCCCCCCCEEEEECCCHHHHHHHHHH
IASTTEHQARASKQIHTHMDDFRQCSHQVSQSTDQLEALSHQLSGIVTELSKSTSQFKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure
MLLSRYINIKVQFIVLLSIISLSLAAIISINVFIHNDNSQRLKQLESSYYPALEHATKIY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHH
SLLPNVKQQFEAAVVMEDEQALDFARQISSELQVEASRGADVLPSQATAFNKLSQQLARY
HHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHH
TDSAYALSEDFINLNDSFESLTSRANQLSTEYDSLVALSETLRASASQKVVDTILHSEKA
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANDAANQSIWLGVFFLISVISVGYAIFKSVISSILLVTEKMKAIATGDGDLTVRIDYAGK
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCH
DEISTLVESFNQFIEKLQGIIASTLTIGHELEVVSDKIRSESNQTLALNSTQRDHIEEVT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
EAVNNIIDLIEQVVNFASHADSQAQKANSSAQTGTQVVLKTSKEIEELATNIRDTACKLK
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ELDQNASNVGSILNTIQSVAEQTNLLALNAAIEAARAGEHGRGFAVVSDEVRVLANNTQQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCHH
SATEINALLVDLKSGSNAAVGAMDQGLASSSQAVGDAQNAGDYLLEISGQVEEITELNKQ
HHHHHHHHHEEECCCCCCCCCCHHHCCCCCHHHCCCCCCCCCEEEEECCCHHHHHHHHHH
IASTTEHQARASKQIHTHMDDFRQCSHQVSQSTDQLEALSHQLSGIVTELSKSTSQFKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]