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The map label for this gene is nhaB

Identifier: 209695589

GI number: 209695589

Start: 2305666

End: 2307261

Strand: Direct

Name: nhaB

Synonym: VSAL_I2148

Alternate gene names: 209695589

Gene position: 2305666-2307261 (Clockwise)

Preceding gene: 209695586

Following gene: 209695590

Centisome position: 69.34

GC content: 39.35

Gene sequence:

>1596_bases
ATGTCTATTTCGCTAGGGAATGCATTTATCAAAAACTTTCTTGGTAAAGCCCCCGACTGGTATAAAATCGCAATAATTTC
GTTTCTAATCATCAACCCGCTGGTTTTCTTTTTTGTTGACCCATTCGCTGCAGGTTGGTTGCTCGTTGTGGAATTCATTT
TCACTCTTGCAATGGCTTTAAAATGCTACCCTCTTCAACCTGGTGGTTTGCTTGCTATTCAAGCAATCGCTATAGGTATG
ACAAGTGCCGAACAAGTAAAACATGAATTAGTAGCTAATATTGAAGTTCTCTTACTGCTTGTGTTTATGGTTGCTGGTAT
TTACTTTATGAAACAGTTGCTGCTGTTCATTTTTACAAAAATACTTATTGGCATAAAATCAAAAACAGCCTTATCAGTGG
CTTTCTGTTTTACCGCGGCATTCTTATCTGCATTTCTTGATGCATTAACCGTTATTGCCGTTGTTATCAGTGTTGCTGTT
GGCTTTTATGCTATTTACCATCGAGTCGCCTCAGGTCAAGGTGGTACACCTAGCCATGATCATACTTGTGATTCGAATGT
AACGGATGAATTAAGTCGTGACGATTTAGAAAACTACCGAGCATTTTTACGTAGCCTATTAATGCATGCTGGTGTTGGTA
CTGCGCTTGGTGGCGTAATGACCATGGTGGGTGAACCGCAAAATTTAATTATTGCGGATCAAGCAAACTGGATGTTTGGT
GAGTTCATCATCCGTATGTTACCAGTGACCGCCCCTGTATTTATTTGCGGTTTGTTAACGTGTGTTGTTGTAGAAAAATT
AGGTATTTGTGGTTACGGTGCAAAACTTCCTGAAAATGTTCGTAATATTCTAGAAGAGTACGAATCAGAAGAACGTAAAA
ATCGTACGAATATCGACAACGCAAAATTGATTATTCAAAGCGTGATTGCCGTATGGTTAATTGTTGCCTTAGCAATGCAC
CTTGCAGCTGTTGGCCTCATTGGTTTATCTGTCATCATTCTTGCAACTGCTTTTACTGGTGTCATTGAAGAGCATGCTAT
GGGTAAGGCATTTGAAGAGGCATTGCCTTTCACTGCATTACTTGCGGTCTTTTTTGCCATTGTCGCAGTGATTATAGATC
AAGAACTATTTAAACCAATTATAGATGCGGTATTAGCAGTTGAAGATAAGAGTTCTCAACTTGCCCTATTCTATGTGGCA
AATGGTATTCTTTCGATGGTCTCTGACAACGTATTTGTTGGTACCGTTTATATTAATGAAGTTAAAACCGCATTACTTGA
TGGTGTTATTACACGAGACCAATTTGACTTATTAGCCGTTGCAATCAATACGGGTACTAACTTACCTTCTGTTGCCACAC
CAAACGGTCAAGCAGCCTTCTTGTTCTTATTAACTTCAGCACTCGCACCATTAATTCAATTATCTTATGGTCGTATGGTT
TGGATGGCTCTGCCATATACCATCGTTTTGGCATTAGTTGGTTTATTTGGTATCTCGTTCTTACTTGAACCAATGACAAC
AATGTTCTACGATTTCGGTTGGATCACACACGGAACGATAGAAGCTGCAACTAATGCCGTTTCTAGTGGTCATTAA

Upstream 100 bases:

>100_bases
TGTTTATCTTTACTAAAAACAATACGTTAGGCGATTATTATCAACTCCTTACTTAACCTTATTTTTATGGAATTAGAGTA
ACAATTGTAGAGAGCATCAC

Downstream 100 bases:

>100_bases
TAATGGCATAGCCACTTTTGATTGACTAAAAGGCTCTGTTTATACGGAGCCTTTCTTTTTACTAAGGAATAATAATGCAA
GCCCTTAACCATTTTTCACG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MSISLGNAFIKNFLGKAPDWYKIAIISFLIINPLVFFFVDPFAAGWLLVVEFIFTLAMALKCYPLQPGGLLAIQAIAIGM
TSAEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAV
GFYAIYHRVASGQGGTPSHDHTCDSNVTDELSRDDLENYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQANWMFG
EFIIRMLPVTAPVFICGLLTCVVVEKLGICGYGAKLPENVRNILEEYESEERKNRTNIDNAKLIIQSVIAVWLIVALAMH
LAAVGLIGLSVIILATAFTGVIEEHAMGKAFEEALPFTALLAVFFAIVAVIIDQELFKPIIDAVLAVEDKSSQLALFYVA
NGILSMVSDNVFVGTVYINEVKTALLDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMV
WMALPYTIVLALVGLFGISFLLEPMTTMFYDFGWITHGTIEAATNAVSSGH

Sequences:

>Translated_531_residues
MSISLGNAFIKNFLGKAPDWYKIAIISFLIINPLVFFFVDPFAAGWLLVVEFIFTLAMALKCYPLQPGGLLAIQAIAIGM
TSAEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAV
GFYAIYHRVASGQGGTPSHDHTCDSNVTDELSRDDLENYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQANWMFG
EFIIRMLPVTAPVFICGLLTCVVVEKLGICGYGAKLPENVRNILEEYESEERKNRTNIDNAKLIIQSVIAVWLIVALAMH
LAAVGLIGLSVIILATAFTGVIEEHAMGKAFEEALPFTALLAVFFAIVAVIIDQELFKPIIDAVLAVEDKSSQLALFYVA
NGILSMVSDNVFVGTVYINEVKTALLDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMV
WMALPYTIVLALVGLFGISFLLEPMTTMFYDFGWITHGTIEAATNAVSSGH
>Mature_530_residues
SISLGNAFIKNFLGKAPDWYKIAIISFLIINPLVFFFVDPFAAGWLLVVEFIFTLAMALKCYPLQPGGLLAIQAIAIGMT
SAEQVKHELVANIEVLLLLVFMVAGIYFMKQLLLFIFTKILIGIKSKTALSVAFCFTAAFLSAFLDALTVIAVVISVAVG
FYAIYHRVASGQGGTPSHDHTCDSNVTDELSRDDLENYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLIIADQANWMFGE
FIIRMLPVTAPVFICGLLTCVVVEKLGICGYGAKLPENVRNILEEYESEERKNRTNIDNAKLIIQSVIAVWLIVALAMHL
AAVGLIGLSVIILATAFTGVIEEHAMGKAFEEALPFTALLAVFFAIVAVIIDQELFKPIIDAVLAVEDKSSQLALFYVAN
GILSMVSDNVFVGTVYINEVKTALLDGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIQLSYGRMVW
MALPYTIVLALVGLFGISFLLEPMTTMFYDFGWITHGTIEAATNAVSSGH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family

Homologues:

Organism=Escherichia coli, GI1787435, Length=515, Percent_Identity=68.7378640776699, Blast_Score=680, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAB_ALISL (B6EIG5)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263518.1
- GeneID:   6988479
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2148
- HOGENOM:   HBG296776
- OMA:   CFLVEKF
- ProtClustDB:   PRK09547
- HAMAP:   MF_01599
- InterPro:   IPR004671
- TIGRFAMs:   TIGR00774

Pfam domain/function: PF06450 NhaB

EC number: NA

Molecular weight: Translated: 57534; Mature: 57403

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x217c06cc)-; HASH(0x21971ea0)-; HASH(0x21976730)-; HASH(0x210e0494)-; HASH(0x213b023c)-; HASH(0x1da12e30)-; HASH(0x215e5d2c)-; HASH(0x2197d4cc)-; HASH(0x1f40ea38)-; HASH(0x219679dc)-; HASH(0x1ffa5a30)-; HASH(0x20c0daf8)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCH
>Mature Secondary Structure 
SISLGNAFIKNFLGKAPDWYKIAIISFLIINPLVFFFVDPFAAGWLLVVEFIFTLAMAL
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA