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The map label for this gene is htpX

Identifier: 21672589

GI number: 21672589

Start: 358928

End: 359806

Strand: Direct

Name: htpX

Synonym: BUsg313

Alternate gene names: 21672589

Gene position: 358928-359806 (Clockwise)

Preceding gene: 21672588

Following gene: 21672590

Centisome position: 55.96

GC content: 30.49

Gene sequence:

>879_bases
ATGATACGTATTATTCTTTTCTTATTAACTAATTTAGCAGTTATGCTAACATTCAGTCTGATTCTTGCTGTGACAGGAAT
TCAGTCTGAAAGTATTTACGGTCTATTGATTATGTCAAGTCTATTTGGTTTTAGTGGATCTATCTTATCACTTATTATGT
CTAAATGGATTGCATTGCGTTCTGTAAATGGTAGAATCATTAATCATCCTAGCAATGAAACAGAAAGTTGGCTAATTGAT
ACTATTCGTCAACAATCTATAAAAAAAAATATTATTATGCCACAAATAGCAATATATGAAGCTGCTGATATCAATGCATT
TGCTACAGGTGCTCGTCGTAATGCAGCTTTGATTGCTATATCAACAGGATTACTAGAAAATATGACACGTAGTGAGGCAG
AAGCAGTAATTGCTCATGAAATTAGTCATGTTTCAAATGGTGATATGATCACAATGACTTTAGTTCAAGGTGTTGTAAAC
ACTTTTGTAATCTTTATATCTCGTATTATTTCACAAGCATTGAGCAGCTTATTATCGAGTAATAGAAATGAAAATAGTGA
AGATGAAAAAGATTCATTTTTATTTTTTTTAATTTCTACATTTCTAGAAATAATTTTTGGTGTACTTGCAAGTATTATTA
CTATGTGGTTTTCTAGACATCGAGAATTTTATGCTGACGCAAGTTCAGCAAAATTAGTCGGAAAAGAAAAAATGATTTCT
GCCCTAAATCGTTTAAAGTCAAGTCATGAGCCTCAAGAATCAGATAGCATAATTGCATTTTGTATTAACGGAAAATCTAA
TTCATTTATAGAATTATTCGCCTCCCATCCATCTTTAGAAAAAAGAATACAGGCGCTAAAAAATAAAAAATATATGTAA

Upstream 100 bases:

>100_bases
ATTATAAATTTAAGTTTAAAAAACATTTTTATATTTTCTTTAATTAAATTTCTTTTTTTAATTAAAACTATTTTATCTAA
ATTGAGGAAGATAATATCTT

Downstream 100 bases:

>100_bases
TCAATAGATATCAGAAATATAAAAACATTATCTCTCTTAGTAGAAAACTTTTCTATTAAGAGATAAAACTTATAAAAACA
CTTTTCAAATAATTTTTAAA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MIRIILFLLTNLAVMLTFSLILAVTGIQSESIYGLLIMSSLFGFSGSILSLIMSKWIALRSVNGRIINHPSNETESWLID
TIRQQSIKKNIIMPQIAIYEAADINAFATGARRNAALIAISTGLLENMTRSEAEAVIAHEISHVSNGDMITMTLVQGVVN
TFVIFISRIISQALSSLLSSNRNENSEDEKDSFLFFLISTFLEIIFGVLASIITMWFSRHREFYADASSAKLVGKEKMIS
ALNRLKSSHEPQESDSIIAFCINGKSNSFIELFASHPSLEKRIQALKNKKYM

Sequences:

>Translated_292_residues
MIRIILFLLTNLAVMLTFSLILAVTGIQSESIYGLLIMSSLFGFSGSILSLIMSKWIALRSVNGRIINHPSNETESWLID
TIRQQSIKKNIIMPQIAIYEAADINAFATGARRNAALIAISTGLLENMTRSEAEAVIAHEISHVSNGDMITMTLVQGVVN
TFVIFISRIISQALSSLLSSNRNENSEDEKDSFLFFLISTFLEIIFGVLASIITMWFSRHREFYADASSAKLVGKEKMIS
ALNRLKSSHEPQESDSIIAFCINGKSNSFIELFASHPSLEKRIQALKNKKYM
>Mature_292_residues
MIRIILFLLTNLAVMLTFSLILAVTGIQSESIYGLLIMSSLFGFSGSILSLIMSKWIALRSVNGRIINHPSNETESWLID
TIRQQSIKKNIIMPQIAIYEAADINAFATGARRNAALIAISTGLLENMTRSEAEAVIAHEISHVSNGDMITMTLVQGVVN
TFVIFISRIISQALSSLLSSNRNENSEDEKDSFLFFLISTFLEIIFGVLASIITMWFSRHREFYADASSAKLVGKEKMIS
ALNRLKSSHEPQESDSIIAFCINGKSNSFIELFASHPSLEKRIQALKNKKYM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=292, Percent_Identity=63.6986301369863, Blast_Score=414, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_BUCAP (Q8K9M1)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660656.1
- ProteinModelPortal:   Q8K9M1
- SMR:   Q8K9M1
- MEROPS:   M48.002
- EnsemblBacteria:   EBBUCT00000000482
- GeneID:   1005517
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg313
- GeneTree:   EBGT00050000008073
- HOGENOM:   HBG739460
- OMA:   NRFLTAN
- ProtClustDB:   PRK05457
- BioCyc:   BAPH198804:BUSG313-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32506; Mature: 32506

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 140-140

Signals:

None

Transmembrane regions:

HASH(0xcaac700)-; HASH(0xc7c4884)-; HASH(0xc2e50dc)-; HASH(0xb8131b4)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIILFLLTNLAVMLTFSLILAVTGIQSESIYGLLIMSSLFGFSGSILSLIMSKWIALR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SVNGRIINHPSNETESWLIDTIRQQSIKKNIIMPQIAIYEAADINAFATGARRNAALIAI
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCHHHCCCCCCEEEEEE
STGLLENMTRSEAEAVIAHEISHVSNGDMITMTLVQGVVNTFVIFISRIISQALSSLLSS
EHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRNENSEDEKDSFLFFLISTFLEIIFGVLASIITMWFSRHREFYADASSAKLVGKEKMIS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALNRLKSSHEPQESDSIIAFCINGKSNSFIELFASHPSLEKRIQALKNKKYM
HHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHCCCCH
>Mature Secondary Structure
MIRIILFLLTNLAVMLTFSLILAVTGIQSESIYGLLIMSSLFGFSGSILSLIMSKWIALR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SVNGRIINHPSNETESWLIDTIRQQSIKKNIIMPQIAIYEAADINAFATGARRNAALIAI
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCHHHCCCCCCEEEEEE
STGLLENMTRSEAEAVIAHEISHVSNGDMITMTLVQGVVNTFVIFISRIISQALSSLLSS
EHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRNENSEDEKDSFLFFLISTFLEIIFGVLASIITMWFSRHREFYADASSAKLVGKEKMIS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALNRLKSSHEPQESDSIIAFCINGKSNSFIELFASHPSLEKRIQALKNKKYM
HHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438