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The map label for this gene is tmk [H]

Identifier: 218549175

GI number: 218549175

Start: 1882991

End: 1883632

Strand: Reverse

Name: tmk [H]

Synonym: EFER_1829

Alternate gene names: 218549175

Gene position: 1883632-1882991 (Counterclockwise)

Preceding gene: 218549176

Following gene: 218549174

Centisome position: 41.05

GC content: 52.02

Gene sequence:

>642_bases
ATGCGCAGTAACTATATCGTCATCGAAGGGCTGGAAGGTGCAGGTAAAACCACTGCGCGTAACGTTGTGGTGGAGACACT
TGAGCAACTGGGCATTCGTGAGATGATTTTTACCCGTGAACCAGGAGGGACGCAGTTGGCTGAGAAACTGAGGAGCCTGG
TGCTGGATATAAAATCCGTCGGTGATGAAGTCATCACTGAGAAGGCTGAAGTTCTGATGTTTTATGCAGCCCGCGTCCAG
TTGGTGGAGACAGTCATTAAGCCTGCACTGGCGAAAGGTACCTGGGTGATTGGTGATCGTCATGATTTATCGACTCAGGC
TTATCAGGGGGGCGGTCGTGGTGTTGATCAAACCATGCTGGCAACACTACGTGATGCCGTGTTAGGTGATTTTCGCCCGG
ACCTGACTCTGTATCTCGACGTTACGCCTGAAGTAGGTCTAAAACGTGCACGAGCGCGTGGTGAACTGGACCGTATTGAG
CAGGAGTCCTTCGACTTCTTTAACCGTACTCGTGCGCGTTATCTGGAACTTGCAGCTCAGGATGCCAGCATCCGCACTAT
CGATGCCACGCAATCGCTTGAGTGTGTCATGGCTGATATTCGACAAACTGTGACAACCTGGGTGAAGGAGCAGGGCGCAT
GA

Upstream 100 bases:

>100_bases
TATTTTGTCGCCGATGGTAAAGGTGGTCATACATTTAACACTAATCTTGCCAGCCACAATCGGTCAGTGCAGGACTATTT
AAAAGTGCTTAAGGAAAAAA

Downstream 100 bases:

>100_bases
AATGGTATCCATGGTTAAGACCAGACTTCGAAAAACTGGTAGCGAACTATCAGGCAGGAAGGGGTCACCATGCGCTACTG
ATTCAGGCGCTGCCAGGTAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MRSNYIVIEGLEGAGKTTARNVVVETLEQLGIREMIFTREPGGTQLAEKLRSLVLDIKSVGDEVITEKAEVLMFYAARVQ
LVETVIKPALAKGTWVIGDRHDLSTQAYQGGGRGVDQTMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIE
QESFDFFNRTRARYLELAAQDASIRTIDATQSLECVMADIRQTVTTWVKEQGA

Sequences:

>Translated_213_residues
MRSNYIVIEGLEGAGKTTARNVVVETLEQLGIREMIFTREPGGTQLAEKLRSLVLDIKSVGDEVITEKAEVLMFYAARVQ
LVETVIKPALAKGTWVIGDRHDLSTQAYQGGGRGVDQTMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIE
QESFDFFNRTRARYLELAAQDASIRTIDATQSLECVMADIRQTVTTWVKEQGA
>Mature_213_residues
MRSNYIVIEGLEGAGKTTARNVVVETLEQLGIREMIFTREPGGTQLAEKLRSLVLDIKSVGDEVITEKAEVLMFYAARVQ
LVETVIKPALAKGTWVIGDRHDLSTQAYQGGGRGVDQTMLATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIE
QESFDFFNRTRARYLELAAQDASIRTIDATQSLECVMADIRQTVTTWVKEQGA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=213, Percent_Identity=92.018779342723, Blast_Score=393, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23707; Mature: 23707

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSNYIVIEGLEGAGKTTARNVVVETLEQLGIREMIFTREPGGTQLAEKLRSLVLDIKSV
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GDEVITEKAEVLMFYAARVQLVETVIKPALAKGTWVIGDRHDLSTQAYQGGGRGVDQTML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCHHHHHH
ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DASIRTIDATQSLECVMADIRQTVTTWVKEQGA
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRSNYIVIEGLEGAGKTTARNVVVETLEQLGIREMIFTREPGGTQLAEKLRSLVLDIKSV
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GDEVITEKAEVLMFYAARVQLVETVIKPALAKGTWVIGDRHDLSTQAYQGGGRGVDQTML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCHHHHHH
ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
DASIRTIDATQSLECVMADIRQTVTTWVKEQGA
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA