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The map label for this gene is lhr [C]

Identifier: 21226527

GI number: 21226527

Start: 539592

End: 541784

Strand: Reverse

Name: lhr [C]

Synonym: MM_0425

Alternate gene names: 21226527

Gene position: 541784-539592 (Counterclockwise)

Preceding gene: 21226528

Following gene: 21226526

Centisome position: 13.23

GC content: 48.52

Gene sequence:

>2193_bases
ATGAAGATAGAAAGCCTCGACCTGCCCGATGAAATAAAGCGCTTTTACGAAAACTCCGGGATTCTTGAACTTTATCCGCC
ACAGGCAGAAGCTGTTGAGAAAGGCCTGCTTGAAGGAAAAAACCTGCTTGCTGCAATTCCTACGGCTTCGGGAAAGACTC
TTCTTGCCGAGCTTGCGATGTTGAAGTCTGTGCTTAATGGAGGAAAGGCACTCTATATCGTGCCCCTGAGAGCTCTTGCT
TCCGAGAAATTCAGGCGGTTTCAGGAATTTTCCGTACTGGGCATGAGGGTCGGGATTTCAACAGGAGACTACGACAGGCG
AGACGAAGGGCTCGGCATAAATGATATTATTGTTGCAACCTCTGAAAAAACAGATTCCCTGCTCAGGAACGAGACTGCCT
GGATGCAGGAGATCTCTGTTGTTGTGGCAGATGAAGTTCACCTTATTGATTCTCCAGACAGGGGTCCGACGCTTGAAATC
ACCCTTTCAAAGCTCAGGCGAATGAACCCTTCCTGTCAGGTCCTTGCACTTTCGGCAACAGTAGGAAATGCCGATGAGCT
TGCAGCCTGGCTTGATGCCGAACTTGTATTAAGCGAGTGGAGGCCCACCGACCTTATGGAAGGGGTGTTTTATAACGGGA
TTTTTTACTGCAAGGATAAGGAGAAGCCTGTTGGGCAGCCAACAAAAGATGAGGCAGTAAACCTGGTTCTCGATACTATA
AAGGAAGGAGGACAGTGCCTTGTTTTCGAGAGCAGCAGGAAGAACTGCATGGGTTTTGCAAAAAAAGCAGTTTCTGCAGT
AAAAAAGACTCTTTCTAATGAAGACCGTGAAACTCTTGCAGGCATTGCTGACGAGATCATTGAAAACAGTGAAACCGATG
TTTCATCAGTTCTTGCCACCTGTGTCCGTTCAGGGACAGCATTCCACCACGCAGGCCTTACAACGCCTTTGAGGGAGCTT
GTAGAAAACGGCTTTCGTGAAGGGCGTATAAAAATTATTTCAAGCACTCCTACCCTTGCAGCAGGGTTGAACCTTCCTGC
CAGGCGTGTGATAATAAGGAGTTACCGGCGTTACTCTTCAGATTCGGGCATGCAGCCAATCCCGGTACTTGAATACAAGC
AGATGGCAGGAAGGGCAGGGAGGCCGAGGCTTGACCCTTACGGAGAAGCTGTCCTGCTTGCAAAGTCTTACGAGGAGTTT
GTCTTCCTTTTCGAAAAATACATCGAAGCCGGAGCTGAAGATATATGGTCCAAGCTGGGTACGGAAAATGCCCTCAGGAC
GCATATACTTTCTACGATCTCGAACGGGTTTGCCCGGACAAGGGAAGAACTCATGGATTTCCTCGAGGCAACATTTTTCG
CTTTCCAGTACTCAAACTTCGGGCTCTCCGCGGTTGTGGACGAATGCCTGGACTTTTTGAGGCGGGAAGGTATGCTTGAA
AAAGACCCCGATGCCCTTGTTTCCACGGTTTTCGGAAAACTCGTATCAAGGCTCTACATCGACCCTCTCTCTGCAGCTCT
TATTGCAAAGGGCTTGAGGGAAGCAGGTACCCTTACCGAGCTTACCCTTCTGCACCTGATATGCAGCACTCCGGATATGC
GTCTTATGTATATGCGGAGCCAGGACTACCAGGAAGTCAACGACTACGTAATGGCTCACGCAGGCGAGTTTTCAAAGGTT
CCGAATCCCTTCAATATCGCCGAGTACGAGTGGTTCCTTGGTGAGGTAAAGACCTCTCTCCTTCTGATGGACTGGATACA
TGAGAAGCCTGAAAACGAGATCTGTCTGAAGTTCGGGATAGGGGAAGGTGATATCCATGCAACTGCAGATATTGCCGAAT
GGATAATGCATGTTACAGCCCAGCTTGCAGGACTTCTCGACCTTAAAGGTGCAAAAGAAGCCTCAGAACTGGAAAAGAGG
ATCAGGTATGGAGCAGCCCCGGAACTTATGGACCTGCTTGATATCAGAAGTGTGGGGCGCGTGAGAGCAAGAAAACTTTA
TGAGGCAGGCTTTAAGTCCACAGCTGAACTCGCAGCAGCTTCTCCTGAACATATAGCCGTACTTGTAGGACCAAAGATTA
CTGAAAGGATTTTCAAGCAGATCGGACGTAGAGAAGCGGTATCTGAATTTTCTGATATTGAGCCTCTGGAAAAAGGTTCT
TCCGATGGGCAGAGGACAATTAGTGATTATTGA

Upstream 100 bases:

>100_bases
TTTACTCAATGAAAACCTCAACCTTTTCAGGGGAACAGCTCCGGCATTTGCACTGCGGTTTCAAAATAGTTTTATCTTAT
GTGTGAGTTTCTGATTTTCA

Downstream 100 bases:

>100_bases
TTCTGACTAATGATTACCGGTTACTTTGAGCTTTCTTTCATGTTTTTTAATTTATTGCTTTTTGGGATTAATTGTTTTCT
CTATCCCTGAGTTCCGAGAG

Product: ski2-like helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 730; Mature: 730

Protein sequence:

>730_residues
MKIESLDLPDEIKRFYENSGILELYPPQAEAVEKGLLEGKNLLAAIPTASGKTLLAELAMLKSVLNGGKALYIVPLRALA
SEKFRRFQEFSVLGMRVGISTGDYDRRDEGLGINDIIVATSEKTDSLLRNETAWMQEISVVVADEVHLIDSPDRGPTLEI
TLSKLRRMNPSCQVLALSATVGNADELAAWLDAELVLSEWRPTDLMEGVFYNGIFYCKDKEKPVGQPTKDEAVNLVLDTI
KEGGQCLVFESSRKNCMGFAKKAVSAVKKTLSNEDRETLAGIADEIIENSETDVSSVLATCVRSGTAFHHAGLTTPLREL
VENGFREGRIKIISSTPTLAAGLNLPARRVIIRSYRRYSSDSGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLLAKSYEEF
VFLFEKYIEAGAEDIWSKLGTENALRTHILSTISNGFARTREELMDFLEATFFAFQYSNFGLSAVVDECLDFLRREGMLE
KDPDALVSTVFGKLVSRLYIDPLSAALIAKGLREAGTLTELTLLHLICSTPDMRLMYMRSQDYQEVNDYVMAHAGEFSKV
PNPFNIAEYEWFLGEVKTSLLLMDWIHEKPENEICLKFGIGEGDIHATADIAEWIMHVTAQLAGLLDLKGAKEASELEKR
IRYGAAPELMDLLDIRSVGRVRARKLYEAGFKSTAELAAASPEHIAVLVGPKITERIFKQIGRREAVSEFSDIEPLEKGS
SDGQRTISDY

Sequences:

>Translated_730_residues
MKIESLDLPDEIKRFYENSGILELYPPQAEAVEKGLLEGKNLLAAIPTASGKTLLAELAMLKSVLNGGKALYIVPLRALA
SEKFRRFQEFSVLGMRVGISTGDYDRRDEGLGINDIIVATSEKTDSLLRNETAWMQEISVVVADEVHLIDSPDRGPTLEI
TLSKLRRMNPSCQVLALSATVGNADELAAWLDAELVLSEWRPTDLMEGVFYNGIFYCKDKEKPVGQPTKDEAVNLVLDTI
KEGGQCLVFESSRKNCMGFAKKAVSAVKKTLSNEDRETLAGIADEIIENSETDVSSVLATCVRSGTAFHHAGLTTPLREL
VENGFREGRIKIISSTPTLAAGLNLPARRVIIRSYRRYSSDSGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLLAKSYEEF
VFLFEKYIEAGAEDIWSKLGTENALRTHILSTISNGFARTREELMDFLEATFFAFQYSNFGLSAVVDECLDFLRREGMLE
KDPDALVSTVFGKLVSRLYIDPLSAALIAKGLREAGTLTELTLLHLICSTPDMRLMYMRSQDYQEVNDYVMAHAGEFSKV
PNPFNIAEYEWFLGEVKTSLLLMDWIHEKPENEICLKFGIGEGDIHATADIAEWIMHVTAQLAGLLDLKGAKEASELEKR
IRYGAAPELMDLLDIRSVGRVRARKLYEAGFKSTAELAAASPEHIAVLVGPKITERIFKQIGRREAVSEFSDIEPLEKGS
SDGQRTISDY
>Mature_730_residues
MKIESLDLPDEIKRFYENSGILELYPPQAEAVEKGLLEGKNLLAAIPTASGKTLLAELAMLKSVLNGGKALYIVPLRALA
SEKFRRFQEFSVLGMRVGISTGDYDRRDEGLGINDIIVATSEKTDSLLRNETAWMQEISVVVADEVHLIDSPDRGPTLEI
TLSKLRRMNPSCQVLALSATVGNADELAAWLDAELVLSEWRPTDLMEGVFYNGIFYCKDKEKPVGQPTKDEAVNLVLDTI
KEGGQCLVFESSRKNCMGFAKKAVSAVKKTLSNEDRETLAGIADEIIENSETDVSSVLATCVRSGTAFHHAGLTTPLREL
VENGFREGRIKIISSTPTLAAGLNLPARRVIIRSYRRYSSDSGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLLAKSYEEF
VFLFEKYIEAGAEDIWSKLGTENALRTHILSTISNGFARTREELMDFLEATFFAFQYSNFGLSAVVDECLDFLRREGMLE
KDPDALVSTVFGKLVSRLYIDPLSAALIAKGLREAGTLTELTLLHLICSTPDMRLMYMRSQDYQEVNDYVMAHAGEFSKV
PNPFNIAEYEWFLGEVKTSLLLMDWIHEKPENEICLKFGIGEGDIHATADIAEWIMHVTAQLAGLLDLKGAKEASELEKR
IRYGAAPELMDLLDIRSVGRVRARKLYEAGFKSTAELAAASPEHIAVLVGPKITERIFKQIGRREAVSEFSDIEPLEKGS
SDGQRTISDY

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain

Homologues:

Organism=Homo sapiens, GI110556640, Length=782, Percent_Identity=29.2838874680307, Blast_Score=236, Evalue=9e-62,
Organism=Homo sapiens, GI139394648, Length=492, Percent_Identity=32.7235772357724, Blast_Score=206, Evalue=6e-53,
Organism=Homo sapiens, GI76880486, Length=530, Percent_Identity=27.7358490566038, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI130484567, Length=399, Percent_Identity=29.5739348370927, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI169218225, Length=405, Percent_Identity=31.358024691358, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI40217847, Length=410, Percent_Identity=30.9756097560976, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI67782311, Length=406, Percent_Identity=29.064039408867, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI193211480, Length=418, Percent_Identity=26.7942583732057, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI222831595, Length=276, Percent_Identity=24.2753623188406, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1787942, Length=389, Percent_Identity=23.6503856041131, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71995032, Length=745, Percent_Identity=26.8456375838926, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI86563272, Length=548, Percent_Identity=29.7445255474453, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17537127, Length=614, Percent_Identity=27.6872964169381, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17542826, Length=441, Percent_Identity=27.6643990929705, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17537519, Length=562, Percent_Identity=26.6903914590747, Blast_Score=139, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI133930973, Length=461, Percent_Identity=27.9826464208243, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71995036, Length=432, Percent_Identity=27.7777777777778, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321020, Length=596, Percent_Identity=26.8456375838926, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321710, Length=527, Percent_Identity=27.3244781783681, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI9755332, Length=584, Percent_Identity=28.5958904109589, Blast_Score=161, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322411, Length=413, Percent_Identity=27.8450363196126, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323430, Length=192, Percent_Identity=31.25, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17933644, Length=754, Percent_Identity=28.5145888594164, Blast_Score=230, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24660651, Length=781, Percent_Identity=28.169014084507, Blast_Score=196, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24647182, Length=436, Percent_Identity=30.7339449541284, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28574898, Length=435, Percent_Identity=29.1954022988506, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17864608, Length=414, Percent_Identity=29.7101449275362, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17933658, Length=99, Percent_Identity=38.3838383838384, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HELS_METMA (Q8PZR7)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632449.1
- ProteinModelPortal:   Q8PZR7
- SMR:   Q8PZR7
- GeneID:   1478767
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0425
- NMPDR:   fig|192952.1.peg.425
- HOGENOM:   HBG496908
- OMA:   FLERTFY
- ProtClustDB:   PRK02362
- BioCyc:   MMAZ192952:MM0425-MONOMER
- HAMAP:   MF_00442
- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR010994
- SMART:   SM00487
- SMART:   SM00490

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; SSF47781 RuvA_2_like

EC number: 3.6.1.-

Molecular weight: Translated: 81075; Mature: 81075

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIESLDLPDEIKRFYENSGILELYPPQAEAVEKGLLEGKNLLAAIPTASGKTLLAELAM
CCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHH
LKSVLNGGKALYIVPLRALASEKFRRFQEFSVLGMRVGISTGDYDRRDEGLGINDIIVAT
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEEE
SEKTDSLLRNETAWMQEISVVVADEVHLIDSPDRGPTLEITLSKLRRMNPSCQVLALSAT
CCHHHHHHHHHHHHHHHHHHHEECCEEEECCCCCCCEEEEEHHHHHCCCCCCEEEEEEEC
VGNADELAAWLDAELVLSEWRPTDLMEGVFYNGIFYCKDKEKPVGQPTKDEAVNLVLDTI
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHH
KEGGQCLVFESSRKNCMGFAKKAVSAVKKTLSNEDRETLAGIADEIIENSETDVSSVLAT
HCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
CVRSGTAFHHAGLTTPLRELVENGFREGRIKIISSTPTLAAGLNLPARRVIIRSYRRYSS
HHHCCCCHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHCC
DSGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLLAKSYEEFVFLFEKYIEAGAEDIWSKLG
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHC
TENALRTHILSTISNGFARTREELMDFLEATFFAFQYSNFGLSAVVDECLDFLRREGMLE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
KDPDALVSTVFGKLVSRLYIDPLSAALIAKGLREAGTLTELTLLHLICSTPDMRLMYMRS
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECC
QDYQEVNDYVMAHAGEFSKVPNPFNIAEYEWFLGEVKTSLLLMDWIHEKPENEICLKFGI
CCHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
GEGDIHATADIAEWIMHVTAQLAGLLDLKGAKEASELEKRIRYGAAPELMDLLDIRSVGR
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRARKLYEAGFKSTAELAAASPEHIAVLVGPKITERIFKQIGRREAVSEFSDIEPLEKGS
HHHHHHHHHCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
SDGQRTISDY
CCCCCCCCCC
>Mature Secondary Structure
MKIESLDLPDEIKRFYENSGILELYPPQAEAVEKGLLEGKNLLAAIPTASGKTLLAELAM
CCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHH
LKSVLNGGKALYIVPLRALASEKFRRFQEFSVLGMRVGISTGDYDRRDEGLGINDIIVAT
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEEE
SEKTDSLLRNETAWMQEISVVVADEVHLIDSPDRGPTLEITLSKLRRMNPSCQVLALSAT
CCHHHHHHHHHHHHHHHHHHHEECCEEEECCCCCCCEEEEEHHHHHCCCCCCEEEEEEEC
VGNADELAAWLDAELVLSEWRPTDLMEGVFYNGIFYCKDKEKPVGQPTKDEAVNLVLDTI
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHH
KEGGQCLVFESSRKNCMGFAKKAVSAVKKTLSNEDRETLAGIADEIIENSETDVSSVLAT
HCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
CVRSGTAFHHAGLTTPLRELVENGFREGRIKIISSTPTLAAGLNLPARRVIIRSYRRYSS
HHHCCCCHHHCCCCHHHHHHHHCCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHCC
DSGMQPIPVLEYKQMAGRAGRPRLDPYGEAVLLAKSYEEFVFLFEKYIEAGAEDIWSKLG
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHC
TENALRTHILSTISNGFARTREELMDFLEATFFAFQYSNFGLSAVVDECLDFLRREGMLE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
KDPDALVSTVFGKLVSRLYIDPLSAALIAKGLREAGTLTELTLLHLICSTPDMRLMYMRS
CCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECC
QDYQEVNDYVMAHAGEFSKVPNPFNIAEYEWFLGEVKTSLLLMDWIHEKPENEICLKFGI
CCHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
GEGDIHATADIAEWIMHVTAQLAGLLDLKGAKEASELEKRIRYGAAPELMDLLDIRSVGR
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRARKLYEAGFKSTAELAAASPEHIAVLVGPKITERIFKQIGRREAVSEFSDIEPLEKGS
HHHHHHHHHCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
SDGQRTISDY
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824