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The map label for this gene is aer [H]

Identifier: 218709100

GI number: 218709100

Start: 1170151

End: 1171611

Strand: Direct

Name: aer [H]

Synonym: VS_1106

Alternate gene names: 218709100

Gene position: 1170151-1171611 (Clockwise)

Preceding gene: 218709099

Following gene: 218709101

Centisome position: 35.47

GC content: 46.34

Gene sequence:

>1461_bases
ATGAACCCAATCAAGCTGTGGCGCGCGCTGTTTCTACCTAAAAGCAATGGCTGGAGTAACAACGAAGTCAGACAAGCCGA
TATCTTATTACTCTTCACTTTTATCGCATTCTTCGTGGGTGTCTATAGCTTAATCAAGTGGACTAAGCACGAAGAGCAAC
TTCTGATCGCCACATCTGTATTTCTTATCGTATTCGAACTGATCTCTGCACTGCTACTTCGTGTGACGAGTAAGCCGAGC
CTTGCACTTAACTTTGGTTTTGTCGGCATGGCTGTTCACGCGTTGAACATCATCTATCAAAGCGGTGGAGTTGTGGCTTC
CACTCAAGCTTATTGGGTGCCTTTGTTAGTGGTCGCTTTTTTCTTATCAGGAACACGAATTGTGGCTTTGGTATGGAGTG
GACTGGTTATCGGTGTTTCATTAGTGATGACCTCAGCACATCTCAATGGATTTGCATTTCCGCAGTTAGTACTTACTCCT
GAAGCGGTAATGGTTGAAACGTGGTCTGGTGTGATTATGCCGCTGGTGGTGATTTGCATTGCTCAAGCATTTACTGCGAA
ACAGAAAGAGGTGGCCATCGAAATGGCAGAGGATGCGATTTCAGAAAGCCAACACGTTGCCAATCAAGCGACGCAAAGTG
AAGGTCGGCTCTCTATCGTGCTCGACCAAGCCAATTCGAATTCAGAGAATCTGCAAGGTGTTTCGGTTTATTTGGATCAG
CAGTCACAAGACTTGCATACTCAAGTTGAGGTGTTGAACATCAATTGTGAATCTCAAGCAAGCGCTGCAGAAGAGATGAG
CCAACAACTCCATCAAATGACTCAAGGCATCGAAGAATCCAATTCATTTGTGGGTGAACTAAAAGAGCGCAGCGAAGCGG
TTGGCACTAAAGCGCAAAAGAGCTCAGAGTCACTAGAAGCGTCAACCGATGCGATCAGCCAGATTATTCAAAGTAATCAA
GAGATAATGAAAGTCGCTGATTTGATCACTTCGGTTGCTGAGCAAACCAATCTATTAGCACTCAACGCGGCAATCGAAGC
GGCTCGTGCTGGTGAGCAAGGACGAGGGTTTGCTGTCGTCGCTGATCAAGTGCGAGAATTATCGGCGAAAAGCAGTCATT
CCGCGATAGAGATTCGAACTTTGTTAGACCGAAGTAAAGAGGAAGTGGAGCATGGCAGAGCAATCATTGAAACCACGGCC
AATGAAATGAACGGGATTATCTCCGAGGTGCAAACCATCTCGACCGACGTTAACCAACTGACTAATATTATGGCGATGCA
GATGAACTCATTGAAAGAGCTCGATCTCGCCAGTTCAGAAGTTGCCCAAAGTGTGGCGGAAACTAAATCGGTGTCAGGCT
TAGTCGCTAATTATGGTTCTGAGCTAACAGGTCATGTGGCTTCGGTTAAAGAATTGGTCGCGAGCTTGAACAGCGTGGTC
TCGCAAGCCAAACAAGCCTAA

Upstream 100 bases:

>100_bases
GAGATCTTTCGAACAGAACCCAGATAATAACATTGCGTGTCATTTAACATGTTATTAACATTGGTCGGAGGTCTTACAAG
TTAATCAAGGATGATCACTG

Downstream 100 bases:

>100_bases
ATTATTCACTTCAAAAAACACAAAGAACTGGATAAGTATCCAGTTCTTTTATATTCTGTCCCTCAAATTAAATTCCATCA
AGAGAGTGAATTGTGATCGG

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MNPIKLWRALFLPKSNGWSNNEVRQADILLLFTFIAFFVGVYSLIKWTKHEEQLLIATSVFLIVFELISALLLRVTSKPS
LALNFGFVGMAVHALNIIYQSGGVVASTQAYWVPLLVVAFFLSGTRIVALVWSGLVIGVSLVMTSAHLNGFAFPQLVLTP
EAVMVETWSGVIMPLVVICIAQAFTAKQKEVAIEMAEDAISESQHVANQATQSEGRLSIVLDQANSNSENLQGVSVYLDQ
QSQDLHTQVEVLNINCESQASAAEEMSQQLHQMTQGIEESNSFVGELKERSEAVGTKAQKSSESLEASTDAISQIIQSNQ
EIMKVADLITSVAEQTNLLALNAAIEAARAGEQGRGFAVVADQVRELSAKSSHSAIEIRTLLDRSKEEVEHGRAIIETTA
NEMNGIISEVQTISTDVNQLTNIMAMQMNSLKELDLASSEVAQSVAETKSVSGLVANYGSELTGHVASVKELVASLNSVV
SQAKQA

Sequences:

>Translated_486_residues
MNPIKLWRALFLPKSNGWSNNEVRQADILLLFTFIAFFVGVYSLIKWTKHEEQLLIATSVFLIVFELISALLLRVTSKPS
LALNFGFVGMAVHALNIIYQSGGVVASTQAYWVPLLVVAFFLSGTRIVALVWSGLVIGVSLVMTSAHLNGFAFPQLVLTP
EAVMVETWSGVIMPLVVICIAQAFTAKQKEVAIEMAEDAISESQHVANQATQSEGRLSIVLDQANSNSENLQGVSVYLDQ
QSQDLHTQVEVLNINCESQASAAEEMSQQLHQMTQGIEESNSFVGELKERSEAVGTKAQKSSESLEASTDAISQIIQSNQ
EIMKVADLITSVAEQTNLLALNAAIEAARAGEQGRGFAVVADQVRELSAKSSHSAIEIRTLLDRSKEEVEHGRAIIETTA
NEMNGIISEVQTISTDVNQLTNIMAMQMNSLKELDLASSEVAQSVAETKSVSGLVANYGSELTGHVASVKELVASLNSVV
SQAKQA
>Mature_486_residues
MNPIKLWRALFLPKSNGWSNNEVRQADILLLFTFIAFFVGVYSLIKWTKHEEQLLIATSVFLIVFELISALLLRVTSKPS
LALNFGFVGMAVHALNIIYQSGGVVASTQAYWVPLLVVAFFLSGTRIVALVWSGLVIGVSLVMTSAHLNGFAFPQLVLTP
EAVMVETWSGVIMPLVVICIAQAFTAKQKEVAIEMAEDAISESQHVANQATQSEGRLSIVLDQANSNSENLQGVSVYLDQ
QSQDLHTQVEVLNINCESQASAAEEMSQQLHQMTQGIEESNSFVGELKERSEAVGTKAQKSSESLEASTDAISQIIQSNQ
EIMKVADLITSVAEQTNLLALNAAIEAARAGEQGRGFAVVADQVRELSAKSSHSAIEIRTLLDRSKEEVEHGRAIIETTA
NEMNGIISEVQTISTDVNQLTNIMAMQMNSLKELDLASSEVAQSVAETKSVSGLVANYGSELTGHVASVKELVASLNSVV
SQAKQA

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=241, Percent_Identity=31.1203319502075, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1788195, Length=190, Percent_Identity=33.1578947368421, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788194, Length=229, Percent_Identity=32.7510917030568, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI2367378, Length=190, Percent_Identity=32.1052631578947, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787690, Length=229, Percent_Identity=30.5676855895196, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 52524; Mature: 52524

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00037 MYB_1 ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIKLWRALFLPKSNGWSNNEVRQADILLLFTFIAFFVGVYSLIKWTKHEEQLLIATSV
CCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLIVFELISALLLRVTSKPSLALNFGFVGMAVHALNIIYQSGGVVASTQAYWVPLLVVAF
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
FLSGTRIVALVWSGLVIGVSLVMTSAHLNGFAFPQLVLTPEAVMVETWSGVIMPLVVICI
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCHHHHHHHCHHHHHHHHHHH
AQAFTAKQKEVAIEMAEDAISESQHVANQATQSEGRLSIVLDQANSNSENLQGVSVYLDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECC
QSQDLHTQVEVLNINCESQASAAEEMSQQLHQMTQGIEESNSFVGELKERSEAVGTKAQK
CCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SSESLEASTDAISQIIQSNQEIMKVADLITSVAEQTNLLALNAAIEAARAGEQGRGFAVV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCCHHH
ADQVRELSAKSSHSAIEIRTLLDRSKEEVEHGRAIIETTANEMNGIISEVQTISTDVNQL
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNIMAMQMNSLKELDLASSEVAQSVAETKSVSGLVANYGSELTGHVASVKELVASLNSVV
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SQAKQA
HHHHCC
>Mature Secondary Structure
MNPIKLWRALFLPKSNGWSNNEVRQADILLLFTFIAFFVGVYSLIKWTKHEEQLLIATSV
CCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLIVFELISALLLRVTSKPSLALNFGFVGMAVHALNIIYQSGGVVASTQAYWVPLLVVAF
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHH
FLSGTRIVALVWSGLVIGVSLVMTSAHLNGFAFPQLVLTPEAVMVETWSGVIMPLVVICI
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCHHHHHHHCHHHHHHHHHHH
AQAFTAKQKEVAIEMAEDAISESQHVANQATQSEGRLSIVLDQANSNSENLQGVSVYLDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECC
QSQDLHTQVEVLNINCESQASAAEEMSQQLHQMTQGIEESNSFVGELKERSEAVGTKAQK
CCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SSESLEASTDAISQIIQSNQEIMKVADLITSVAEQTNLLALNAAIEAARAGEQGRGFAVV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCCHHH
ADQVRELSAKSSHSAIEIRTLLDRSKEEVEHGRAIIETTANEMNGIISEVQTISTDVNQL
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNIMAMQMNSLKELDLASSEVAQSVAETKSVSGLVANYGSELTGHVASVKELVASLNSVV
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SQAKQA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]