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The map label for this gene is tktB [H]

Identifier: 218548102

GI number: 218548102

Start: 732503

End: 734506

Strand: Reverse

Name: tktB [H]

Synonym: EFER_0714

Alternate gene names: 218548102

Gene position: 734506-732503 (Counterclockwise)

Preceding gene: 218548103

Following gene: 218548098

Centisome position: 16.01

GC content: 53.69

Gene sequence:

>2004_bases
ATGTCCCGAAAAGACCTTGCCAATGCGATTCGCGCACTCAGTATGGATGCGGTGCAAAAAGCCAATTCCGGTCATCCCGG
CGCGCCGATGGGCATGGCAGATATTGCCGAAGTGCTGTGGAACGATTTTCTTAAACATAACCCCAGCGATCCAACCTGGT
ATGATCGCGACCGCTTTATTCTCTCCAACGGTCACGCGTCGATGCTGCTCTACAGTTTGCTTCATCTGACCGGTTACGAC
CTGCCGCTGGAAGAGCTGAAGAACTTCCGTCAGTTGCATTCGAAAACCCCAGGCCACCCGGAGATTGGCTATACACCAGG
TGTTGAAACCACCACCGGTCCACTTGGACAAGGTTTGGCTAACGCCGTCGGGCTGGCGATAGCAGAGCGTACACTGGCGG
CGCAGTTTAACCAGCCGGATCATGAGATCGTCGATCACTTCACCTATGTGTTTATGGGCGACGGCTGTCTGATGGAAGGT
ATCTCTCACGAAGTCTGTTCGCTGGCGGGCACACTGGGGCTGGGCAAACTGATTGGTTTTTACGATCACAACGGTATTTC
GATTGATGGAGAAACCGAAGGCTGGTTTACCGACGATACGGCAAAGCGTTTTGAAGCCTATCACTGGCATGTGATCCATG
AAATCGACGGCCACGATCCGCAGGCGGTGAAGGAAGCGATTCTTGAAGCGCAAAGCGTAAAAGATAAGCCATCGCTGATT
ATCTGCCGTACGGTGATTGGCTTTGGTTCACCGAATAAAGCAGGTAAGGAAGAGGCGCACGGCGCACCGCTTGGGGAAGA
AGAAGTGGCGCTGGCACGGCAAAAACTGGGCTGGCACCATCCGCCATTTGAGATCCCTAAAGAGATTTATCACGCCTGGG
ATGCCCGCGAAAAAGGCGAAAAAGCGCAGCAGAGCTGGAATGAGAAGTTTGCCGCCTATAAAAAGGCTCATCCGCAACTG
GCAGAAGAGTTTACCCGTCGGATGAGCGGTGGTTTACCGAAAGACTGGGAAAAAACGACACAGAAATATATCAATGAGTT
GCAGGCGAATCCGGCGAAAATCGCTACCCGTAAGGCTTCGCAAAATACGCTTAACGCTTACGGGCCAATGCTGCCTGAAC
TGCTTGGCGGTTCGGCGGATCTGGCCCCCAGCAATCTCACCATCTGGAAAGGTTCTGTGTCGCTGAAGGAAGATCCGGCG
GGTAACTACATTCACTACGGGGTGCGTGAATTTGGCATGACCGCTATCGCCAATGGCATTGCGCACCACGGCGGCTTCGT
GCCGTATACCGCGACGTTCCTGATGTTTGTTGAATACGCCCGTAACGCCGCGCGGATGGCAGCACTGATGAAAGCGCGGC
AGATAATGGTTTATACCCACGACTCTATTGGCTTAGGGGAAGATGGTCCGACGCACCAGGCCGTTGAGCAACTGGCCAGT
CTGCGCCTGACGCCGAATTTCAGCACCTGGCGACCGTGCGATCAGGTGGAAGCAGCGGTGGGCTGGAAGCTGGCGGTTGA
GCGCCACAATGGACCAACAGCACTGATCCTCTCAAGGCAGAATCTGGCACAGGTAGAACGAACGCCGGATCAGGTAAAAG
AGATTGCCCGTGGCGGTTATGTGCTGAAAGATAGCGGCGGTAAGCCAGATATTATTCTTATTGCTACCGGTTCAGAGATG
GAAATTACCCTGCAAGCAGCGGAGAAATTAGCGGGAGAAGGTCGCAATGTTCGCGTTGTTTCCCTGCCCTCGACGGATAT
TTTCGACGCTCAGGATGAGGAATATCGCGAGTCGGTACTGCCTTCTAATGTTTCAGCCCGCGTGGCGGTGGAAGCGGGTA
TTGCCGATTACTGGTACAAATATGTTGGTCTGAAAGGGGCAATTGTCGGGATGACCAGCTACGGGGAATCTGCCCCGGCG
GATAAACTGTTCCCATTCTTTGGCTTTACCCCCGAGAATATTGTGGCAAAAGCGCATAAGGTTCTGGGGGTTAAAAGCGC
CTGA

Upstream 100 bases:

>100_bases
GAAAAACTTTCTGAGGGTATCCGTCTGTTTGCCGTTGACCAACGAAAACTGGAAGACCTGCTTGCCGCTAAATTCTAAAA
AACCAGCCACGGAGTGTTTT

Downstream 100 bases:

>100_bases
TACGTGCACACAATATCTTTAACGGGTGATCCACAATGTGGGCCAGGCATCTGGCCCATGCCAGTTATCACAGGTAGGCT
CTGCGGCGTAACGCACCAGA

Product: transketolase

Products: NA

Alternate protein names: TK 2 [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPSDPTWYDRDRFILSNGHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGEKAQQSWNEKFAAYKKAHPQL
AEEFTRRMSGGLPKDWEKTTQKYINELQANPAKIATRKASQNTLNAYGPMLPELLGGSADLAPSNLTIWKGSVSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAVERHNGPTALILSRQNLAQVERTPDQVKEIARGGYVLKDSGGKPDIILIATGSEM
EITLQAAEKLAGEGRNVRVVSLPSTDIFDAQDEEYRESVLPSNVSARVAVEAGIADYWYKYVGLKGAIVGMTSYGESAPA
DKLFPFFGFTPENIVAKAHKVLGVKSA

Sequences:

>Translated_667_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPSDPTWYDRDRFILSNGHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGEKAQQSWNEKFAAYKKAHPQL
AEEFTRRMSGGLPKDWEKTTQKYINELQANPAKIATRKASQNTLNAYGPMLPELLGGSADLAPSNLTIWKGSVSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAVERHNGPTALILSRQNLAQVERTPDQVKEIARGGYVLKDSGGKPDIILIATGSEM
EITLQAAEKLAGEGRNVRVVSLPSTDIFDAQDEEYRESVLPSNVSARVAVEAGIADYWYKYVGLKGAIVGMTSYGESAPA
DKLFPFFGFTPENIVAKAHKVLGVKSA
>Mature_666_residues
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPSDPTWYDRDRFILSNGHASMLLYSLLHLTGYDL
PLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEGI
SHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLII
CRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGEKAQQSWNEKFAAYKKAHPQLA
EEFTRRMSGGLPKDWEKTTQKYINELQANPAKIATRKASQNTLNAYGPMLPELLGGSADLAPSNLTIWKGSVSLKEDPAG
NYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLASL
RLTPNFSTWRPCDQVEAAVGWKLAVERHNGPTALILSRQNLAQVERTPDQVKEIARGGYVLKDSGGKPDIILIATGSEME
ITLQAAEKLAGEGRNVRVVSLPSTDIFDAQDEEYRESVLPSNVSARVAVEAGIADYWYKYVGLKGAIVGMTSYGESAPAD
KLFPFFGFTPENIVAKAHKVLGVKSA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=579, Percent_Identity=29.1882556131261, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI4507521, Length=579, Percent_Identity=29.1882556131261, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI133778974, Length=678, Percent_Identity=26.9911504424779, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788808, Length=667, Percent_Identity=99.2503748125937, Blast_Score=1375, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=75.4916792738275, Blast_Score=1080, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=671, Percent_Identity=25.4843517138599, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=48.3483483483483, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319593, Length=668, Percent_Identity=44.9101796407186, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=597, Percent_Identity=27.8056951423786, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI45550715, Length=597, Percent_Identity=27.8056951423786, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24645119, Length=557, Percent_Identity=27.4685816876122, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24666278, Length=294, Percent_Identity=32.6530612244898, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73131; Mature: 73000

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPSDPTWYDRDRFI
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGE
EEEHHHCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHH
KAQQSWNEKFAAYKKAHPQLAEEFTRRMSGGLPKDWEKTTQKYINELQANPAKIATRKAS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCC
QNTLNAYGPMLPELLGGSADLAPSNLTIWKGSVSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAVERHNGPTALILSRQNLAQVERTPDQVKEIARGGY
EECCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
VLKDSGGKPDIILIATGSEMEITLQAAEKLAGEGRNVRVVSLPSTDIFDAQDEEYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHC
PSNVSARVAVEAGIADYWYKYVGLKGAIVGMTSYGESAPADKLFPFFGFTPENIVAKAHK
CCCCCEEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHH
VLGVKSA
HHCCCCC
>Mature Secondary Structure 
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPSDPTWYDRDRFI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGE
EEEHHHCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHH
KAQQSWNEKFAAYKKAHPQLAEEFTRRMSGGLPKDWEKTTQKYINELQANPAKIATRKAS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCC
QNTLNAYGPMLPELLGGSADLAPSNLTIWKGSVSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAVERHNGPTALILSRQNLAQVERTPDQVKEIARGGY
EECCCCCCCCCCHHHHHHHHCEEEEEEECCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
VLKDSGGKPDIILIATGSEMEITLQAAEKLAGEGRNVRVVSLPSTDIFDAQDEEYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHC
PSNVSARVAVEAGIADYWYKYVGLKGAIVGMTSYGESAPADKLFPFFGFTPENIVAKAHK
CCCCCEEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHH
VLGVKSA
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8396116; 9205837; 9278503 [H]