Click here to switch to the map view.

The map label for this gene is mltA [H]

Identifier: 218708701

GI number: 218708701

Start: 714535

End: 715638

Strand: Direct

Name: mltA [H]

Synonym: VS_0680

Alternate gene names: 218708701

Gene position: 714535-715638 (Clockwise)

Preceding gene: 218708700

Following gene: 218708702

Centisome position: 21.66

GC content: 47.1

Gene sequence:

>1104_bases
GTGATTAAAAAATGGCTTCCCCTTGTTGCTGCCTCTTTCTTATTTGGCTGTGCTCAACCCACTGATCTTGCCCAACAACA
CCTTGATGGTGAATTTCCCCGAACCTTAAATAAGGTCGATTTGGTTGAATCTAATAAACCAAGAGACTTCACCGCATTTG
CAGAGCAAGCTGAGATGGTGGTTTCTAAATCCCCTTCGATGGCTAAAATCTATGAGCCGCTTTATCAGCAGCTCAATGAA
TGGGCGGTGCTGAGTGGAGAGCCAAGCGAGCTAGCGAATTTTGGCGTTCAAACTGCTCAATTAGGTGGTGGTGATAAACA
AGGTAATGTTTTATTCACGGGTTACTTTTCTCCTGTAATGGAATTGCGACATGAAGCAAACGAAGAATACCGATTCCCTG
TTTATGGGCTTCCAGAGTGTGATAAAGAGTGTCCAACACGCGAAGAGATCTACAACGGTGCATTAGAAGGCCAAGGTCTT
GAGTTAGGTTATTCAGCAAACCGTATCGACCCATTTATGATGGAAGTACAGGGCAGCGGCTTTGTGCATTTCGGAGATGA
TGACACGCTGCAGTATTTTGCATACGCGGGTAAGAACAATAAAGCTTACGTGAGTATTGGTCGTGTTTTGATCGAAAGAG
GTTTAGTGCCACGCGAAAAAATGTCACTGAAAGCAATCAAAGAGTGGGTATTGGCGAACGATCCTGAAGTGGTAAAAGAA
CTGCTTGAGCAAAACCCATCTTTCGTCTTCTTTAGCGCGAGAGATGATCTATCCGTAATGGGTAGCGCTGGCATTCCTCT
ATTACCGATGGCGGCGGTAGCGGGCGATCGCTCTATCTTACCAATGGGAACTCCTATCCTGGCTGAGGTTCCGTTACTGA
ATGCTGATGGTACTTGGAGCGGCGCGCACCAACTAAGACTACTATTGGTTTTAGATACCGGTGGTGCGGTTAAGCAAAAC
CATTTGGACCTCTACCATGGTATGGGCCCACGAGCAGGAACTGAAGCGGGTCATTACAAGCATTTTGGTCGGGTGTGGAA
GCTGGGTCTAGATGGCAGCGCAACCGAAGCGCCTTGGGCTTTGCCTCCTGAAAAGGTCGAGTAA

Upstream 100 bases:

>100_bases
CTTACTGTGATTGGTATTATTGTAAACATTTACAATCTAAGATTGTGTTATCTGATCGTTTTTGTCATCCTCGATGCATA
GAATATTTAGGATGACTCTT

Downstream 100 bases:

>100_bases
ACAACAATAAAATGGGGCATTGAAAGCGAATCGCTAATCCCCTAGACTTTTAATTCAAGAGTGCGTATAAAACGCACTCT
TTTCTTTTTCTCAGAAATAA

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MIKKWLPLVAASFLFGCAQPTDLAQQHLDGEFPRTLNKVDLVESNKPRDFTAFAEQAEMVVSKSPSMAKIYEPLYQQLNE
WAVLSGEPSELANFGVQTAQLGGGDKQGNVLFTGYFSPVMELRHEANEEYRFPVYGLPECDKECPTREEIYNGALEGQGL
ELGYSANRIDPFMMEVQGSGFVHFGDDDTLQYFAYAGKNNKAYVSIGRVLIERGLVPREKMSLKAIKEWVLANDPEVVKE
LLEQNPSFVFFSARDDLSVMGSAGIPLLPMAAVAGDRSILPMGTPILAEVPLLNADGTWSGAHQLRLLLVLDTGGAVKQN
HLDLYHGMGPRAGTEAGHYKHFGRVWKLGLDGSATEAPWALPPEKVE

Sequences:

>Translated_367_residues
MIKKWLPLVAASFLFGCAQPTDLAQQHLDGEFPRTLNKVDLVESNKPRDFTAFAEQAEMVVSKSPSMAKIYEPLYQQLNE
WAVLSGEPSELANFGVQTAQLGGGDKQGNVLFTGYFSPVMELRHEANEEYRFPVYGLPECDKECPTREEIYNGALEGQGL
ELGYSANRIDPFMMEVQGSGFVHFGDDDTLQYFAYAGKNNKAYVSIGRVLIERGLVPREKMSLKAIKEWVLANDPEVVKE
LLEQNPSFVFFSARDDLSVMGSAGIPLLPMAAVAGDRSILPMGTPILAEVPLLNADGTWSGAHQLRLLLVLDTGGAVKQN
HLDLYHGMGPRAGTEAGHYKHFGRVWKLGLDGSATEAPWALPPEKVE
>Mature_367_residues
MIKKWLPLVAASFLFGCAQPTDLAQQHLDGEFPRTLNKVDLVESNKPRDFTAFAEQAEMVVSKSPSMAKIYEPLYQQLNE
WAVLSGEPSELANFGVQTAQLGGGDKQGNVLFTGYFSPVMELRHEANEEYRFPVYGLPECDKECPTREEIYNGALEGQGL
ELGYSANRIDPFMMEVQGSGFVHFGDDDTLQYFAYAGKNNKAYVSIGRVLIERGLVPREKMSLKAIKEWVLANDPEVVKE
LLEQNPSFVFFSARDDLSVMGSAGIPLLPMAAVAGDRSILPMGTPILAEVPLLNADGTWSGAHQLRLLLVLDTGGAVKQN
HLDLYHGMGPRAGTEAGHYKHFGRVWKLGLDGSATEAPWALPPEKVE

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=349, Percent_Identity=43.5530085959885, Blast_Score=303, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40406; Mature: 40406

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKWLPLVAASFLFGCAQPTDLAQQHLDGEFPRTLNKVDLVESNKPRDFTAFAEQAEMV
CCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHCHHHHCCCCCCCCHHHHHHHHHHH
VSKSPSMAKIYEPLYQQLNEWAVLSGEPSELANFGVQTAQLGGGDKQGNVLFTGYFSPVM
HHCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHCCCEEEECCCCCCCCCEEEEEHHHHHH
ELRHEANEEYRFPVYGLPECDKECPTREEIYNGALEGQGLELGYSANRIDPFMMEVQGSG
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCCCCCCEEEEECCCC
FVHFGDDDTLQYFAYAGKNNKAYVSIGRVLIERGLVPREKMSLKAIKEWVLANDPEVVKE
EEEECCCCCEEEEEEECCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
LLEQNPSFVFFSARDDLSVMGSAGIPLLPMAAVAGDRSILPMGTPILAEVPLLNADGTWS
HHHCCCCEEEEECCCCCHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHEECCEECCCCCCC
GAHQLRLLLVLDTGGAVKQNHLDLYHGMGPRAGTEAGHYKHFGRVWKLGLDGSATEAPWA
CCCEEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCC
LPPEKVE
CCCCCCC
>Mature Secondary Structure
MIKKWLPLVAASFLFGCAQPTDLAQQHLDGEFPRTLNKVDLVESNKPRDFTAFAEQAEMV
CCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHCHHHHCCCCCCCCHHHHHHHHHHH
VSKSPSMAKIYEPLYQQLNEWAVLSGEPSELANFGVQTAQLGGGDKQGNVLFTGYFSPVM
HHCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHCCCEEEECCCCCCCCCEEEEEHHHHHH
ELRHEANEEYRFPVYGLPECDKECPTREEIYNGALEGQGLELGYSANRIDPFMMEVQGSG
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCCCCCCEEEEECCCC
FVHFGDDDTLQYFAYAGKNNKAYVSIGRVLIERGLVPREKMSLKAIKEWVLANDPEVVKE
EEEECCCCCEEEEEEECCCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
LLEQNPSFVFFSARDDLSVMGSAGIPLLPMAAVAGDRSILPMGTPILAEVPLLNADGTWS
HHHCCCCEEEEECCCCCHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHEECCEECCCCCCC
GAHQLRLLLVLDTGGAVKQNHLDLYHGMGPRAGTEAGHYKHFGRVWKLGLDGSATEAPWA
CCCEEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCC
LPPEKVE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]