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The map label for this gene is 21226235

Identifier: 21226235

GI number: 21226235

Start: 164917

End: 166167

Strand: Direct

Name: 21226235

Synonym: MM_0133

Alternate gene names: NA

Gene position: 164917-166167 (Clockwise)

Preceding gene: 21226234

Following gene: 21226236

Centisome position: 4.03

GC content: 48.68

Gene sequence:

>1251_bases
ATGGGAAGATTCACATTAAAATGTCTGAAATGCGGAAGGGAATACGGACAGGAATACAGGTTAACCTGTGATAATGACGA
CTCCCTTTTGAGGGCGGATTACTTTGAAAAAAAGCTGGAACTTAGAGACCAGCCCGGAATAGGGAGATTCCATTCCTGGC
TCCCTGTACAGGAAGAGCTTACCACAGAAGCGGGGCCAATCACTTACAAAAGCGAAGCTCTCGCAAAGGAACTCGGGCTT
TCCAACCTGTATATAGGGTTCAGCGGGTACTGGCCCGAAAGAGAAGCATTAATTAAAACCTGCAGTTTCAAAGAACTGGA
AGCCCACCCTACAATGCAGCTTCTGAAAGAGTCAGGCGGAAAAGCCATAGTTCTTGCCTCTGCAGGCAACACTGGAAGAG
CTTTTGCATATTCTTCGTCCCTTACAGGCACGGACGCTTATATAGTGGTCCCGGATTCAGGCGTTTCGAGCATCTGGCTT
CCTGAAGAACCTGCTAATTCCATTCATCTTATCAGCATGACTCCGGGTAATGATTACACAGATGCTATCAACCTTGCAGG
CAGGCTTGCAAAACTCCCGGGAATGGTTCCTGAAGGAGGGGCAAGAAACGTTGCCAGAAGGGAAGGGATGGGAACTGTAA
TGCTTGATGCAGCCGTGACCATAGGAAAAATGCCTGACCACTATTTCCAGGCTGTAGGGAGCGGTACGGGAGGAATGTCA
GCATGGGAAGCTTCACTGCGGCTCAGGGACGACGGGCGTTTCGGCTCAAAGCTTCCAAAACTCCAGCTTGCCCAGAACCT
CCCATTTGTTCCCATGTACAATGCCTGGAAGGCAGGAAGAAGGGAAATCATCCCTGACATTGACATGAAGGATGCAAAAA
AGCAGATAGAAGAGACATATGCTACAGTTCTCACCAACAGGGCTCCTCCCTATTCCATAACTGGAGGGCTATATGATGCA
CTTGTCGACACGGACGGGATAATGTATGCCATCACAAGAGAAGAGGCCCTTGAAGCAAAAGCCCTTTTTGAGTCCCTCGA
AGGGATAGACATCCTGGAACCTTCCGCAGTTGCGGCTGCTTCCCTGTTAAAAGCCGTAGAAGCCGGAAACGTGGAAAAAG
ACGATGTCATTCTCCTTAATATTGCAGGCGGAGGTTTTAAGCGGCTGAAAGAAGACTTTACGCTATTCCAGGTTGAACCT
GAGGTTACGGTCAGCAGTTCTGAAGTCTCACTTGATGAACTGAAGATTTGA

Upstream 100 bases:

>100_bases
AAATAGGAAACTAATAATAAAAAATATCACATAAAGGATATAAAGCGGATGTTTCAGGAACATATATTTAGTAAAAGAAA
CCCAATTTTCTTTGATAGCA

Downstream 100 bases:

>100_bases
ACTTCCATTACATCCGGAATCAAATTTCAAAAAACATAACAAAAATCTGTGTAAATCTGTTAATAGAAACCTGTAAGAAA
AACAGGCTCAGAATACTCAT

Product: threonine synthase

Products: NA

Alternate protein names: CS; Cya synthase

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MGRFTLKCLKCGREYGQEYRLTCDNDDSLLRADYFEKKLELRDQPGIGRFHSWLPVQEELTTEAGPITYKSEALAKELGL
SNLYIGFSGYWPEREALIKTCSFKELEAHPTMQLLKESGGKAIVLASAGNTGRAFAYSSSLTGTDAYIVVPDSGVSSIWL
PEEPANSIHLISMTPGNDYTDAINLAGRLAKLPGMVPEGGARNVARREGMGTVMLDAAVTIGKMPDHYFQAVGSGTGGMS
AWEASLRLRDDGRFGSKLPKLQLAQNLPFVPMYNAWKAGRREIIPDIDMKDAKKQIEETYATVLTNRAPPYSITGGLYDA
LVDTDGIMYAITREEALEAKALFESLEGIDILEPSAVAAASLLKAVEAGNVEKDDVILLNIAGGGFKRLKEDFTLFQVEP
EVTVSSSEVSLDELKI

Sequences:

>Translated_416_residues
MGRFTLKCLKCGREYGQEYRLTCDNDDSLLRADYFEKKLELRDQPGIGRFHSWLPVQEELTTEAGPITYKSEALAKELGL
SNLYIGFSGYWPEREALIKTCSFKELEAHPTMQLLKESGGKAIVLASAGNTGRAFAYSSSLTGTDAYIVVPDSGVSSIWL
PEEPANSIHLISMTPGNDYTDAINLAGRLAKLPGMVPEGGARNVARREGMGTVMLDAAVTIGKMPDHYFQAVGSGTGGMS
AWEASLRLRDDGRFGSKLPKLQLAQNLPFVPMYNAWKAGRREIIPDIDMKDAKKQIEETYATVLTNRAPPYSITGGLYDA
LVDTDGIMYAITREEALEAKALFESLEGIDILEPSAVAAASLLKAVEAGNVEKDDVILLNIAGGGFKRLKEDFTLFQVEP
EVTVSSSEVSLDELKI
>Mature_415_residues
GRFTLKCLKCGREYGQEYRLTCDNDDSLLRADYFEKKLELRDQPGIGRFHSWLPVQEELTTEAGPITYKSEALAKELGLS
NLYIGFSGYWPEREALIKTCSFKELEAHPTMQLLKESGGKAIVLASAGNTGRAFAYSSSLTGTDAYIVVPDSGVSSIWLP
EEPANSIHLISMTPGNDYTDAINLAGRLAKLPGMVPEGGARNVARREGMGTVMLDAAVTIGKMPDHYFQAVGSGTGGMSA
WEASLRLRDDGRFGSKLPKLQLAQNLPFVPMYNAWKAGRREIIPDIDMKDAKKQIEETYATVLTNRAPPYSITGGLYDAL
VDTDGIMYAITREEALEAKALFESLEGIDILEPSAVAAASLLKAVEAGNVEKDDVILLNIAGGGFKRLKEDFTLFQVEPE
VTVSSSEVSLDELKI

Specific function: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family. Cysteate synthase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYAS_METMA (Q8Q0K3)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632157.1
- ProteinModelPortal:   Q8Q0K3
- SMR:   Q8Q0K3
- GeneID:   1478475
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0133
- NMPDR:   fig|192952.1.peg.133
- HOGENOM:   HBG538357
- OMA:   CSFKELE
- ProtClustDB:   CLSK900494
- BioCyc:   MMAZ192952:MM0133-MONOMER
- HAMAP:   MF_02109
- InterPro:   IPR022401
- InterPro:   IPR001926
- TIGRFAMs:   TIGR03844

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =2.5.1.76

Molecular weight: Translated: 45396; Mature: 45265

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: BINDING 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRFTLKCLKCGREYGQEYRLTCDNDDSLLRADYFEKKLELRDQPGIGRFHSWLPVQEEL
CCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHH
TTEAGPITYKSEALAKELGLSNLYIGFSGYWPEREALIKTCSFKELEAHPTMQLLKESGG
CCCCCCCEECHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHHCCCHHHHHHHHCCC
KAIVLASAGNTGRAFAYSSSLTGTDAYIVVPDSGVSSIWLPEEPANSIHLISMTPGNDYT
CEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEECCCCCCH
DAINLAGRLAKLPGMVPEGGARNVARREGMGTVMLDAAVTIGKMPDHYFQAVGSGTGGMS
HHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEHHHHHCCCCHHHHHHHCCCCCCCC
AWEASLRLRDDGRFGSKLPKLQLAQNLPFVPMYNAWKAGRREIIPDIDMKDAKKQIEETY
CCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
ATVLTNRAPPYSITGGLYDALVDTDGIMYAITREEALEAKALFESLEGIDILEPSAVAAA
HHHHHCCCCCCEECCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SLLKAVEAGNVEKDDVILLNIAGGGFKRLKEDFTLFQVEPEVTVSSSEVSLDELKI
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHCCCEEEEECCCEEECCCCCCHHHHCC
>Mature Secondary Structure 
GRFTLKCLKCGREYGQEYRLTCDNDDSLLRADYFEKKLELRDQPGIGRFHSWLPVQEEL
CCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCCCHHHH
TTEAGPITYKSEALAKELGLSNLYIGFSGYWPEREALIKTCSFKELEAHPTMQLLKESGG
CCCCCCCEECHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHHCCCHHHHHHHHCCC
KAIVLASAGNTGRAFAYSSSLTGTDAYIVVPDSGVSSIWLPEEPANSIHLISMTPGNDYT
CEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEECCCCCCH
DAINLAGRLAKLPGMVPEGGARNVARREGMGTVMLDAAVTIGKMPDHYFQAVGSGTGGMS
HHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEEHHHHHCCCCHHHHHHHCCCCCCCC
AWEASLRLRDDGRFGSKLPKLQLAQNLPFVPMYNAWKAGRREIIPDIDMKDAKKQIEETY
CCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
ATVLTNRAPPYSITGGLYDALVDTDGIMYAITREEALEAKALFESLEGIDILEPSAVAAA
HHHHHCCCCCCEECCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHH
SLLKAVEAGNVEKDDVILLNIAGGGFKRLKEDFTLFQVEPEVTVSSSEVSLDELKI
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHCCCEEEEECCCEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824