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The map label for this gene is lpxB

Identifier: 209695838

GI number: 209695838

Start: 2583776

End: 2584927

Strand: Reverse

Name: lpxB

Synonym: VSAL_I2414

Alternate gene names: 209695838

Gene position: 2584927-2583776 (Counterclockwise)

Preceding gene: 209695839

Following gene: 209695837

Centisome position: 77.74

GC content: 39.32

Gene sequence:

>1152_bases
ATGACCAAACCATTACGAATCGGTATCGTTGCAGGAGAACTCTCTGGTGACACGCTAGGTGAAGGCTTTATTAAGTCGGT
TAAAGCACAATATCCTAATGCTGAGTTTGTAGGGATCGGTGGACCTAAAATGATAGCTCAAGGGTGTGAGTCATTATTTG
ATATGGAAGAGCTGGCGGTAATGGGCTTGGTTGAGGTTCTTGGACGTTTACCTCGTTTATTAAAAGTTAAAGCTGAACTT
GTCCGTTATTTTTCTCAAAATCCACCGGATGTTTTTATTGGTATTGATGCGCCTGATTTTAACTTACGTTTAGAGAAAAC
GTTGAAAGATTCGGGTATCAAAACCGTTCATTATGTGAGCCCTTCTGTTTGGGCTTGGCGTCCAAAGCGTATTTTTAAAA
TCGATGCAGCAACTGATTTAGTTCTCGCCTTTTTACCGTTTGAAAAAGTATTTTATGATAAATACAATGTGGCTTGTGAA
TTTATTGGTCATACATTGGCAGATGCGATCCCAATGCAGAGTGATAAAATAGCGGCTCGTAAATTGTTGGGTCTAGAATT
AGATCGCCAATGGTTAGCGGTATTACCTGGGAGCCGTGGTGGTGAAGTGGCATTAATCGCAAAACCGTTTATAGAGACGT
GTCAGAGAATACATCAAAAACACCCTAATATGGGGTTTGTTGTGGCGGCCGTGAATGAAAAACGTCGTGAGCAATTTGAA
GTGATTTGGAAAGAAACGGCTCCTGAACTTAAATTTATTATCATTCAAGATACCGCTCGTAATGTAATGACTGCCGCAGA
TTCTGTTTTATTGGCTTCTGGTACAGTAGCACTTGAATGTATGCTAATTAAAAGACCAATGGTTGTTGGTTACCAAGTGA
ATAAATTAACCGGATGGATTGCGCAAAAACTCTCTATCACCGAATTTGTTTCATTGCCTAATGTGTTAGCAGGAAAGGAA
TTGGTTCAAGAGTTTATTCAAGAAGAGTGTCATCCTGATTTTCTATACCCTGCGATGGAAAAAGTATTAAGCCAAGATAA
CAGCGAATTGATCGATAGATTTACAGAGATGCACCAGTGGATTAAAAAAGATGCAGATAAACAAGCTGCTAATGCCGTCT
TACGTCTAATTAATAAAGAAACAGCAGAATAA

Upstream 100 bases:

>100_bases
TCTACGCGCGGTATTATTCGTTAATTATGGCGTTTAGATAATTATATAAGCATATTATAAAGGCCTATTTCGTGTAGGCC
TTTTTTATTTTGGAGTAAAT

Downstream 100 bases:

>100_bases
TCTAATGACAAAGAAAATAGATTCTAAAGAATTACCTCCATTTGAGTACCCACAAGGCTATCAGTTATTTGCGGGCGTTG
ATGAAGTTGGACGCGGCCCG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTKPLRIGIVAGELSGDTLGEGFIKSVKAQYPNAEFVGIGGPKMIAQGCESLFDMEELAVMGLVEVLGRLPRLLKVKAEL
VRYFSQNPPDVFIGIDAPDFNLRLEKTLKDSGIKTVHYVSPSVWAWRPKRIFKIDAATDLVLAFLPFEKVFYDKYNVACE
FIGHTLADAIPMQSDKIAARKLLGLELDRQWLAVLPGSRGGEVALIAKPFIETCQRIHQKHPNMGFVVAAVNEKRREQFE
VIWKETAPELKFIIIQDTARNVMTAADSVLLASGTVALECMLIKRPMVVGYQVNKLTGWIAQKLSITEFVSLPNVLAGKE
LVQEFIQEECHPDFLYPAMEKVLSQDNSELIDRFTEMHQWIKKDADKQAANAVLRLINKETAE

Sequences:

>Translated_383_residues
MTKPLRIGIVAGELSGDTLGEGFIKSVKAQYPNAEFVGIGGPKMIAQGCESLFDMEELAVMGLVEVLGRLPRLLKVKAEL
VRYFSQNPPDVFIGIDAPDFNLRLEKTLKDSGIKTVHYVSPSVWAWRPKRIFKIDAATDLVLAFLPFEKVFYDKYNVACE
FIGHTLADAIPMQSDKIAARKLLGLELDRQWLAVLPGSRGGEVALIAKPFIETCQRIHQKHPNMGFVVAAVNEKRREQFE
VIWKETAPELKFIIIQDTARNVMTAADSVLLASGTVALECMLIKRPMVVGYQVNKLTGWIAQKLSITEFVSLPNVLAGKE
LVQEFIQEECHPDFLYPAMEKVLSQDNSELIDRFTEMHQWIKKDADKQAANAVLRLINKETAE
>Mature_382_residues
TKPLRIGIVAGELSGDTLGEGFIKSVKAQYPNAEFVGIGGPKMIAQGCESLFDMEELAVMGLVEVLGRLPRLLKVKAELV
RYFSQNPPDVFIGIDAPDFNLRLEKTLKDSGIKTVHYVSPSVWAWRPKRIFKIDAATDLVLAFLPFEKVFYDKYNVACEF
IGHTLADAIPMQSDKIAARKLLGLELDRQWLAVLPGSRGGEVALIAKPFIETCQRIHQKHPNMGFVVAAVNEKRREQFEV
IWKETAPELKFIIIQDTARNVMTAADSVLLASGTVALECMLIKRPMVVGYQVNKLTGWIAQKLSITEFVSLPNVLAGKEL
VQEFIQEECHPDFLYPAMEKVLSQDNSELIDRFTEMHQWIKKDADKQAANAVLRLINKETAE

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=376, Percent_Identity=57.7127659574468, Blast_Score=443, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_ALISL (B6EJW7)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263768.1
- GeneID:   6989138
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2414
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42930; Mature: 42798

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPLRIGIVAGELSGDTLGEGFIKSVKAQYPNAEFVGIGGPKMIAQGCESLFDMEELAV
CCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
MGLVEVLGRLPRLLKVKAELVRYFSQNPPDVFIGIDAPDFNLRLEKTLKDSGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEHHHHHCCCCCEEEEEC
PSVWAWRPKRIFKIDAATDLVLAFLPFEKVFYDKYNVACEFIGHTLADAIPMQSDKIAAR
CCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLLGLELDRQWLAVLPGSRGGEVALIAKPFIETCQRIHQKHPNMGFVVAAVNEKRREQFE
HHHCCCCCCCCCEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
VIWKETAPELKFIIIQDTARNVMTAADSVLLASGTVALECMLIKRPMVVGYQVNKLTGWI
HHHHCCCCCEEEEEEECCHHHHHHHHHHHHEECCHHHEEEEEECCCEEEEEEHHHHHHHH
AQKLSITEFVSLPNVLAGKELVQEFIQEECHPDFLYPAMEKVLSQDNSELIDRFTEMHQW
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
IKKDADKQAANAVLRLINKETAE
HHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKPLRIGIVAGELSGDTLGEGFIKSVKAQYPNAEFVGIGGPKMIAQGCESLFDMEELAV
CCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
MGLVEVLGRLPRLLKVKAELVRYFSQNPPDVFIGIDAPDFNLRLEKTLKDSGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEHHHHHCCCCCEEEEEC
PSVWAWRPKRIFKIDAATDLVLAFLPFEKVFYDKYNVACEFIGHTLADAIPMQSDKIAAR
CCCEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLLGLELDRQWLAVLPGSRGGEVALIAKPFIETCQRIHQKHPNMGFVVAAVNEKRREQFE
HHHCCCCCCCCCEECCCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHH
VIWKETAPELKFIIIQDTARNVMTAADSVLLASGTVALECMLIKRPMVVGYQVNKLTGWI
HHHHCCCCCEEEEEEECCHHHHHHHHHHHHEECCHHHEEEEEECCCEEEEEEHHHHHHHH
AQKLSITEFVSLPNVLAGKELVQEFIQEECHPDFLYPAMEKVLSQDNSELIDRFTEMHQW
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
IKKDADKQAANAVLRLINKETAE
HHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA