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The map label for this gene is curA [H]

Identifier: 218532882

GI number: 218532882

Start: 5352139

End: 5353425

Strand: Reverse

Name: curA [H]

Synonym: Mchl_5005

Alternate gene names: 218532882

Gene position: 5353425-5352139 (Counterclockwise)

Preceding gene: 218532883

Following gene: 218532881

Centisome position: 92.65

GC content: 71.33

Gene sequence:

>1287_bases
ATGCCAGAACCGCGCTCCTCCTCCACCCACGATGCACTGGGCCGCCCGCTCGTCGCGGTGACGGGCCTCGGCATCGTCAC
CTCGCTCGGCCGCGGCGCCACCGAGAACTGGGACGCGCTGACGACCGGACGCTCCGGCATCCGCGCCATCAGCCGCTTCC
CTACCGAGGGCCTGCGCACCCGCATCGCCGGCACCGTCGATTTCCTCGACACCGACCCGCTAGTGGCCCCGCTCCTGTCC
GAGCGCTTCGCCATGGTGGCGGCCGAGGAGGCGGTGACGCAATCCGGCATCGGTGCCGGCTTTCCGGGCGGGCTGTTCGT
GGCGGTGCCGCCGGTCGAGATGGAATGGCCGCAGCGACAGGCTCTGGCGGATGCTGCGGGCGAGCCCGACGCGGTGACCT
ATGCCGGCCTCCAGCGCGCCGCCGCGTCCCGCCGTTTTGACGCGTGGCACGACCTGTTCATCTTCGGCACGGTGGCCGAC
CGGCTCGCCGACCGCTTCGGCACCCGCGGTTCGCCGATCTCGCTCTCGACCGCCTGCTCGTCGGGCGCCACCGCGATCCA
GCTCGGCGTCGAGGCCATCCGCCGGGGCGAGATGGACGCCGCGCTCTGCATCGGCACCGACGGCTCGGTGAATCCGGAAT
CGCTGATCCGCTTCTCGCTGCTCTCGGCGCTCTCGACGCAGAACGATCCGCCGGAGGGCGCCTCGAAGCCGTTCTCGAAG
AACCGCGACGGCTTCGTCATGGGTGAGGGCGCCGCCGCCCTGGTGCTGGAGAGCGCCGAGTCGGCGCGAGCGCGCGGCGC
AAAAATCCTCGGCTATGTCCTCGGATGCGGCGAGAAGGGCGACGGCTTCCACCGGACCCGCTCCAGTCCCGACGGCGCGC
CGGTCATCGCGGCGATGCGCGCGGCCCTCGATGACGCCGGCGTCACGCCCGAGGCCATCGATCACGTCAACGCCCACGGC
ACCTCGACGCCGGAGAACGACAAGATGGAGGCGCTCGGCTGCTCGGCGGTGTTCGGCGAGCGGGTGGCCCGCCTGCCGAT
CTCCTCCAACAAGTCGATGATCGGCCACACGCTCACCGCGGCCGGGGCGATCGAGGCGGTGGTCTCGCTGCTGACGATCC
AGAAGGGGCGCATCCCGCCGACCATCAACTACGCGGTGCCCGATCCGGCGCTTCTCCTCGACGTGGTCGGGACCGCCCGC
GACACCCGCGTCTCGCGGATCCTCTCGAATTCCTTCGGCTTCGGCGGGCAGAACACCTGCCTCGTCCTGGGAGACGAGCC
GGCATGA

Upstream 100 bases:

>100_bases
TCGGGACGATGGCGATGCGAGAACGAGTGCCCGCCGCTTCGGAGACCGCCGTCGCGGCGGTCCGGATGCGTGCCGGCCGA
AACCATGGTCTGAGGCCCCG

Downstream 100 bases:

>100_bases
GTGCGGACATGAGCGACGAAAGAAAATCCGTCCTCGTCGTCGGCGGCGCCTCCGGACTTGGTGCGGCCACCGTCCGCGCC
CTGGCGGCAGCCGGCCACGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MPEPRSSSTHDALGRPLVAVTGLGIVTSLGRGATENWDALTTGRSGIRAISRFPTEGLRTRIAGTVDFLDTDPLVAPLLS
ERFAMVAAEEAVTQSGIGAGFPGGLFVAVPPVEMEWPQRQALADAAGEPDAVTYAGLQRAAASRRFDAWHDLFIFGTVAD
RLADRFGTRGSPISLSTACSSGATAIQLGVEAIRRGEMDAALCIGTDGSVNPESLIRFSLLSALSTQNDPPEGASKPFSK
NRDGFVMGEGAAALVLESAESARARGAKILGYVLGCGEKGDGFHRTRSSPDGAPVIAAMRAALDDAGVTPEAIDHVNAHG
TSTPENDKMEALGCSAVFGERVARLPISSNKSMIGHTLTAAGAIEAVVSLLTIQKGRIPPTINYAVPDPALLLDVVGTAR
DTRVSRILSNSFGFGGQNTCLVLGDEPA

Sequences:

>Translated_428_residues
MPEPRSSSTHDALGRPLVAVTGLGIVTSLGRGATENWDALTTGRSGIRAISRFPTEGLRTRIAGTVDFLDTDPLVAPLLS
ERFAMVAAEEAVTQSGIGAGFPGGLFVAVPPVEMEWPQRQALADAAGEPDAVTYAGLQRAAASRRFDAWHDLFIFGTVAD
RLADRFGTRGSPISLSTACSSGATAIQLGVEAIRRGEMDAALCIGTDGSVNPESLIRFSLLSALSTQNDPPEGASKPFSK
NRDGFVMGEGAAALVLESAESARARGAKILGYVLGCGEKGDGFHRTRSSPDGAPVIAAMRAALDDAGVTPEAIDHVNAHG
TSTPENDKMEALGCSAVFGERVARLPISSNKSMIGHTLTAAGAIEAVVSLLTIQKGRIPPTINYAVPDPALLLDVVGTAR
DTRVSRILSNSFGFGGQNTCLVLGDEPA
>Mature_427_residues
PEPRSSSTHDALGRPLVAVTGLGIVTSLGRGATENWDALTTGRSGIRAISRFPTEGLRTRIAGTVDFLDTDPLVAPLLSE
RFAMVAAEEAVTQSGIGAGFPGGLFVAVPPVEMEWPQRQALADAAGEPDAVTYAGLQRAAASRRFDAWHDLFIFGTVADR
LADRFGTRGSPISLSTACSSGATAIQLGVEAIRRGEMDAALCIGTDGSVNPESLIRFSLLSALSTQNDPPEGASKPFSKN
RDGFVMGEGAAALVLESAESARARGAKILGYVLGCGEKGDGFHRTRSSPDGAPVIAAMRAALDDAGVTPEAIDHVNAHGT
STPENDKMEALGCSAVFGERVARLPISSNKSMIGHTLTAAGAIEAVVSLLTIQKGRIPPTINYAVPDPALLLDVVGTARD
TRVSRILSNSFGFGGQNTCLVLGDEPA

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Has A Preference For Short Chain Acid Substrates And May Function To Supply The Octanoic Substrates For Lipoic Acid Biosynthe

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=436, Percent_Identity=34.4036697247706, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI41872631, Length=274, Percent_Identity=33.5766423357664, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=39.8648648648649, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1787337, Length=421, Percent_Identity=36.104513064133, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=33.8129496402878, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71983541, Length=422, Percent_Identity=29.3838862559242, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=35.361216730038, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=29.5774647887324, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=267, Percent_Identity=28.4644194756554, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=30.6997742663657, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24644341, Length=431, Percent_Identity=37.3549883990719, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=30.4659498207885, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=30.4659498207885, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24581345, Length=276, Percent_Identity=28.6231884057971, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: 2.3.1.41

Molecular weight: Translated: 44406; Mature: 44274

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPRSSSTHDALGRPLVAVTGLGIVTSLGRGATENWDALTTGRSGIRAISRFPTEGLRT
CCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHCCCHHHHH
RIAGTVDFLDTDPLVAPLLSERFAMVAAEEAVTQSGIGAGFPGGLFVAVPPVEMEWPQRQ
HHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHH
ALADAAGEPDAVTYAGLQRAAASRRFDAWHDLFIFGTVADRLADRFGTRGSPISLSTACS
HHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCC
SGATAIQLGVEAIRRGEMDAALCIGTDGSVNPESLIRFSLLSALSTQNDPPEGASKPFSK
CCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NRDGFVMGEGAAALVLESAESARARGAKILGYVLGCGEKGDGFHRTRSSPDGAPVIAAMR
CCCCEEEECCCEEEEEECHHHHHHCCHHEEEHHEECCCCCCCCCCCCCCCCCCHHHHHHH
AALDDAGVTPEAIDHVNAHGTSTPENDKMEALGCSAVFGERVARLPISSNKSMIGHTLTA
HHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AGAIEAVVSLLTIQKGRIPPTINYAVPDPALLLDVVGTARDTRVSRILSNSFGFGGQNTC
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEE
LVLGDEPA
EEECCCCC
>Mature Secondary Structure 
PEPRSSSTHDALGRPLVAVTGLGIVTSLGRGATENWDALTTGRSGIRAISRFPTEGLRT
CCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHCCCHHHHH
RIAGTVDFLDTDPLVAPLLSERFAMVAAEEAVTQSGIGAGFPGGLFVAVPPVEMEWPQRQ
HHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHH
ALADAAGEPDAVTYAGLQRAAASRRFDAWHDLFIFGTVADRLADRFGTRGSPISLSTACS
HHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCC
SGATAIQLGVEAIRRGEMDAALCIGTDGSVNPESLIRFSLLSALSTQNDPPEGASKPFSK
CCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NRDGFVMGEGAAALVLESAESARARGAKILGYVLGCGEKGDGFHRTRSSPDGAPVIAAMR
CCCCEEEECCCEEEEEECHHHHHHCCHHEEEHHEECCCCCCCCCCCCCCCCCCHHHHHHH
AALDDAGVTPEAIDHVNAHGTSTPENDKMEALGCSAVFGERVARLPISSNKSMIGHTLTA
HHHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AGAIEAVVSLLTIQKGRIPPTINYAVPDPALLLDVVGTARDTRVSRILSNSFGFGGQNTC
HHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEE
LVLGDEPA
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: None [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl-ACP-decarboxylation, Cerulenin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644304 [H]