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The map label for this gene is atpB [H]

Identifier: 21226881

GI number: 21226881

Start: 931631

End: 933067

Strand: Reverse

Name: atpB [H]

Synonym: MM_0779

Alternate gene names: 21226881

Gene position: 933067-931631 (Counterclockwise)

Preceding gene: 21226882

Following gene: 21226880

Centisome position: 22.78

GC content: 50.66

Gene sequence:

>1437_bases
ATGCTGTTCTTGCAAAGATGGATAAAGAGTTTGCAGCCCTGGGAGGTAAATAAGATGGCAAAAGAGTACAAGACGATCAC
TCAGATTGCAGGGCCTCTTATTTTTGTCGAGAAAACAGAGCCTGTAGGTTATAATGAAATCGTTAACATTAAGATGGGTG
ATGGAACTGTTCGCAGAGGACAGGTGCTGGACTCTTCCGCTGACATTGTGGTTGTCCAGGTTTTCGAAGGTACTGGTGGG
CTTGACAAGGACTGCGGTGTAATTTTCACCGGTGAAACTCTGAAGCTTCCCGCATCCGTCGATCTTCTCGGCAGGATCCT
GTCCGGTTCAGGAGAACCAAGGGACGGTGGACCTAGGATCGTTCCAGACCAGTTGCTGGACATCAACGGTGCCGCAATGA
ACCCTTACGCCAGGCTGCCTCCAAAGGACTTTATCCAGACAGGTATCTCCACAATTGACGGGACAAATACCCTGGTTCGT
GGGCAGAAACTGCCTATTTTCTCAGCATCAGGTCTCCCACACAATGAAATCGCCCTGCAGATTGCAAGGCAGGCTTCTGT
GCCCGGTTCCGAATCTGCTTTCGCAGTAGTTTTCGCAGCAATGGGTATCACCAATGAAGAAGCCCAGTATTTCATGAGCG
ACTTTGAGAAAACCGGCGCACTGGAAAGGGCAGTTGTGTTCCTTAACCTTGCAGACGACCCTGCTGTCGAACGTATCGTT
ACCCCGCGTATGGCTCTCACAGCAGCCGAATACCTCGCGTACGAACACGGCATGCACGTTCTCGTAATTCTGACTGACAT
TACAAACTATGCAGAAGCTCTCCGTCAGATGGGTGCCGCCCGTAACGAAGTTCCTGGTCGCCGTGGGTATCCGGGTTACA
TGTATACTGACCTTGCAACCCTCTACGAGCGTGCAGGTATTGTCAAAGGTGCCAAGGGATCCGTTACTCAGATTCCGATC
CTCTCAATGCCTGGTGATGACATTACCCACCCGATTCCTGACCTGTCCGGTTATATTACCGAAGGCCAGATTGTGGTTGC
CAGGGAACTGCACAGGAAGGGTATTTACCCGCCAATTAATGTGCTGCCGTCCCTGTCAAGGCTGATGAACTCCGGTATCG
GAGCCGGCAAAACAAGAGAAGACCACAAGGCGGTTTCTGACCAGATGTATGCAGGTTATGCAGAAGGGCGTGACCTGAGA
GGTCTGGTGGCAATCGTCGGTAAGGAAGCTCTGTCAGAAAGAGACACCAAGTTCCTCGAGTTTGCCGACCTGTTTGAGGA
CAAGTTTGTCCGTCAGGGCAGAAACGAAAACAGGACAATCGAGGATACTCTGGAGATCGGATGGCAGATTCTCACTCACC
TTCCTGAAAACCAGTTGGGTAGGATTGACAACAAATATATCCAGAAATATCACCCGGCACACAGAAAGGCTAAGTGA

Upstream 100 bases:

>100_bases
GCCCTGAAATCAGGTGTACTTTCTTCGGAAATTCTCAAGATGCAGTCAAAGGACGAGCTTCCCAAAGTTAAGTTCGAAGA
GGACTTCGAAGGCTCTTTGA

Downstream 100 bases:

>100_bases
TTGCCATGGCTCAGCAGGACGTAAAACCAACTCGTTCGGAGTTAATTAATCTCAAGAAAAAGATCAAGCTCTCTGAAAGT
GGGCACAAGCTCCTGAAGAT

Product: V-type ATP synthase subunit B

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit B [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MLFLQRWIKSLQPWEVNKMAKEYKTITQIAGPLIFVEKTEPVGYNEIVNIKMGDGTVRRGQVLDSSADIVVVQVFEGTGG
LDKDCGVIFTGETLKLPASVDLLGRILSGSGEPRDGGPRIVPDQLLDINGAAMNPYARLPPKDFIQTGISTIDGTNTLVR
GQKLPIFSASGLPHNEIALQIARQASVPGSESAFAVVFAAMGITNEEAQYFMSDFEKTGALERAVVFLNLADDPAVERIV
TPRMALTAAEYLAYEHGMHVLVILTDITNYAEALRQMGAARNEVPGRRGYPGYMYTDLATLYERAGIVKGAKGSVTQIPI
LSMPGDDITHPIPDLSGYITEGQIVVARELHRKGIYPPINVLPSLSRLMNSGIGAGKTREDHKAVSDQMYAGYAEGRDLR
GLVAIVGKEALSERDTKFLEFADLFEDKFVRQGRNENRTIEDTLEIGWQILTHLPENQLGRIDNKYIQKYHPAHRKAK

Sequences:

>Translated_478_residues
MLFLQRWIKSLQPWEVNKMAKEYKTITQIAGPLIFVEKTEPVGYNEIVNIKMGDGTVRRGQVLDSSADIVVVQVFEGTGG
LDKDCGVIFTGETLKLPASVDLLGRILSGSGEPRDGGPRIVPDQLLDINGAAMNPYARLPPKDFIQTGISTIDGTNTLVR
GQKLPIFSASGLPHNEIALQIARQASVPGSESAFAVVFAAMGITNEEAQYFMSDFEKTGALERAVVFLNLADDPAVERIV
TPRMALTAAEYLAYEHGMHVLVILTDITNYAEALRQMGAARNEVPGRRGYPGYMYTDLATLYERAGIVKGAKGSVTQIPI
LSMPGDDITHPIPDLSGYITEGQIVVARELHRKGIYPPINVLPSLSRLMNSGIGAGKTREDHKAVSDQMYAGYAEGRDLR
GLVAIVGKEALSERDTKFLEFADLFEDKFVRQGRNENRTIEDTLEIGWQILTHLPENQLGRIDNKYIQKYHPAHRKAK
>Mature_478_residues
MLFLQRWIKSLQPWEVNKMAKEYKTITQIAGPLIFVEKTEPVGYNEIVNIKMGDGTVRRGQVLDSSADIVVVQVFEGTGG
LDKDCGVIFTGETLKLPASVDLLGRILSGSGEPRDGGPRIVPDQLLDINGAAMNPYARLPPKDFIQTGISTIDGTNTLVR
GQKLPIFSASGLPHNEIALQIARQASVPGSESAFAVVFAAMGITNEEAQYFMSDFEKTGALERAVVFLNLADDPAVERIV
TPRMALTAAEYLAYEHGMHVLVILTDITNYAEALRQMGAARNEVPGRRGYPGYMYTDLATLYERAGIVKGAKGSVTQIPI
LSMPGDDITHPIPDLSGYITEGQIVVARELHRKGIYPPINVLPSLSRLMNSGIGAGKTREDHKAVSDQMYAGYAEGRDLR
GLVAIVGKEALSERDTKFLEFADLFEDKFVRQGRNENRTIEDTLEIGWQILTHLPENQLGRIDNKYIQKYHPAHRKAK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit [H]

COG id: COG1156

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913428, Length=459, Percent_Identity=57.2984749455338, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI19913426, Length=458, Percent_Identity=55.0218340611354, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI32189394, Length=347, Percent_Identity=25.9365994236311, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI50345984, Length=433, Percent_Identity=25.1732101616628, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4757810, Length=433, Percent_Identity=25.1732101616628, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19913424, Length=310, Percent_Identity=26.4516129032258, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI1788251, Length=314, Percent_Identity=30.8917197452229, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790170, Length=322, Percent_Identity=25.4658385093168, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790172, Length=326, Percent_Identity=26.3803680981595, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17570191, Length=457, Percent_Identity=57.1115973741794, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17510931, Length=461, Percent_Identity=56.1822125813449, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25144756, Length=417, Percent_Identity=24.220623501199, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71988080, Length=347, Percent_Identity=26.2247838616715, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=347, Percent_Identity=26.2247838616715, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17565854, Length=330, Percent_Identity=26.3636363636364, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988074, Length=295, Percent_Identity=26.1016949152542, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319603, Length=458, Percent_Identity=58.296943231441, Blast_Score=553, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322581, Length=373, Percent_Identity=26.8096514745308, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319370, Length=292, Percent_Identity=28.7671232876712, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320016, Length=218, Percent_Identity=27.9816513761468, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281361666, Length=460, Percent_Identity=56.7391304347826, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24646341, Length=460, Percent_Identity=56.7391304347826, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17136796, Length=460, Percent_Identity=56.7391304347826, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24638766, Length=347, Percent_Identity=25.3602305475504, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24658560, Length=348, Percent_Identity=27.5862068965517, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574560, Length=353, Percent_Identity=25.4957507082153, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20129479, Length=311, Percent_Identity=25.7234726688103, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583992, Length=310, Percent_Identity=25.8064516129032, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24583988, Length=310, Percent_Identity=25.4838709677419, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583986, Length=310, Percent_Identity=25.4838709677419, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583984, Length=310, Percent_Identity=25.4838709677419, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005724
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022879 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: 3.6.3.14

Molecular weight: Translated: 52582; Mature: 52582

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLQRWIKSLQPWEVNKMAKEYKTITQIAGPLIFVEKTEPVGYNEIVNIKMGDGTVRRG
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCC
QVLDSSADIVVVQVFEGTGGLDKDCGVIFTGETLKLPASVDLLGRILSGSGEPRDGGPRI
EEECCCCCEEEEEEECCCCCCCCCCCEEEECCCEECCCCHHHHHHHHCCCCCCCCCCCCC
VPDQLLDINGAAMNPYARLPPKDFIQTGISTIDGTNTLVRGQKLPIFSASGLPHNEIALQ
CCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCEEECCCCCHHHHHHH
IARQASVPGSESAFAVVFAAMGITNEEAQYFMSDFEKTGALERAVVFLNLADDPAVERIV
HHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHH
TPRMALTAAEYLAYEHGMHVLVILTDITNYAEALRQMGAARNEVPGRRGYPGYMYTDLAT
CCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHH
LYERAGIVKGAKGSVTQIPILSMPGDDITHPIPDLSGYITEGQIVVARELHRKGIYPPIN
HHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEECCEEEEHHHHHHCCCCCCHH
VLPSLSRLMNSGIGAGKTREDHKAVSDQMYAGYAEGRDLRGLVAIVGKEALSERDTKFLE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FADLFEDKFVRQGRNENRTIEDTLEIGWQILTHLPENQLGRIDNKYIQKYHPAHRKAK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MLFLQRWIKSLQPWEVNKMAKEYKTITQIAGPLIFVEKTEPVGYNEIVNIKMGDGTVRRG
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCCCCC
QVLDSSADIVVVQVFEGTGGLDKDCGVIFTGETLKLPASVDLLGRILSGSGEPRDGGPRI
EEECCCCCEEEEEEECCCCCCCCCCCEEEECCCEECCCCHHHHHHHHCCCCCCCCCCCCC
VPDQLLDINGAAMNPYARLPPKDFIQTGISTIDGTNTLVRGQKLPIFSASGLPHNEIALQ
CCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCEEECCCCCHHHHHHH
IARQASVPGSESAFAVVFAAMGITNEEAQYFMSDFEKTGALERAVVFLNLADDPAVERIV
HHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHH
TPRMALTAAEYLAYEHGMHVLVILTDITNYAEALRQMGAARNEVPGRRGYPGYMYTDLAT
CCHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHH
LYERAGIVKGAKGSVTQIPILSMPGDDITHPIPDLSGYITEGQIVVARELHRKGIYPPIN
HHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEECCEEEEHHHHHHCCCCCCHH
VLPSLSRLMNSGIGAGKTREDHKAVSDQMYAGYAEGRDLRGLVAIVGKEALSERDTKFLE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FADLFEDKFVRQGRNENRTIEDTLEIGWQILTHLPENQLGRIDNKYIQKYHPAHRKAK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; Diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines various reactions catalyzed by ATPase, analogs; Oligomycin; Quercetin; Trialkyl tinderivatives; Venturicidin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]