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The map label for this gene is hflC

Identifier: 21672808

GI number: 21672808

Start: 600138

End: 601061

Strand: Reverse

Name: hflC

Synonym: BUsg547

Alternate gene names: 21672808

Gene position: 601061-600138 (Counterclockwise)

Preceding gene: 21672809

Following gene: 21672807

Centisome position: 93.7

GC content: 28.46

Gene sequence:

>924_bases
ATGAATAAAATAGTTATTTGTATACTAAGTTTTTTTCTTCTTATTTTCTCATCTTCTTTTTTTATTGTTAAAGAAGGAGA
ACGTGGAATTATACTTCAGTTTGGAAAAGTTTTAAGAAATAATAAACAGAAAACTTTAGTTTATACACCTGGACTACATT
TTAAAATACCTTTTTTTGAAAATGTTAAAATTTTAGATTCACGTATTCATACTATGGATAATCAAGCAGATCGTTTTGTT
ACAAAAGAAAAAAAAGATCTTATTGTTGACTCCTATATTAAATGGCGTATTAGTGATTTTAGTCGTTATTACCTAGCTAC
TGGAGGAGGGGATTTTTTTCAAGCTGAAGTTTTATTAAAAAGAAAGTTTAGCGATCGATTACGTTCTGAAATAGGACGTC
TTAATGTAAAAGAAATTGTTACAGATTCAAGAGGTAGATTAACAACAGACGTTCTTTACTCTTTGAATAAGGGAACAATC
AATTTAGACAGCACATCACTAATCAATGTAAATAGTATGAATGCTTTAGGAATTGAAGTGGTAGATGTGCGTATTAAACA
AATTAATTTACCTCTAGAAGTATCTGATGCTATATATAATAGGATGAGAGCAGAAAGGGAATCAGTAGCTAGAAGTCAAC
GGTCTCAAGGACAAGAAAAAGCAGAAAAATTACGCGCAACAGCAGATTATAGAGTTTCTCTTATTTTGGCAGAAGCACAA
AAAAAAGCTTTAATGATAAAAGGTCAAGGAGAAGCTGAAGTGGCTAAATTATTTTTAGAAAATTTTGGTCAAGAATCTTC
TTTTTATTTTTTTATTCGTAGCTTACATGCTTACGAAAACAGTTTTAAAAACAGTAATAACATAATGTTAATTAATTCAG
ATAACGAGTTTTTTAAATATATGAATACAGAAATCAAAAATTAA

Upstream 100 bases:

>100_bases
TAAATGATGTTTCTTCGTTACCTCCTAGTGATTTTTTTAAAAAACGTCGTATAGAATCTATACGTACTAATATTAAAAAT
ATAGAAAGAGAATGAAAAAT

Downstream 100 bases:

>100_bases
AAGTACATTTCAAAAAATTGATAAAATAGGTATTAAAAATATGAATACAAACATTGTAATATTAGGTACTCAATGGGGTG
ATGAAGGTAAAGGAAAAATA

Product: FtsH protease regulator HflC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MNKIVICILSFFLLIFSSSFFIVKEGERGIILQFGKVLRNNKQKTLVYTPGLHFKIPFFENVKILDSRIHTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDFFQAEVLLKRKFSDRLRSEIGRLNVKEIVTDSRGRLTTDVLYSLNKGTI
NLDSTSLINVNSMNALGIEVVDVRIKQINLPLEVSDAIYNRMRAERESVARSQRSQGQEKAEKLRATADYRVSLILAEAQ
KKALMIKGQGEAEVAKLFLENFGQESSFYFFIRSLHAYENSFKNSNNIMLINSDNEFFKYMNTEIKN

Sequences:

>Translated_307_residues
MNKIVICILSFFLLIFSSSFFIVKEGERGIILQFGKVLRNNKQKTLVYTPGLHFKIPFFENVKILDSRIHTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDFFQAEVLLKRKFSDRLRSEIGRLNVKEIVTDSRGRLTTDVLYSLNKGTI
NLDSTSLINVNSMNALGIEVVDVRIKQINLPLEVSDAIYNRMRAERESVARSQRSQGQEKAEKLRATADYRVSLILAEAQ
KKALMIKGQGEAEVAKLFLENFGQESSFYFFIRSLHAYENSFKNSNNIMLINSDNEFFKYMNTEIKN
>Mature_307_residues
MNKIVICILSFFLLIFSSSFFIVKEGERGIILQFGKVLRNNKQKTLVYTPGLHFKIPFFENVKILDSRIHTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDFFQAEVLLKRKFSDRLRSEIGRLNVKEIVTDSRGRLTTDVLYSLNKGTI
NLDSTSLINVNSMNALGIEVVDVRIKQINLPLEVSDAIYNRMRAERESVARSQRSQGQEKAEKLRATADYRVSLILAEAQ
KKALMIKGQGEAEVAKLFLENFGQESSFYFFIRSLHAYENSFKNSNNIMLINSDNEFFKYMNTEIKN

Specific function: HflC and HflK could encode or regulate a protease

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily

Homologues:

Organism=Escherichia coli, GI1790617, Length=310, Percent_Identity=65.8064516129032, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17569497, Length=221, Percent_Identity=27.6018099547511, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HFLC_BUCAP (Q8K915)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660875.1
- ProteinModelPortal:   Q8K915
- SMR:   Q8K915
- EnsemblBacteria:   EBBUCT00000000317
- GeneID:   1005822
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg547
- GeneTree:   EBGT00050000007794
- HOGENOM:   HBG427952
- OMA:   KIRADAD
- ProtClustDB:   PRK11029
- BioCyc:   BAPH198804:BUSG547-MONOMER
- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972
- PANTHER:   PTHR10264
- SMART:   SM00244
- TIGRFAMs:   TIGR01932

Pfam domain/function: PF01145 Band_7

EC number: 3.4.-.-

Molecular weight: Translated: 35444; Mature: 35444

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbea0750)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIVICILSFFLLIFSSSFFIVKEGERGIILQFGKVLRNNKQKTLVYTPGLHFKIPFFE
CCCEEHHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHCCCCEEEEECCCCEEECCCCC
NVKILDSRIHTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDFFQAEVLLK
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLNVKEIVTDSRGRLTTDVLYSLNKGTINLDSTSLINVNSMNALGIEV
HHHHHHHHHHHCCCCHHHHHCCCCCCEEHHHHHCCCCCEEEECCCEEEEECCCCCCCEEE
VDVRIKQINLPLEVSDAIYNRMRAERESVARSQRSQGQEKAEKLRATADYRVSLILAEAQ
EEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEECC
KKALMIKGQGEAEVAKLFLENFGQESSFYFFIRSLHAYENSFKNSNNIMLINSDNEFFKY
CCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
MNTEIKN
HHHHCCH
>Mature Secondary Structure
MNKIVICILSFFLLIFSSSFFIVKEGERGIILQFGKVLRNNKQKTLVYTPGLHFKIPFFE
CCCEEHHHHHHHHHHHCCCEEEEEECCCCEEHHHHHHHHCCCCEEEEECCCCEEECCCCC
NVKILDSRIHTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDFFQAEVLLK
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLNVKEIVTDSRGRLTTDVLYSLNKGTINLDSTSLINVNSMNALGIEV
HHHHHHHHHHHCCCCHHHHHCCCCCCEEHHHHHCCCCCEEEECCCEEEEECCCCCCCEEE
VDVRIKQINLPLEVSDAIYNRMRAERESVARSQRSQGQEKAEKLRATADYRVSLILAEAQ
EEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEEECC
KKALMIKGQGEAEVAKLFLENFGQESSFYFFIRSLHAYENSFKNSNNIMLINSDNEFFKY
CCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
MNTEIKN
HHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438