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The map label for this gene is mutT

Identifier: 21672482

GI number: 21672482

Start: 222237

End: 222629

Strand: Direct

Name: mutT

Synonym: BUsg196

Alternate gene names: 21672482

Gene position: 222237-222629 (Clockwise)

Preceding gene: 21672481

Following gene: 21672484

Centisome position: 34.65

GC content: 20.87

Gene sequence:

>393_bases
ATGAAGTATACAAATATAGTAATTGGAATAATTATAAAAAAAAATAAAATTTATATTACTAAAGCAAGAAAAAAAAAATA
TGTCTTAGATTTATGGGAATTTCCTGGGGGAAAGGTAAAAGAAAATGAAAATTTAACATACTCGTTGAAACGAGAATTAT
CAGAAGAGGTAGGTCTTAAAATATTAAGATTTCGTTTTTTTCGGTGTATTAAATATTTTTATAAAAAAATAAAATTATAT
TTTTTTTTAATTACTAGATGGAAAGGTAGAATATATAGTAAAGAAGGATATTTATATAAATGGATATTTCTTGATGATCT
AAAATATTTTAACTTTCCTAGTCCAAATAGTCATATTATTCATGATTTACAGAAAATGATTTTTTTTAAGTGA

Upstream 100 bases:

>100_bases
AAATGGGAAGAAATACGCCCTGTTTTTGCAAATCTGGAAAAAAATATAAGTATTGTCATGGAAGTTTATAATTTTTTTTT
AAAAATTTGGATTCTATTTA

Downstream 100 bases:

>100_bases
AAATTTATATTCTTAGTAAAATTAGTTATATTATTTTTTTCATGTTTTTTGGATTGTTCTGTTTTGATAAATATATATAA
AAGTTATTAAGATAATGAAT

Product: mutator MutT

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MKYTNIVIGIIIKKNKIYITKARKKKYVLDLWEFPGGKVKENENLTYSLKRELSEEVGLKILRFRFFRCIKYFYKKIKLY
FFLITRWKGRIYSKEGYLYKWIFLDDLKYFNFPSPNSHIIHDLQKMIFFK

Sequences:

>Translated_130_residues
MKYTNIVIGIIIKKNKIYITKARKKKYVLDLWEFPGGKVKENENLTYSLKRELSEEVGLKILRFRFFRCIKYFYKKIKLY
FFLITRWKGRIYSKEGYLYKWIFLDDLKYFNFPSPNSHIIHDLQKMIFFK
>Mature_130_residues
MKYTNIVIGIIIKKNKIYITKARKKKYVLDLWEFPGGKVKENENLTYSLKRELSEEVGLKILRFRFFRCIKYFYKKIKLY
FFLITRWKGRIYSKEGYLYKWIFLDDLKYFNFPSPNSHIIHDLQKMIFFK

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1786288, Length=129, Percent_Identity=34.8837209302326, Blast_Score=87, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTT_BUCAP (Q8K9U2)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660549.1
- ProteinModelPortal:   Q8K9U2
- SMR:   Q8K9U2
- EnsemblBacteria:   EBBUCT00000000491
- GeneID:   1005393
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg196
- GeneTree:   EBGT00050000008079
- HOGENOM:   HBG741910
- ProtClustDB:   CLSK315783
- BioCyc:   BAPH198804:BUSG196-MONOMER
- InterPro:   IPR020476
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.-

Molecular weight: Translated: 16090; Mature: 16090

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTNIVIGIIIKKNKIYITKARKKKYVLDLWEFPGGKVKENENLTYSLKRELSEEVGLK
CCCCEEEEEEEEECCEEEEEECCCCCEEEEEECCCCCCEECCCCCEEHHHHHHHHHHHHH
ILRFRFFRCIKYFYKKIKLYFFLITRWKGRIYSKEGYLYKWIFLDDLKYFNFPSPNSHII
HHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCEEEEEEEECHHCCCCCCCCCHHH
HDLQKMIFFK
HHHHHHHCCC
>Mature Secondary Structure
MKYTNIVIGIIIKKNKIYITKARKKKYVLDLWEFPGGKVKENENLTYSLKRELSEEVGLK
CCCCEEEEEEEEECCEEEEEECCCCCEEEEEECCCCCCEECCCCCEEHHHHHHHHHHHHH
ILRFRFFRCIKYFYKKIKLYFFLITRWKGRIYSKEGYLYKWIFLDDLKYFNFPSPNSHII
HHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCEEEEEEEECHHCCCCCCCCCHHH
HDLQKMIFFK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438