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The map label for this gene is guaC

Identifier: 21672484

GI number: 21672484

Start: 223437

End: 224486

Strand: Direct

Name: guaC

Synonym: BUsg198

Alternate gene names: 21672484

Gene position: 223437-224486 (Clockwise)

Preceding gene: 21672482

Following gene: 21672485

Centisome position: 34.83

GC content: 31.43

Gene sequence:

>1050_bases
ATGCGTATTGAAGAAGATATTAAACTGGGTTTTAAAGATGTATTAATAAGACCGAAAAGATCTACCTTAAAAAGTCGTTC
TGAAGTTAATCTCATTCGTTGTTTTTCCTTTAAATATTCCACCATGAAATGGTTTGGAATTCCACTTATTGCTGCTAATA
TGGACACTATAGGTACCTTTCGTATGGCTGAAGCTTTATCAAAATTTAATATATTAACAGCAGTACATAAATATTATTCT
TTTGATGAATGGAAAAATTTTATTAGTGTTTCTTCTAAAGAAATATTAGAACATGTTATTGTGTCAATTGGAACGTCTAA
TCTAGATTTTTTTAAAATAAAAAAAATTTTTTCATTATCTTCTGAATTGAAATATATTTGTATTGATGTAGCTAATGGTT
ATTCCGAACATTTTGTGTCTTTTTTAAAAAAAATAAGAAGTTTTTTTCCAGATAAAATAATTTGTGCAGGTAACGTTGTT
ACTGGTGAAATGGTAGAAGAACTAATTTTGTCTGGCGCAGATATAGTAAAAGTAGGAATAGGACCTGGTTCTGTATGTAC
TACACGACTCAAAACGGGAATAGGTTATCCTCAACTTTCAGCTATCATAGAATGCGCTGACGCTGCACATGGATTAAATG
GTCAAATTATTAGTGATGGTGGTTGTACTGTTTCAGGAGATATTGCAAAAGCCTTCGGAGGAGGTGCAGATTTTGTTATG
TTGGGTGGTATGTTTGCAGGACATACTGAATGTTTAGGAGAAATAATTCAAGAAAAATCTAAAAAATTTATGTTGTTTTA
TGGTATGAGTTCGACTTCTGCAATGAAACGCTATACAGGAAAAATTCCAGGATATCGTGCATCTGAAGGTAAAATCGTGA
AAATACCTTTTCGTGGGAATGTAGATGTGACTGTACGTGACATTTTAGGAGGACTCCGTTCTTCTTGCACTTATGTAGGA
GCCCAAAAGTTAAAGGAATTGACTAAAAGAACTACTTTTATACGAGTTAGTGAACAAGAAAATTGTATTTTTAATAATTT
TAAAAATTAA

Upstream 100 bases:

>100_bases
AAATATTTAATTTTTATTAAAAAAAAGAATTTTAATATATTTTTATATTATAAAATTTTTTATATCATATTTTTACTATT
CAGTATAGGATTTTTATTTT

Downstream 100 bases:

>100_bases
AACATATTTTTTGTTAAAAAGTTAAATAAAATCAATAAAATTAATTATACTCATAGTTAATTTTATTGATTTTTTTTAGA
AAAAATAATTTTTTAAAAAA

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MRIEEDIKLGFKDVLIRPKRSTLKSRSEVNLIRCFSFKYSTMKWFGIPLIAANMDTIGTFRMAEALSKFNILTAVHKYYS
FDEWKNFISVSSKEILEHVIVSIGTSNLDFFKIKKIFSLSSELKYICIDVANGYSEHFVSFLKKIRSFFPDKIICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRLKTGIGYPQLSAIIECADAAHGLNGQIISDGGCTVSGDIAKAFGGGADFVM
LGGMFAGHTECLGEIIQEKSKKFMLFYGMSSTSAMKRYTGKIPGYRASEGKIVKIPFRGNVDVTVRDILGGLRSSCTYVG
AQKLKELTKRTTFIRVSEQENCIFNNFKN

Sequences:

>Translated_349_residues
MRIEEDIKLGFKDVLIRPKRSTLKSRSEVNLIRCFSFKYSTMKWFGIPLIAANMDTIGTFRMAEALSKFNILTAVHKYYS
FDEWKNFISVSSKEILEHVIVSIGTSNLDFFKIKKIFSLSSELKYICIDVANGYSEHFVSFLKKIRSFFPDKIICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRLKTGIGYPQLSAIIECADAAHGLNGQIISDGGCTVSGDIAKAFGGGADFVM
LGGMFAGHTECLGEIIQEKSKKFMLFYGMSSTSAMKRYTGKIPGYRASEGKIVKIPFRGNVDVTVRDILGGLRSSCTYVG
AQKLKELTKRTTFIRVSEQENCIFNNFKN
>Mature_349_residues
MRIEEDIKLGFKDVLIRPKRSTLKSRSEVNLIRCFSFKYSTMKWFGIPLIAANMDTIGTFRMAEALSKFNILTAVHKYYS
FDEWKNFISVSSKEILEHVIVSIGTSNLDFFKIKKIFSLSSELKYICIDVANGYSEHFVSFLKKIRSFFPDKIICAGNVV
TGEMVEELILSGADIVKVGIGPGSVCTTRLKTGIGYPQLSAIIECADAAHGLNGQIISDGGCTVSGDIAKAFGGGADFVM
LGGMFAGHTECLGEIIQEKSKKFMLFYGMSSTSAMKRYTGKIPGYRASEGKIVKIPFRGNVDVTVRDILGGLRSSCTYVG
AQKLKELTKRTTFIRVSEQENCIFNNFKN

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily

Homologues:

Organism=Homo sapiens, GI50541956, Length=345, Percent_Identity=65.2173913043478, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI50541954, Length=345, Percent_Identity=65.2173913043478, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI50541952, Length=345, Percent_Identity=65.2173913043478, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI50541948, Length=345, Percent_Identity=65.2173913043478, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI156104880, Length=344, Percent_Identity=62.7906976744186, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI66933016, Length=233, Percent_Identity=28.3261802575107, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI217035146, Length=233, Percent_Identity=28.755364806867, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI217035148, Length=233, Percent_Identity=28.755364806867, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217035152, Length=234, Percent_Identity=29.4871794871795, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217035150, Length=233, Percent_Identity=28.755364806867, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI156616279, Length=235, Percent_Identity=29.3617021276596, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI34328930, Length=234, Percent_Identity=29.4871794871795, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI34328928, Length=235, Percent_Identity=29.3617021276596, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786293, Length=347, Percent_Identity=72.6224783861671, Blast_Score=536, Evalue=1e-154,
Organism=Escherichia coli, GI1788855, Length=226, Percent_Identity=35.3982300884956, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560440, Length=347, Percent_Identity=60.5187319884726, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71994385, Length=192, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994389, Length=154, Percent_Identity=35.7142857142857, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323585, Length=250, Percent_Identity=30, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322012, Length=250, Percent_Identity=30, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323464, Length=250, Percent_Identity=30, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319352, Length=133, Percent_Identity=33.0827067669173, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641071, Length=255, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24641073, Length=255, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571163, Length=255, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): GUAC_BUCAP (Q8K9U0)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660551.1
- ProteinModelPortal:   Q8K9U0
- SMR:   Q8K9U0
- EnsemblBacteria:   EBBUCT00000000172
- GeneID:   1005395
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg198
- GeneTree:   EBGT00050000008003
- HOGENOM:   HBG298985
- OMA:   FRNSKQM
- ProtClustDB:   PRK05096
- BioCyc:   BAPH198804:BUSG198-MONOMER
- HAMAP:   MF_00596
- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000235
- TIGRFAMs:   TIGR01305

Pfam domain/function: PF00478 IMPDH

EC number: =1.7.1.7

Molecular weight: Translated: 38618; Mature: 38618

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 186-186

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEEDIKLGFKDVLIRPKRSTLKSRSEVNLIRCFSFKYSTMKWFGIPLIAANMDTIGTF
CCCCHHHHCCHHHHEECCCHHHHHCCCCCCEEEEEECCCCCEEEECCEEEEECCCHHHHH
RMAEALSKFNILTAVHKYYSFDEWKNFISVSSKEILEHVIVSIGTSNLDFFKIKKIFSLS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
SELKYICIDVANGYSEHFVSFLKKIRSFFPDKIICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRLKTGIGYPQLSAIIECADAAHGLNGQIISDGGCTVSGDIAKAFGGGADFVM
CCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCCCEEECCHHHHCCCCCCEEE
LGGMFAGHTECLGEIIQEKSKKFMLFYGMSSTSAMKRYTGKIPGYRASEGKIVKIPFRGN
ECCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEECCCCCEEEEECCCC
VDVTVRDILGGLRSSCTYVGAQKLKELTKRTTFIRVSEQENCIFNNFKN
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MRIEEDIKLGFKDVLIRPKRSTLKSRSEVNLIRCFSFKYSTMKWFGIPLIAANMDTIGTF
CCCCHHHHCCHHHHEECCCHHHHHCCCCCCEEEEEECCCCCEEEECCEEEEECCCHHHHH
RMAEALSKFNILTAVHKYYSFDEWKNFISVSSKEILEHVIVSIGTSNLDFFKIKKIFSLS
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
SELKYICIDVANGYSEHFVSFLKKIRSFFPDKIICAGNVVTGEMVEELILSGADIVKVGI
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEC
GPGSVCTTRLKTGIGYPQLSAIIECADAAHGLNGQIISDGGCTVSGDIAKAFGGGADFVM
CCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCCCEEECCHHHHCCCCCCEEE
LGGMFAGHTECLGEIIQEKSKKFMLFYGMSSTSAMKRYTGKIPGYRASEGKIVKIPFRGN
ECCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCEECCCCCEEEEECCCC
VDVTVRDILGGLRSSCTYVGAQKLKELTKRTTFIRVSEQENCIFNNFKN
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438