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The map label for this gene is pcoS [H]

Identifier: 218697171

GI number: 218697171

Start: 3968993

End: 3970393

Strand: Reverse

Name: pcoS [H]

Synonym: EC55989_3901

Alternate gene names: 218697171

Gene position: 3970393-3968993 (Counterclockwise)

Preceding gene: 218697172

Following gene: 218697170

Centisome position: 77.02

GC content: 47.25

Gene sequence:

>1401_bases
GTGAGGTTCAAAATTTCCCTGACCACACGCCTGAGCCTGATTTTTTCTGCGGTGATGCTTACGGTATGGTGGTTATCAAG
TTTTATCCTGATTAGCACCCTTAATGGCTATTTCGATAATCAGGACCGCGATTTTCTGACAGGTAAACTTCAGCTCACCG
AAGAGTTTCTTAAAACAGAGACGTTCAGGAACAAAACGGATATTAAGTCATTATCAGAAAAAATAAACGATGCGATGGTG
GGGCACAATGGCTTATTCATTTCTATAAAAAACATGGAAAATGAAAAAATTGTTGAACTCTATGCCAAAAATTCTGTTGT
TCCAGCGATCCTGCTTAATAAGTCGGGTGATATTCTCGACTATATGATCCAGACGGAAGAAAATAACACCGTGTACCGCA
GTATCTCGCGGCGGGTTGCCGTGACGCCGGAACAGGGTAAAAGCAAACATGTCATCATTACGGTTGCCACGGATACTGGG
TATCACACCCTGTTTATGGACAAACTCAGTACCTGGCTGTTCTGGTTCAATATCGGTCTGGTCTTTATTTCTGTTTTTCT
GGGCTGGCTGACCACACGTATTGGTCTGAAACCGCTACGGGAAATGACCAGTCTGGCTTCCTCCATGACCGTACACAGCC
TGGATCAGCGTCTAAATCCCGATCTGGCTCCGCCGGAAATCTCTGAGACCATGCAGGAGTTCAATAATATGTTTGATCGC
CTGGAGGGGGCATTCCGGAAACTGTCAGATTTCTCGTCTGACATCGCGCATGAGCTGCGCACACCAGTCAGTAATCTGAT
GATGCAGACGCAGTTTGCACTGGCTAAGGAAAGGGATGTTTCGCATTACCGCGAAATTTTATTCGCTAACCTGGAAGAAC
TGAAAAGGTTGTCACGAATGACCAGTGACATGCTTTTTCTGGCACGTTCAGAGCATGGTCTGCTGCGGCTGGATAAACAT
GATGTGGATCTGGCAGCCGAACTGAATGAATTACGTGAGTTGTTCGAGCCCCTGGCAGACGAAACAGGAAAGACAATCAC
GGTTGAAGGAGAGGGCGTTGTTGCCGGAGACAGCGATATGCTCCGACGTGCTTTCAGTAACCTGCTTTCCAATGCAATCA
AGTATTCTCCCGATAACACCTGTACAGCGATACACCTTGAGCGTGACAGTGACTGTGTGAACGTGATGATTACGAATACG
ATGTCCGGCCAGGTTCCCGCTAATCTGGAACGTTTGTTTGACCGGTTCTATCGCGCAGACTCATCAAGGTTCTACAACAC
GGAAGGCGCGGGGCTGGGATTATCAATTACAAGGTCGATCATTCATGCTCACGGCGGCGAGCTGTCAGCAGAACAGCAGG
GGCGTGAAATTGTGTTCAAAGTGCGCCTGTTAATGGATTAA

Upstream 100 bases:

>100_bases
TCGCCGTGAGACGTCTGAGAAGTAAAATTGATGATGACTTTGAGCCAAAACTGATCCATACCGTTCGCGGTGCCGGATAT
GTCCTGGAGATCAGAGAAGA

Downstream 100 bases:

>100_bases
TCCCGTTGTTCAGGAGAAACCTGGAAGGTGACAAAATTGTCATCATTCAGTCACGCGATAAACAGAGGCGGTTTTTTATA
ATTATTCATAAATCAGGAGC

Product: putative sensor protein pcoS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MRFKISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTETFRNKTDIKSLSEKINDAMV
GHNGLFISIKNMENEKIVELYAKNSVVPAILLNKSGDILDYMIQTEENNTVYRSISRRVAVTPEQGKSKHVIITVATDTG
YHTLFMDKLSTWLFWFNIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPPEISETMQEFNNMFDR
LEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKH
DVDLAAELNELRELFEPLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNT
MSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRLLMD

Sequences:

>Translated_466_residues
MRFKISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTETFRNKTDIKSLSEKINDAMV
GHNGLFISIKNMENEKIVELYAKNSVVPAILLNKSGDILDYMIQTEENNTVYRSISRRVAVTPEQGKSKHVIITVATDTG
YHTLFMDKLSTWLFWFNIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPPEISETMQEFNNMFDR
LEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKH
DVDLAAELNELRELFEPLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNT
MSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRLLMD
>Mature_466_residues
MRFKISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTETFRNKTDIKSLSEKINDAMV
GHNGLFISIKNMENEKIVELYAKNSVVPAILLNKSGDILDYMIQTEENNTVYRSISRRVAVTPEQGKSKHVIITVATDTG
YHTLFMDKLSTWLFWFNIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPPEISETMQEFNNMFDR
LEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKH
DVDLAAELNELRELFEPLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNT
MSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRLLMD

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May activate pcoR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=310, Percent_Identity=37.4193548387097, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1788279, Length=289, Percent_Identity=32.8719723183391, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=29.0697674418605, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=28.6792452830189, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=214, Percent_Identity=28.5046728971963, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789403, Length=490, Percent_Identity=25.9183673469388, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=28.3950617283951, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=29.9559471365639, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=340, Percent_Identity=25.5882352941176, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=280, Percent_Identity=27.1428571428571, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786912, Length=204, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=25.1063829787234, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=26.4957264957265, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=22.5589225589226, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53061; Mature: 53061

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFKISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTE
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TFRNKTDIKSLSEKINDAMVGHNGLFISIKNMENEKIVELYAKNSVVPAILLNKSGDILD
HHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCCEEEECCCCCEEE
YMIQTEENNTVYRSISRRVAVTPEQGKSKHVIITVATDTGYHTLFMDKLSTWLFWFNIGL
EEEEECCCCHHHHHHHCCEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
VFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPPEISETMQEFNNMFDR
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRM
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TSDMLFLARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEGVVAGDSDM
HHHHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCHHH
LRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRAD
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCC
SSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRLLMD
CCCEECCCCCCCCHHHHHHHHHHCCCCCCCHHCCCEEEEEEEEECC
>Mature Secondary Structure
MRFKISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTE
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TFRNKTDIKSLSEKINDAMVGHNGLFISIKNMENEKIVELYAKNSVVPAILLNKSGDILD
HHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCCEEEECCCCCEEE
YMIQTEENNTVYRSISRRVAVTPEQGKSKHVIITVATDTGYHTLFMDKLSTWLFWFNIGL
EEEEECCCCHHHHHHHCCEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
VFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPPEISETMQEFNNMFDR
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRM
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TSDMLFLARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEGVVAGDSDM
HHHHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCHHH
LRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRAD
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCC
SSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRLLMD
CCCEECCCCCCCCHHHHHHHHHHCCCCCCCHHCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]