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The map label for this gene is lrgA [H]

Identifier: 21226210

GI number: 21226210

Start: 135048

End: 135449

Strand: Reverse

Name: lrgA [H]

Synonym: MM_0108

Alternate gene names: 21226210

Gene position: 135449-135048 (Counterclockwise)

Preceding gene: 21226217

Following gene: 21226209

Centisome position: 3.31

GC content: 43.78

Gene sequence:

>402_bases
TTGCTAAAACAATTTTCAATTATTCTCAGCATTTATTTTCTGGGCGAGCTGCTTCAAAAAACATTCGGGCTGCCCATTCC
CGGCAATATCCTGGGCATGTTAATCCTTTTTTTCGGTCTTCTTGCAGGTGTGGTCAGGCTTGAAATGATAGACAGGATAA
GCGATTTTCTGCTCGATAACCTGGCTTTTTTCTTTCTCCCGGCAGGGGTCAGCCTCATAACATGCTTTGCCGTGCTTGAA
GGTAAATGGACTGCAGTTCTCGGGGTCTCCATTATCTCAACAGTAATAATCCTGGGAGTTACGGGATTGACAGTTGAATT
TGTCAAAAAGTTAAGTGGAAAAGAGGTCATGGTGCATAAAAAAGCGAAGTCATCCGACAGGAAGACAGAAGAGGTGACCT
GA

Upstream 100 bases:

>100_bases
TCTGTAATCCTGAGTACACTGTAACAACTTTTCCTTATCGAGAAGGTATTTATAATTCAATTTCTTTAGTCCATTTCCAA
TTAAGGAGGAAAATGAGCTT

Downstream 100 bases:

>100_bases
AGTGCAGGCCGATTTTTTGAATGAATTTCTAGGCACGCCTCTTTTTGGGATTCTTCTTTCCCTTGCTGCTTTTCAGGCAG
GCAGCCTGCTCTATAAGAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MLKQFSIILSIYFLGELLQKTFGLPIPGNILGMLILFFGLLAGVVRLEMIDRISDFLLDNLAFFFLPAGVSLITCFAVLE
GKWTAVLGVSIISTVIILGVTGLTVEFVKKLSGKEVMVHKKAKSSDRKTEEVT

Sequences:

>Translated_133_residues
MLKQFSIILSIYFLGELLQKTFGLPIPGNILGMLILFFGLLAGVVRLEMIDRISDFLLDNLAFFFLPAGVSLITCFAVLE
GKWTAVLGVSIISTVIILGVTGLTVEFVKKLSGKEVMVHKKAKSSDRKTEEVT
>Mature_133_residues
MLKQFSIILSIYFLGELLQKTFGLPIPGNILGMLILFFGLLAGVVRLEMIDRISDFLLDNLAFFFLPAGVSLITCFAVLE
GKWTAVLGVSIISTVIILGVTGLTVEFVKKLSGKEVMVHKKAKSSDRKTEEVT

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in p

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. LrgA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 14595; Mature: 14595

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQFSIILSIYFLGELLQKTFGLPIPGNILGMLILFFGLLAGVVRLEMIDRISDFLLDN
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFFFLPAGVSLITCFAVLEGKWTAVLGVSIISTVIILGVTGLTVEFVKKLSGKEVMVHK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
KAKSSDRKTEEVT
HHCCCCCCCCCCC
>Mature Secondary Structure
MLKQFSIILSIYFLGELLQKTFGLPIPGNILGMLILFFGLLAGVVRLEMIDRISDFLLDN
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFFFLPAGVSLITCFAVLEGKWTAVLGVSIISTVIILGVTGLTVEFVKKLSGKEVMVHK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
KAKSSDRKTEEVT
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA