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The map label for this gene is mutH [H]

Identifier: 218708556

GI number: 218708556

Start: 540395

End: 541108

Strand: Reverse

Name: mutH [H]

Synonym: VS_0522

Alternate gene names: 218708556

Gene position: 541108-540395 (Counterclockwise)

Preceding gene: 218708564

Following gene: 218708549

Centisome position: 16.4

GC content: 46.22

Gene sequence:

>714_bases
ATGGTGATAACTTCTGGTAAAATCATTTTTTTGATCATGCCTTTTATTATGAAACCAGAACCACAAACACAACAAGAGCT
GTTAGACAGAGCATATGCTATTGCAGGAATGACCTTCAAAGAGCTCGCCGATGAAGCCAATATGGTTGTACCAAACGACC
TAAAGCGAGATAAAGGCTGGGTTGGACAACTATTGGAATGGCACTTGGGTGCGCCAGCTGGCAGTAAACCAGAACAAGAT
TTTGCCAAGCTCGGGATCGAGCTAAAAAGTATCCCGATTGGCTATTCAGGGAAGCCACTCGAAACCACCTTTGTTTGTGT
CGCGCCATTGATGGGCGTGCAAGGCATAACTTGGGAAACCAGTCACGTTCGAAACAAGCTGTCTAAAGTGTTGTGGATCC
CGGTAGAGGGAGAAAGAGAGATCCCACTGGCAGAAAGGCATGTAGGATCCCCTTTATTGTGGACACCAACCCAAGCGGAA
GACGAGATCTTAAAAAGGGATTGGGAAGAGCTCATGGAGCTGATCGTGTTAGGTAATGTTGAACAGATAACAGCAAGACA
CGGCGAAGCACTGCATTTGCGACCAAAAGCCGCCAACAGTCGAGTGTTAACAGAAGCTTACGGTGCAAGTGGAAAACCAA
TAAAGACCAAACCTCGTGGTTTCTATCTACGAACTCAATTCACCCACAGATTGCTGACAACCCATTACGCATAG

Upstream 100 bases:

>100_bases
CACTAAATTAATATTTCAATTAATTACCTTCATGTCCTGTGGATAACCATGAGTTTGATCCCTTCTCTAGCTAGGCGATC
ATTTCTTAACCAGTCGTCAT

Downstream 100 bases:

>100_bases
AAAGCCATTACGCATAGAGGTTTTATCTAGCATAGATATGCTAAAAGATCAGTACGTTATAAACCGTCTCAATTTAGAAG
TAATTTCTCACTACAACGCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MVITSGKIIFLIMPFIMKPEPQTQQELLDRAYAIAGMTFKELADEANMVVPNDLKRDKGWVGQLLEWHLGAPAGSKPEQD
FAKLGIELKSIPIGYSGKPLETTFVCVAPLMGVQGITWETSHVRNKLSKVLWIPVEGEREIPLAERHVGSPLLWTPTQAE
DEILKRDWEELMELIVLGNVEQITARHGEALHLRPKAANSRVLTEAYGASGKPIKTKPRGFYLRTQFTHRLLTTHYA

Sequences:

>Translated_237_residues
MVITSGKIIFLIMPFIMKPEPQTQQELLDRAYAIAGMTFKELADEANMVVPNDLKRDKGWVGQLLEWHLGAPAGSKPEQD
FAKLGIELKSIPIGYSGKPLETTFVCVAPLMGVQGITWETSHVRNKLSKVLWIPVEGEREIPLAERHVGSPLLWTPTQAE
DEILKRDWEELMELIVLGNVEQITARHGEALHLRPKAANSRVLTEAYGASGKPIKTKPRGFYLRTQFTHRLLTTHYA
>Mature_237_residues
MVITSGKIIFLIMPFIMKPEPQTQQELLDRAYAIAGMTFKELADEANMVVPNDLKRDKGWVGQLLEWHLGAPAGSKPEQD
FAKLGIELKSIPIGYSGKPLETTFVCVAPLMGVQGITWETSHVRNKLSKVLWIPVEGEREIPLAERHVGSPLLWTPTQAE
DEILKRDWEELMELIVLGNVEQITARHGEALHLRPKAANSRVLTEAYGASGKPIKTKPRGFYLRTQFTHRLLTTHYA

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=216, Percent_Identity=64.8148148148148, Blast_Score=293, Evalue=9e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 26644; Mature: 26644

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVITSGKIIFLIMPFIMKPEPQTQQELLDRAYAIAGMTFKELADEANMVVPNDLKRDKGW
CEECCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCEECCCCCCCCCHH
VGQLLEWHLGAPAGSKPEQDFAKLGIELKSIPIGYSGKPLETTFVCVAPLMGVQGITWET
HHHHHHHHCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCH
SHVRNKLSKVLWIPVEGEREIPLAERHVGSPLLWTPTQAEDEILKRDWEELMELIVLGNV
HHHHHHHHHEEEEECCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCH
EQITARHGEALHLRPKAANSRVLTEAYGASGKPIKTKPRGFYLRTQFTHRLLTTHYA
HHHHHCCCCEEEECCCCCCCEEEHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MVITSGKIIFLIMPFIMKPEPQTQQELLDRAYAIAGMTFKELADEANMVVPNDLKRDKGW
CEECCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCEECCCCCCCCCHH
VGQLLEWHLGAPAGSKPEQDFAKLGIELKSIPIGYSGKPLETTFVCVAPLMGVQGITWET
HHHHHHHHCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCH
SHVRNKLSKVLWIPVEGEREIPLAERHVGSPLLWTPTQAEDEILKRDWEELMELIVLGNV
HHHHHHHHHEEEEECCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCH
EQITARHGEALHLRPKAANSRVLTEAYGASGKPIKTKPRGFYLRTQFTHRLLTTHYA
HHHHHCCCCEEEECCCCCCCEEEHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA