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The map label for this gene is cobB [H]

Identifier: 21226615

GI number: 21226615

Start: 637715

End: 639211

Strand: Reverse

Name: cobB [H]

Synonym: MM_0513

Alternate gene names: 21226615

Gene position: 639211-637715 (Counterclockwise)

Preceding gene: 21226616

Following gene: 21226614

Centisome position: 15.6

GC content: 50.9

Gene sequence:

>1497_bases
ATGTCCCAAAGCAACCATCCGGGCGGAAAAGATGCCGGGAGCATTCCCAGAGTCCTGATTTCCGCAGACCGCTCTTCTTC
AGGCAAGACCACAATTTCCATGGGGCTCATGGCTGCCCTTGTCTCACGAGGGTATAAAGTCCAGCCTTTCAAGGTCGCCC
TTGACTATATCGACCCCAGTTACCATACCGAGATCACGGGCAGGTTCTGCAGGAACCTTGACGGATACCTTATGGATGAG
CACGGAATTCTTGATGTTTACACCCATGCCTGTGAAACCGGTGGTGGGGCCGATATTGCAATTATTGAAGGTGTTCGCGG
GCTTTTTGAGGGTTTTGAAAGTCTAAGCGACGTCGGGAGCACTGCCCAGATTGCAAAGATCCTTAAATGCCCTGTGGTTT
TCGTAATCAATGCTCGCAGCATTACACGCTCAGCTGCTGCTCTCATAGGCGGGTATAAGAACTTCGACCCCGATGTTGAG
ATCGCGGGAGTAATCCTCAATAATATCGGAGGCCGCCGCCACGCACAGAAGGCAAAAGAGGCAATAGAACATTATACCGG
CGTGCCTGTTTTAGGGATCATTCCAAGGGACCCTTCGATGCAGATTTCCATGCGGCACCTCGGGCTTATGCCGGCTCTGG
AAGGAAGGCGGAGGTTCGGAGACGGAGGGTTTGAGAACAGGCTACACGGCATTGAAGAGATTATCAATAAAGGAATTGAT
GTGGACCGTTTTCTGGGAATTGCAGAAAGTGCAAAACCTCTGACAGCCCTGGAAAACAGCATCTTTTCCCCTGCCGTAAA
TGAAAATTCTCAAAAGCCGAAGATAGGGGTTGCTCTTGATGAAGCTTTTAATTTCTACTACCGCGACAATATCGACCTCC
TGGAAATTGCAGGTGCTGAGATTGTTTACTTCAGCCCTGTAAATGACCCCGGGCTTCCTGAGGTTGACGGGCTTTACATA
GGAGGCGGCTACCCCGAACTTTTTGCAGCCGAACTTGAAGCCAACGAAACCATGCGGAAATCCATCAAAGAAGCTTCCGC
TGCAGGTATGCCCATATATGCCGAATGCGGAGGGCTCATGTACCTTACGGAAAAAATCAGCACCGGTGTCCCCGGGAAAG
GCACTTATCACGATGCTTCCATGCCAGAGTCCACCTATTCAATGGTCGGGGCTCTTCCGGGCCACACAATTATGGGACAG
ACAAGGGTTGTCAGTTACAATATCGGGACCCTTGCAAGGGACTGCCCTATAGGGAAAAAAGGCAACAGCTTCAAGGGGCA
CGAGTTCCACCACTCTGAAATCCTTGAAATTCCGGATGATGCGGAATTTGCAATAGCACTCACAAGGGGCACGGGGATAA
GAGGCGACAGGGACGGGCTTATAGTTAACAATACCATTGGCTCTTATGCCCACCTTCACGGAGTTGCATACAGGGAGCTT
GCCGGCTCTCTAGTCGAAGCTGCAAGAAAGTTCAGGGATTCCAGGGTTTCCAGCTAA

Upstream 100 bases:

>100_bases
TGAAAAAATAAATTCTTAAAAGCAGCATAACTGCAAAACTATCCGTAAAAACTACCTGTGCCGCAGTAAATAGAAAAACC
ACATCAGGGGTAGTGAAAAC

Downstream 100 bases:

>100_bases
AGAGCTGTGAGCAACTTGCCTCCTCTGCAGGTAGAAAAAACAATATTATATTAAGCCAGATTATTATACACCAGTTATTA
ATAAGAGCCGGATTTTTAAA

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSQSNHPGGKDAGSIPRVLISADRSSSGKTTISMGLMAALVSRGYKVQPFKVALDYIDPSYHTEITGRFCRNLDGYLMDE
HGILDVYTHACETGGGADIAIIEGVRGLFEGFESLSDVGSTAQIAKILKCPVVFVINARSITRSAAALIGGYKNFDPDVE
IAGVILNNIGGRRHAQKAKEAIEHYTGVPVLGIIPRDPSMQISMRHLGLMPALEGRRRFGDGGFENRLHGIEEIINKGID
VDRFLGIAESAKPLTALENSIFSPAVNENSQKPKIGVALDEAFNFYYRDNIDLLEIAGAEIVYFSPVNDPGLPEVDGLYI
GGGYPELFAAELEANETMRKSIKEASAAGMPIYAECGGLMYLTEKISTGVPGKGTYHDASMPESTYSMVGALPGHTIMGQ
TRVVSYNIGTLARDCPIGKKGNSFKGHEFHHSEILEIPDDAEFAIALTRGTGIRGDRDGLIVNNTIGSYAHLHGVAYREL
AGSLVEAARKFRDSRVSS

Sequences:

>Translated_498_residues
MSQSNHPGGKDAGSIPRVLISADRSSSGKTTISMGLMAALVSRGYKVQPFKVALDYIDPSYHTEITGRFCRNLDGYLMDE
HGILDVYTHACETGGGADIAIIEGVRGLFEGFESLSDVGSTAQIAKILKCPVVFVINARSITRSAAALIGGYKNFDPDVE
IAGVILNNIGGRRHAQKAKEAIEHYTGVPVLGIIPRDPSMQISMRHLGLMPALEGRRRFGDGGFENRLHGIEEIINKGID
VDRFLGIAESAKPLTALENSIFSPAVNENSQKPKIGVALDEAFNFYYRDNIDLLEIAGAEIVYFSPVNDPGLPEVDGLYI
GGGYPELFAAELEANETMRKSIKEASAAGMPIYAECGGLMYLTEKISTGVPGKGTYHDASMPESTYSMVGALPGHTIMGQ
TRVVSYNIGTLARDCPIGKKGNSFKGHEFHHSEILEIPDDAEFAIALTRGTGIRGDRDGLIVNNTIGSYAHLHGVAYREL
AGSLVEAARKFRDSRVSS
>Mature_497_residues
SQSNHPGGKDAGSIPRVLISADRSSSGKTTISMGLMAALVSRGYKVQPFKVALDYIDPSYHTEITGRFCRNLDGYLMDEH
GILDVYTHACETGGGADIAIIEGVRGLFEGFESLSDVGSTAQIAKILKCPVVFVINARSITRSAAALIGGYKNFDPDVEI
AGVILNNIGGRRHAQKAKEAIEHYTGVPVLGIIPRDPSMQISMRHLGLMPALEGRRRFGDGGFENRLHGIEEIINKGIDV
DRFLGIAESAKPLTALENSIFSPAVNENSQKPKIGVALDEAFNFYYRDNIDLLEIAGAEIVYFSPVNDPGLPEVDGLYIG
GGYPELFAAELEANETMRKSIKEASAAGMPIYAECGGLMYLTEKISTGVPGKGTYHDASMPESTYSMVGALPGHTIMGQT
RVVSYNIGTLARDCPIGKKGNSFKGHEFHHSEILEIPDDAEFAIALTRGTGIRGDRDGLIVNNTIGSYAHLHGVAYRELA
GSLVEAARKFRDSRVSS

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 53615; Mature: 53483

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSNHPGGKDAGSIPRVLISADRSSSGKTTISMGLMAALVSRGYKVQPFKVALDYIDPS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEECCCCC
YHTEITGRFCRNLDGYLMDEHGILDVYTHACETGGGADIAIIEGVRGLFEGFESLSDVGS
CCHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
TAQIAKILKCPVVFVINARSITRSAAALIGGYKNFDPDVEIAGVILNNIGGRRHAQKAKE
HHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHH
AIEHYTGVPVLGIIPRDPSMQISMRHLGLMPALEGRRRFGDGGFENRLHGIEEIINKGID
HHHHHCCCCEEEEECCCCCCEEEHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCC
VDRFLGIAESAKPLTALENSIFSPAVNENSQKPKIGVALDEAFNFYYRDNIDLLEIAGAE
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHCEEECCCCCEEEECCCE
IVYFSPVNDPGLPEVDGLYIGGGYPELFAAELEANETMRKSIKEASAAGMPIYAECGGLM
EEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCEE
YLTEKISTGVPGKGTYHDASMPESTYSMVGALPGHTIMGQTRVVSYNIGTLARDCPIGKK
EEEHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCEEEEEEECCHHHHCCCCCCC
GNSFKGHEFHHSEILEIPDDAEFAIALTRGTGIRGDRDGLIVNNTIGSYAHLHGVAYREL
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHH
AGSLVEAARKFRDSRVSS
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQSNHPGGKDAGSIPRVLISADRSSSGKTTISMGLMAALVSRGYKVQPFKVALDYIDPS
CCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCHHEEEEECCCCC
YHTEITGRFCRNLDGYLMDEHGILDVYTHACETGGGADIAIIEGVRGLFEGFESLSDVGS
CCHHHHHHHHCCCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
TAQIAKILKCPVVFVINARSITRSAAALIGGYKNFDPDVEIAGVILNNIGGRRHAQKAKE
HHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHH
AIEHYTGVPVLGIIPRDPSMQISMRHLGLMPALEGRRRFGDGGFENRLHGIEEIINKGID
HHHHHCCCCEEEEECCCCCCEEEHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCC
VDRFLGIAESAKPLTALENSIFSPAVNENSQKPKIGVALDEAFNFYYRDNIDLLEIAGAE
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHCEEECCCCCEEEECCCE
IVYFSPVNDPGLPEVDGLYIGGGYPELFAAELEANETMRKSIKEASAAGMPIYAECGGLM
EEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCEE
YLTEKISTGVPGKGTYHDASMPESTYSMVGALPGHTIMGQTRVVSYNIGTLARDCPIGKK
EEEHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCEEEEEEECCHHHHCCCCCCC
GNSFKGHEFHHSEILEIPDDAEFAIALTRGTGIRGDRDGLIVNNTIGSYAHLHGVAYREL
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHH
AGSLVEAARKFRDSRVSS
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA