Definition Methanosarcina mazei Go1 chromosome, complete genome.
Accession NC_003901
Length 4,096,345

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The map label for this gene is dys2 [H]

Identifier: 21226389

GI number: 21226389

Start: 386949

End: 387998

Strand: Direct

Name: dys2 [H]

Synonym: MM_0287

Alternate gene names: 21226389

Gene position: 386949-387998 (Clockwise)

Preceding gene: 21226388

Following gene: 21226390

Centisome position: 9.45

GC content: 48.57

Gene sequence:

>1050_bases
ATGGAGAATGGTATGCATCACAATGTATTTACTAACACCCCGACAATTCCGATTGATGTAAAGGACAGGTCTGTAAGCGA
ATTAATGGACGGAATGCTCAGGACAGGTTTTCAGGGCAGAAAGCTTGCGGAATCGGTTCAGGCATGGAGCAACATGCTCA
AAGAAAAGGACACTACCGTACTCATGGGCCTGTCCGGAGCCATGGTTCCTGCCGGCATGCGCAGGGTTATTTCTTACCTT
ATCCGGGAAAGAATGATCGACTGCCTTGTAAGCACAGGAGCAAACCTCTTCCATGATTCTCACGAAGCCCTCGGGAGAAA
ACATTATGTGGGCTCTCATCTTGCCAATGATGAAAAACTCTTTGAACACGGTGTGGACAGGATTTATGACGTCTTTGCAG
TTGAAGAAGAGTTCAGGAACGCAGACAACCTGATTGCGGATTTTGCAGAGGAAATCGGAGAGATAAGCTGTTCTTCAAGA
GAGTTTATGTACCTTCTTGGGAAGGAGCTCGTAAGGAGAGGAGCTGCCGAGGATTCGATAGTAGTAAGTGCATACAGGCA
TAACGTCCCCATATTCGTGCCCGCCCTATCGGACAGTTCCATAGGTATAGGGCTTACCATTGCAAGGAGAAGAGGGCTCA
AACTTGAAATAGACCAGATAAAAGACGTTGACGAAATCACACAGATCGTTGAAAAGTCAGGGCATACGGGTGTGGTCTAT
GTAGGAGGAGGAGTCCCGAAGAATTTTATCCAGCAGACCGAAGTGATAGCTTCTATTCTGGGAATGGACGTTCCGGGGCA
TGAATATGCTATCCAGTATACCTCGGACTCTCCTCACTGGGGTGGGCTCTCAGGCTGCACTTTTGACGAAGCGGTTTCCT
GGGGCAAGGTTGCAGCTCAGGCAAAAAAAGTGCAGGTTTTCGTGGATGCCACCATTGCCCTTCCTATTGTTGCCCATGCT
TTGCATGAAAAGACGCGCGGAGTTAAACGCACTGCCCCTGTCTTTTCCTGGGACGGGCCCGAAGGGCTTGAGATTGCTTA
TAACGAATAA

Upstream 100 bases:

>100_bases
TCCCTTAACGCTGTTTGCGCCTCTTACCGTATATTGCCAGGTACCTGCGGGAAGGCAGTAAGGGCTACAGGCAAAACATA
TCGCAATCTGTTATATTTAT

Downstream 100 bases:

>100_bases
TTACATTACAAATCTTTATTATATTTGAAACTGATAAGATAAGGCGAGAAGGAGAGGACATAAATGGGTAAACGAACTCG
AATAATTAACGATCCTTCCT

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS 2 [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MENGMHHNVFTNTPTIPIDVKDRSVSELMDGMLRTGFQGRKLAESVQAWSNMLKEKDTTVLMGLSGAMVPAGMRRVISYL
IRERMIDCLVSTGANLFHDSHEALGRKHYVGSHLANDEKLFEHGVDRIYDVFAVEEEFRNADNLIADFAEEIGEISCSSR
EFMYLLGKELVRRGAAEDSIVVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQIVEKSGHTGVVY
VGGGVPKNFIQQTEVIASILGMDVPGHEYAIQYTSDSPHWGGLSGCTFDEAVSWGKVAAQAKKVQVFVDATIALPIVAHA
LHEKTRGVKRTAPVFSWDGPEGLEIAYNE

Sequences:

>Translated_349_residues
MENGMHHNVFTNTPTIPIDVKDRSVSELMDGMLRTGFQGRKLAESVQAWSNMLKEKDTTVLMGLSGAMVPAGMRRVISYL
IRERMIDCLVSTGANLFHDSHEALGRKHYVGSHLANDEKLFEHGVDRIYDVFAVEEEFRNADNLIADFAEEIGEISCSSR
EFMYLLGKELVRRGAAEDSIVVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQIVEKSGHTGVVY
VGGGVPKNFIQQTEVIASILGMDVPGHEYAIQYTSDSPHWGGLSGCTFDEAVSWGKVAAQAKKVQVFVDATIALPIVAHA
LHEKTRGVKRTAPVFSWDGPEGLEIAYNE
>Mature_349_residues
MENGMHHNVFTNTPTIPIDVKDRSVSELMDGMLRTGFQGRKLAESVQAWSNMLKEKDTTVLMGLSGAMVPAGMRRVISYL
IRERMIDCLVSTGANLFHDSHEALGRKHYVGSHLANDEKLFEHGVDRIYDVFAVEEEFRNADNLIADFAEEIGEISCSSR
EFMYLLGKELVRRGAAEDSIVVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQIVEKSGHTGVVY
VGGGVPKNFIQQTEVIASILGMDVPGHEYAIQYTSDSPHWGGLSGCTFDEAVSWGKVAAQAKKVQVFVDATIALPIVAHA
LHEKTRGVKRTAPVFSWDGPEGLEIAYNE

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=326, Percent_Identity=25.4601226993865, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI7108338, Length=227, Percent_Identity=23.7885462555066, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7108340, Length=228, Percent_Identity=24.1228070175439, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536927, Length=336, Percent_Identity=26.7857142857143, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321859, Length=351, Percent_Identity=23.0769230769231, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45550569, Length=320, Percent_Identity=25.625, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 38474; Mature: 38474

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENGMHHNVFTNTPTIPIDVKDRSVSELMDGMLRTGFQGRKLAESVQAWSNMLKEKDTTV
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
LMGLSGAMVPAGMRRVISYLIRERMIDCLVSTGANLFHDSHEALGRKHYVGSHLANDEKL
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHCHHHHHHHHCCCHHHH
FEHGVDRIYDVFAVEEEFRNADNLIADFAEEIGEISCSSREFMYLLGKELVRRGAAEDSI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
VVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQIVEKSGHTGVVY
EEEEECCCCCEEEEECCCCCCCEEEEEECCCCCEEEHHHHCCHHHHHHHHHCCCCCEEEE
VGGGVPKNFIQQTEVIASILGMDVPGHEYAIQYTSDSPHWGGLSGCTFDEAVSWGKVAAQ
ECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
AKKVQVFVDATIALPIVAHALHEKTRGVKRTAPVFSWDGPEGLEIAYNE
HHEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECC
>Mature Secondary Structure
MENGMHHNVFTNTPTIPIDVKDRSVSELMDGMLRTGFQGRKLAESVQAWSNMLKEKDTTV
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
LMGLSGAMVPAGMRRVISYLIRERMIDCLVSTGANLFHDSHEALGRKHYVGSHLANDEKL
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHCHHHHHHHHCCCHHHH
FEHGVDRIYDVFAVEEEFRNADNLIADFAEEIGEISCSSREFMYLLGKELVRRGAAEDSI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
VVSAYRHNVPIFVPALSDSSIGIGLTIARRRGLKLEIDQIKDVDEITQIVEKSGHTGVVY
EEEEECCCCCEEEEECCCCCCCEEEEEECCCCCEEEHHHHCCHHHHHHHHHCCCCCEEEE
VGGGVPKNFIQQTEVIASILGMDVPGHEYAIQYTSDSPHWGGLSGCTFDEAVSWGKVAAQ
ECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
AKKVQVFVDATIALPIVAHALHEKTRGVKRTAPVFSWDGPEGLEIAYNE
HHEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]