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The map label for this gene is hdrA2 [H]

Identifier: 21226489

GI number: 21226489

Start: 496300

End: 498717

Strand: Direct

Name: hdrA2 [H]

Synonym: MM_0387

Alternate gene names: 21226489

Gene position: 496300-498717 (Clockwise)

Preceding gene: 21226486

Following gene: 21226490

Centisome position: 12.12

GC content: 47.6

Gene sequence:

>2418_bases
ATGACTGACGGGACTACTGACGGGTTGAACAAAGCTGCTGTATTTATCTGCCACTGCAGCGGGAATATCTCGGAACACGT
TGATATCAATACAGTGAAAAAGACCCTAAAGGCAGAAGGTTTTTCAGTTTATGATTATGAATACCTGTGTTCAAGCCAGG
GACAGGCTCTGATTAAAAAGAAAATTTCGGAAGGGCATGTGGACAGGGTGGTAATAGGTTCATGTACTCCTTCCAAACAC
GGCACTCTTTTCAAAAAGTGCATACAGGAAACCGGATTGAACAGGGCAGGGCTTGAGATTGCAAACCTGAGGGAACAGTG
TGCCTGGGTGCACCCTGACAGAGAAGGAGCTACTGAAAAAGCTCTCTCCCTCCTTAAAGCCAAGCTGAAGCGCCTGGAAA
ACATAGAGCCGCTGGAAGATATAAAAGTAGACATTGCCCAGCAGGTTCTTGTTATCGGCGGAGGGATTGCAGGGATCACG
GCTGCTCTTAACCTTGCAGATAACGGGGTTCCCACTTTCCTTGTGGAGAAAGACTCAAGCATAGGCGGGCAGATGGCTAA
AATCGGGAAAATCTTTTCTCCTGATAAGCTTGCGGAAGAGTGTGCGATGTGCTCGCTCAGCCCCCTTATGAATGAGGTTG
CAGCCCACCCAAGGATTACTCTTTTGACCTGGACGGAAGTAGAAAAGCTTAGCGGAAGTGCAGGAAACTTTACTGTCAGG
CTAAAAAAGAAACCGAGATATGTGAAAGACAACTGTATAGCATGTGGGAAGTGCAGCAGGGTCTGTCCTGTCTCTGTTGA
AGACGAGTTCAACTGCGGCTATATGGACAAAAAGGCAATTTCTCTTCGTTTCTCTCAGTCAGTCCCAAAGGTTTACTTCA
TTGACCCTGACAGCTGCCTGCGGTTAAAAGGGGAAAACTGCGGAAAGTGTGCAGAAGCCTGCAAAACAGGAGCTATCGAT
TTCTCTCAGAAAGAAGAGATCATAGAACTGAATGTGGGTGCAGTTGTCGTTGCAACAGGCTTTGAAGAGTATGACGTTTC
CCAGAAACCCCAGTACGGGTATGGGATTTTTGAAAATGTTCTTACCCAGATGGAACTTGCAAGAGTCCTGGGCATCAACG
GACCTACAAAAGGGGAACTTCTCAGGATCTCCGATTTCAGCAAAGCTTCCAGCGACCCTGCTCCTTCAACATGTGATTCA
AGGTGCGAAAGCTCGTCTGATCATCCCTTTGAGGTTGAAACTCCAGAAAGGATAGTCATGATCCAGTGTGTTGGTTCAAG
GGACGAAAAGGAAGGAGGAAACCGCTACTGCTCAAGGTACTGCTGTATGGCAGCCCTGAAGCATGCAAGCCTGATAAAGA
AAAGGTATCCGAAAACGGAAATCACGATCTGCTATATTGACATGAGGGCTTTTGGCTTTTACGAAAACTACTACCGTGCA
GTCCAGGAGACCGGGGTTAACTTTGTGAGGGGAAGGCCTGCAGAAGTCATTGAAAAACCGGATAAGAGCCTTGTTGTAAG
GGTTGAAGACACCCTTAGCCAGAAAATAAAGGAAATCCCTGCCGACATGGTAGTACTTTCCGCAGCTATGGTACCATCTC
CGGGGACAAAGAAAATTGCCAGTGTGCTGAACCTCAGCCAGGACGAAAGCGGGTTCATCAAAGAGAGGCACTCCAAACTG
AAGCCGGTGGACTGTTCCCTTGATGGGATTTTTGTCTGCGGCACTGCTCAGAGCCCCAAGGATGTTACTGATACAATTGC
CCAGGCAGGACTTGCAGCCGTAAGAGCAAGGGCTTTCATTACAGACAGCCCGAAGGTGCTGGATAACGAAATTGCAGCCA
TAAACCAGCTACTCTGCACCCGGTGCGGGGAATGTCTTAAGTGCCCGTTTGATGCCCTTTCTATAAATGAAAATGGGAGG
GTTGTTCTTGACCCACTTATATGCACAGGCTGCGGGTACTGTACCGAACTCTGCAGGGAAGGAGCTGTCCAGATTGCAGG
TTTTACGAAATCCCAGCTAAAGGCTGAGTTAGAAGGCGTTCTTGAAGAAGGGGACGTACTTGGCTTTGTGAACAGCGGAA
TATCTTCCCTTACCTGTGACAATATCGGTAACAGTGTGCTCACATATCCTTCAAGTGTTAAATTGATCAAGGTTCCTACC
TGCCTGATAGTTGACAGAGACCTGGTGCTGCATGCATTCAGGCATGGGGCGTCTTCTGTTCTTTTTGTGGAAGACCCGCC
TGACAGCCCGAGAGCTGAAGTGATATATCCTCTTACTGTCAGCCATTTCGAAAAACTCAAAGAAGAACTTGGAGATTCAG
GAAAGAGGATCCATTTCAAAAAAGCGTATGTTCCGAATATCAAAGGGCTTGCAGGAACTTTTACCAGCCTTGCCCGGGAA
GGAGAGATGATAAAATGA

Upstream 100 bases:

>100_bases
CCTGTTTCTGCAACAACTATCAAAAAATTGTCCTTTTTGAGACATTCAGTATACCTTTTCTGGCAAGTCTTATATACAAA
TCCCTGAAAGATTTAGTATA

Downstream 100 bases:

>100_bases
TTCCATATGTAAACGAATATGATACTCCGAACTGTAATACTCTTGCAGAGACAGCAAAAAAGAGTATCAGAACCCCTGAA
TCTCTGGGGCTTGACCGCTG

Product: heterodisulfide reductase subunit HdrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MTDGTTDGLNKAAVFICHCSGNISEHVDINTVKKTLKAEGFSVYDYEYLCSSQGQALIKKKISEGHVDRVVIGSCTPSKH
GTLFKKCIQETGLNRAGLEIANLREQCAWVHPDREGATEKALSLLKAKLKRLENIEPLEDIKVDIAQQVLVIGGGIAGIT
AALNLADNGVPTFLVEKDSSIGGQMAKIGKIFSPDKLAEECAMCSLSPLMNEVAAHPRITLLTWTEVEKLSGSAGNFTVR
LKKKPRYVKDNCIACGKCSRVCPVSVEDEFNCGYMDKKAISLRFSQSVPKVYFIDPDSCLRLKGENCGKCAEACKTGAID
FSQKEEIIELNVGAVVVATGFEEYDVSQKPQYGYGIFENVLTQMELARVLGINGPTKGELLRISDFSKASSDPAPSTCDS
RCESSSDHPFEVETPERIVMIQCVGSRDEKEGGNRYCSRYCCMAALKHASLIKKRYPKTEITICYIDMRAFGFYENYYRA
VQETGVNFVRGRPAEVIEKPDKSLVVRVEDTLSQKIKEIPADMVVLSAAMVPSPGTKKIASVLNLSQDESGFIKERHSKL
KPVDCSLDGIFVCGTAQSPKDVTDTIAQAGLAAVRARAFITDSPKVLDNEIAAINQLLCTRCGECLKCPFDALSINENGR
VVLDPLICTGCGYCTELCREGAVQIAGFTKSQLKAELEGVLEEGDVLGFVNSGISSLTCDNIGNSVLTYPSSVKLIKVPT
CLIVDRDLVLHAFRHGASSVLFVEDPPDSPRAEVIYPLTVSHFEKLKEELGDSGKRIHFKKAYVPNIKGLAGTFTSLARE
GEMIK

Sequences:

>Translated_805_residues
MTDGTTDGLNKAAVFICHCSGNISEHVDINTVKKTLKAEGFSVYDYEYLCSSQGQALIKKKISEGHVDRVVIGSCTPSKH
GTLFKKCIQETGLNRAGLEIANLREQCAWVHPDREGATEKALSLLKAKLKRLENIEPLEDIKVDIAQQVLVIGGGIAGIT
AALNLADNGVPTFLVEKDSSIGGQMAKIGKIFSPDKLAEECAMCSLSPLMNEVAAHPRITLLTWTEVEKLSGSAGNFTVR
LKKKPRYVKDNCIACGKCSRVCPVSVEDEFNCGYMDKKAISLRFSQSVPKVYFIDPDSCLRLKGENCGKCAEACKTGAID
FSQKEEIIELNVGAVVVATGFEEYDVSQKPQYGYGIFENVLTQMELARVLGINGPTKGELLRISDFSKASSDPAPSTCDS
RCESSSDHPFEVETPERIVMIQCVGSRDEKEGGNRYCSRYCCMAALKHASLIKKRYPKTEITICYIDMRAFGFYENYYRA
VQETGVNFVRGRPAEVIEKPDKSLVVRVEDTLSQKIKEIPADMVVLSAAMVPSPGTKKIASVLNLSQDESGFIKERHSKL
KPVDCSLDGIFVCGTAQSPKDVTDTIAQAGLAAVRARAFITDSPKVLDNEIAAINQLLCTRCGECLKCPFDALSINENGR
VVLDPLICTGCGYCTELCREGAVQIAGFTKSQLKAELEGVLEEGDVLGFVNSGISSLTCDNIGNSVLTYPSSVKLIKVPT
CLIVDRDLVLHAFRHGASSVLFVEDPPDSPRAEVIYPLTVSHFEKLKEELGDSGKRIHFKKAYVPNIKGLAGTFTSLARE
GEMIK
>Mature_804_residues
TDGTTDGLNKAAVFICHCSGNISEHVDINTVKKTLKAEGFSVYDYEYLCSSQGQALIKKKISEGHVDRVVIGSCTPSKHG
TLFKKCIQETGLNRAGLEIANLREQCAWVHPDREGATEKALSLLKAKLKRLENIEPLEDIKVDIAQQVLVIGGGIAGITA
ALNLADNGVPTFLVEKDSSIGGQMAKIGKIFSPDKLAEECAMCSLSPLMNEVAAHPRITLLTWTEVEKLSGSAGNFTVRL
KKKPRYVKDNCIACGKCSRVCPVSVEDEFNCGYMDKKAISLRFSQSVPKVYFIDPDSCLRLKGENCGKCAEACKTGAIDF
SQKEEIIELNVGAVVVATGFEEYDVSQKPQYGYGIFENVLTQMELARVLGINGPTKGELLRISDFSKASSDPAPSTCDSR
CESSSDHPFEVETPERIVMIQCVGSRDEKEGGNRYCSRYCCMAALKHASLIKKRYPKTEITICYIDMRAFGFYENYYRAV
QETGVNFVRGRPAEVIEKPDKSLVVRVEDTLSQKIKEIPADMVVLSAAMVPSPGTKKIASVLNLSQDESGFIKERHSKLK
PVDCSLDGIFVCGTAQSPKDVTDTIAQAGLAAVRARAFITDSPKVLDNEIAAINQLLCTRCGECLKCPFDALSINENGRV
VLDPLICTGCGYCTELCREGAVQIAGFTKSQLKAELEGVLEEGDVLGFVNSGISSLTCDNIGNSVLTYPSSVKLIKVPTC
LIVDRDLVLHAFRHGASSVLFVEDPPDSPRAEVIYPLTVSHFEKLKEELGDSGKRIHFKKAYVPNIKGLAGTFTSLAREG
EMIK

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 87748; Mature: 87617

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDGTTDGLNKAAVFICHCSGNISEHVDINTVKKTLKAEGFSVYDYEYLCSSQGQALIKK
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHCCCCHHHHHH
KISEGHVDRVVIGSCTPSKHGTLFKKCIQETGLNRAGLEIANLREQCAWVHPDREGATEK
HHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHH
ALSLLKAKLKRLENIEPLEDIKVDIAQQVLVIGGGIAGITAALNLADNGVPTFLVEKDSS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHECCCCCCCEEEEECCCC
IGGQMAKIGKIFSPDKLAEECAMCSLSPLMNEVAAHPRITLLTWTEVEKLSGSAGNFTVR
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCEEEE
LKKKPRYVKDNCIACGKCSRVCPVSVEDEFNCGYMDKKAISLRFSQSVPKVYFIDPDSCL
EECCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHE
RLKGENCGKCAEACKTGAIDFSQKEEIIELNVGAVVVATGFEEYDVSQKPQYGYGIFENV
EECCCCCHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCHHCCCCCCCCCCHHHHHHH
LTQMELARVLGINGPTKGELLRISDFSKASSDPAPSTCDSRCESSSDHPFEVETPERIVM
HHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCCCEEECCCCEEEE
IQCVGSRDEKEGGNRYCSRYCCMAALKHASLIKKRYPKTEITICYIDMRAFGFYENYYRA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHH
VQETGVNFVRGRPAEVIEKPDKSLVVRVEDTLSQKIKEIPADMVVLSAAMVPSPGTKKIA
HHHCCCCEECCCCHHHHCCCCCEEEEEEHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHH
SVLNLSQDESGFIKERHSKLKPVDCSLDGIFVCGTAQSPKDVTDTIAQAGLAAVRARAFI
HHHCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHEE
TDSPKVLDNEIAAINQLLCTRCGECLKCPFDALSINENGRVVLDPLICTGCGYCTELCRE
CCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEECCCCCEEECCHHHCCCHHHHHHHHC
GAVQIAGFTKSQLKAELEGVLEEGDVLGFVNSGISSLTCDNIGNSVLTYPSSVKLIKVPT
CCEEEECCCHHHHHHHHHHHHHCCCEEEEHHCCCCCEEHHHCCCCEEECCCCEEEEECCE
CLIVDRDLVLHAFRHGASSVLFVEDPPDSPRAEVIYPLTVSHFEKLKEELGDSGKRIHFK
EEEECHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEEE
KAYVPNIKGLAGTFTSLAREGEMIK
ECCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDGTTDGLNKAAVFICHCSGNISEHVDINTVKKTLKAEGFSVYDYEYLCSSQGQALIKK
CCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHCCCCHHHHHH
KISEGHVDRVVIGSCTPSKHGTLFKKCIQETGLNRAGLEIANLREQCAWVHPDREGATEK
HHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHH
ALSLLKAKLKRLENIEPLEDIKVDIAQQVLVIGGGIAGITAALNLADNGVPTFLVEKDSS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHECCCCCCCEEEEECCCC
IGGQMAKIGKIFSPDKLAEECAMCSLSPLMNEVAAHPRITLLTWTEVEKLSGSAGNFTVR
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCEEEE
LKKKPRYVKDNCIACGKCSRVCPVSVEDEFNCGYMDKKAISLRFSQSVPKVYFIDPDSCL
EECCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHE
RLKGENCGKCAEACKTGAIDFSQKEEIIELNVGAVVVATGFEEYDVSQKPQYGYGIFENV
EECCCCCHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCHHCCCCCCCCCCHHHHHHH
LTQMELARVLGINGPTKGELLRISDFSKASSDPAPSTCDSRCESSSDHPFEVETPERIVM
HHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCCCEEECCCCEEEE
IQCVGSRDEKEGGNRYCSRYCCMAALKHASLIKKRYPKTEITICYIDMRAFGFYENYYRA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHHHH
VQETGVNFVRGRPAEVIEKPDKSLVVRVEDTLSQKIKEIPADMVVLSAAMVPSPGTKKIA
HHHCCCCEECCCCHHHHCCCCCEEEEEEHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHH
SVLNLSQDESGFIKERHSKLKPVDCSLDGIFVCGTAQSPKDVTDTIAQAGLAAVRARAFI
HHHCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHEE
TDSPKVLDNEIAAINQLLCTRCGECLKCPFDALSINENGRVVLDPLICTGCGYCTELCRE
CCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEECCCCCEEECCHHHCCCHHHHHHHHC
GAVQIAGFTKSQLKAELEGVLEEGDVLGFVNSGISSLTCDNIGNSVLTYPSSVKLIKVPT
CCEEEECCCHHHHHHHHHHHHHCCCEEEEHHCCCCCEEHHHCCCCEEECCCCEEEEECCE
CLIVDRDLVLHAFRHGASSVLFVEDPPDSPRAEVIYPLTVSHFEKLKEELGDSGKRIHFK
EEEECHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEEE
KAYVPNIKGLAGTFTSLAREGEMIK
ECCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]