Click here to switch to the map view.

The map label for this gene is hisD

Identifier: 21226526

GI number: 21226526

Start: 537677

End: 538978

Strand: Reverse

Name: hisD

Synonym: MM_0424

Alternate gene names: 21226526

Gene position: 538978-537677 (Counterclockwise)

Preceding gene: 21226527

Following gene: 21226525

Centisome position: 13.16

GC content: 47.24

Gene sequence:

>1302_bases
ATGATTATAATGTTATTCAAAAAGTTGTCTGATGTTTCGGAAGCTGAAATGCAGAGGTTAATTTCCCGGGGGTCCGGGCT
TGCAGATGTTGGAGATACCGTATCAGCCGTACTTTCTGACGTGCGCATGAAAGGAGATGCTGCCCTCAGGGAGTATACAA
AAAAGTTCGATAAAGTTGAACTTGCAAATTTTGAGGTAAGTGAAGAAGAGTTTGAAAAAGCTCTCTCCGAGATCGGTTCG
GAACTGCTTGGACACCTTAGAATTGCAGCTGAAAATATTCGGGCTTTCCACAGGGCTCAGATGCCTGAAACTACCTGGTT
TATGGAACTTCAGCCCGGGGTTGTCCTCGGGCAGAAGGCAACACCCCTTGAAAGTGTAGGGGCTTATGCTCCCGGAGGGA
GGGCTTCCTATCCATCGACTGTATTGATGACAGTAATCCCTGCCAGGGTTGCAGGAGTTGAGCAGGTTATTGTGTGTACT
CCTCCCAGGGCTGACGGTTCCGTACACCCTCTTACCCTTGCTGCTGCAAAGGTTGCAGGTGCGGATAAGGTTTTCAAGCT
CGGGGGAGTGCAGGCAATAGGGGCTATGGCTTACGGGACTGAAACCGTTCCCAGGGTGGACAAAATTGTCGGTCCAGGAA
ATGTTTTTGTGACCTCTGCCAAAATGCAGGTAAGGGATATTGCTGAGATTGATTTTCCGGCAGGTCCGAGTGAGGTCCTT
ATCATAGCAGACGAGTCTGCAGATGCTGCTATGGCTGCTTCGGATATTATAGCCCAGGCAGAACATGACCCGAATGCGGT
TTCCGTGCTTGTGACGACTTCGGAAACTCTTGCAGAAGAAGTGGAGCAGGAAGTGCTCGCCCAGGCCGAAAGTACTGCAA
GGAGTGAAATTGTGAAAATTTCTCTTGAAAATGCAGCAGTTCTGATTGCAGACTCTCTTGATCAGTGCATTGACTTTAGC
AATAAATTTGCACCTGAGCACCTTGAAATTATGGTGGAAGATTCCGATTTTGTGCTTGACAGAATTAAAAATGCAGGATC
GATATTTATAGGGAACTATGCTCCTGTTCCTGTCGGAGACTACGCTTCCGGTACCAATCATGTGCTTCCTACGGCAGGGT
ATGCGAAGATCTATTCCGGGCTGAACATAAATCACTTCCTCAAGTATTCCAGTATACAGAAAATCAGCAAGAGTGGGCTT
GAAAGTTTGAAAGAAACTGTAATCGCATTAGCTGAGGAAGAAGGTTTGAAGGCACATGCTGACTCTATCAGGGCTCGTTT
CGGATACAGACCCTCTAAATAA

Upstream 100 bases:

>100_bases
GATTTAATGAGAGCAGATTATATCAGATTCTAAATTAGTACCGAATTTATTCAATCCGATCAGGATCAATTATATTCAGT
TTTATTGGGTAATCTCAGAG

Downstream 100 bases:

>100_bases
TATTTCTGCTAATCGATACGTATATAAAATGTTAATGCGTAAACAAAATTTGATTTTTAAATAAATAAAAATTTAATTCG
TAAATAATGAGTGGGGACTA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MIIMLFKKLSDVSEAEMQRLISRGSGLADVGDTVSAVLSDVRMKGDAALREYTKKFDKVELANFEVSEEEFEKALSEIGS
ELLGHLRIAAENIRAFHRAQMPETTWFMELQPGVVLGQKATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCT
PPRADGSVHPLTLAAAKVAGADKVFKLGGVQAIGAMAYGTETVPRVDKIVGPGNVFVTSAKMQVRDIAEIDFPAGPSEVL
IIADESADAAMAASDIIAQAEHDPNAVSVLVTTSETLAEEVEQEVLAQAESTARSEIVKISLENAAVLIADSLDQCIDFS
NKFAPEHLEIMVEDSDFVLDRIKNAGSIFIGNYAPVPVGDYASGTNHVLPTAGYAKIYSGLNINHFLKYSSIQKISKSGL
ESLKETVIALAEEEGLKAHADSIRARFGYRPSK

Sequences:

>Translated_433_residues
MIIMLFKKLSDVSEAEMQRLISRGSGLADVGDTVSAVLSDVRMKGDAALREYTKKFDKVELANFEVSEEEFEKALSEIGS
ELLGHLRIAAENIRAFHRAQMPETTWFMELQPGVVLGQKATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCT
PPRADGSVHPLTLAAAKVAGADKVFKLGGVQAIGAMAYGTETVPRVDKIVGPGNVFVTSAKMQVRDIAEIDFPAGPSEVL
IIADESADAAMAASDIIAQAEHDPNAVSVLVTTSETLAEEVEQEVLAQAESTARSEIVKISLENAAVLIADSLDQCIDFS
NKFAPEHLEIMVEDSDFVLDRIKNAGSIFIGNYAPVPVGDYASGTNHVLPTAGYAKIYSGLNINHFLKYSSIQKISKSGL
ESLKETVIALAEEEGLKAHADSIRARFGYRPSK
>Mature_433_residues
MIIMLFKKLSDVSEAEMQRLISRGSGLADVGDTVSAVLSDVRMKGDAALREYTKKFDKVELANFEVSEEEFEKALSEIGS
ELLGHLRIAAENIRAFHRAQMPETTWFMELQPGVVLGQKATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCT
PPRADGSVHPLTLAAAKVAGADKVFKLGGVQAIGAMAYGTETVPRVDKIVGPGNVFVTSAKMQVRDIAEIDFPAGPSEVL
IIADESADAAMAASDIIAQAEHDPNAVSVLVTTSETLAEEVEQEVLAQAESTARSEIVKISLENAAVLIADSLDQCIDFS
NKFAPEHLEIMVEDSDFVLDRIKNAGSIFIGNYAPVPVGDYASGTNHVLPTAGYAKIYSGLNINHFLKYSSIQKISKSGL
ESLKETVIALAEEEGLKAHADSIRARFGYRPSK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=432, Percent_Identity=42.5925925925926, Blast_Score=330, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6319819, Length=421, Percent_Identity=42.5178147268409, Blast_Score=344, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_METMA (Q8PZR8)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632448.1
- ProteinModelPortal:   Q8PZR8
- SMR:   Q8PZR8
- GeneID:   1478766
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0424
- NMPDR:   fig|192952.1.peg.424
- HOGENOM:   HBG329596
- OMA:   YVLYVAK
- ProtClustDB:   PRK00877
- BioCyc:   MMAZ192952:MM0424-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46324; Mature: 46324

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 326-326 ACT_SITE 327-327 BINDING 129-129 BINDING 191-191 BINDING 214-214 BINDING 237-237 BINDING 259-259 BINDING 262-262 BINDING 327-327 BINDING 360-360 BINDING 414-414 BINDING 419-419

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIMLFKKLSDVSEAEMQRLISRGSGLADVGDTVSAVLSDVRMKGDAALREYTKKFDKVE
CEEEEEHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
LANFEVSEEEFEKALSEIGSELLGHLRIAAENIRAFHRAQMPETTWFMELQPGVVLGQKA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCC
TPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCTPPRADGSVHPLTLAAAKVAG
CCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHCC
ADKVFKLGGVQAIGAMAYGTETVPRVDKIVGPGNVFVTSAKMQVRDIAEIDFPAGPSEVL
CCHHHHHCCHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEE
IIADESADAAMAASDIIAQAEHDPNAVSVLVTTSETLAEEVEQEVLAQAESTARSEIVKI
EEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHEEEE
SLENAAVLIADSLDQCIDFSNKFAPEHLEIMVEDSDFVLDRIKNAGSIFIGNYAPVPVGD
EECCCEEEEEHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCCCCC
YASGTNHVLPTAGYAKIYSGLNINHFLKYSSIQKISKSGLESLKETVIALAEEEGLKAHA
CCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DSIRARFGYRPSK
HHHHHHCCCCCCC
>Mature Secondary Structure
MIIMLFKKLSDVSEAEMQRLISRGSGLADVGDTVSAVLSDVRMKGDAALREYTKKFDKVE
CEEEEEHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
LANFEVSEEEFEKALSEIGSELLGHLRIAAENIRAFHRAQMPETTWFMELQPGVVLGQKA
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCC
TPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCTPPRADGSVHPLTLAAAKVAG
CCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHCC
ADKVFKLGGVQAIGAMAYGTETVPRVDKIVGPGNVFVTSAKMQVRDIAEIDFPAGPSEVL
CCHHHHHCCHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEE
IIADESADAAMAASDIIAQAEHDPNAVSVLVTTSETLAEEVEQEVLAQAESTARSEIVKI
EEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHEEEE
SLENAAVLIADSLDQCIDFSNKFAPEHLEIMVEDSDFVLDRIKNAGSIFIGNYAPVPVGD
EECCCEEEEEHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCCCCC
YASGTNHVLPTAGYAKIYSGLNINHFLKYSSIQKISKSGLESLKETVIALAEEEGLKAHA
CCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DSIRARFGYRPSK
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824