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The map label for this gene is mepA [H]

Identifier: 21226217

GI number: 21226217

Start: 142500

End: 143927

Strand: Reverse

Name: mepA [H]

Synonym: MM_0115

Alternate gene names: 21226217

Gene position: 143927-142500 (Counterclockwise)

Preceding gene: 21226218

Following gene: 21226210

Centisome position: 3.51

GC content: 47.83

Gene sequence:

>1428_bases
TTGCTGCCGGTCTTGAAGGGGAAAAGCATGACCGATGAAAGGGAAATAAGGTCTGAAAGCATCGAAAAGCTTTTTCTGAA
ATTTGTTTTTCCGGCAACCATCGGATTGATTGTTGCGGGAATTCAGGGAGTCATTGACGGTTTCTTTATCGGGAATGCGG
TAGGTAGCCAGGGGCTTGCAGGGGTGACCCTTGCATTTCCTGCACTTATAGTCGTAGTAGCAGTAGGACATATGATAGGG
ATCGGGACTTCAAGTCTTGTGGCTCTAGCCCGTGGAAGAGGTGATCTTCAGGAAGCTATCAGGCTTGTACATAATGCTTT
TCCTTTGCTCCTGCTAGTGGGAATAGGGCTTACCGCCTTCGGACTGGCTTTTTCGGATTCTTATCTCCTCCTTTTGGGAG
CTTCCGGTGCGGTCTTTGCCATGGCAAATGCTTACCTCAAGGTCCTATTTGCAGGTTCGGTATTTATGCTTCTGGCAATT
GCCCTTGACCCACTTGTCCGAAATGACGGAAAACCAGGATTTGCCATGATATGTATGGTCGTGGGTGTTCTCATAAACCT
CGTTCTTGACTATATCTTTGTTATGCGCATGGGAATGGGAGTCACAGGTGCTGCCATAGCCACGGTAATCGCTTTTTCCC
TTTCCGGAATACTTCTGTCACTCTACTTTTTCAGCAGGTGGGCCGGATTGAGGCTAAAATACCGGGCCTTCTGCCTGGAG
CCGGGAACTATTTTCAGGATCATGAAGGTAGGCCTCCCCTCCTTTGCAATGCAGTTTTCAACCTCCTTCCTGCTCTTTAC
TAACAATTACATGCTGCTCAAATACGGCTCGGAACTTGCGGTTTCAGGCTACGGTATCATAGGTTACGTTTTCTCGACCT
TTTCCCTGATCTTTGAAGGAATCGCAGTCGGTACCCAGCCGATCATAGGTTTCAATTATGGAGCCCGTTGTTATTCCAGG
GTTGCCGGGACCCTGAAGATGGCTTTTATCTCCTGCCTCGGGACCGGAGCAGTCGGTTTTATGCTCCTATCTATATTTCC
TGAACAGGTTATCCGCATCTTCAACCATGACAGCCCAGAACTTCTGGAAATTACCCTTAACGGTATGGGGATTTTCATGT
TTGCCCTACTTGCCCAGGGGACGGTTATGCTTGGTTCGGTTTATTTCCAGTCCATAAACAGGGTCAGGTCCGCTCTTTTC
ATCCAGCTAGGAAAAGTCTTTCTCTTCTTTCTTCCCTTGCTCTTGATTTTGCCCCCATTACTTGGCCTTAATGGAGTCTG
GCTCGCAACTCCGGCTGCGGAATTCCTGATGCTAATGGTCGTACTGGGCTTGCTCTGGAAAGAGTTTTGTTTTCTCAAAA
ATGGAAAGCCTGTGAGTGAAGAAAGCTACTGCCCTGCTTCTGAGATTGTATTAGCGCCAAACGATTAA

Upstream 100 bases:

>100_bases
ATTGAGATCGAAAACGGGGCTGATATGAAATTTTTCGAAAAGATCCGGGAAATTCTGGACGAAGAAGAACTTGAGGTTCT
GGAGAGGATCTTTGAGAAAA

Downstream 100 bases:

>100_bases
ACTGAGCCTCCATGCTCCGATGAACACTGCCGCCAGAACTCCCTGCATAAGGAAGGTAAGCCCCACTGTGTCAGGGAGGC
AAAAAATGCATCACCTTTTT

Product: putative transmembrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MLPVLKGKSMTDEREIRSESIEKLFLKFVFPATIGLIVAGIQGVIDGFFIGNAVGSQGLAGVTLAFPALIVVVAVGHMIG
IGTSSLVALARGRGDLQEAIRLVHNAFPLLLLVGIGLTAFGLAFSDSYLLLLGASGAVFAMANAYLKVLFAGSVFMLLAI
ALDPLVRNDGKPGFAMICMVVGVLINLVLDYIFVMRMGMGVTGAAIATVIAFSLSGILLSLYFFSRWAGLRLKYRAFCLE
PGTIFRIMKVGLPSFAMQFSTSFLLFTNNYMLLKYGSELAVSGYGIIGYVFSTFSLIFEGIAVGTQPIIGFNYGARCYSR
VAGTLKMAFISCLGTGAVGFMLLSIFPEQVIRIFNHDSPELLEITLNGMGIFMFALLAQGTVMLGSVYFQSINRVRSALF
IQLGKVFLFFLPLLLILPPLLGLNGVWLATPAAEFLMLMVVLGLLWKEFCFLKNGKPVSEESYCPASEIVLAPND

Sequences:

>Translated_475_residues
MLPVLKGKSMTDEREIRSESIEKLFLKFVFPATIGLIVAGIQGVIDGFFIGNAVGSQGLAGVTLAFPALIVVVAVGHMIG
IGTSSLVALARGRGDLQEAIRLVHNAFPLLLLVGIGLTAFGLAFSDSYLLLLGASGAVFAMANAYLKVLFAGSVFMLLAI
ALDPLVRNDGKPGFAMICMVVGVLINLVLDYIFVMRMGMGVTGAAIATVIAFSLSGILLSLYFFSRWAGLRLKYRAFCLE
PGTIFRIMKVGLPSFAMQFSTSFLLFTNNYMLLKYGSELAVSGYGIIGYVFSTFSLIFEGIAVGTQPIIGFNYGARCYSR
VAGTLKMAFISCLGTGAVGFMLLSIFPEQVIRIFNHDSPELLEITLNGMGIFMFALLAQGTVMLGSVYFQSINRVRSALF
IQLGKVFLFFLPLLLILPPLLGLNGVWLATPAAEFLMLMVVLGLLWKEFCFLKNGKPVSEESYCPASEIVLAPND
>Mature_475_residues
MLPVLKGKSMTDEREIRSESIEKLFLKFVFPATIGLIVAGIQGVIDGFFIGNAVGSQGLAGVTLAFPALIVVVAVGHMIG
IGTSSLVALARGRGDLQEAIRLVHNAFPLLLLVGIGLTAFGLAFSDSYLLLLGASGAVFAMANAYLKVLFAGSVFMLLAI
ALDPLVRNDGKPGFAMICMVVGVLINLVLDYIFVMRMGMGVTGAAIATVIAFSLSGILLSLYFFSRWAGLRLKYRAFCLE
PGTIFRIMKVGLPSFAMQFSTSFLLFTNNYMLLKYGSELAVSGYGIIGYVFSTFSLIFEGIAVGTQPIIGFNYGARCYSR
VAGTLKMAFISCLGTGAVGFMLLSIFPEQVIRIFNHDSPELLEITLNGMGIFMFALLAQGTVMLGSVYFQSINRVRSALF
IQLGKVFLFFLPLLLILPPLLGLNGVWLATPAAEFLMLMVVLGLLWKEFCFLKNGKPVSEESYCPASEIVLAPND

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51191; Mature: 51191

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPVLKGKSMTDEREIRSESIEKLFLKFVFPATIGLIVAGIQGVIDGFFIGNAVGSQGLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GVTLAFPALIVVVAVGHMIGIGTSSLVALARGRGDLQEAIRLVHNAFPLLLLVGIGLTAF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GLAFSDSYLLLLGASGAVFAMANAYLKVLFAGSVFMLLAIALDPLVRNDGKPGFAMICMV
HHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VGVLINLVLDYIFVMRMGMGVTGAAIATVIAFSLSGILLSLYFFSRWAGLRLKYRAFCLE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
PGTIFRIMKVGLPSFAMQFSTSFLLFTNNYMLLKYGSELAVSGYGIIGYVFSTFSLIFEG
CHHHHHHHHHCCCHHHHHHCCEEEEEECCEEEEEECCCEEECCCHHHHHHHHHHHHHHHH
IAVGTQPIIGFNYGARCYSRVAGTLKMAFISCLGTGAVGFMLLSIFPEQVIRIFNHDSPE
HHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LLEITLNGMGIFMFALLAQGTVMLGSVYFQSINRVRSALFIQLGKVFLFFLPLLLILPPL
EEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLNGVWLATPAAEFLMLMVVLGLLWKEFCFLKNGKPVSEESYCPASEIVLAPND
HCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCEEECCCC
>Mature Secondary Structure
MLPVLKGKSMTDEREIRSESIEKLFLKFVFPATIGLIVAGIQGVIDGFFIGNAVGSQGLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GVTLAFPALIVVVAVGHMIGIGTSSLVALARGRGDLQEAIRLVHNAFPLLLLVGIGLTAF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GLAFSDSYLLLLGASGAVFAMANAYLKVLFAGSVFMLLAIALDPLVRNDGKPGFAMICMV
HHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VGVLINLVLDYIFVMRMGMGVTGAAIATVIAFSLSGILLSLYFFSRWAGLRLKYRAFCLE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
PGTIFRIMKVGLPSFAMQFSTSFLLFTNNYMLLKYGSELAVSGYGIIGYVFSTFSLIFEG
CHHHHHHHHHCCCHHHHHHCCEEEEEECCEEEEEECCCEEECCCHHHHHHHHHHHHHHHH
IAVGTQPIIGFNYGARCYSRVAGTLKMAFISCLGTGAVGFMLLSIFPEQVIRIFNHDSPE
HHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LLEITLNGMGIFMFALLAQGTVMLGSVYFQSINRVRSALFIQLGKVFLFFLPLLLILPPL
EEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLNGVWLATPAAEFLMLMVVLGLLWKEFCFLKNGKPVSEESYCPASEIVLAPND
HCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA