BacMap

Definition	Methylobacterium chloromethanicum CM4, complete genome.
Accession	NC_011757
Length	5,777,908

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The map label for this gene is fabG [H]

Identifier: 218532881

GI number: 218532881

Start: 5351369

End: 5352142

Strand: Reverse

Name: fabG [H]

Synonym: Mchl_5004

Alternate gene names: 218532881

Gene position: 5352142-5351369 (Counterclockwise)

Preceding gene: 218532882

Following gene: 218532880

Centisome position: 92.63

GC content: 70.16

Gene sequence:

>774_bases
ATGAGTGCGGACATGAGCGACGAAAGAAAATCCGTCCTCGTCGTCGGCGGCGCCTCCGGACTTGGTGCGGCCACCGTCCG
CGCCCTGGCGGCAGCCGGCCACGCCGTCACCTTCACCTATCGCTCCTCGCCGGAGCGGGCGCAGGCGCTCGCCGACGAAC
TCGTGCCGATGCACGGCGAAGGCAGCGTCACCGCCCGCGCCCTCGACCTGTCGGACCGCGACGCAGTGGAGGCGTTCTGC
GAGTGGGCCGAGGGCCAGGGCTTCTACGGCTACGTCCACAATGCCGGCCAGTCGGCGGACGCGCTGGCGGCCATGCTCGA
CCGTGAGCGGGCCGAGGCGGCGATGCAGGTGAACTTCTGGTCGATGACCCGGATCGCCAAGGCGCTGGTGCGTGGGATGA
TCCGGGCGCGCGCCGGCCGCATCGTCGCCATCGGATCGGTGGCCGCGCTCCAGGCCAATGCCGGCAACGCGGCCTACGCG
GCGACCAAGGGCGCCCTGATCGCCTATTGCCGCACACTGGCGATCGAGTCGGCCAAGCGCGGCGTCACCGTCAACGTCAT
CGCGCCCGGCTTCATCGATACTGAGATGCTGGCAGCCTATGCCAGCCACCGCGAGGGGATCGAGCGCCAGATCCCGCTCG
GACGTTTCGCCAAGCCGGAAGAGGTCGCGGCGATGGCTGCCTTCCTGATCGGGGAGGGCGGGGCCTACATCACCGGCGCG
GTGCTGCCCGTCGATGGCGGCTTGACCGCGATGATGGGCATCCACCGCACCTGA

Upstream 100 bases:

>100_bases
TGGTCGGGACCGCCCGCGACACCCGCGTCTCGCGGATCCTCTCGAATTCCTTCGGCTTCGGCGGGCAGAACACCTGCCTC
GTCCTGGGAGACGAGCCGGC

Downstream 100 bases:

>100_bases
ACCGGCCCGCGATGTCTCGCTCCTTGCCCCGCCTCGCCTTTGCCCTGCTGCTCGCTGGCGGTGGTTCAGCCTGGGGTGCG
GAGACCTTCCGGGTCGAAGG

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSADMSDERKSVLVVGGASGLGAATVRALAAAGHAVTFTYRSSPERAQALADELVPMHGEGSVTARALDLSDRDAVEAFC
EWAEGQGFYGYVHNAGQSADALAAMLDRERAEAAMQVNFWSMTRIAKALVRGMIRARAGRIVAIGSVAALQANAGNAAYA
ATKGALIAYCRTLAIESAKRGVTVNVIAPGFIDTEMLAAYASHREGIERQIPLGRFAKPEEVAAMAAFLIGEGGAYITGA
VLPVDGGLTAMMGIHRT

Sequences:

>Translated_257_residues
MSADMSDERKSVLVVGGASGLGAATVRALAAAGHAVTFTYRSSPERAQALADELVPMHGEGSVTARALDLSDRDAVEAFC
EWAEGQGFYGYVHNAGQSADALAAMLDRERAEAAMQVNFWSMTRIAKALVRGMIRARAGRIVAIGSVAALQANAGNAAYA
ATKGALIAYCRTLAIESAKRGVTVNVIAPGFIDTEMLAAYASHREGIERQIPLGRFAKPEEVAAMAAFLIGEGGAYITGA
VLPVDGGLTAMMGIHRT
>Mature_256_residues
SADMSDERKSVLVVGGASGLGAATVRALAAAGHAVTFTYRSSPERAQALADELVPMHGEGSVTARALDLSDRDAVEAFCE
WAEGQGFYGYVHNAGQSADALAAMLDRERAEAAMQVNFWSMTRIAKALVRGMIRARAGRIVAIGSVAALQANAGNAAYAA
TKGALIAYCRTLAIESAKRGVTVNVIAPGFIDTEMLAAYASHREGIERQIPLGRFAKPEEVAAMAAFLIGEGGAYITGAV
LPVDGGLTAMMGIHRT

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=34.4398340248963, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI32483357, Length=247, Percent_Identity=31.1740890688259, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=30.1204819277108, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66933014, Length=200, Percent_Identity=27, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI15277342, Length=269, Percent_Identity=29.7397769516729, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI19923817, Length=246, Percent_Identity=27.2357723577236, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI126723750, Length=250, Percent_Identity=28, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=31.4720812182741, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI59889578, Length=163, Percent_Identity=34.9693251533742, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=39.3574297188755, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI2367365, Length=242, Percent_Identity=35.5371900826446, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=34.6456692913386, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=26.1224489795918, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=29.9212598425197, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=29.5081967213115, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=28.4584980237154, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=27.906976744186, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=30.4526748971193, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=28.1853281853282, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786701, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=241, Percent_Identity=29.8755186721992, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=30.4526748971193, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=29.6992481203008, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=30, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=26.953125, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=28.8973384030418, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=30.4182509505703, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=28.0769230769231, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=274, Percent_Identity=28.8321167883212, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=29.368029739777, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=29.8804780876494, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=269, Percent_Identity=27.1375464684015, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=30.7116104868914, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=28.8617886178862, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=28.0898876404494, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=274, Percent_Identity=28.8321167883212, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=279, Percent_Identity=29.7491039426523, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=249, Percent_Identity=25.7028112449799, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=29.4776119402985, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=26.1992619926199, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=27.6752767527675, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=28.3400809716599, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=26.0700389105058, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=263, Percent_Identity=28.1368821292776, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=32.2448979591837, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=29.8039215686275, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=29.2490118577075, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=30.1652892561983, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=30.1960784313725, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644337, Length=120, Percent_Identity=38.3333333333333, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=28.968253968254, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=27.9527559055118, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358495, Length=195, Percent_Identity=28.7179487179487, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26761; Mature: 26630

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADMSDERKSVLVVGGASGLGAATVRALAAAGHAVTFTYRSSPERAQALADELVPMHGE
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCC
GSVTARALDLSDRDAVEAFCEWAEGQGFYGYVHNAGQSADALAAMLDRERAEAAMQVNFW
CCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEECHH
SMTRIAKALVRGMIRARAGRIVAIGSVAALQANAGNAAYAATKGALIAYCRTLAIESAKR
HHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCC
GVTVNVIAPGFIDTEMLAAYASHREGIERQIPLGRFAKPEEVAAMAAFLIGEGGAYITGA
CEEEEEEECCCCCHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEE
VLPVDGGLTAMMGIHRT
EEECCCCHHHHHCCCCC
>Mature Secondary Structure 
SADMSDERKSVLVVGGASGLGAATVRALAAAGHAVTFTYRSSPERAQALADELVPMHGE
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCC
GSVTARALDLSDRDAVEAFCEWAEGQGFYGYVHNAGQSADALAAMLDRERAEAAMQVNFW
CCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEECHH
SMTRIAKALVRGMIRARAGRIVAIGSVAALQANAGNAAYAATKGALIAYCRTLAIESAKR
HHHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCC
GVTVNVIAPGFIDTEMLAAYASHREGIERQIPLGRFAKPEEVAAMAAFLIGEGGAYITGA
CEEEEEEECCCCCHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEE
VLPVDGGLTAMMGIHRT
EEECCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]