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The map label for this gene is zwf

Identifier: 21672588

GI number: 21672588

Start: 357259

End: 358731

Strand: Direct

Name: zwf

Synonym: BUsg312

Alternate gene names: 21672588

Gene position: 357259-358731 (Clockwise)

Preceding gene: 21672586

Following gene: 21672589

Centisome position: 55.7

GC content: 25.8

Gene sequence:

>1473_bases
ATGATTATAGAAACTAATCAAGCTTGCGATCTAGTGATTTTTGGAACAAAAGGAGATTTAGCAAGAAGAAAATTGTTACC
AGCTTTATATAAATTAGAAAAATCTCAAAAAATACATCCAGATACACGTATAATTGGTACAGGTCGTGCTGATTGGAATA
CAGAAGATTATATAAAGATAGTAAAAAAAGCAATAAAAATGTTTTTAAATGAAAAAATTGATGAAAAAATTTGGAAAAAA
TTACGTTCACGTTTAAATTTTTTTTATATTGATGTATTTCAAGATCTTCACTTTTTAGAATTAAAAAATATATTAAATCA
AAAAAAAAACATTATTATTTATTATTGTGCAGTTCCTTCAAATACATTTAATGCTATTTTTACAGGATTAGGAAAAGTTA
ATTTAAATTCTTTTCCATCAAGAATCATAATCGAAAAACCACTCGGTGTATCTTTAGAAACATCAAAAAAAATCAATAAT
CAAATTGCTAAATATTTTTTAGAATCGCAAATCTTTCGTATTGATCACTATCTTGGAAAAGAATCAATATTAAATCTTTT
AGCATTACGTTTCTCAAATTCATTTTTTTTTCATAGTTGGAATAATAAAATTATTGATCATATTCAAATTACTGTATCTG
AAGAAGTTGGTATTGAAAATAGATGGAATTATTTTGATCAAATGGGACAAACACGAGATATGGTACAAAATCATCTCCTG
CAAATTCTTACAATCGTTTCTATGGATAAACCAAAAAATATTACACCTGAAGGCATAAGAGATGAAAAATTAAAAATATT
GCGTTCTCTTAAAAAAATTGACTTAAATGAAATTCATATTAAGACAGCACGAGGTCAATATGCATCTGGAATTATAAATG
GTAAAAAGGTACCTTCTTACATAGAAGAAAATGGTGCAAACAAACATAGTAAAACAGAAACATTTGTTTCAATTAAAGTT
GATATTAATAATGATCGATGGTTTGGAGTTCCATTTTATTTAAGAACGGGTAAACGTTTAGCATATAAATACTCTGAAAT
AGTTATTGTCTTTAAAAAAATATCTAAGAACTTGTTTCAAGAATTCAATAAAAATTTATCACCTAACAAATTGATTATAC
GTCTAGAACCTAATGAAAGTATTAAAATATATTTTTTAAATAAAGTACCAGGACTCAGTAAGGAATATAAATTAAAAAGT
GATAAAATGGAATTTAATTTTAATATAAATAATACTAAAAATTTTGTCGACGCTTATGAAAGGCTATTATTTGAAAGTAT
GAGAGGAATACAATCATTATTTGTATGTCGAGAAGAAGTAGAAGAAGCGTGGAAATGGATTGATCCAATAATAAACGGTT
GGAAAAAAACAAATATAAATACTGTACAGTTATATAAATCTGGTACATGGGGGCCAAAAAGTTCGGACGAAATCATTATG
CGAGATGGTCGATTTTGGGAAACATTTAATTAA

Upstream 100 bases:

>100_bases
CTATTAAAAAATATTTTAAATAAAGTATATTTTAACATATAAATATTTTAAAAAAAAATGTAAAAACGATGTATATATTT
TAAATTTTAAAGAGAAAATT

Downstream 100 bases:

>100_bases
AATCCACTCTGAATAATTTATCTATCTTGACTTAATTAAGAAAATTATGTTAGCTTAAAAAATTATTTTTTAATACCTTT
ATTTTCTATAATTAACATTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MIIETNQACDLVIFGTKGDLARRKLLPALYKLEKSQKIHPDTRIIGTGRADWNTEDYIKIVKKAIKMFLNEKIDEKIWKK
LRSRLNFFYIDVFQDLHFLELKNILNQKKNIIIYYCAVPSNTFNAIFTGLGKVNLNSFPSRIIIEKPLGVSLETSKKINN
QIAKYFLESQIFRIDHYLGKESILNLLALRFSNSFFFHSWNNKIIDHIQITVSEEVGIENRWNYFDQMGQTRDMVQNHLL
QILTIVSMDKPKNITPEGIRDEKLKILRSLKKIDLNEIHIKTARGQYASGIINGKKVPSYIEENGANKHSKTETFVSIKV
DINNDRWFGVPFYLRTGKRLAYKYSEIVIVFKKISKNLFQEFNKNLSPNKLIIRLEPNESIKIYFLNKVPGLSKEYKLKS
DKMEFNFNINNTKNFVDAYERLLFESMRGIQSLFVCREEVEEAWKWIDPIINGWKKTNINTVQLYKSGTWGPKSSDEIIM
RDGRFWETFN

Sequences:

>Translated_490_residues
MIIETNQACDLVIFGTKGDLARRKLLPALYKLEKSQKIHPDTRIIGTGRADWNTEDYIKIVKKAIKMFLNEKIDEKIWKK
LRSRLNFFYIDVFQDLHFLELKNILNQKKNIIIYYCAVPSNTFNAIFTGLGKVNLNSFPSRIIIEKPLGVSLETSKKINN
QIAKYFLESQIFRIDHYLGKESILNLLALRFSNSFFFHSWNNKIIDHIQITVSEEVGIENRWNYFDQMGQTRDMVQNHLL
QILTIVSMDKPKNITPEGIRDEKLKILRSLKKIDLNEIHIKTARGQYASGIINGKKVPSYIEENGANKHSKTETFVSIKV
DINNDRWFGVPFYLRTGKRLAYKYSEIVIVFKKISKNLFQEFNKNLSPNKLIIRLEPNESIKIYFLNKVPGLSKEYKLKS
DKMEFNFNINNTKNFVDAYERLLFESMRGIQSLFVCREEVEEAWKWIDPIINGWKKTNINTVQLYKSGTWGPKSSDEIIM
RDGRFWETFN
>Mature_490_residues
MIIETNQACDLVIFGTKGDLARRKLLPALYKLEKSQKIHPDTRIIGTGRADWNTEDYIKIVKKAIKMFLNEKIDEKIWKK
LRSRLNFFYIDVFQDLHFLELKNILNQKKNIIIYYCAVPSNTFNAIFTGLGKVNLNSFPSRIIIEKPLGVSLETSKKINN
QIAKYFLESQIFRIDHYLGKESILNLLALRFSNSFFFHSWNNKIIDHIQITVSEEVGIENRWNYFDQMGQTRDMVQNHLL
QILTIVSMDKPKNITPEGIRDEKLKILRSLKKIDLNEIHIKTARGQYASGIINGKKVPSYIEENGANKHSKTETFVSIKV
DINNDRWFGVPFYLRTGKRLAYKYSEIVIVFKKISKNLFQEFNKNLSPNKLIIRLEPNESIKIYFLNKVPGLSKEYKLKS
DKMEFNFNINNTKNFVDAYERLLFESMRGIQSLFVCREEVEEAWKWIDPIINGWKKTNINTVQLYKSGTWGPKSSDEIIM
RDGRFWETFN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI108773793, Length=491, Percent_Identity=31.3645621181263, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI109389365, Length=491, Percent_Identity=31.3645621181263, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI52145310, Length=503, Percent_Identity=23.0616302186879, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=55.8282208588957, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=36.1396303901437, Blast_Score=280, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6324088, Length=483, Percent_Identity=31.8840579710145, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=32.0083682008368, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=32.0083682008368, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI221513548, Length=478, Percent_Identity=27.1966527196653, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD_BUCAP (Q8K9M2)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660655.1
- ProteinModelPortal:   Q8K9M2
- SMR:   Q8K9M2
- EnsemblBacteria:   EBBUCT00000000353
- GeneID:   1005516
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg312
- GeneTree:   EBGT00050000008153
- HOGENOM:   HBG322449
- OMA:   LEPNESI
- ProtClustDB:   PRK05722
- BioCyc:   BAPH198804:BUSG312-MONOMER
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 57531; Mature: 57531

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 238-238 BINDING 17-17 BINDING 49-49 BINDING 176-176 BINDING 180-180 BINDING 343-343

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIETNQACDLVIFGTKGDLARRKLLPALYKLEKSQKIHPDTRIIGTGRADWNTEDYIKI
CEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHH
VKKAIKMFLNEKIDEKIWKKLRSRLNFFYIDVFQDLHFLELKNILNQKKNIIIYYCAVPS
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCC
NTFNAIFTGLGKVNLNSFPSRIIIEKPLGVSLETSKKINNQIAKYFLESQIFRIDHYLGK
CCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
ESILNLLALRFSNSFFFHSWNNKIIDHIQITVSEEVGIENRWNYFDQMGQTRDMVQNHLL
HHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCHHHHHHHCHHHHHHHHHHH
QILTIVSMDKPKNITPEGIRDEKLKILRSLKKIDLNEIHIKTARGQYASGIINGKKVPSY
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCCCHH
IEENGANKHSKTETFVSIKVDINNDRWFGVPFYLRTGKRLAYKYSEIVIVFKKISKNLFQ
HHHCCCCCCCCCEEEEEEEEEECCCEEECCEEEEECCCHHEEEHHHHHHHHHHHHHHHHH
EFNKNLSPNKLIIRLEPNESIKIYFLNKVPGLSKEYKLKSDKMEFNFNINNTKNFVDAYE
HHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHCCCCCCCEEEEEECCCCHHHHHHHH
RLLFESMRGIQSLFVCREEVEEAWKWIDPIINGWKKTNINTVQLYKSGTWGPKSSDEIIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEE
RDGRFWETFN
ECCCEECCCC
>Mature Secondary Structure
MIIETNQACDLVIFGTKGDLARRKLLPALYKLEKSQKIHPDTRIIGTGRADWNTEDYIKI
CEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHH
VKKAIKMFLNEKIDEKIWKKLRSRLNFFYIDVFQDLHFLELKNILNQKKNIIIYYCAVPS
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCC
NTFNAIFTGLGKVNLNSFPSRIIIEKPLGVSLETSKKINNQIAKYFLESQIFRIDHYLGK
CCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
ESILNLLALRFSNSFFFHSWNNKIIDHIQITVSEEVGIENRWNYFDQMGQTRDMVQNHLL
HHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCHHHHHHHCHHHHHHHHHHH
QILTIVSMDKPKNITPEGIRDEKLKILRSLKKIDLNEIHIKTARGQYASGIINGKKVPSY
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCCCCCHH
IEENGANKHSKTETFVSIKVDINNDRWFGVPFYLRTGKRLAYKYSEIVIVFKKISKNLFQ
HHHCCCCCCCCCEEEEEEEEEECCCEEECCEEEEECCCHHEEEHHHHHHHHHHHHHHHHH
EFNKNLSPNKLIIRLEPNESIKIYFLNKVPGLSKEYKLKSDKMEFNFNINNTKNFVDAYE
HHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHCCCCCCCEEEEEECCCCHHHHHHHH
RLLFESMRGIQSLFVCREEVEEAWKWIDPIINGWKKTNINTVQLYKSGTWGPKSSDEIIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEE
RDGRFWETFN
ECCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438