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The map label for this gene is acs

Identifier: 21244896

GI number: 21244896

Start: 4914007

End: 4915950

Strand: Direct

Name: acs

Synonym: XAC4179

Alternate gene names: 21244896

Gene position: 4914007-4915950 (Clockwise)

Preceding gene: 21244889

Following gene: 21244897

Centisome position: 94.95

GC content: 64.87

Gene sequence:

>1944_bases
ATGGCTGATGTTTATCCCGTCGATCCCGCGTTCGCCGCCGATGCGCGCGTGACGCGCGAGCAGTACGCCGCGCTGTACCG
CGAATCGATCCAACACCCCGAGCAGTTCTGGGGCAAGGCCGCGCAGCGGCTCGAGTGGTTCAAGCAACCCACCCAGATCA
AGGACGTCAGCTACGCGCTGGACGACTTCCATATCCGCTGGTTCGGCGATGGCGAGCTCAATGCCAGCGTCAACTGCCTG
GACCGCCAGCTGGCCACGCGCGGCGACAAGACCGCGCTGCTGTTCGAACCCGACAGCCCGGACGCAGCGTCGTACCCGGT
GACCTACCGCGAGTTGTACGAGCGCGTCTGCAAGCTGGGCAATGCGCTGCGCAACCTGGGCGTCAAGAAGGGCGACCGGG
TCACCATCTATCTGCCGATGATCGTCGATGCTGCCGTGGCCATGCTCGCCTGCGCGCGCATCGGTGCGGTGCACTCGGTG
GTGTTCGGCGGCTTTGCCGCCAACTCGATCGCCGACCGCGTGATCGATTGCCAGAGCAAGCTGATCATCACCGCCGACGA
AGGCCTGCGTGGCGGCAAGAAGATTCCGCTCAAGGCCAATGTCGATGCAGCGCTGAAGATTCCCGGCACCAATACGGTGG
AAACCGTGCTGGTGGTGCGTCATACCGGCGGCGCAGTGGAGATGCAGGCACCGCGCGACCGCTGGTTCCATGATGTGGTC
GACGGCCAGCCGGCCGCGTGCGAACCCGAGCGCATGAACGCCGAAGACCCGCTCTTCATCCTCTACACCTCCGGCTCCAC
CGGCAAACCCAAGGGCGTGCTGCACACCACCGCCGGCTATCTGTTGTTTGCCAGTTACACGCATGAAGTAGTGTTCGACC
TGCGCGAGGACGACATCTATTGGTGCACTGCGGACGTGGGCTGGGTCACTGGCCACAGCTACATCGTCTACGGCCCGCTC
GCCAATGGCGCCACCGCGGTGATGTTCGAAGGTGTGCCCAATTACCCGAACGTGTCGCGCTTCTGGGAAGTGATCGACAA
GCATCAGGTCACCATCTTCTACACCGCACCTACTGCGATTCGCGCGTTGATGCGCGACGGTGCGGACCCGGTCAAAAAGA
CCTCGCGCAAGAGCCTGCGCCTGCTCGGCAGCGTCGGCGAGCCGATCAATCCGGAAGCCTGGCGCTGGTATTACGAGGTG
GTCGGCGACAGCCGTTGCCCGATCGTGGACACGTGGTGGCAGACCGAAACCGGCGGCATCCTGATCTCGCCGCTGGCCGG
CGCGGTCGATCTCAAGCCGGGCTCGGCCACCTTGCCGTTCTTCGGCGTGCAGCCGGCGCTGGTCGATGCCGAAGGCAAGA
TTCTGGAAGGCGCCACCGAAGGCAACCTGGTGCTGCTCGATTCCTGGCCGGGCCAGATGCGTAGCGTGTATGGCGACCAC
CAGCGTTTCATCGACACCTACTTCCGCACCTATCCGGGCAGCTACTTCACCGGCGACGGCTGCCGCCGCGATGCCGACGG
CTACTACTGGATCACCGGCCGCGTGGACGATGTGATCAACGTCTCCGGGCACCGCATCGGCACCGCCGAAGTGGAAAGCG
CGCTGGTCTCGCACCCCAAGGTCGCCGAAGCGGCCGTGGTGGGCTTCCCGCATGACGTCAAGGGCCAGGGCATCTATGCC
TACGTCACCCTGATCGCGGGGCAGACCCCGAGCGAGGACCTGCACAAGGAATTGGTCAGCTGGGTGCGCAAGGAGATCGG
CCCGATCGCCTCGCCCGATCACCTGCAGTGGGCGCCCGGCCTGCCCAAGACCCGCTCGGGCAAGATCATGCGCCGCATCC
TGCGCAAGATCGCCGAAAACGCCCCTGACCAGTTGGGCGATACCTCCACGCTGGCAGATCCGTCGGTGGTGGATTCGCTG
GTCAATGAGCGTCTGGCGCGCTGA

Upstream 100 bases:

>100_bases
GCCGTTGACCGCCGGGACAGAATGGATGCGGCACACTGATTGTCTACCGAGGGCAGCCGCAACGCCCTCTTCCGACAAGT
TCATCGCAAGTGAGGGTGCC

Downstream 100 bases:

>100_bases
CGCGCTGGGAATGGGGAATCGGGAGCAGGGAATCGGTAGAGCGATTCCCTGGTTGCTGATAGTGCAATTGGGATGGGGAT
TGGTTGGAAGCGAATCTCCT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MADVYPVDPAFAADARVTREQYAALYRESIQHPEQFWGKAAQRLEWFKQPTQIKDVSYALDDFHIRWFGDGELNASVNCL
DRQLATRGDKTALLFEPDSPDAASYPVTYRELYERVCKLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSV
VFGGFAANSIADRVIDCQSKLIITADEGLRGGKKIPLKANVDAALKIPGTNTVETVLVVRHTGGAVEMQAPRDRWFHDVV
DGQPAACEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIYWCTADVGWVTGHSYIVYGPL
ANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAIRALMRDGADPVKKTSRKSLRLLGSVGEPINPEAWRWYYEV
VGDSRCPIVDTWWQTETGGILISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPKVAEAAVVGFPHDVKGQGIYA
YVTLIAGQTPSEDLHKELVSWVRKEIGPIASPDHLQWAPGLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSL
VNERLAR

Sequences:

>Translated_647_residues
MADVYPVDPAFAADARVTREQYAALYRESIQHPEQFWGKAAQRLEWFKQPTQIKDVSYALDDFHIRWFGDGELNASVNCL
DRQLATRGDKTALLFEPDSPDAASYPVTYRELYERVCKLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSV
VFGGFAANSIADRVIDCQSKLIITADEGLRGGKKIPLKANVDAALKIPGTNTVETVLVVRHTGGAVEMQAPRDRWFHDVV
DGQPAACEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIYWCTADVGWVTGHSYIVYGPL
ANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAIRALMRDGADPVKKTSRKSLRLLGSVGEPINPEAWRWYYEV
VGDSRCPIVDTWWQTETGGILISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPKVAEAAVVGFPHDVKGQGIYA
YVTLIAGQTPSEDLHKELVSWVRKEIGPIASPDHLQWAPGLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSL
VNERLAR
>Mature_646_residues
ADVYPVDPAFAADARVTREQYAALYRESIQHPEQFWGKAAQRLEWFKQPTQIKDVSYALDDFHIRWFGDGELNASVNCLD
RQLATRGDKTALLFEPDSPDAASYPVTYRELYERVCKLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSVV
FGGFAANSIADRVIDCQSKLIITADEGLRGGKKIPLKANVDAALKIPGTNTVETVLVVRHTGGAVEMQAPRDRWFHDVVD
GQPAACEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIYWCTADVGWVTGHSYIVYGPLA
NGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAIRALMRDGADPVKKTSRKSLRLLGSVGEPINPEAWRWYYEVV
GDSRCPIVDTWWQTETGGILISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDHQ
RFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPKVAEAAVVGFPHDVKGQGIYAY
VTLIAGQTPSEDLHKELVSWVRKEIGPIASPDHLQWAPGLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSLV
NERLAR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=52.7736131934033, Blast_Score=691, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=51.6176470588235, Blast_Score=687, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=626, Percent_Identity=49.6805111821086, Blast_Score=625, Evalue=1e-179,
Organism=Homo sapiens, GI13375727, Length=630, Percent_Identity=37.3015873015873, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI31982927, Length=644, Percent_Identity=25.776397515528, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI42544132, Length=519, Percent_Identity=30.2504816955684, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=29.6511627906977, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=28.6549707602339, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI115511026, Length=519, Percent_Identity=27.9383429672447, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI58082049, Length=515, Percent_Identity=26.6019417475728, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI157311624, Length=517, Percent_Identity=26.3056092843327, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI157311622, Length=517, Percent_Identity=26.3056092843327, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI187761345, Length=547, Percent_Identity=28.1535648994516, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI187761343, Length=547, Percent_Identity=28.1535648994516, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI195947378, Length=427, Percent_Identity=25.9953161592506, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI42544134, Length=338, Percent_Identity=26.6272189349112, Blast_Score=93, Evalue=9e-19,
Organism=Escherichia coli, GI1790505, Length=639, Percent_Identity=61.8153364632238, Blast_Score=843, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=36.608557844691, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI221142682, Length=544, Percent_Identity=23.3455882352941, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI145693145, Length=533, Percent_Identity=24.202626641651, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788107, Length=561, Percent_Identity=23.5294117647059, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786810, Length=520, Percent_Identity=22.3076923076923, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=660, Percent_Identity=50.4545454545455, Blast_Score=627, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71982997, Length=660, Percent_Identity=50.4545454545455, Blast_Score=627, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17569507, Length=599, Percent_Identity=24.2070116861436, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17538037, Length=545, Percent_Identity=24.4036697247706, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32563687, Length=558, Percent_Identity=22.9390681003584, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=546, Percent_Identity=23.6263736263736, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17557194, Length=551, Percent_Identity=23.7749546279492, Blast_Score=89, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=639, Percent_Identity=49.2957746478873, Blast_Score=624, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6319264, Length=642, Percent_Identity=49.0654205607477, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319699, Length=371, Percent_Identity=25.3369272237197, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24667955, Length=660, Percent_Identity=53.1818181818182, Blast_Score=705, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=57.6512455516014, Blast_Score=658, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=58.2692307692308, Blast_Score=613, Evalue=1e-176,
Organism=Drosophila melanogaster, GI21355225, Length=634, Percent_Identity=36.1198738170347, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI21355181, Length=547, Percent_Identity=23.9488117001828, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859661, Length=521, Percent_Identity=24.3761996161228, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656500, Length=546, Percent_Identity=23.6263736263736, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24581924, Length=523, Percent_Identity=22.5621414913958, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_XANAC (Q8PF09)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644478.1
- ProteinModelPortal:   Q8PF09
- SMR:   Q8PF09
- GeneID:   1158250
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC4179
- NMPDR:   fig|190486.1.peg.4122
- HOGENOM:   HBG547964
- OMA:   RAFMKSG
- ProtClustDB:   PRK00174
- BioCyc:   XAXO190486:XAC4179-MONOMER
- BRENDA:   6.2.1.1
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 71277; Mature: 71146

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVYPVDPAFAADARVTREQYAALYRESIQHPEQFWGKAAQRLEWFKQPTQIKDVSYAL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHEEE
DDFHIRWFGDGELNASVNCLDRQLATRGDKTALLFEPDSPDAASYPVTYRELYERVCKLG
CCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
NALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSVVFGGFAANSIADRVIDCQSK
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
LIITADEGLRGGKKIPLKANVDAALKIPGTNTVETVLVVRHTGGAVEMQAPRDRWFHDVV
EEEEECCCCCCCCCCCEEECCCEEEECCCCCCEEEEEEEEECCCEEEECCCHHHHHHHHH
DGQPAACEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIY
CCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEECCCEEEEEEECCCCEE
WCTADVGWVTGHSYIVYGPLANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAI
EEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECHHHH
RALMRDGADPVKKTSRKSLRLLGSVGEPINPEAWRWYYEVVGDSRCPIVDTWWQTETGGI
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCCEEECCCCCCCCCE
LISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
EEECCCCEEEECCCCCCCCEECCCCEEECCCCCEEECCCCCCEEEEECCCHHHHHHHHHH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPK
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCC
VAEAAVVGFPHDVKGQGIYAYVTLIAGQTPSEDLHKELVSWVRKEIGPIASPDHLQWAPG
HHHEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
LPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSLVNERLAR
CCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADVYPVDPAFAADARVTREQYAALYRESIQHPEQFWGKAAQRLEWFKQPTQIKDVSYAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHEEE
DDFHIRWFGDGELNASVNCLDRQLATRGDKTALLFEPDSPDAASYPVTYRELYERVCKLG
CCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
NALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAVHSVVFGGFAANSIADRVIDCQSK
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
LIITADEGLRGGKKIPLKANVDAALKIPGTNTVETVLVVRHTGGAVEMQAPRDRWFHDVV
EEEEECCCCCCCCCCCEEECCCEEEECCCCCCEEEEEEEEECCCEEEECCCHHHHHHHHH
DGQPAACEPERMNAEDPLFILYTSGSTGKPKGVLHTTAGYLLFASYTHEVVFDLREDDIY
CCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEECCCEEEEEEECCCCEE
WCTADVGWVTGHSYIVYGPLANGATAVMFEGVPNYPNVSRFWEVIDKHQVTIFYTAPTAI
EEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECHHHH
RALMRDGADPVKKTSRKSLRLLGSVGEPINPEAWRWYYEVVGDSRCPIVDTWWQTETGGI
HHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEECCCCCCEEECCCCCCCCCE
LISPLAGAVDLKPGSATLPFFGVQPALVDAEGKILEGATEGNLVLLDSWPGQMRSVYGDH
EEECCCCEEEECCCCCCCCEECCCCEEECCCCCEEECCCCCCEEEEECCCHHHHHHHHHH
QRFIDTYFRTYPGSYFTGDGCRRDADGYYWITGRVDDVINVSGHRIGTAEVESALVSHPK
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCC
VAEAAVVGFPHDVKGQGIYAYVTLIAGQTPSEDLHKELVSWVRKEIGPIASPDHLQWAPG
HHHEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCC
LPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVDSLVNERLAR
CCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217