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The map label for this gene is atpA [H]

Identifier: 21226882

GI number: 21226882

Start: 933015

End: 934751

Strand: Reverse

Name: atpA [H]

Synonym: MM_0780

Alternate gene names: 21226882

Gene position: 934751-933015 (Counterclockwise)

Preceding gene: 21226883

Following gene: 21226881

Centisome position: 22.82

GC content: 49.45

Gene sequence:

>1737_bases
GTGGAAGTAAAAGGTGAAATTTATCGTGTGGCTGGGCCTGTCGTCACCGCTATCGGCTTGGATGCAAAGATGTATGACCT
TTGCAAAGTCGGTAACGAAGGGCTGATGGGCGAAGTCATCCAAATAGTAGGAGACAAAACCATCATCCAGGTATACGAAG
AGACAGGCGGCGTCAGGCCGGGAGAACCCTGTGTCACTACAGGTATGTCTCTTGCCGTGGAGCTTGGTCCAGGTCTTCTT
TCCAGTATTTATGATGGGGTTCAGAGGCCACTGCATGTCCTTCTGGAAAGGACGGGCGGTTTTATTGGTAGAGGTGTCAC
TGCAGATGGGCTTGACCACAAAAAACTCTGGGAGTTTAAGCCCGTTGTCAAAAAAGGCGACCGTGTAATTGGTGGAGATG
TTATCGGTGTTGTACAGGAAACTGTGAACATTGAACACAAAATTATGGTTCGTCCTGACATTTCCGGAACAGTCGCCGAC
ATAAAGAGCGGAAGCTTCACTGTCGTAGATACCATCTGTACCTTGACTGATGGAACAGAACTGCAGATGATGCAGAGATG
GCCAGTCAGAAAACCAAGGCCGGTAAAGAGAAAACTTACTCCTGAAAAGCCTCTGGTCACAGGGCAGAGAATCCTTGACG
GACTTTTCCCTGTCGCAAAGGGAGGAACTGCTGCAATTCCAGGACCTTTCGGGTCGGGCAAAACCGTTACTCAGCAGCAG
CTTTCAAAGTGGAGTGACACTGAGATTGTGGTCTACATCGGCTGCGGTGAACGTGGAAACGAGATGGCAGATGTTCTGTG
GGAGTTCCCGGAACTTGAAGACCCGCAGACCGGAAGGCCGCTCATGGAGCGTACCATCCTTGTCGCTAACACTTCAAACA
TGCCTGTGGCTGCAAGAGAAGCATCTGTTTATACAGGAATGACACTTGCGGAATACTTCCGTGACATGGGCTATGACGTC
TCCCTGATGGCAGACTCCACCTCAAGGTGGGCAGAAGCCATGAGAGAAATTTCCTCCCGTCTTGAAGAAATGCCTGGTGA
AGAAGGTTACCCGGCATACCTGTCTGCAAGGCTGGCAGAATTCTACGAGCGTGCCGGTGTTGCCGAAACACTCTGCGGTG
AGAAAGGTTCAATTACTGCTATCGGTGCAGTATCTCCACCTGGCGGTGACTTCTCCGAACCTGTTACTCAGAACACTCTG
CGTATCGTGAAGGTGTTCTGGGCTCTGGATGCAAAGTTATCCCAGAAGCGCCACTTCCCGGCAATTAACTGGCTGAACAG
CTACAGCCTGTATAAGGAAGACCTCAATGACTGGTTTACCGAAAATGTGGCTCCGGACTACGTCCCTATGAGAGAAAGGG
CAATGGATATGCTGCAGACAGAATCCGAATTGCAGGAAATCGTGCAGCTTGTCGGTTCTGATGCTCTGCCTGAAGAACAG
CAGCTTCTGCTTGAAATTACCCGTATGATAAGGGAAATCTTCTTGCAGCAGAATGCATTCCACCCGATCGACACATACAG
CCCGTTCGAAAAACAGTATAAGATCATGAAAGCCATCATGAAATGGGGAGACGCTGCAATGGACGCCCTGAAATCAGGTG
TACTTTCTTCGGAAATTCTCAAGATGCAGTCAAAGGACGAGCTTCCCAAAGTTAAGTTCGAAGAGGACTTCGAAGGCTCT
TTGAATGCTGTTCTTGCAAAGATGGATAAAGAGTTTGCAGCCCTGGGAGGTAAATAA

Upstream 100 bases:

>100_bases
TAAACGAGTCTGTCCAGCCTACAGTAGTAGCGCTAGGAGGCAGCGGATCAGGCTCAACGAGTTTAAGAGAAAAAATAAAA
CAAGCGGTAGGTGTTGATCT

Downstream 100 bases:

>100_bases
GATGGCAAAAGAGTACAAGACGATCACTCAGATTGCAGGGCCTCTTATTTTTGTCGAGAAAACAGAGCCTGTAGGTTATA
ATGAAATCGTTAACATTAAG

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MEVKGEIYRVAGPVVTAIGLDAKMYDLCKVGNEGLMGEVIQIVGDKTIIQVYEETGGVRPGEPCVTTGMSLAVELGPGLL
SSIYDGVQRPLHVLLERTGGFIGRGVTADGLDHKKLWEFKPVVKKGDRVIGGDVIGVVQETVNIEHKIMVRPDISGTVAD
IKSGSFTVVDTICTLTDGTELQMMQRWPVRKPRPVKRKLTPEKPLVTGQRILDGLFPVAKGGTAAIPGPFGSGKTVTQQQ
LSKWSDTEIVVYIGCGERGNEMADVLWEFPELEDPQTGRPLMERTILVANTSNMPVAAREASVYTGMTLAEYFRDMGYDV
SLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAETLCGEKGSITAIGAVSPPGGDFSEPVTQNTL
RIVKVFWALDAKLSQKRHFPAINWLNSYSLYKEDLNDWFTENVAPDYVPMRERAMDMLQTESELQEIVQLVGSDALPEEQ
QLLLEITRMIREIFLQQNAFHPIDTYSPFEKQYKIMKAIMKWGDAAMDALKSGVLSSEILKMQSKDELPKVKFEEDFEGS
LNAVLAKMDKEFAALGGK

Sequences:

>Translated_578_residues
MEVKGEIYRVAGPVVTAIGLDAKMYDLCKVGNEGLMGEVIQIVGDKTIIQVYEETGGVRPGEPCVTTGMSLAVELGPGLL
SSIYDGVQRPLHVLLERTGGFIGRGVTADGLDHKKLWEFKPVVKKGDRVIGGDVIGVVQETVNIEHKIMVRPDISGTVAD
IKSGSFTVVDTICTLTDGTELQMMQRWPVRKPRPVKRKLTPEKPLVTGQRILDGLFPVAKGGTAAIPGPFGSGKTVTQQQ
LSKWSDTEIVVYIGCGERGNEMADVLWEFPELEDPQTGRPLMERTILVANTSNMPVAAREASVYTGMTLAEYFRDMGYDV
SLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAETLCGEKGSITAIGAVSPPGGDFSEPVTQNTL
RIVKVFWALDAKLSQKRHFPAINWLNSYSLYKEDLNDWFTENVAPDYVPMRERAMDMLQTESELQEIVQLVGSDALPEEQ
QLLLEITRMIREIFLQQNAFHPIDTYSPFEKQYKIMKAIMKWGDAAMDALKSGVLSSEILKMQSKDELPKVKFEEDFEGS
LNAVLAKMDKEFAALGGK
>Mature_578_residues
MEVKGEIYRVAGPVVTAIGLDAKMYDLCKVGNEGLMGEVIQIVGDKTIIQVYEETGGVRPGEPCVTTGMSLAVELGPGLL
SSIYDGVQRPLHVLLERTGGFIGRGVTADGLDHKKLWEFKPVVKKGDRVIGGDVIGVVQETVNIEHKIMVRPDISGTVAD
IKSGSFTVVDTICTLTDGTELQMMQRWPVRKPRPVKRKLTPEKPLVTGQRILDGLFPVAKGGTAAIPGPFGSGKTVTQQQ
LSKWSDTEIVVYIGCGERGNEMADVLWEFPELEDPQTGRPLMERTILVANTSNMPVAAREASVYTGMTLAEYFRDMGYDV
SLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAETLCGEKGSITAIGAVSPPGGDFSEPVTQNTL
RIVKVFWALDAKLSQKRHFPAINWLNSYSLYKEDLNDWFTENVAPDYVPMRERAMDMLQTESELQEIVQLVGSDALPEEQ
QLLLEITRMIREIFLQQNAFHPIDTYSPFEKQYKIMKAIMKWGDAAMDALKSGVLSSEILKMQSKDELPKVKFEEDFEGS
LNAVLAKMDKEFAALGGK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=588, Percent_Identity=48.9795918367347, Blast_Score=554, Evalue=1e-158,
Organism=Homo sapiens, GI32189394, Length=327, Percent_Identity=29.6636085626911, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI19913428, Length=339, Percent_Identity=25.3687315634218, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI50345984, Length=450, Percent_Identity=26.2222222222222, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI4757810, Length=450, Percent_Identity=26.2222222222222, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI19913426, Length=243, Percent_Identity=27.9835390946502, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790170, Length=320, Percent_Identity=30, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790172, Length=244, Percent_Identity=27.8688524590164, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788251, Length=237, Percent_Identity=31.2236286919831, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17565854, Length=542, Percent_Identity=52.0295202952029, Blast_Score=555, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25144756, Length=375, Percent_Identity=27.4666666666667, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71988080, Length=439, Percent_Identity=26.4236902050114, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988063, Length=439, Percent_Identity=26.4236902050114, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17510931, Length=314, Percent_Identity=26.4331210191083, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71988074, Length=333, Percent_Identity=27.027027027027, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17570191, Length=239, Percent_Identity=27.6150627615063, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320016, Length=336, Percent_Identity=48.8095238095238, Blast_Score=319, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6322581, Length=331, Percent_Identity=30.8157099697885, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=239, Percent_Identity=28.8702928870293, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319370, Length=372, Percent_Identity=26.0752688172043, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583988, Length=539, Percent_Identity=52.8756957328386, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24583986, Length=539, Percent_Identity=52.8756957328386, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24583984, Length=539, Percent_Identity=52.8756957328386, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24583992, Length=590, Percent_Identity=48.9830508474576, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI20129479, Length=540, Percent_Identity=50.1851851851852, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI28574560, Length=304, Percent_Identity=32.8947368421053, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638766, Length=332, Percent_Identity=29.5180722891566, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281361666, Length=243, Percent_Identity=27.1604938271605, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646341, Length=243, Percent_Identity=27.1604938271605, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136796, Length=243, Percent_Identity=27.1604938271605, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24658560, Length=438, Percent_Identity=25.5707762557078, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005726
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 63884; Mature: 63884

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKGEIYRVAGPVVTAIGLDAKMYDLCKVGNEGLMGEVIQIVGDKTIIQVYEETGGVRP
CCCCCCEEEHHCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCC
GEPCVTTGMSLAVELGPGLLSSIYDGVQRPLHVLLERTGGFIGRGVTADGLDHKKLWEFK
CCCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHH
PVVKKGDRVIGGDVIGVVQETVNIEHKIMVRPDISGTVADIKSGSFTVVDTICTLTDGTE
HHHHCCCEEECCHHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCCEEEEHHHHHCCCCHH
LQMMQRWPVRKPRPVKRKLTPEKPLVTGQRILDGLFPVAKGGTAAIPGPFGSGKTVTQQQ
HHHHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
LSKWSDTEIVVYIGCGERGNEMADVLWEFPELEDPQTGRPLMERTILVANTSNMPVAARE
HHCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHHHCEEEEEECCCCCCEECC
ASVYTGMTLAEYFRDMGYDVSLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLSARLAE
CHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FYERAGVAETLCGEKGSITAIGAVSPPGGDFSEPVTQNTLRIVKVFWALDAKLSQKRHFP
HHHHCCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AINWLNSYSLYKEDLNDWFTENVAPDYVPMRERAMDMLQTESELQEIVQLVGSDALPEEQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
QLLLEITRMIREIFLQQNAFHPIDTYSPFEKQYKIMKAIMKWGDAAMDALKSGVLSSEIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
KMQSKDELPKVKFEEDFEGSLNAVLAKMDKEFAALGGK
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEVKGEIYRVAGPVVTAIGLDAKMYDLCKVGNEGLMGEVIQIVGDKTIIQVYEETGGVRP
CCCCCCEEEHHCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCC
GEPCVTTGMSLAVELGPGLLSSIYDGVQRPLHVLLERTGGFIGRGVTADGLDHKKLWEFK
CCCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHH
PVVKKGDRVIGGDVIGVVQETVNIEHKIMVRPDISGTVADIKSGSFTVVDTICTLTDGTE
HHHHCCCEEECCHHHHHHHHHHCCCEEEEECCCCCCCHHHCCCCCEEEEHHHHHCCCCHH
LQMMQRWPVRKPRPVKRKLTPEKPLVTGQRILDGLFPVAKGGTAAIPGPFGSGKTVTQQQ
HHHHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
LSKWSDTEIVVYIGCGERGNEMADVLWEFPELEDPQTGRPLMERTILVANTSNMPVAARE
HHCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHHHCEEEEEECCCCCCEECC
ASVYTGMTLAEYFRDMGYDVSLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLSARLAE
CHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FYERAGVAETLCGEKGSITAIGAVSPPGGDFSEPVTQNTLRIVKVFWALDAKLSQKRHFP
HHHHCCHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AINWLNSYSLYKEDLNDWFTENVAPDYVPMRERAMDMLQTESELQEIVQLVGSDALPEEQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
QLLLEITRMIREIFLQQNAFHPIDTYSPFEKQYKIMKAIMKWGDAAMDALKSGVLSSEIL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
KMQSKDELPKVKFEEDFEGSLNAVLAKMDKEFAALGGK
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]