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The map label for this gene is ribA

Identifier: 21672541

GI number: 21672541

Start: 297655

End: 298245

Strand: Direct

Name: ribA

Synonym: BUsg261

Alternate gene names: 21672541

Gene position: 297655-298245 (Clockwise)

Preceding gene: 21672540

Following gene: 21672550

Centisome position: 46.4

GC content: 26.9

Gene sequence:

>591_bases
ATGCAATTAATTCAAATAGAAAAAGCTATTTTACCAACGCCTTGGGGGGATTTTTTGATCTTTGGTTTTGAAGAGAAAAA
GAATGGAAAAAATCATATTGCTCTTGTATATGGAAAGATAAAAAAAAATATTCCTATTCTTGCAAGAATACATTCTGAAT
GTTTAACAGGAGATGCTTTCTTTAGTTTAAGATGTGACTGCGGTATTCAATTAGAAATGGCAATGAGTAGAATTGCATCG
GAAGGAAATGGTATATTAATATATCATCGTCAAGAAGGAAGAAATATTGGTCTTTTAAATAAAATTAAAGCATATTCTTT
ACAAGACAAGGGTTTAGATACTGTTGAAGCTAATCAAAAACTTGGTTTTTCTGCAGATGAGAGAGATTTTTCATTGTGTG
CTGATATTTTTAATATTTTAAATATAAAAAAAATTCGTTTATTAACAAATAATCCATTTAAAGTTGATATGCTTATAGCA
TCTGGAATAGAAATTGTAGAAAGAATTCCTATTATTGTAGAGAAAAATGATAAAAATGCTCATTATTTAAAAACTAAAGC
TGAAAAAATGGGTCATTTACTATTTAAATAA

Upstream 100 bases:

>100_bases
CATAAAATAATTTTGTAATAATATTTTAAGATATATCTTTCTAAGATAAATTGTTAATTATTTTTTTAAATAATTAAATT
TAGTAAAAATAGGAGAATTT

Downstream 100 bases:

>100_bases
AATTTTTTAAAAATATATATGTAATTTATTTTTTTAATTCATGAAATATTTTTATATAGTATGTCATTATTACGTATATG
TTTTTTAAAAATTTTCATTT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MQLIQIEKAILPTPWGDFLIFGFEEKKNGKNHIALVYGKIKKNIPILARIHSECLTGDAFFSLRCDCGIQLEMAMSRIAS
EGNGILIYHRQEGRNIGLLNKIKAYSLQDKGLDTVEANQKLGFSADERDFSLCADIFNILNIKKIRLLTNNPFKVDMLIA
SGIEIVERIPIIVEKNDKNAHYLKTKAEKMGHLLFK

Sequences:

>Translated_196_residues
MQLIQIEKAILPTPWGDFLIFGFEEKKNGKNHIALVYGKIKKNIPILARIHSECLTGDAFFSLRCDCGIQLEMAMSRIAS
EGNGILIYHRQEGRNIGLLNKIKAYSLQDKGLDTVEANQKLGFSADERDFSLCADIFNILNIKKIRLLTNNPFKVDMLIA
SGIEIVERIPIIVEKNDKNAHYLKTKAEKMGHLLFK
>Mature_196_residues
MQLIQIEKAILPTPWGDFLIFGFEEKKNGKNHIALVYGKIKKNIPILARIHSECLTGDAFFSLRCDCGIQLEMAMSRIAS
EGNGILIYHRQEGRNIGLLNKIKAYSLQDKGLDTVEANQKLGFSADERDFSLCADIFNILNIKKIRLLTNNPFKVDMLIA
SGIEIVERIPIIVEKNDKNAHYLKTKAEKMGHLLFK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=68.3673469387755, Blast_Score=297, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=44.7058823529412, Blast_Score=129, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_BUCAP (Q8K9Q0)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660608.1
- ProteinModelPortal:   Q8K9Q0
- SMR:   Q8K9Q0
- EnsemblBacteria:   EBBUCT00000000127
- GeneID:   1005463
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg261
- GeneTree:   EBGT00050000008019
- HOGENOM:   HBG735778
- OMA:   QGFILYL
- ProtClustDB:   PRK00393
- BioCyc:   BAPH198804:BUSG261-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 22202; Mature: 22202

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 128-128 BINDING 70-70 BINDING 114-114 BINDING 149-149 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIQIEKAILPTPWGDFLIFGFEEKKNGKNHIALVYGKIKKNIPILARIHSECLTGDAF
CCEEEECHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCEEEEEHHHHCCCCCE
FSLRCDCGIQLEMAMSRIASEGNGILIYHRQEGRNIGLLNKIKAYSLQDKGLDTVEANQK
EEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHEEEEECCCCCCCCCCCCC
LGFSADERDFSLCADIFNILNIKKIRLLTNNPFKVDMLIASGIEIVERIPIIVEKNDKNA
CCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCEEEEEEECCCHHHHHHCCEEEEECCCCC
HYLKTKAEKMGHLLFK
EEHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLIQIEKAILPTPWGDFLIFGFEEKKNGKNHIALVYGKIKKNIPILARIHSECLTGDAF
CCEEEECHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCEEEEEHHHHCCCCCE
FSLRCDCGIQLEMAMSRIASEGNGILIYHRQEGRNIGLLNKIKAYSLQDKGLDTVEANQK
EEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHEEEEECCCCCCCCCCCCC
LGFSADERDFSLCADIFNILNIKKIRLLTNNPFKVDMLIASGIEIVERIPIIVEKNDKNA
CCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCEEEEEEECCCHHHHHHCCEEEEECCCCC
HYLKTKAEKMGHLLFK
EEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438