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The map label for this gene is pcoR [H]

Identifier: 218697172

GI number: 218697172

Start: 3970390

End: 3971076

Strand: Reverse

Name: pcoR [H]

Synonym: EC55989_3902

Alternate gene names: 218697172

Gene position: 3971076-3970390 (Counterclockwise)

Preceding gene: 218697173

Following gene: 218697171

Centisome position: 77.04

GC content: 51.67

Gene sequence:

>687_bases
TTGACCATGCAGCGTATTTTAATCGTTGAAGACGAACAAAAAACAGGTCGTTACCTGCAGCAGGGACTGGTTGAGGAAGG
CTATCAGGCCGATCTCTTTAATAATGGCCGCGATGGTCTCGGGGCCGCGTCGAAGGGACAGTATGATTTGATAATACTGG
ACGTGATGCTGCCTTTCCTCGACGGGTGGCAAATCATCAGCGCACTGAGGGAGTCCGGGCACGAAGAACCGGTCCTGTTT
TTAACCGCAAAGGACAACGTGCGGGACAAAGTGAAAGGACTGGAGCTTGGCGCAGATGACTACCTGATTAAGCCCTTTGA
TTTTACGGAGCTGGTTGCACGTGTAAGAACCCTACTGCGCCGGGCACGCTCGCAGGCCGCAACAGTCTGCACCATCGCCG
ATATGACCGTTGATATGGTGCGCCGGACCGTGATCCGTTCGGGGAAGAAGATCCATCTCACCGGTAAAGAATACGTTCTG
CTTGAGTTGCTGCTGCAACGCACCGGAGAAGTGTTACCCAGGAGTCTTATCTCGTCCCTGGTCTGGAACATGAATTTTGA
CAGTGATACGAATGTGATTGATGTCGCCGTGAGACGTCTGAGAAGTAAAATTGATGATGACTTTGAGCCAAAACTGATCC
ATACCGTTCGCGGTGCCGGATATGTCCTGGAGATCAGAGAAGAGTGA

Upstream 100 bases:

>100_bases
TCTGGGCGCCGTAGCGTGGCTCGGAATGCTTGCTCCGTCTCAGGTCAGCTAGGGGACAGCCAAAGCTCATGCGTGAGATT
TTTACTTTCATATCAGCGAG

Downstream 100 bases:

>100_bases
GGTTCAAAATTTCCCTGACCACACGCCTGAGCCTGATTTTTTCTGCGGTGATGCTTACGGTATGGTGGTTATCAAGTTTT
ATCCTGATTAGCACCCTTAA

Product: Transcriptional regulatory protein pcoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTMQRILIVEDEQKTGRYLQQGLVEEGYQADLFNNGRDGLGAASKGQYDLIILDVMLPFLDGWQIISALRESGHEEPVLF
LTAKDNVRDKVKGLELGADDYLIKPFDFTELVARVRTLLRRARSQAATVCTIADMTVDMVRRTVIRSGKKIHLTGKEYVL
LELLLQRTGEVLPRSLISSLVWNMNFDSDTNVIDVAVRRLRSKIDDDFEPKLIHTVRGAGYVLEIREE

Sequences:

>Translated_228_residues
MTMQRILIVEDEQKTGRYLQQGLVEEGYQADLFNNGRDGLGAASKGQYDLIILDVMLPFLDGWQIISALRESGHEEPVLF
LTAKDNVRDKVKGLELGADDYLIKPFDFTELVARVRTLLRRARSQAATVCTIADMTVDMVRRTVIRSGKKIHLTGKEYVL
LELLLQRTGEVLPRSLISSLVWNMNFDSDTNVIDVAVRRLRSKIDDDFEPKLIHTVRGAGYVLEIREE
>Mature_227_residues
TMQRILIVEDEQKTGRYLQQGLVEEGYQADLFNNGRDGLGAASKGQYDLIILDVMLPFLDGWQIISALRESGHEEPVLFL
TAKDNVRDKVKGLELGADDYLIKPFDFTELVARVRTLLRRARSQAATVCTIADMTVDMVRRTVIRSGKKIHLTGKEYVLL
ELLLQRTGEVLPRSLISSLVWNMNFDSDTNVIDVAVRRLRSKIDDDFEPKLIHTVRGAGYVLEIREE

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May be involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=60.4444444444444, Blast_Score=269, Evalue=1e-73,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=52.073732718894, Blast_Score=227, Evalue=4e-61,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=40.6392694063927, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=38.5964912280702, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.7777777777778, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=36.9369369369369, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=37.280701754386, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=33.1858407079646, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.6071428571429, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.0649350649351, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=35.8078602620087, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.4372294372294, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.5423728813559, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=35.4545454545455, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=138, Percent_Identity=32.6086956521739, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=36, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=35.2941176470588, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=125, Percent_Identity=29.6, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25908; Mature: 25777

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMQRILIVEDEQKTGRYLQQGLVEEGYQADLFNNGRDGLGAASKGQYDLIILDVMLPFL
CCCCEEEEEECCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHH
DGWQIISALRESGHEEPVLFLTAKDNVRDKVKGLELGADDYLIKPFDFTELVARVRTLLR
CHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCEECCCCCEECCCCHHHHHHHHHHHHH
RARSQAATVCTIADMTVDMVRRTVIRSGKKIHLTGKEYVLLELLLQRTGEVLPRSLISSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VWNMNFDSDTNVIDVAVRRLRSKIDDDFEPKLIHTVRGAGYVLEIREE
HHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
TMQRILIVEDEQKTGRYLQQGLVEEGYQADLFNNGRDGLGAASKGQYDLIILDVMLPFL
CCCEEEEEECCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHH
DGWQIISALRESGHEEPVLFLTAKDNVRDKVKGLELGADDYLIKPFDFTELVARVRTLLR
CHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCEECCCCCEECCCCHHHHHHHHHHHHH
RARSQAATVCTIADMTVDMVRRTVIRSGKKIHLTGKEYVLLELLLQRTGEVLPRSLISSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
VWNMNFDSDTNVIDVAVRRLRSKIDDDFEPKLIHTVRGAGYVLEIREE
HHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8594334; 9141682 [H]