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The map label for this gene is tdcD [H]

Identifier: 218691113

GI number: 218691113

Start: 3395189

End: 3396496

Strand: Direct

Name: tdcD [H]

Synonym: ECED1_3455

Alternate gene names: 218691113

Gene position: 3395189-3396496 (Clockwise)

Preceding gene: 218691112

Following gene: 218691114

Centisome position: 65.17

GC content: 53.75

Gene sequence:

>1308_bases
GTGTTGAGGAAGATATGCTCATCGCCCGCCAGGCGATGGCGCAGTTTAGCGTTCTGCGTTATCCCCTCACAACAACCCGT
TAATTTTTTGCAGTCCATTTCAGGGGGCATCATGTCTTTAGCTTGTGTATTAGTGATTAATTGTGGTTCCTCATCAATGA
AATTCTCCGTCATTCCTCAGGATGCAGATCAGCCGTTGCTGTCGGGCCTAGCGGAACGACTGGGTATTGATCATGCTGTC
ATAACGTTTAAAGACCGAGACGGCCATAAATCCACTGTCGCGCTGGATGACGCCAGCCATCAGCATGCGCTCAAAGTGCT
CTTCGCGAAGCTCGACGAACAGCAACTGTTGGAAGCCATCAACGCCGTTGGGCACCGCGTGGCTCATGGCGGCAGCGACT
TCAAAAGATCAGTACTGGTTACCGATGATGTGATCGAAAAAGTCCGCGCGCTGTCGGTGCTGGCCCCTTTGCATAACCCT
GCCAACCTGATTGGTATTGAAGCGGCTCGGGCTCTGTTGCCCGCGTTGCCGCATATTGCGGTGTTCGATACTGCGTTCCA
CCAGACCTTGTCTCCGGCTGCTTACACCTATGCGATCCCGCTGGAGTTCCAGCAAGATTATATGGTGCGACGTTACGGCT
TTCACGGAACATCTCACCGCTATATTGCCGCCGAGGCGCTTGCATCACTAGATCTCGACCCGGCGGATCATGGCATCGTG
ATTGCCCACTTGGGCAACGGTTCATCGCTATGTGCGGTGCAAAACGGCACGAGCATTGACACCTCAATGGGTATGACCCC
GCTGGAAGGGCTGGTAATGGGCACGCGCTGCGGGGATCTTGATTTTGGTGTCGTCGCATATCTGGCGAAACGCACAGGTC
AAACGTTCGACACGCTGTACAAAATGCTCAATAACCAGTCCGGCCTAATGGGGATTTCCGGCTTATCCAGCGATTGCCGC
ACCCTTCAGCAGGCGCGTGATGAGGGCCACGAACGGGCAGCGTTAGCCATCGACGTGTTAGTACATCGTCTCGCACGACA
TATCGGCGGCCACGTGACCTCGCTTAAACGCTTCGATGCGCTGATTTTCACCGGTGGAATTGGCGAAAACTCGGCGTTAA
TTCGAGAACTTACCGTGCAACGCCTTCAGGCGCTGGGATTGGAACTGGATAAAGAACGTAACCAGCAGCTGTTCGGCGGA
CGTAGCGGACTGATTTCTAAAACCGACACCACGAAGATTGCGGTCATCCCAACCAATGAAGAAAAAATGATTGCTATAGA
TGCAGCGGAGATTGCCCGCACGGCATAA

Upstream 100 bases:

>100_bases
TACGGCCTTGAGAAAGAAAAAGATATCTGCTGCTTCGGCGGTGGTTTTCCCTGCTGGTCGGGCAGGCGCTTACTAGGCGG
CATCGGCATCAGCGGCGGCA

Downstream 100 bases:

>100_bases
CTAATTGGCAAAAATACGACAGTTTTAACAGTAATTATGATTGCTATTCAGAGCGGGGCTATTTTGCAAGGAAGTTTAAA
CGCAGATCTTTTATTACAAA

Product: propionate/acetate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLRKICSSPARRWRSLAFCVIPSQQPVNFLQSISGGIMSLACVLVINCGSSSMKFSVIPQDADQPLLSGLAERLGIDHAV
ITFKDRDGHKSTVALDDASHQHALKVLFAKLDEQQLLEAINAVGHRVAHGGSDFKRSVLVTDDVIEKVRALSVLAPLHNP
ANLIGIEAARALLPALPHIAVFDTAFHQTLSPAAYTYAIPLEFQQDYMVRRYGFHGTSHRYIAAEALASLDLDPADHGIV
IAHLGNGSSLCAVQNGTSIDTSMGMTPLEGLVMGTRCGDLDFGVVAYLAKRTGQTFDTLYKMLNNQSGLMGISGLSSDCR
TLQQARDEGHERAALAIDVLVHRLARHIGGHVTSLKRFDALIFTGGIGENSALIRELTVQRLQALGLELDKERNQQLFGG
RSGLISKTDTTKIAVIPTNEEKMIAIDAAEIARTA

Sequences:

>Translated_435_residues
MLRKICSSPARRWRSLAFCVIPSQQPVNFLQSISGGIMSLACVLVINCGSSSMKFSVIPQDADQPLLSGLAERLGIDHAV
ITFKDRDGHKSTVALDDASHQHALKVLFAKLDEQQLLEAINAVGHRVAHGGSDFKRSVLVTDDVIEKVRALSVLAPLHNP
ANLIGIEAARALLPALPHIAVFDTAFHQTLSPAAYTYAIPLEFQQDYMVRRYGFHGTSHRYIAAEALASLDLDPADHGIV
IAHLGNGSSLCAVQNGTSIDTSMGMTPLEGLVMGTRCGDLDFGVVAYLAKRTGQTFDTLYKMLNNQSGLMGISGLSSDCR
TLQQARDEGHERAALAIDVLVHRLARHIGGHVTSLKRFDALIFTGGIGENSALIRELTVQRLQALGLELDKERNQQLFGG
RSGLISKTDTTKIAVIPTNEEKMIAIDAAEIARTA
>Mature_435_residues
MLRKICSSPARRWRSLAFCVIPSQQPVNFLQSISGGIMSLACVLVINCGSSSMKFSVIPQDADQPLLSGLAERLGIDHAV
ITFKDRDGHKSTVALDDASHQHALKVLFAKLDEQQLLEAINAVGHRVAHGGSDFKRSVLVTDDVIEKVRALSVLAPLHNP
ANLIGIEAARALLPALPHIAVFDTAFHQTLSPAAYTYAIPLEFQQDYMVRRYGFHGTSHRYIAAEALASLDLDPADHGIV
IAHLGNGSSLCAVQNGTSIDTSMGMTPLEGLVMGTRCGDLDFGVVAYLAKRTGQTFDTLYKMLNNQSGLMGISGLSSDCR
TLQQARDEGHERAALAIDVLVHRLARHIGGHVTSLKRFDALIFTGGIGENSALIRELTVQRLQALGLELDKERNQQLFGG
RSGLISKTDTTKIAVIPTNEEKMIAIDAAEIARTA

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG0282

COG function: function code C; Acetate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetokinase family. TdcD subfamily [H]

Homologues:

Organism=Escherichia coli, GI145693184, Length=393, Percent_Identity=51.6539440203562, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788633, Length=400, Percent_Identity=45, Blast_Score=337, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000890
- InterPro:   IPR004372 [H]

Pfam domain/function: PF00871 Acetate_kinase [H]

EC number: =2.7.2.15 [H]

Molecular weight: Translated: 46974; Mature: 46974

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS01075 ACETATE_KINASE_1 ; PS01076 ACETATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKICSSPARRWRSLAFCVIPSQQPVNFLQSISGGIMSLACVLVINCGSSSMKFSVIPQ
CCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHCCHHHHHHHHHEEECCCCCEEEEECCC
DADQPLLSGLAERLGIDHAVITFKDRDGHKSTVALDDASHQHALKVLFAKLDEQQLLEAI
CCCCHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHH
NAVGHRVAHGGSDFKRSVLVTDDVIEKVRALSVLAPLHNPANLIGIEAARALLPALPHIA
HHHHHHHHCCCCCHHCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
VFDTAFHQTLSPAAYTYAIPLEFQQDYMVRRYGFHGTSHRYIAAEALASLDLDPADHGIV
HHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCEE
IAHLGNGSSLCAVQNGTSIDTSMGMTPLEGLVMGTRCGDLDFGVVAYLAKRTGQTFDTLY
EEEECCCCEEEEECCCCCCCCCCCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCHHHHHH
KMLNNQSGLMGISGLSSDCRTLQQARDEGHERAALAIDVLVHRLARHIGGHVTSLKRFDA
HHHCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCE
LIFTGGIGENSALIRELTVQRLQALGLELDKERNQQLFGGRSGLISKTDTTKIAVIPTNE
EEEECCCCCCHHHHHHHHHHHHHHHCCHHCHHHCHHHHCCCCCCCCCCCCCEEEEEECCC
EKMIAIDAAEIARTA
CCEEEEEHHHHHHCC
>Mature Secondary Structure
MLRKICSSPARRWRSLAFCVIPSQQPVNFLQSISGGIMSLACVLVINCGSSSMKFSVIPQ
CCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHCCHHHHHHHHHEEECCCCCEEEEECCC
DADQPLLSGLAERLGIDHAVITFKDRDGHKSTVALDDASHQHALKVLFAKLDEQQLLEAI
CCCCHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHH
NAVGHRVAHGGSDFKRSVLVTDDVIEKVRALSVLAPLHNPANLIGIEAARALLPALPHIA
HHHHHHHHCCCCCHHCEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
VFDTAFHQTLSPAAYTYAIPLEFQQDYMVRRYGFHGTSHRYIAAEALASLDLDPADHGIV
HHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCEE
IAHLGNGSSLCAVQNGTSIDTSMGMTPLEGLVMGTRCGDLDFGVVAYLAKRTGQTFDTLY
EEEECCCCEEEEECCCCCCCCCCCCCCHHHEEEECCCCCCCHHHHHHHHHHCCCHHHHHH
KMLNNQSGLMGISGLSSDCRTLQQARDEGHERAALAIDVLVHRLARHIGGHVTSLKRFDA
HHHCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCE
LIFTGGIGENSALIRELTVQRLQALGLELDKERNQQLFGGRSGLISKTDTTKIAVIPTNE
EEEECCCCCCHHHHHHHHHHHHHHHCCHHCHHHCHHHHCCCCCCCCCCCCCEEEEEECCC
EKMIAIDAAEIARTA
CCEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA