Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 209695944

GI number: 209695944

Start: 2707990

End: 2708892

Strand: Reverse

Name: lepB [H]

Synonym: VSAL_I2526

Alternate gene names: 209695944

Gene position: 2708892-2707990 (Counterclockwise)

Preceding gene: 209695945

Following gene: 209695943

Centisome position: 81.47

GC content: 41.42

Gene sequence:

>903_bases
ATGGCTAACACTTTTTCACTGATTTTAGTTTTAGTAACACTGTTTACTGGTGTTATTTGGACTATTGATAAATTCGTCTT
GGCACCAAAGCGCAAACAAAAAATTGCAGCCGCCCGTGAGCAAGCGAATGGACAAGTTGATGATGCAACACTTGTAAAAG
TCGCTCCTCAACCAGCATGGATAGAACAAGCTGTTTCTATTTTTCCAGTGATTGGCCTTGTTTTAGTGTTGCGCTCATTT
ATTTATGAGCCGTTCCAGATCCCATCCGGTTCGATGATGCCGACGCTTTTAGTCGGTGATTTTATCTTGGTCGAAAAATT
CTCTTATGGAATTAAAGATCCTGTTTGGCGTACACAACTTGTAGATGTGGGGAAACCAGAACGTGGTGATATTGTTGTTT
TTAAATATCCACCACAACCAAATATCGACTATATTAAACGTGTAGTAGGTAAACCTGGTGACACTGTTATTTACAGCGCT
TCTAAGCAAATTTGTGTGAAACCAAAGGGTGAGAGCAAGTGTAATATTATCCCGTTAACGAACATGAAAGACAGTGAATT
CATGCAAGATCGCACTAACTTAGTTCAATATACCGAGCAGTTAGCAAGTGATACTACGCATGATATTTTGGTTAACCCAA
TGCGTTCTGATCGAGTATCTATGTACCAACCACGACCAGGGTATAACGAGTGGGTAGTACCAGAAGGTAACTATTTTGTA
ATGGGCGATAATCGTGACAACAGTGCTGACAGCCGTTATTGGGGCTTTGTCCCAGAAGCGAATTTAGTTGGTAAAGCGGT
CGGGATCTGGATCAGCTTTGAATTTGAACGTGGTAGCGATAGTATGCTGCCTTCCTTTATTCCTACTGGTGTTCGTTTTA
ACCGCATCGGTGGCATAGACTGA

Upstream 100 bases:

>100_bases
AGAGTGAAGTAAATTAAACTTTATTACAGCTCAAAGAAAGCGATGATCAATGGTCTTCGCTTTCTTTGTTATGCAACACT
TAATAACTTAAGGGAATGTA

Downstream 100 bases:

>100_bases
TTGAAATAATATGACATCTCCATTACAACGCCTAGAACGCAAAATAGGCTATAAATTTAATGATGAAGGCTTTCTTAAGT
TAGCACTGACTCACCGTAGT

Product: signal peptidase I (leader peptidase I)

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MANTFSLILVLVTLFTGVIWTIDKFVLAPKRKQKIAAAREQANGQVDDATLVKVAPQPAWIEQAVSIFPVIGLVLVLRSF
IYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRTQLVDVGKPERGDIVVFKYPPQPNIDYIKRVVGKPGDTVIYSA
SKQICVKPKGESKCNIIPLTNMKDSEFMQDRTNLVQYTEQLASDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFERGSDSMLPSFIPTGVRFNRIGGID

Sequences:

>Translated_300_residues
MANTFSLILVLVTLFTGVIWTIDKFVLAPKRKQKIAAAREQANGQVDDATLVKVAPQPAWIEQAVSIFPVIGLVLVLRSF
IYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRTQLVDVGKPERGDIVVFKYPPQPNIDYIKRVVGKPGDTVIYSA
SKQICVKPKGESKCNIIPLTNMKDSEFMQDRTNLVQYTEQLASDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFERGSDSMLPSFIPTGVRFNRIGGID
>Mature_299_residues
ANTFSLILVLVTLFTGVIWTIDKFVLAPKRKQKIAAAREQANGQVDDATLVKVAPQPAWIEQAVSIFPVIGLVLVLRSFI
YEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRTQLVDVGKPERGDIVVFKYPPQPNIDYIKRVVGKPGDTVIYSAS
KQICVKPKGESKCNIIPLTNMKDSEFMQDRTNLVQYTEQLASDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFVM
GDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFERGSDSMLPSFIPTGVRFNRIGGID

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=330, Percent_Identity=52.1212121212121, Blast_Score=330, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 33691; Mature: 33560

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTFSLILVLVTLFTGVIWTIDKFVLAPKRKQKIAAAREQANGQVDDATLVKVAPQPAW
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHH
IEQAVSIFPVIGLVLVLRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRTQL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHE
VDVGKPERGDIVVFKYPPQPNIDYIKRVVGKPGDTVIYSASKQICVKPKGESKCNIIPLT
EECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCEEEECC
NMKDSEFMQDRTNLVQYTEQLASDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEECCCCCCCCEEEECCCEEE
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFERGSDSMLPSFIPTGVRFNRIGGID
EECCCCCCCCCCEECCCCCCHHHCEEEEEEEEEEEECCCCCCCHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
ANTFSLILVLVTLFTGVIWTIDKFVLAPKRKQKIAAAREQANGQVDDATLVKVAPQPAW
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHH
IEQAVSIFPVIGLVLVLRSFIYEPFQIPSGSMMPTLLVGDFILVEKFSYGIKDPVWRTQL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHE
VDVGKPERGDIVVFKYPPQPNIDYIKRVVGKPGDTVIYSASKQICVKPKGESKCNIIPLT
EECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCEEEECC
NMKDSEFMQDRTNLVQYTEQLASDTTHDILVNPMRSDRVSMYQPRPGYNEWVVPEGNYFV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEECCCCCCCCEEEECCCEEE
MGDNRDNSADSRYWGFVPEANLVGKAVGIWISFEFERGSDSMLPSFIPTGVRFNRIGGID
EECCCCCCCCCCEECCCCCCHHHCEEEEEEEEEEEECCCCCCCHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]