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The map label for this gene is lpxA

Identifier: 209695839

GI number: 209695839

Start: 2585004

End: 2585792

Strand: Reverse

Name: lpxA

Synonym: VSAL_I2415

Alternate gene names: 209695839

Gene position: 2585792-2585004 (Counterclockwise)

Preceding gene: 209695840

Following gene: 209695838

Centisome position: 77.76

GC content: 39.67

Gene sequence:

>789_bases
ATGATTCATGAAACGGCTCAAATTCACCCATCCGCAGTTATTGAAGGTGATGTGACTATTGAAGCTAATGTATCTGTTGG
CCCATTTAGTTATATTTCAGGCAATGTAACTATTGGAGAAGGTACAGAAGTAATGTCGCATGTTGTCATCAAAGGTGACA
CGATAATCGGCAAAGATAACCGTATTTTTTCATTCGCGATTATTGGTGAAGAAAGCCAAGATAAAAAATATGGCGGTGAA
GCAACAAAAGTCGTTGTTGGTGATCGTAACTTTATCCGTGAAAGTGTTCAGATTCATCGCGGTACGGTTCAAGATCGTGG
TGTAACAACCGTAGGTAATGACAACTTACTTTGTGTGAATGTACATATCGCGCATGATTGTATTGTTGGCAGTAACATCA
TCATGGGTAACAATGCAACGTTAGCGGGCCATGTCACTATTGAAGATTATGCGATTGTTTCTGCATTATCTCCAGTGCAT
CAGTTCTGTACAGTTGGAGCTCATAGCTTTATTGGCGGTGCATCTGTTGTTGTTCAAGACGTTCCTCCTTTTGTTATGGC
ACAAGGAAATCACTGTAAACCTTTTGGTATTAATATCGAAGGGCTAAAGCGCCGTGGTTTTGAAAAGCCTGAAATTCATG
CTATTCGCCGTGCTTATAAAGCGCTTTACCGTAACGGTAATACGTTAGAAGAAGCAAAAGAAGAGATAAAGACAGAAATT
GAAGCATTCCCAGTTCTTCAAGGTTTCTTAGATTTGTTTGAAAAATCTACGCGCGGTATTATTCGTTAA

Upstream 100 bases:

>100_bases
AAGATCGTCGCGGTATTGCTCTATTTAATGGTGTCGCAAAAGTTGATGGCGCTGTCGTATGTTCTGCTGAACTTAAATGT
GCGAGACGAGAGTTTTAATT

Downstream 100 bases:

>100_bases
TTATGGCGTTTAGATAATTATATAAGCATATTATAAAGGCCTATTTCGTGTAGGCCTTTTTTATTTTGGAGTAAATATGA
CCAAACCATTACGAATCGGT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIHETAQIHPSAVIEGDVTIEANVSVGPFSYISGNVTIGEGTEVMSHVVIKGDTIIGKDNRIFSFAIIGEESQDKKYGGE
ATKVVVGDRNFIRESVQIHRGTVQDRGVTTVGNDNLLCVNVHIAHDCIVGSNIIMGNNATLAGHVTIEDYAIVSALSPVH
QFCTVGAHSFIGGASVVVQDVPPFVMAQGNHCKPFGINIEGLKRRGFEKPEIHAIRRAYKALYRNGNTLEEAKEEIKTEI
EAFPVLQGFLDLFEKSTRGIIR

Sequences:

>Translated_262_residues
MIHETAQIHPSAVIEGDVTIEANVSVGPFSYISGNVTIGEGTEVMSHVVIKGDTIIGKDNRIFSFAIIGEESQDKKYGGE
ATKVVVGDRNFIRESVQIHRGTVQDRGVTTVGNDNLLCVNVHIAHDCIVGSNIIMGNNATLAGHVTIEDYAIVSALSPVH
QFCTVGAHSFIGGASVVVQDVPPFVMAQGNHCKPFGINIEGLKRRGFEKPEIHAIRRAYKALYRNGNTLEEAKEEIKTEI
EAFPVLQGFLDLFEKSTRGIIR
>Mature_262_residues
MIHETAQIHPSAVIEGDVTIEANVSVGPFSYISGNVTIGEGTEVMSHVVIKGDTIIGKDNRIFSFAIIGEESQDKKYGGE
ATKVVVGDRNFIRESVQIHRGTVQDRGVTTVGNDNLLCVNVHIAHDCIVGSNIIMGNNATLAGHVTIEDYAIVSALSPVH
QFCTVGAHSFIGGASVVVQDVPPFVMAQGNHCKPFGINIEGLKRRGFEKPEIHAIRRAYKALYRNGNTLEEAKEEIKTEI
EAFPVLQGFLDLFEKSTRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=58.0152671755725, Blast_Score=322, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_ALISL (B6EJW8)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263769.1
- ProteinModelPortal:   B6EJW8
- GeneID:   6988758
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2415
- HOGENOM:   HBG659295
- OMA:   GHTSIGE
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28451; Mature: 28451

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHETAQIHPSAVIEGDVTIEANVSVGPFSYISGNVTIGEGTEVMSHVVIKGDTIIGKDN
CCCCCCCCCCCEEEECCEEEEECCCCCCCEEEECCEEECCCHHHHHEEEEECCEEECCCC
RIFSFAIIGEESQDKKYGGEATKVVVGDRNFIRESVQIHRGTVQDRGVTTVGNDNLLCVN
CEEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEE
VHIAHDCIVGSNIIMGNNATLAGHVTIEDYAIVSALSPVHQFCTVGAHSFIGGASVVVQD
EEEEEEEEECCEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEC
VPPFVMAQGNHCKPFGINIEGLKRRGFEKPEIHAIRRAYKALYRNGNTLEEAKEEIKTEI
CCCCEEECCCCCCEECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EAFPVLQGFLDLFEKSTRGIIR
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIHETAQIHPSAVIEGDVTIEANVSVGPFSYISGNVTIGEGTEVMSHVVIKGDTIIGKDN
CCCCCCCCCCCEEEECCEEEEECCCCCCCEEEECCEEECCCHHHHHEEEEECCEEECCCC
RIFSFAIIGEESQDKKYGGEATKVVVGDRNFIRESVQIHRGTVQDRGVTTVGNDNLLCVN
CEEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEE
VHIAHDCIVGSNIIMGNNATLAGHVTIEDYAIVSALSPVHQFCTVGAHSFIGGASVVVQD
EEEEEEEEECCEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEC
VPPFVMAQGNHCKPFGINIEGLKRRGFEKPEIHAIRRAYKALYRNGNTLEEAKEEIKTEI
CCCCEEECCCCCCEECCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EAFPVLQGFLDLFEKSTRGIIR
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA